Kainic acid (BioDeep_00000396427)

 

Secondary id: BioDeep_00000003872

PANOMIX_OTCML-2023 Chemicals and Drugs natural product


代谢物信息卡片


(2S,3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-carboxylic acid

化学式: C10H15NO4 (213.1001)
中文名称: 海人草酸, 海藻酸, 卡英酸
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 80.37%

Reviewed

Last reviewed on 2024-08-14.

Cite this Page

Kainic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/kainic_acid (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000396427). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C=C(C)C1CNC(C(=O)O)C1CC(=O)O
InChI: InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1

描述信息

Kainic acid is a dicarboxylic acid, a pyrrolidinecarboxylic acid, a L-proline derivative and a non-proteinogenic L-alpha-amino acid. It has a role as an antinematodal drug and an excitatory amino acid agonist. It is a conjugate acid of a kainate(1-).
(2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018690 - Excitatory Amino Acid Agonists
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
Kainic acid is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid induces seizures[1][2].
Kainic acid is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid induces seizures[1][2].

同义名列表

56 个代谢物同义名

InChI=1/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s; 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, (2S-(2-alpha,3-beta,4-beta))-; (2S-(2.ALPHA.,3.BETA.,4.BETA.))-2-CARBOXY-4-(1-METHYLETHENYL)-3-PYRROLIDINEACETIC ACID; 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, (2S-(2alpha,3beta,4beta))-; (2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid; (2S,3S,4S)-3-(Carboxymethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid; (2S,3S,4S)-3-(Carboxymethyl)-4-Prop-1-En-2-yl-Pyrrolidine-2-Carboxylicacid; (2S,3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-carboxylic acid; 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, (2S,3S,4S)-; (2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid; L-proline, 3-(carboxymethyl)-4-(1-methylethenyl)-, (3S,4S)-; 2S-CARBOXY-4S-(1-METHYLETHENYL)-3S-PYRROLDINEACETIC ACID; (3S,4R)-3-(carboxymethyl)-4-(prop-1-en-2-yl)-L-proline; rel-(3R,4R)-3-(carboxymethyl)-4-isopropenyl-D-proline; (3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-yl-L-proline; 3-Pyrrolidineacetic acid, 2-carboxy-4-isopropenyl-; 2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine; 2-Carboxy-4-isopropenyl-3-pyrrolidineacetic acid; 4-22-00-01523 (Beilstein Handbook Reference); 3-(Carboxymethyl)-4-isopropenylproline; Acide kainique [INN-French]; Acidum kainicum [INN-Latin]; Acido kainico [INN-Spanish]; (-)-(.alpha.)-Kainic Acid; Kainic acid (synthetic); Kainic acid [INN:JAN]; KAINIC ACID [WHO-DD]; L-alpha-Kainic acid; alpha- Kainic acid; KAINIC ACID [INN]; alpha-Kainic acid; KAINIC ACID [MI]; Acidum kainicum; rac Kainic Acid; Acide kainique; Tox21_110905_1; BPBio1_001306; Lopac0_000656; Acid, Digenic; Acido kainico; Tox21_500656; Digenic acid; Acid, Kainic; Tox21_110905; Kainic acid; Digensaeure; kainic-acid; Kainsaeure; C10H15NO4; Helminal; Digenin; Kainate; 1p1n; KAI; Kainic acid; (-)-?Kainic acid



