Mulberrofuran_G (BioDeep_00000396553)

Main id: BioDeep_00000006947

 

PANOMIX_OTCML-2023


代谢物信息卡片


3aH-Benzo[3,4][2]benzopyrano[1,8-bc][1]-benzopyran-4,11-diol, 8a-(2,4-dihydroxphenyl)-1,8a,13b,13c-tetrahydro-6-(6-hydroxy-2-benzofuranyl)-2-methyl-, (3a,S,8aS,13bS,13cR)-

化学式: C34H26O8 (562.1628)
中文名称: 桑呋喃 G
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC2C3C(C1)C4=C(C=C(C=C4)O)OC3(OC5=CC(=CC(=C25)O)C6=CC7=C(O6)C=C(C=C7)O)C8=C(C=C(C=C8)O)O
InChI: InChI=1S/C34H26O8/c1-16-8-23-22-6-4-21(37)15-30(22)41-34(25-7-5-19(35)13-26(25)38)33(23)24(9-16)32-27(39)10-18(12-31(32)42-34)28-11-17-2-3-20(36)14-29(17)40-28/h2-7,9-15,23-24,33,35-39H,8H2,1H3

描述信息

1-(2,4-Dihydroxyphenyl)-17-(6-hydroxy-1-benzofuran-2-yl)-11-methyl-2,20-dioxapentacyclo[11.7.1.03,8.09,21.014,19]henicosa-3(8),4,6,11,14,16,18-heptaene-5,15-diol is a natural product found in Morus lhou, Morus alba, and Broussonetia with data available.
Mulberrofuran G protects ischemic injury-induced cell death via inhibition of NOX4-mediated ROS generation and ER stress[1]. Mulberrofuran G shows moderate inhibiting activity of hepatitis B virus (HBV) DNA replication with IC50 of 3.99 μM[2].
Mulberrofuran G protects ischemic injury-induced cell death via inhibition of NOX4-mediated ROS generation and ER stress[1]. Mulberrofuran G shows moderate inhibiting activity of hepatitis B virus (HBV) DNA replication with IC50 of 3.99 μM[2].
Mulberrofuran G protects ischemic injury-induced cell death via inhibition of NOX4-mediated ROS generation and ER stress[1]. Mulberrofuran G shows moderate inhibiting activity of hepatitis B virus (HBV) DNA replication with IC50 of 3.99 μM[2].

同义名列表

7 个代谢物同义名

3aH-Benzo[3,4][2]benzopyrano[1,8-bc][1]-benzopyran-4,11-diol, 8a-(2,4-dihydroxphenyl)-1,8a,13b,13c-tetrahydro-6-(6-hydroxy-2-benzofuranyl)-2-methyl-, (3a,S,8aS,13bS,13cR)-; 1-(2,4-Dihydroxyphenyl)-17-(6-hydroxy-1-benzofuran-2-yl)-11-methyl-2,20-dioxapentacyclo[11.7.1.03,8.09,21.014,19]henicosa-3(8),4,6,11,14,16,18-heptaene-5,15-diol; UNII-39PXQ8D28J; Mulberrofuran G; 39PXQ8D28J; Albanol A; Albanol A



