Digenin (BioDeep_00000003872)
Main id: BioDeep_00000396427
PANOMIX_OTCML-2023
代谢物信息卡片
(2S,3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-carboxylic acid
化学式: C10H15NO4 (213.100103)
中文名称: 海藻酸(mM/ml)
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C=C(C)C1CNC(C(=O)O)C1CC(=O)O
InChI: InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
描述信息
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018690 - Excitatory Amino Acid Agonists
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
Kainic acid is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid induces seizures[1][2].
Kainic acid is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid induces seizures[1][2].
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:31746
- KEGG: C12819
- PubChem: 10255
- PubChem: 3816
- Metlin: METLIN44252
- ChEMBL: CHEMBL275040
- MeSH: Kainic Acid
- CAS: 4071-38-9
- CAS: 487-79-6
- PMhub: MS000012853
- PubChem: 583208
- PDB-CCD: KAI
- NIKKAJI: J9.244D
- medchemexpress: HY-N2309
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Cheng-Wei Lu, Tzu-Yu Lin, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang. Gypenoside XVII Reduces Synaptic Glutamate Release and Protects against Excitotoxic Injury in Rats.
Biomolecules.
2024 May; 14(5):. doi:
10.3390/biom14050589. [PMID: 38785996] - Tzu-Kang Lin, Kun-Chieh Yeh, Ming-Shang Pai, Pei-Wen Hsieh, Su-Jane Wang. Ursolic acid inhibits the synaptic release of glutamate and prevents glutamate excitotoxicity in rats.
European journal of pharmacology.
2024 Jan; 963(?):176280. doi:
10.1016/j.ejphar.2023.176280. [PMID: 38113967] - Ming-Shang Pai, Kaw-Chen Wang, Kun-Chieh Yeh, Su-Jane Wang. Stabilization of mitochondrial function by chlorogenic acid protects against kainic acid-induced seizures and neuronal cell death in rats.
European journal of pharmacology.
2023 Dec; 961(?):176197. doi:
10.1016/j.ejphar.2023.176197. [PMID: 38000721] - Miaomiao Du, Jing Wang, Yuan Jin, Jingfeng Fan, Shuaijun Zan, Zelong Li. Response mechanism of microbial community during anaerobic biotransformation of marine toxin domoic acid.
Environmental research.
2022 12; 215(Pt 2):114410. doi:
10.1016/j.envres.2022.114410. [PMID: 36154856] - Antoine Kavaye Kandeda, Saleh Nodeina, Symphorien Talom Mabou. An aqueous extract of Syzygium cumini protects against kainate-induced status epilepticus and amnesia: evidence for antioxidant and anti-inflammatory intervention.
Metabolic brain disease.
2022 10; 37(7):2581-2602. doi:
10.1007/s11011-022-01052-y. [PMID: 35916986] - Taiwo G Olubodun-Obadun, Ismail O Ishola, Benneth Ben-Azu, Olasunmbo Afolayan, Ekene Nwose, Ayorinde B James, Abayomi M Ajayi, Solomon Umukoro, Olufunmilayo O Adeyemi. Probable mechanisms involved in the antiepileptic activity of Clerodendrum polycephalum Baker (Labiatae) leaf extract in mice exposed to chemical-induced seizures.
Journal of food biochemistry.
2022 10; 46(10):e14342. doi:
10.1111/jfbc.14342. [PMID: 35851712] - Zhangjin Qin, Jiaqi Song, Aolei Lin, Wei Yang, Wenbo Zhang, Fuxin Zhong, Lihong Huang, Yang Lü, Weihua Yu. GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome.
Journal of neuroinflammation.
2022 May; 19(1):121. doi:
10.1186/s12974-022-02482-2. [PMID: 35624482] - Wei-Horng Jean, Chih-Ta Huang, Jung-Hsuan Hsu, Kuan-Ming Chiu, Ming-Yi Lee, Jiann-Shing Shieh, Tzu-Yu Lin, Su-Jane Wang. Anticonvulsive and Neuroprotective Effects of Eupafolin in Rats Are Associated with the Inhibition of Glutamate Overexcitation and Upregulation of the Wnt/β-Catenin Signaling Pathway.
ACS chemical neuroscience.