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

44 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 CA2, DCX, DLG4, GAD1, GRIN2B, PVALB, RBFOX3
Golgi apparatus, trans-Golgi network membrane 1 DLG4
Endoplasmic reticulum membrane 2 GRIN2B, GRIN2D
Nucleus 2 FOS, RBFOX3
cytosol 5 CA2, DCX, DLG4, FOS, PRKCQ
dendrite 3 DRD2, GRIA2, HTR1A
nucleoplasm 2 FOS, GRIK5
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 10 CA2, DLG4, DRD2, GRIA2, GRIK1, GRIK4, GRIK5, GRIN2B, GRIN2D, HTR1A
Lipid-anchor 1 DLG4
Cytoplasmic side 1 DLG4
Cell projection, axon 1 DLG4
Early endosome membrane 1 DLG4
Multi-pass membrane protein 9 CACNA1I, DRD2, GRIA2, GRIK1, GRIK4, GRIK5, GRIN2B, HTR1A, KCNA3
Golgi apparatus membrane 2 DLG4, DRD2
Synapse 5 CRH, DLG4, DRD2, HTR1A, PVALB
cell cortex 1 GAD1
cell junction 1 DLG4
cell surface 1 GRIN2B
glutamatergic synapse 6 DCX, DLG4, DRD2, GRIN2D, KCNA3, NETO2
Golgi membrane 2 DLG4, DRD2
neuromuscular junction 1 DLG4
neuronal cell body 1 GRIA2
postsynapse 1 GRIA2
presynaptic membrane 5 DRD2, GRIK1, GRIK4, GRIK5, KCNA3
synaptic vesicle 1 DLG4
Lysosome 1 GRIN2B
Presynapse 1 DLG4
acrosomal vesicle 1 DRD2
plasma membrane 14 CA2, CACNA1I, DLG4, DRD2, GAD1, GRIA2, GRIK1, GRIK4, GRIK5, GRIN2B, GRIN2D, HTR1A, KCNA3, PRKCQ
presynaptic active zone 1 GAD1
synaptic vesicle membrane 1 DRD2
Membrane 7 CACNA1I, GRIA2, GRIK4, GRIK5, GRIN2B, KCNA3, NETO2
axon 4 DLG4, DRD2, KCNA3, PVALB
basolateral plasma membrane 1 DLG4
extracellular exosome 1 CA2
endoplasmic reticulum 3 DLG4, FOS, GRIK5
extracellular space 1 CRH
perinuclear region of cytoplasm 2 GAD1, KCNA3
adherens junction 1 DLG4
intracellular membrane-bounded organelle 1 GRIK1
postsynaptic density 4 DLG4, GRIA2, GRIN2B, NETO2
Single-pass type I membrane protein 1 NETO2
Secreted 1 CRH
extracellular region 1 CRH
excitatory synapse 2 DLG4, GRIA2
hippocampal mossy fiber to CA3 synapse 3 GRIK4, GRIK5, GRIN2D
centriolar satellite 1 PRKCQ
ciliary membrane 1 DRD2
external side of plasma membrane 1 GRIA2
varicosity 1 CRH
dendritic spine 3 DLG4, DRD2, GRIA2
neuronal dense core vesicle lumen 1 CRH
