4-Hydroxyphenylpyruvic acid (BioDeep_00000400000)

Main id: BioDeep_00000001655

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


4-Hydroxyphenylpyruvic acid

化学式: C9H8O4 (180.0423)
中文名称: 4-羟苯基丙酮酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1CC(=O)C(=O)O)O
InChI: InChI=1S/C9H8O4/c10-7(8(11)9(12)13)6-4-2-1-3-5-6/h1-5,7,10H,(H,12,13)

描述信息

A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.
4-Hydroxyphenylpyruvic acid (4-HPPA) is a keto acid. It is a product of the enzyme (R)-4-hydroxyphenyllactate dehydrogenase [EC 1.1.1.222] and is formed during tyrosine metabolism (KEGG). There are two isomers of HPPA, specifically 4HPPA and 3HPPA, of which 4HPPA is the most common. The enzyme 4-hydroxyphenylpyruvic acid dioxygenase (HPD) catalyzes the reaction of 4-hydroxyphenylpyruvic acid to homogentisic acid in the tyrosine catabolism pathway. A deficiency in the catalytic activity of HPD is known to lead to tyrosinemia type III, an autosomal recessive disorder characterized by elevated levels of blood tyrosine and massive excretion of tyrosine derivatives into urine. It has been shown that hawkinsinuria, an autosomal dominant disorder characterized by the excretion of hawkinsin, may also be a result of HPD deficiency (PMID: 11073718). [HMDB]
4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine.
4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine.

同义名列表

5 个代谢物同义名

4-Hydroxyphenylpyruvic acid; 3-(4-Hydroxyphenyl)pyruvate; 4-?Hydroxyphenylpyruvic acid; 3-(4-Hydroxyphenyl)pyruvate; 4-Hydroxyphenylpyruvic acid



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(6)

BioCyc(2)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

65 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ALB, CAT, DDT, FDPS, HPD, MIF, TYR
Peripheral membrane protein 2 HPD, HSD17B6
Endoplasmic reticulum membrane 3 CD4, HPD, TKT
Nucleus 1 ALB
cytosol 10 ALB, CAT, FAH, FDPS, HGD, HPD, MIF, PAH, TAT, TKT
nuclear body 1 TKT
centrosome 1 ALB
nucleoplasm 3 FDPS, MIF, TKT
Cell membrane 2 CD4, TKT
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 2 SLC25A13, SPG7
Golgi apparatus membrane 1 HPD
cell surface 1 MIF
Golgi apparatus 1 ALB
Golgi membrane 1 HPD
lysosomal membrane 1 CP
mitochondrial inner membrane 2 SLC25A13, SPG7
Lysosome 2 IL4I1, TYR
acrosomal vesicle 1 IL4I1
plasma membrane 5 CD4, CP, MIF, SLC25A13, TKT
Membrane 3 CAT, FDPS, SPG7
apical plasma membrane 1 TKT
extracellular exosome 9 ALB, CAT, CP, DDT, FAH, HGD, HPD, MIF, TKT
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 ALB, HSD17B6
extracellular space 4 ALB, CP, DDT, MIF
perinuclear region of cytoplasm 1 TYR
mitochondrion 4 CAT, HPDL, SLC25A13, SPG7
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 3 CAT, HSD17B6, TYR
Microsome membrane 1 HSD17B6
Single-pass type I membrane protein 3 CD4, TKT, TYR
Secreted 4 ALB, CP, IL4I1, MIF
extracellular region 5 ALB, CAT, CP, IL4I1, MIF
mitochondrial matrix 3 CAT, FDPS, HPDL
anchoring junction 1 ALB
external side of plasma membrane 1 CD4
actin cytoskeleton 1 TKT
axon cytoplasm 1 SPG7
Melanosome membrane 1 TYR
Early endosome 1 CD4
Golgi-associated vesicle 1 TYR
vesicle 2 MIF, TKT
Mitochondrion inner membrane 2 SLC25A13, SPG7
Membrane raft 1 CD4
focal adhesion 2 CAT, TKT
Peroxisome 3 CAT, FDPS, TKT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 SLC25A13
mitochondrial intermembrane space 1 SLC25A13
receptor complex 1 TKT
ciliary basal body 1 ALB
centriole 1 ALB
Cytoplasmic vesicle, secretory vesicle, acrosome 1 IL4I1
spindle pole 1 ALB
blood microparticle 2 ALB, CP
sperm midpiece 1 IL4I1
Melanosome 1 TYR
ficolin-1-rich granule lumen 2 CAT, MIF
secretory granule lumen 2 CAT, MIF
endoplasmic reticulum lumen 3 ALB, CD4, CP
platelet alpha granule lumen 1 ALB
immunological synapse 1 IL4I1
clathrin-coated endocytic vesicle membrane 1 CD4
T cell receptor complex 1 CD4
catalase complex 1 CAT
mitochondrial permeability transition pore complex 1 SPG7
ciliary transition fiber 1 ALB
m-AAA complex 1 SPG7


文献列表

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