2022 05; 13(10):1594-1603. doi:
10.1021/acschemneuro.2c00227. [PMID: 35500294] - Edavalath Methal Ramya, Garlapati Phani Kumar, Yadavalli Chandrasekhar, Kandangath Raghavan Anilakumar. Adaptogenic potential of ginsenosides against domoic acid-induced toxicity by regulating neuronal stress and kinate receptors: Ex vivo and in silico studies.
Journal of food biochemistry.
2022 05; 46(5):e14089. doi:
10.1111/jfbc.14089. [PMID: 35102569] - Antoine Kavaye Kandeda, Symphorien Talom Mabou, Clémentine Moutchida. An aqueous extract of Lantana camara attenuates seizures, memory impairment, and anxiety in kainate-treated mice: Evidence of GABA level, oxidative stress, immune and neuronal loss modulation.
Epilepsy & behavior : E&B.
2022 04; 129(?):108611. doi:
10.1016/j.yebeh.2022.108611. [PMID: 35193072] - Milos Bogdanovic, Hila Asraf, Noa Gottesman, Israel Sekler, Elias Aizenman, Michal Hershfinkel. The ZIP3 Zinc Transporter Is Localized to Mossy Fiber Terminals and Is Required for Kainate-Induced Degeneration of CA3 Neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2022 03; 42(13):2824-2834. doi:
10.1523/jneurosci.0908-21.2022. [PMID: 35169020] - Cheng-Wei Lu, Chen-Jung Lin, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin, Su-Jane Wang. An Anthranilate Derivative Inhibits Glutamate Release and Glutamate Excitotoxicity in Rats.
International journal of molecular sciences.
2022 Feb; 23(5):. doi:
10.3390/ijms23052641. [PMID: 35269784] - Ali Hasanvand, Azam Hosseinzadeh, Morteza Saeedavi, Mehdi Goudarzi, Zahra Basir, Saeed Mehrzadi. Neuroprotective effects of tannic acid against kainic acid-induced seizures in mice.
Human & experimental toxicology.
2022 Jan; 41(?):9603271221093989. doi:
10.1177/09603271221093989. [PMID: 35544363] - Xiaomao Li, Yan Liu, Siyi Wang, Yikai Jiang, Adnan Mohammed Algradi, Yuanyuan Zhou, Juan Pan, Wei Guan, Haixue Kuang, Bingyou Yang. The Aerial Parts of Bupleurum Chinense DC. Aromatic Oil Attenuate Kainic Acid-Induced Epilepsy-Like Behavior and Its Potential Mechanisms.
BioMed research international.
2022; 2022(?):1234612. doi:
10.1155/2022/1234612. [PMID: 35445130] - Lubing Li, Xiahatai Ayiding, Ran Han. miRNA-Gene Interaction Network Construction Strategy to Discern Promising Traditional Chinese Medicine against Osteoporosis.
BioMed research international.
2022; 2022(?):9093614. doi:
10.1155/2022/9093614. [PMID: 35757478] - Tomoya Sano, Yasushi Masuda, Hironobu Yasuno, Tadahiro Shinozawa, Takeshi Watanabe, Masaaki Kakehi. Blood Neurofilament Light Chain as a Potential Biomarker for Central and Peripheral Nervous Toxicity in Rats.
Toxicological sciences : an official journal of the Society of Toxicology.
2021 12; 185(1):10-18. doi:
10.1093/toxsci/kfab122. [PMID: 34677616] - Emmanuel S Ojo, Ismail O Ishola, Olasunmbo Afolayan, Ayorinde B James, Benneth Ben-Azu, Olufunmilayo O Adeyemi. Cnestis ferruginea Vahl ex DC (Connaraceae) downregulates expression of immediate early genes in kainic acid-induced temporal lobe epilepsy in mice.
Drug metabolism and personalized therapy.
2021 12; 37(2):191-200. doi:
10.1515/dmpt-2021-0145. [PMID: 34881530] - Yi-Chieh Hung, Yi-Hsiu Kuo, Pei-Wen Hsieh, Ting-Yang Hsieh, Jinn-Rung Kuo, Su-Jane Wang. Chlorogenic Acid Decreases Glutamate Release from Rat Cortical Nerve Terminals by P/Q-Type Ca2+ Channel Suppression: A Possible Neuroprotective Mechanism.
International journal of molecular sciences.