perikaryon 3 CRH, DRD2, RBFOX3
neuron spine 1 DLG4
apical part of cell 1 CA2
postsynaptic membrane 8 DLG4, DRD2, GRIA2, GRIK1, GRIK4, GRIN2B, GRIN2D, KCNA3
presynaptic active zone membrane 1 GRIN2D
Membrane raft 1 KCNA3
Cytoplasm, cytoskeleton 2 DLG4, GRIN2B
microtubule 1 DCX
GABA-ergic synapse 2 DRD2, GAD1
Cell projection, dendritic spine 1 DLG4
lateral plasma membrane 1 DRD2
Postsynaptic cell membrane 5 GRIA2, GRIK1, GRIK4, GRIK5, GRIN2B
dendrite cytoplasm 1 DLG4
kainate selective glutamate receptor complex 3 GRIK1, GRIK4, GRIK5
Late endosome 1 GRIN2B
Cell projection, neuron projection 1 DCX
neuron projection 3 DCX, DLG4, GRIN2B
cilium 1 DRD2
chromatin 1 FOS
microtubule associated complex 1 DCX
cell projection 2 GRIK4, GRIK5
cytoskeleton 3 DCX, DLG4, GRIN2B
non-motile cilium 1 DRD2
[Isoform 2]: Cell membrane 1 KCNA3
sperm flagellum 1 DRD2
AMPA glutamate receptor complex 2 DLG4, GRIA2
Cell projection, dendrite 3 DLG4, GRIN2B, HTR1A
Presynaptic cell membrane 2 GRIK4, GRIK5
myelin sheath 1 CA2
synaptic membrane 2 DLG4, GRIN2B
voltage-gated potassium channel complex 1 KCNA3
trans-Golgi network membrane 1 DLG4
nuclear matrix 1 FOS
cortical actin cytoskeleton 1 DLG4
axon terminus 2 DRD2, GAD1
voltage-gated calcium channel complex 1 CACNA1I
endocytic vesicle membrane 2 DLG4, GRIA2
endocytic vesicle 1 DRD2
cerebellar mossy fiber 1 DLG4
postsynaptic density membrane 8 DLG4, GRIA2, GRIK1, GRIK4, GRIK5, GRIN2B, GRIN2D, NETO2
postsynaptic endocytic zone 1 GRIA2
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
calyx of Held 1 KCNA3
vesicle membrane 1 GAD1
protein-DNA complex 1 FOS
NMDA selective glutamate receptor complex 2 GRIN2B, GRIN2D
[Isoform 1]: Cell membrane 1 KCNA3
dopaminergic synapse 1 DRD2
inhibitory synapse 1 GAD1
transcription factor AP-1 complex 1 FOS
cortical cytoskeleton 1 DLG4
asymmetric synapse 1 GRIA2
neuron projection terminus 1 DLG4
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane 1 GAD1
G protein-coupled receptor complex 1 DRD2
juxtaparanode region of axon 1 DLG4
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
Golgi cis cisterna 1 DLG4