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 BCL2, CASP2, CASP3, CASP9, NOX4, PTGS2, TYR, XBP1
Peripheral membrane protein 2 PTGS2, XBP1
Endoplasmic reticulum membrane 8 ATP2A1, ATP2A2, BCL2, HMOX1, HSP90B1, NOX4, PTGS2, XBP1
Nucleus 9 BCL2, CASP2, CASP3, CASP9, GABPA, HMOX1, HSP90B1, NOX4, XBP1
cytosol 7 BCL2, CASP2, CASP3, CASP9, HMOX1, HSP90B1, XBP1
nucleoplasm 4 CASP3, GABPA, HMOX1, XBP1
RNA polymerase II transcription regulator complex 1 XBP1
Cell membrane 1 NOX4
Cytoplasmic side 1 HMOX1
Multi-pass membrane protein 4 ATP2A1, ATP2A2, DUOX1, NOX4
cell surface 1 DUOX1
glutamatergic synapse 1 CASP3
Golgi membrane 1 INS
lysosomal membrane 1 GAA
neuronal cell body 1 CASP3
smooth endoplasmic reticulum 1 HSP90B1
Lysosome 2 GAA, TYR
plasma membrane 5 ATP2A2, DUOX1, GAA, MUC5AC, NOX4
Membrane 9 ATP2A1, ATP2A2, BCL2, DUOX1, GAA, HMOX1, HSP90B1, NOX4, XBP1
apical plasma membrane 1 DUOX1
caveola 1 PTGS2
extracellular exosome 3 GAA, HSP90B1, MUC5AC
Lysosome membrane 1 GAA
endoplasmic reticulum 8 ATP2A2, BCL2, DUOX1, HMOX1, HSP90B1, NOX4, PTGS2, XBP1
extracellular space 5 CTRL, HMOX1, IL6, INS, MUC5AC
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 5 ATP2A1, HMOX1, HSP90B1, NOX4, TYR
mitochondrion 4 ATP2A1, BCL2, CASP9, NOX4
protein-containing complex 4 BCL2, CASP9, HSP90B1, PTGS2
intracellular membrane-bounded organelle 2 GAA, TYR
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 TYR
Secreted 4 GAA, IL6, INS, MUC5AC
extracellular region 6 DNAH9, GAA, HSP90B1, IL6, INS, MUC5AC
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
motile cilium 1 DNAH9
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
nucleolus 2 CASP2, NOX4
Melanosome membrane 1 TYR
midbody 1 HSP90B1
Golgi-associated vesicle 1 TYR
Single-pass type II membrane protein 1 XBP1
Apical cell membrane 1 DUOX1
Cytoplasm, perinuclear region 1 NOX4
pore complex 1 BCL2
Cell junction, focal adhesion 1 NOX4
focal adhesion 2 HSP90B1, NOX4
microtubule 1 DNAH9
extracellular matrix 1 MUC5AC
sarcoplasmic reticulum 2 ATP2A1, ATP2A2
collagen-containing extracellular matrix 1 HSP90B1
axoneme 1 DNAH9
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
chromatin 1 GABPA
cell leading edge 1 DUOX1
[Isoform 5]: Cytoplasm 1 NOX4
Nucleus, nucleolus 1 NOX4
Cytoplasm, cytoskeleton, cilium axoneme 1 DNAH9
Endomembrane system 1 ATP2A1
endosome lumen 1 INS
I band 1 ATP2A1
tertiary granule membrane 1 GAA
Melanosome 2 HSP90B1, TYR
myelin sheath 1 BCL2
sperm plasma membrane 1 HSP90B1
[Isoform 3]: Cytoplasm 1 NOX4
secretory granule lumen 1 INS
Golgi lumen 2 INS, MUC5AC
endoplasmic reticulum lumen 4 HSP90B1, IL6, INS, PTGS2
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Sarcoplasmic reticulum membrane 2 ATP2A1, ATP2A2
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
9+2 motile cilium 1 DNAH9
dynein complex 1 DNAH9
Single-pass type IV membrane protein 1 HMOX1
perinuclear endoplasmic reticulum 1 NOX4
apoptosome 1 CASP9
Sarcoplasmic reticulum lumen 1 HSP90B1
calcium channel complex 1 ATP2A1
endoplasmic reticulum-Golgi intermediate compartment 1 ATP2A1
H zone 1 ATP2A1
platelet dense tubular network membrane 2 ATP2A1, ATP2A2
[Isoform 2]: Nucleus 1 XBP1
[Isoform 1]: Nucleus 1 XBP1
ficolin-1-rich granule membrane 1 GAA
death-inducing signaling complex 1 CASP3
mucus layer 1 MUC5AC
ribbon synapse 1 ATP2A2
[Isoform 4]: Nucleus 1 NOX4
endocytic vesicle lumen 1 HSP90B1
NADPH oxidase complex 2 DUOX1, NOX4
interleukin-6 receptor complex 1 IL6
endoplasmic reticulum chaperone complex 1 HSP90B1
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
[Isoform 6]: Cytoplasm 1 NOX4
calcium ion-transporting ATPase complex 1 ATP2A2
longitudinal sarcoplasmic reticulum 1 ATP2A2
[X-box-binding protein 1, cytoplasmic form]: Cytoplasm 1 XBP1
endopeptidase complex 1 CASP2
caspase complex 1 CASP9
outer dynein arm 1 DNAH9
distal portion of axoneme 1 DNAH9