2021 Oct; 22(21):. doi:
10.3390/ijms222111447. [PMID: 34768876] - Wei Lin, Xiao Qian, Li-Kun Yang, Jie Zhu, Dan Wang, Chun-Hua Hang, Yuhai Wang, Tao Chen. Inhibition of miR-134-5p protects against kainic acid-induced excitotoxicity through Sirt3-mediated preservation of mitochondrial function.
Epilepsy research.
2021 10; 176(?):106722. doi:
10.1016/j.eplepsyres.2021.106722. [PMID: 34273723] - Cara L Field, Sophie T Whoriskey, Xianguo Zhao, Mark G Papich. PHARMACOKINETICS OF SUBCUTANEOUS ALPHA LIPOIC ACID, A PROPOSED THERAPEUTIC AID FOR DOMOIC ACID INTOXICATION IN CALIFORNIA SEA LIONS (ZALOPHUS CALIFORNIANUS).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2021 Sep; 52(3):872-879. doi:
10.1638/2020-0223. [PMID: 34687502] - Yingchun Xiang, Yumiao Niu, Yacong Xie, Shishuo Chen, Feng Zhu, Weida Shen, Ling-Hui Zeng. Inhibition of RhoA/Rho kinase signaling pathway by fasudil protects against kainic acid-induced neurite injury.
Brain and behavior.
2021 08; 11(8):e2266. doi:
10.1002/brb3.2266. [PMID: 34156163] - Shaunik Sharma, Steven Carlson, Adriana Gregory-Flores, Andy Hinojo-Perez, Ashley Olson, Thimmasettappa Thippeswamy. Mechanisms of disease-modifying effect of saracatinib (AZD0530), a Src/Fyn tyrosine kinase inhibitor, in the rat kainate model of temporal lobe epilepsy.
Neurobiology of disease.
2021 08; 156(?):105410. doi:
10.1016/j.nbd.2021.105410. [PMID: 34087381] - Emily K Bowers, Raphaela Stimmelmayr, Kathi A Lefebvre. Stability of Domoic Acid in 50\% Methanol Extracts and Raw Fecal Material from Bowhead Whales (Balaena mysticetus).
Marine drugs.
2021 Jul; 19(8):. doi:
10.3390/md19080423. [PMID: 34436262] - Zhou Wu, Tushar Deshpande, Lukas Henning, Peter Bedner, Gerald Seifert, Christian Steinhäuser. Cell death of hippocampal CA1 astrocytes during early epileptogenesis.
Epilepsia.
2021 07; 62(7):1569-1583. doi:
10.1111/epi.16910. [PMID: 33955001] - Elva Martin-Batista, Laura E Maglio, Natalia Armas-Capote, Guadalberto Hernández, Diego Alvarez de la Rosa, Teresa Giraldez. SGK1.1 limits brain damage after status epilepticus through M current-dependent and independent mechanisms.
Neurobiology of disease.
2021 06; 153(?):105317. doi:
10.1016/j.nbd.2021.105317. [PMID: 33639207] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Corinne M Gibble, Raphael M Kudela, Susan Knowles, Barbara Bodenstein, Kathi A Lefebvre. Domoic acid and saxitoxin in seabirds in the United States between 2007 and 2018.
Harmful algae.
2021 03; 103(?):101981. doi:
10.1016/j.hal.2021.101981. [PMID: 33980431] - Antoine Kavaye Kandeda, Fleur Clarisse Okomolo Moto, Jean Pierre Omam Omam, Rigobert Espoir Mbomo Ayissi, Lucie Ojong, Elisabeth Ngo Bum. Pergularia daemia alters epileptogenesis and attenuates cognitive impairment in kainate-treated mice: Insight into anti-inflammatory mechanisms.
Epilepsy & behavior : E&B.
2021 02; 115(?):107707. doi:
10.1016/j.yebeh.2020.107707. [PMID: 33429138] - Spencer E Fire, Andrea Bogomolni, Robert A DiGiovanni, Greg Early, Tod A Leighfield, Keith Matassa, Glenn A Miller, Kathleen M T Moore, Michael Moore, Misty Niemeyer, Katie Pugliares, Zhihong Wang, Frederick W Wenzel. An assessment of temporal, spatial and taxonomic trends in harmful algal toxin exposure in stranded marine mammals from the U.S. New England coast.
PloS one.