文献列表

  • Cheng-Wei Lu, Tzu-Yu Lin, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang. Gypenoside XVII Reduces Synaptic Glutamate Release and Protects against Excitotoxic Injury in Rats. Biomolecules. 2024 May; 14(5):. doi: 10.3390/biom14050589. [PMID: 38785996]
  • Tzu-Kang Lin, Kun-Chieh Yeh, Ming-Shang Pai, Pei-Wen Hsieh, Su-Jane Wang. Ursolic acid inhibits the synaptic release of glutamate and prevents glutamate excitotoxicity in rats. European journal of pharmacology. 2024 Jan; 963(?):176280. doi: 10.1016/j.ejphar.2023.176280. [PMID: 38113967]
  • Ming-Shang Pai, Kaw-Chen Wang, Kun-Chieh Yeh, Su-Jane Wang. Stabilization of mitochondrial function by chlorogenic acid protects against kainic acid-induced seizures and neuronal cell death in rats. European journal of pharmacology. 2023 Dec; 961(?):176197. doi: 10.1016/j.ejphar.2023.176197. [PMID: 38000721]
  • Miaomiao Du, Jing Wang, Yuan Jin, Jingfeng Fan, Shuaijun Zan, Zelong Li. Response mechanism of microbial community during anaerobic biotransformation of marine toxin domoic acid. Environmental research. 2022 12; 215(Pt 2):114410. doi: 10.1016/j.envres.2022.114410. [PMID: 36154856]
  • Antoine Kavaye Kandeda, Saleh Nodeina, Symphorien Talom Mabou. An aqueous extract of Syzygium cumini protects against kainate-induced status epilepticus and amnesia: evidence for antioxidant and anti-inflammatory intervention. Metabolic brain disease. 2022 10; 37(7):2581-2602. doi: 10.1007/s11011-022-01052-y. [PMID: 35916986]
  • Taiwo G Olubodun-Obadun, Ismail O Ishola, Benneth Ben-Azu, Olasunmbo Afolayan, Ekene Nwose, Ayorinde B James, Abayomi M Ajayi, Solomon Umukoro, Olufunmilayo O Adeyemi. Probable mechanisms involved in the antiepileptic activity of Clerodendrum polycephalum Baker (Labiatae) leaf extract in mice exposed to chemical-induced seizures. Journal of food biochemistry. 2022 10; 46(10):e14342. doi: 10.1111/jfbc.14342. [PMID: 35851712]
  • Zhangjin Qin, Jiaqi Song, Aolei Lin, Wei Yang, Wenbo Zhang, Fuxin Zhong, Lihong Huang, Yang Lü, Weihua Yu. GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome. Journal of neuroinflammation. 2022 May; 19(1):121. doi: 10.1186/s12974-022-02482-2. [PMID: 35624482]
  • Wei-Horng Jean, Chih-Ta Huang, Jung-Hsuan Hsu, Kuan-Ming Chiu, Ming-Yi Lee, Jiann-Shing Shieh, Tzu-Yu Lin, Su-Jane Wang. Anticonvulsive and Neuroprotective Effects of Eupafolin in Rats Are Associated with the Inhibition of Glutamate Overexcitation and Upregulation of the Wnt/β-Catenin Signaling Pathway. ACS chemical neuroscience. 2022 05; 13(10):1594-1603. doi: 10.1021/acschemneuro.2c00227. [PMID: 35500294]
  • Edavalath Methal Ramya, Garlapati Phani Kumar, Yadavalli Chandrasekhar, Kandangath Raghavan Anilakumar. Adaptogenic potential of ginsenosides against domoic acid-induced toxicity by regulating neuronal stress and kinate receptors: Ex vivo and in silico studies. Journal of food biochemistry. 2022 05; 46(5):e14089. doi: 10.1111/jfbc.14089. [PMID: 35102569]
  • Antoine Kavaye Kandeda, Symphorien Talom Mabou, Clémentine Moutchida. An aqueous extract of Lantana camara attenuates seizures, memory impairment, and anxiety in kainate-treated mice: Evidence of GABA level, oxidative stress, immune and neuronal loss modulation. Epilepsy & behavior : E&B. 2022 04; 129(?):108611. doi: 10.1016/j.yebeh.2022.108611. [PMID: 35193072]
  • Milos Bogdanovic, Hila Asraf, Noa Gottesman, Israel Sekler, Elias Aizenman, Michal Hershfinkel. The ZIP3 Zinc Transporter Is Localized to Mossy Fiber Terminals and Is Required for Kainate-Induced Degeneration of CA3 Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022 03; 42(13):2824-2834. doi: 10.1523/jneurosci.0908-21.2022. [PMID: 35169020]