文献列表

  • Fatma M Abdel Bar, Ghada M Abbas, Ahmed A Gohar, Mohamed-Farid I Lahloub. Antiproliferative activity of stilbene derivatives and other constituents from the stem bark of Morus nigra L. Natural product research. 2020 Dec; 34(24):3506-3513. doi: 10.1080/14786419.2019.1573236. [PMID: 30822142]
  • Pradeep Paudel, Se Eun Park, Su Hui Seong, Hyun Ah Jung, Jae Sue Choi. Novel Diels-Alder Type Adducts from Morus alba Root Bark Targeting Human Monoamine Oxidase and Dopaminergic Receptors for the Management of Neurodegenerative Diseases. International journal of molecular sciences. 2019 Dec; 20(24):. doi: 10.3390/ijms20246232. [PMID: 31835621]
  • Pradeep Paudel, Ting Yu, Su Hui Seong, Eun Bi Kuk, Hyun Ah Jung, Jae Sue Choi. Protein Tyrosine Phosphatase 1B Inhibition and Glucose Uptake Potentials of Mulberrofuran G, Albanol B, and Kuwanon G from Root Bark of Morus alba L. in Insulin-Resistant HepG2 Cells: An In Vitro and In Silico Study. International journal of molecular sciences. 2018 May; 19(5):. doi: 10.3390/ijms19051542. [PMID: 29786669]
  • Ming Li, Xuewei Wu, Xiaoning Wang, Tao Shen, Dongmei Ren. Two novel compounds from the root bark of Morus alba L. Natural product research. 2018 Jan; 32(1):36-42. doi: 10.1080/14786419.2017.1327862. [PMID: 28521570]
  • Ghada M Abbas, Fatma M Abdel Bar, Hany N Baraka, Ahmed A Gohar, Mohammed-Farid Lahloub. A new antioxidant stilbene and other constituents from the stem bark of Morus nigra L. Natural product research. 2014; 28(13):952-9. doi: 10.1080/14786419.2014.900770. [PMID: 24673367]
  • Chang-An Geng, Yun-Bao Ma, Xue-Mei Zhang, Shu-Ying Yao, Duo-Qing Xue, Rong-Ping Zhang, Ji-Jun Chen. Mulberrofuran G and isomulberrofuran G from Morus alba L.: anti-hepatitis B virus activity and mass spectrometric fragmentation. Journal of agricultural and food chemistry. 2012 Aug; 60(33):8197-202. doi: 10.1021/jf302639b. [PMID: 22835135]
  • Takashi Kikuchi, Masatoshi Nihei, Hisashi Nagai, Hidekuni Fukushi, Keiichi Tabata, Takashi Suzuki, Toshihiro Akihisa. Albanol A from the root bark of Morus alba L. induces apoptotic cell death in HL60 human leukemia cell line. Chemical & pharmaceutical bulletin. 2010 Apr; 58(4):568-71. doi: 10.1248/cpb.58.568. [PMID: 20410645]
  • Qing-Jian Zhang, Yan-Bo Tang, Ruo-Yun Chen, De-Quan Yu. Three new cytotoxic Diels-Alder-type adducts from Morus australis. Chemistry & biodiversity. 2007 Jul; 4(7):1533-40. doi: 10.1002/cbdv.200790133. [PMID: 17638335]