2021; 16(1):e0243570. doi:
10.1371/journal.pone.0243570. [PMID: 33406141] - Szu Kai Hsu, Chi Feng Hung, Hsiao Ching Yang, Jing Ru Weng, Su Jane Wang. TCD, a triterpenoid isolated from wild bitter gourd, reduces synaptosomal release of glutamate and protects against kainic acid-induced neuronal death.
Food & function.
2020 Nov; 11(11):9858-9867. doi:
10.1039/d0fo02039g. [PMID: 33089839] - Gary P Brennan, Sebastian Bauer, Tobias Engel, Eva M Jimenez-Mateos, Federico Del Gallo, Thomas D M Hill, Niamh M C Connolly, Lara S Costard, Valentin Neubert, Beatrice Salvetti, Amaya Sanz-Rodriguez, Mona Heiland, Omar Mamad, Elizabeth Brindley, Braxton Norwood, Aasia Batool, Rana Raoof, Hany El-Naggar, Cristina R Reschke, Norman Delanty, Jochen H M Prehn, Paolo Fabene, Catherine Mooney, Felix Rosenow, David C Henshall. Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy.
Neurobiology of disease.
2020 10; 144(?):105048. doi:
10.1016/j.nbd.2020.105048. [PMID: 32800995] - Santosh Rijal, Dong Hyu Cho, Seon-Ah Park, Seon Hui Jang, István M Ábrahám, Seong Kyu Han. Melatonin Suppresses the Kainate Receptor-Mediated Excitation on Gonadotropin-Releasing Hormone Neurons in Female and Male Prepubertal Mice.
International journal of molecular sciences.
2020 Aug; 21(17):. doi:
10.3390/ijms21175991. [PMID: 32825350] - Jianwen Cao, Cheng Tang, Manman Gao, Yanggang Rui, Jie Zhang, Li Wang, Yang Wang, Bo Xu, Bing Chun Yan. Hyperoside alleviates epilepsy-induced neuronal damage by enhancing antioxidant levels and reducing autophagy.
Journal of ethnopharmacology.
2020 Jul; 257(?):112884. doi:
10.1016/j.jep.2020.112884. [PMID: 32311482] - Sara Shum, Jing Jing, Rebekah Petroff, Brenda Crouthamel, Kimberly S Grant, Thomas M Burbacher, Nina Isoherranen. Maternal-fetal disposition of domoic acid following repeated oral dosing during pregnancy in nonhuman primate.
Toxicology and applied pharmacology.
2020 07; 398(?):115027. doi:
10.1016/j.taap.2020.115027. [PMID: 32360744] - Natalia Armas-Capote, Laura E Maglio, Leonel Pérez-Atencio, Elva Martin-Batista, Antonio Reboreda, Juan A Barios, Guadalberto Hernandez, Diego Alvarez de la Rosa, José Antonio Lamas, Luis C Barrio, Teresa Giraldez. SGK1.1 Reduces Kainic Acid-Induced Seizure Severity and Leads to Rapid Termination of Seizures.
Cerebral cortex (New York, N.Y. : 1991).
2020 05; 30(5):3184-3197. doi:
10.1093/cercor/bhz302. [PMID: 31819941] - Cheng Wei Lu, Tzu Yu Lin, Su Jane Wang. 11-Keto-β-Boswellic Acid Attenuates Glutamate Release and Kainic Acid-Induced Excitotoxicity in the Rat Hippocampus.
Planta medica.
2020 Apr; 86(6):434-441. doi:
10.1055/a-1107-9337. [PMID: 32097973] - Ning Weng, Jingbo Sun, Shixiang Kuang, Hai Lan, Qiansong He, Hui Yang, Lin Zhang, Hong Xue. MicroRNA-451 Aggravates Kainic Acid-induced Seizure and Neuronal Apoptosis by Targeting GDNF.
Current neurovascular research.
2020; 17(1):50-57. doi:
10.2174/1567202617666191223150510. [PMID: 31870266] - Shun Nagashima, Keisuke Takeda, Isshin Shiiba, Mizuho Higashi, Toshifumi Fukuda, Takeshi Tokuyama, Nobuko Matsushita, Seiichi Nagano, Toshiyuki Araki, Mari Kaneko, Go Shioi, Ryoko Inatome, Shigeru Yanagi. Critical role of CRAG, a splicing variant of centaurin-γ3/AGAP3, in ELK1-dependent SRF activation at PML bodies.