  • Cheng-Wei Lu, Chen-Jung Lin, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin, Su-Jane Wang. An Anthranilate Derivative Inhibits Glutamate Release and Glutamate Excitotoxicity in Rats. International journal of molecular sciences. 2022 Feb; 23(5):. doi: 10.3390/ijms23052641. [PMID: 35269784]
  • Lubing Li, Xiahatai Ayiding, Ran Han. miRNA-Gene Interaction Network Construction Strategy to Discern Promising Traditional Chinese Medicine against Osteoporosis. BioMed research international. 2022; 2022(?):9093614. doi: 10.1155/2022/9093614. [PMID: 35757478]
  • Xiaomao Li, Yan Liu, Siyi Wang, Yikai Jiang, Adnan Mohammed Algradi, Yuanyuan Zhou, Juan Pan, Wei Guan, Haixue Kuang, Bingyou Yang. The Aerial Parts of Bupleurum Chinense DC. Aromatic Oil Attenuate Kainic Acid-Induced Epilepsy-Like Behavior and Its Potential Mechanisms. BioMed research international. 2022; 2022(?):1234612. doi: 10.1155/2022/1234612. [PMID: 35445130]
  • Ali Hasanvand, Azam Hosseinzadeh, Morteza Saeedavi, Mehdi Goudarzi, Zahra Basir, Saeed Mehrzadi. Neuroprotective effects of tannic acid against kainic acid-induced seizures in mice. Human & experimental toxicology. 2022 Jan; 41(?):9603271221093989. doi: 10.1177/09603271221093989. [PMID: 35544363]
  • Tomoya Sano, Yasushi Masuda, Hironobu Yasuno, Tadahiro Shinozawa, Takeshi Watanabe, Masaaki Kakehi. Blood Neurofilament Light Chain as a Potential Biomarker for Central and Peripheral Nervous Toxicity in Rats. Toxicological sciences : an official journal of the Society of Toxicology. 2021 12; 185(1):10-18. doi: 10.1093/toxsci/kfab122. [PMID: 34677616]
  • Emmanuel S Ojo, Ismail O Ishola, Olasunmbo Afolayan, Ayorinde B James, Benneth Ben-Azu, Olufunmilayo O Adeyemi. Cnestis ferruginea Vahl ex DC (Connaraceae) downregulates expression of immediate early genes in kainic acid-induced temporal lobe epilepsy in mice. Drug metabolism and personalized therapy. 2021 12; 37(2):191-200. doi: 10.1515/dmpt-2021-0145. [PMID: 34881530]
  • Yi-Chieh Hung, Yi-Hsiu Kuo, Pei-Wen Hsieh, Ting-Yang Hsieh, Jinn-Rung Kuo, Su-Jane Wang. Chlorogenic Acid Decreases Glutamate Release from Rat Cortical Nerve Terminals by P/Q-Type Ca2+ Channel Suppression: A Possible Neuroprotective Mechanism. International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111447. [PMID: 34768876]
  • Wei Lin, Xiao Qian, Li-Kun Yang, Jie Zhu, Dan Wang, Chun-Hua Hang, Yuhai Wang, Tao Chen. Inhibition of miR-134-5p protects against kainic acid-induced excitotoxicity through Sirt3-mediated preservation of mitochondrial function. Epilepsy research. 2021 10; 176(?):106722. doi: 10.1016/j.eplepsyres.2021.106722. [PMID: 34273723]
  • Cara L Field, Sophie T Whoriskey, Xianguo Zhao, Mark G Papich. PHARMACOKINETICS OF SUBCUTANEOUS ALPHA LIPOIC ACID, A PROPOSED THERAPEUTIC AID FOR DOMOIC ACID INTOXICATION IN CALIFORNIA SEA LIONS (ZALOPHUS CALIFORNIANUS). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2021 Sep; 52(3):872-879. doi: 10.1638/2020-0223. [PMID: 34687502]
  • Yingchun Xiang, Yumiao Niu, Yacong Xie, Shishuo Chen, Feng Zhu, Weida Shen, Ling-Hui Zeng. Inhibition of RhoA/Rho kinase signaling pathway by fasudil protects against kainic acid-induced neurite injury. Brain and behavior. 2021 08; 11(8):e2266. doi: 10.1002/brb3.2266. [PMID: 34156163]