Scientific reports.
2019 12; 9(1):20107. doi:
10.1038/s41598-019-56559-9. [PMID: 31882856] - Houria Manouze, Otmane Bouchatta, Mohamed Bennis, Zahra Sokar, Saâdia Ba-M'hamed. Anticonvulsive and neuroprotective effects of aqueous and methanolic extracts of Anacyclus pyrethrum root in kainic acid-induced-status epilepticus in mice.
Epilepsy research.
2019 12; 158(?):106225. doi:
10.1016/j.eplepsyres.2019.106225. [PMID: 31710948] - Yi-Min Kuo, Pei-Chien Hsu, Chia-Chi Hung, Ya-Yu Hu, Yu-Jie Huang, Yu-Ling Gan, Chun-Hua Lin, Feng-Shiun Shie, Wen-Kuei Chang, Lung-Sen Kao, Mei-Yung Tsou, Yi-Hsuan Lee. Soluble Epoxide Hydrolase Inhibition Attenuates Excitotoxicity Involving 14,15-Epoxyeicosatrienoic Acid-Mediated Astrocytic Survival and Plasticity to Preserve Glutamate Homeostasis.
Molecular neurobiology.
2019 Dec; 56(12):8451-8474. doi:
10.1007/s12035-019-01669-8. [PMID: 31257558] - Haiyan Yang, Rui Zhang, Chen Jia, Mengyu Chen, Wen Yin, Liming Wei, Haisheng Jiao. Neuronal protective effect of Songling Xuemaikang capsules alone and in combination with carbamazepine on epilepsy in kainic acid-kindled rats.
Pharmaceutical biology.
2019 Dec; 57(1):22-28. doi:
10.1080/13880209.2018.1563619. [PMID: 30724642] - Caitlyn E Bowman, Ebru S Selen Alpergin, Jessica M Ellis, Michael J Wolfgang. Loss of ACOT7 potentiates seizures and metabolic dysfunction.
American journal of physiology. Endocrinology and metabolism.
2019 11; 317(5):E941-E951. doi:
10.1152/ajpendo.00537.2018. [PMID: 31039008] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Kuan-Ho Lin, Chien-Yu Li, Yuan-Man Hsu, Chang-Hai Tsai, Fuu-Jen Tsai, Chih-Hsin Tang, Jai-Sing Yang, Zhi-Hong Wang, Mei-Chin Yin. Oridonin, A natural diterpenoid, protected NGF-differentiated PC12 cells against MPP+- and kainic acid-induced injury.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Nov; 133(?):110765. doi:
10.1016/j.fct.2019.110765. [PMID: 31430510] - Emmanuel S Ojo, Ismail O Ishola, Benneth Ben-Azu, Olasunmbo O Afolayan, Ayorinde B James, Abayomi M Ajayi, Solomon Umukoro, Olufunmilayo O Adeyemi. Ameliorative influence of Cnestis ferruginea vahl ex DC (Connaraceae) root extract on kainic acid-induced temporal lobe epilepsy in mice: Role of oxidative stress and neuroinflammation.
Journal of ethnopharmacology.
2019 Oct; 243(?):112117. doi:
10.1016/j.jep.2019.112117. [PMID: 31351192] - S Gill, V M Ruvin Kumara. Detecting Neurodevelopmental Toxicity of Domoic Acid and Ochratoxin A Using Rat Fetal Neural Stem Cells.
Marine drugs.
2019 Oct; 17(10):. doi:
10.3390/md17100566. [PMID: 31590222] - Gisela H Maia, Joana I Soares, Sérgio G Almeida, Juliana M Leite, Helena X Baptista, Alisa N Lukoyanova, Cátia S Brazete, Nikolai V Lukoyanov. Altered serotonin innervation in the rat epileptic brain.
Brain research bulletin.
2019 10; 152(?):95-106. doi:
10.1016/j.brainresbull.2019.07.009. [PMID: 31301378] - A Vega-García, C E Santana-Gómez, L Rocha, V M Magdaleno-Madrigal, A Morales-Otal, V Buzoianu-Anguiano, I Feria-Romero, S Orozco-Suárez. Magnolia officinalis reduces the long-term effects of the status epilepticus induced by kainic acid in immature rats.
Brain research bulletin.
2019 07; 149(?):156-167. doi:
10.1016/j.brainresbull.2019.04.003. [PMID: 30978383] - Farah Chali, Giampaolo Milior, Serge Marty, Mélanie Morin-Brureau, Caroline Le Duigou, Etienne Savary, Corinne Blugeon, Laurent Jourdren, Richard Miles. Lipid markers and related transcripts during excitotoxic neurodegeneration in kainate-treated mice.
The European journal of neuroscience.
2019 07; 50(1):1759-1778. doi:
10.1111/ejn.14375. [PMID: 30767299] - Patrizia Ambrogini, Pierangelo Torquato, Desirée Bartolini, Maria Cristina Albertini, Davide Lattanzi, Michael Di Palma, Rita Marinelli, Michele Betti, Andrea Minelli, Riccardo Cuppini, Francesco Galli. Excitotoxicity, neuroinflammation and oxidant stress as molecular bases of epileptogenesis and epilepsy-derived neurodegeneration: The role of vitamin E.
Biochimica et biophysica acta. Molecular basis of disease.
2019 06; 1865(6):1098-1112. doi:
10.1016/j.bbadis.2019.01.026. [PMID: 30703511] - Kathi A Lefebvre, Betsy Jean Yakes, Elizabeth Frame, Preston Kendrick, Sara Shum, Nina Isoherranen, Bridget E Ferriss, Alison Robertson, Alicia Hendrix, David J Marcinek, Lynn Grattan. Discovery of a Potential Human Serum Biomarker for Chronic Seafood Toxin Exposure Using an SPR Biosensor.
Toxins.
2019 05; 11(5):. doi:
10.3390/toxins11050293. [PMID: 31126088] - Laura Zielewicz, Jiali Wang, Elias Ndaru, Christof T Grewer. Transient Kinetics Reveal Mechanism and Voltage Dependence of Inhibitor and Substrate Binding to Glutamate Transporters.
ACS chemical biology.
2019 05; 14(5):1002-1010. doi:
10.1021/acschembio.9b00194. [PMID: 31026143] - Christel Becker, Angelina Mancic, Antoine Ghestem, Victoria Poillerat, Damien Claverie, Fabrice Bartolomei, Franck Brouillard, Jean-Jacques Benoliel, Christophe Bernard. Antioxidant treatment after epileptogenesis onset prevents comorbidities in rats sensitized by a past stressful event.
Epilepsia.
2019 04; 60(4):648-655. doi:
10.1111/epi.14692. [PMID: 30866060] - Thomas M Burbacher, Kimberly S Grant, Rebekah Petroff, Sara Shum, Brenda Crouthamel, Courtney Stanley, Noelle McKain, Jing Jing, Nina Isoherranen. Effects of oral domoic acid exposure on maternal reproduction and infant birth characteristics in a preclinical nonhuman primate model.
Neurotoxicology and teratology.
2019 Mar; 72(?):10-21. doi:
10.1016/j.ntt.2019.01.001. [PMID: 30615984] - María Fernanda Munguía-Martínez, Concepción Nava-Ruíz, Amairani Ruíz-Díaz, Araceli Díaz-Ruíz, Petra Yescas-Gómez, Marisela Méndez-Armenta. Immunohistochemical Study of Antioxidant Enzymes Regulated by Nrf2 in the Models of Epileptic Seizures (KA and PTZ).
Oxidative medicine and cellular longevity.
2019; 2019(?):1327986. doi:
10.1155/2019/1327986. [PMID: 31019649] - Liliana Carmona-Aparicio, Noemí Cárdenas-Rodríguez, Guillermo Delgado-Lamas, José Pedraza-Chaverri, Hortencia Montesinos-Correa, Liliana Rivera-Espinosa, Luz María Torres-Espíndola, Maria Eugenia Hernández, Teresita López-Aceves, Diana Leticia Pérez-Lozano, Natalia Hernández-Velasco, Omar Narváez-Delgado, Ana Paulina Gutiérrez-Alejandre, Monserrat Fuentes-Mejía, Edith Bello-Robles, Karina Martínez-Ponce, Vicente Sánchez-Valle, Aristides Sampieri, Leticia Granados-Rojas, Elvia Coballase-Urrutia. Dose-Dependent Behavioral and Antioxidant Effects of Quercetin and Methanolic and Acetonic Extracts from Heterotheca inuloides on Several Rat Tissues following Kainic Acid-Induced Status Epilepticus.