  • Shaunik Sharma, Steven Carlson, Adriana Gregory-Flores, Andy Hinojo-Perez, Ashley Olson, Thimmasettappa Thippeswamy. Mechanisms of disease-modifying effect of saracatinib (AZD0530), a Src/Fyn tyrosine kinase inhibitor, in the rat kainate model of temporal lobe epilepsy. Neurobiology of disease. 2021 08; 156(?):105410. doi: 10.1016/j.nbd.2021.105410. [PMID: 34087381]
  • Emily K Bowers, Raphaela Stimmelmayr, Kathi A Lefebvre. Stability of Domoic Acid in 50\% Methanol Extracts and Raw Fecal Material from Bowhead Whales (Balaena mysticetus). Marine drugs. 2021 Jul; 19(8):. doi: 10.3390/md19080423. [PMID: 34436262]
  • Zhou Wu, Tushar Deshpande, Lukas Henning, Peter Bedner, Gerald Seifert, Christian Steinhäuser. Cell death of hippocampal CA1 astrocytes during early epileptogenesis. Epilepsia. 2021 07; 62(7):1569-1583. doi: 10.1111/epi.16910. [PMID: 33955001]
  • Elva Martin-Batista, Laura E Maglio, Natalia Armas-Capote, Guadalberto Hernández, Diego Alvarez de la Rosa, Teresa Giraldez. SGK1.1 limits brain damage after status epilepticus through M current-dependent and independent mechanisms. Neurobiology of disease. 2021 06; 153(?):105317. doi: 10.1016/j.nbd.2021.105317. [PMID: 33639207]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Corinne M Gibble, Raphael M Kudela, Susan Knowles, Barbara Bodenstein, Kathi A Lefebvre. Domoic acid and saxitoxin in seabirds in the United States between 2007 and 2018. Harmful algae. 2021 03; 103(?):101981. doi: 10.1016/j.hal.2021.101981. [PMID: 33980431]
  • Antoine Kavaye Kandeda, Fleur Clarisse Okomolo Moto, Jean Pierre Omam Omam, Rigobert Espoir Mbomo Ayissi, Lucie Ojong, Elisabeth Ngo Bum. Pergularia daemia alters epileptogenesis and attenuates cognitive impairment in kainate-treated mice: Insight into anti-inflammatory mechanisms. Epilepsy & behavior : E&B. 2021 02; 115(?):107707. doi: 10.1016/j.yebeh.2020.107707. [PMID: 33429138]
  • Spencer E Fire, Andrea Bogomolni, Robert A DiGiovanni, Greg Early, Tod A Leighfield, Keith Matassa, Glenn A Miller, Kathleen M T Moore, Michael Moore, Misty Niemeyer, Katie Pugliares, Zhihong Wang, Frederick W Wenzel. An assessment of temporal, spatial and taxonomic trends in harmful algal toxin exposure in stranded marine mammals from the U.S. New England coast. PloS one. 2021; 16(1):e0243570. doi: 10.1371/journal.pone.0243570. [PMID: 33406141]
  • Szu Kai Hsu, Chi Feng Hung, Hsiao Ching Yang, Jing Ru Weng, Su Jane Wang. TCD, a triterpenoid isolated from wild bitter gourd, reduces synaptosomal release of glutamate and protects against kainic acid-induced neuronal death. Food & function. 2020 Nov; 11(11):9858-9867. doi: 10.1039/d0fo02039g. [PMID: 33089839]
  • Gary P Brennan, Sebastian Bauer, Tobias Engel, Eva M Jimenez-Mateos, Federico Del Gallo, Thomas D M Hill, Niamh M C Connolly, Lara S Costard, Valentin Neubert, Beatrice Salvetti, Amaya Sanz-Rodriguez, Mona Heiland, Omar Mamad, Elizabeth Brindley, Braxton Norwood, Aasia Batool, Rana Raoof, Hany El-Naggar, Cristina R Reschke, Norman Delanty, Jochen H M Prehn, Paolo Fabene, Catherine Mooney, Felix Rosenow, David C Henshall. Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy. Neurobiology of disease. 2020 10; 144(?):105048. doi: 10.1016/j.nbd.2020.105048. [PMID: 32800995]
  • Santosh Rijal, Dong Hyu Cho, Seon-Ah Park, Seon Hui Jang, István M Ábrahám, Seong Kyu Han. Melatonin Suppresses the Kainate Receptor-Mediated Excitation on Gonadotropin-Releasing Hormone Neurons in Female and Male Prepubertal Mice. International journal of molecular sciences. 2020 Aug; 21(17):. doi: 10.3390/ijms21175991. [PMID: 32825350]
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