Oxidative medicine and cellular longevity.
2019; 2019(?):5287507. doi:
10.1155/2019/5287507. [PMID: 31949879] - Chaitra Venugopal, Y S Harish Chandra Prasad, K Shobha, Venkata Bharatkumar Pinnelli, Anandh Dhanushkodi. HEK-293 secretome attenuates kainic acid neurotoxicity through insulin like growth factor-phosphatidylinositol-3-kinases pathway and by temporal regulation of antioxidant defense machineries.
Neurotoxicology.
2018 12; 69(?):189-200. doi:
10.1016/j.neuro.2017.11.010. [PMID: 29208536] - Kathi A Lefebvre, Alicia Hendrix, Barbie Halaska, Padraig Duignan, Sara Shum, Nina Isoherranen, David J Marcinek, Frances M D Gulland. Domoic acid in California sea lion fetal fluids indicates continuous exposure to a neuroteratogen poses risks to mammals.
Harmful algae.
2018 11; 79(?):53-57. doi:
10.1016/j.hal.2018.06.003. [PMID: 30420016] - Felix Neumaier, Isha Akhtar-Schäfer, Jan Niklas Lüke, Maxine Dibué-Adjei, Jürgen Hescheler, Toni Schneider. Reciprocal modulation of Cav 2.3 voltage-gated calcium channels by copper(II) ions and kainic acid.
Journal of neurochemistry.
2018 11; 147(3):310-322. doi:
10.1111/jnc.14546. [PMID: 29972687] - Federica Frigerio, Giulia Pasqualini, Ilaria Craparotta, Sergio Marchini, Erwin A van Vliet, Patrick Foerch, Catherine Vandenplas, Karin Leclercq, Eleonora Aronica, Luca Porcu, Kimberly Pistorius, Romain A Colas, Trond V Hansen, Mauro Perretti, Rafal M Kaminski, Jesmond Dalli, Annamaria Vezzani. n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis.
Brain : a journal of neurology.
2018 11; 141(11):3130-3143. doi:
10.1093/brain/awy247. [PMID: 30307467] - Cheng Wei Lu, Hsi Lung Hsieh, Tzu Yu Lin, Ting Yang Hsieh, Shu Kuei Huang, Su Jane Wang. Echinacoside, an Active Constituent of Cistanche Herba, Exerts a Neuroprotective Effect in a Kainic Acid Rat Model by Inhibiting Inflammatory Processes and Activating the Akt/GSK3β Pathway.
Biological & pharmaceutical bulletin.
2018 Nov; 41(11):1685-1693. doi:
10.1248/bpb.b18-00407. [PMID: 30197410] - Peter J West, Gerald W Saunders, Peggy Billingsley, Misty D Smith, H Steve White, Cameron S Metcalf, Karen S Wilcox. Recurrent epileptiform discharges in the medial entorhinal cortex of kainate-treated rats are differentially sensitive to antiseizure drugs.
Epilepsia.
2018 11; 59(11):2035-2048. doi:
10.1111/epi.14563. [PMID: 30328622] - Patrizia Ambrogini, Maria Cristina Albertini, Michele Betti, Claudia Galati, Davide Lattanzi, David Savelli, Michael Di Palma, Stefania Saccomanno, Desirée Bartolini, Pierangelo Torquato, Gabriele Ruffolo, Fabiola Olivieri, Francesco Galli, Eleonora Palma, Andrea Minelli, Riccardo Cuppini. Neurobiological Correlates of Alpha-Tocopherol Antiepileptogenic Effects and MicroRNA Expression Modulation in a Rat Model of Kainate-Induced Seizures.
Molecular neurobiology.
2018 Oct; 55(10):7822-7838. doi:
10.1007/s12035-018-0946-7. [PMID: 29468563] - Jung-Min Yon, Yun-Bae Kim, Dongsun Park. The Ethanol Fraction of White Rose Petal Extract Abrogates Excitotoxicity-Induced Neuronal Damage In Vivo and In Vitro through Inhibition of Oxidative Stress and Proinflammation.
Nutrients.
2018 Sep; 10(10):. doi:
10.3390/nu10101375. [PMID: 30261613] - W-S Huang, L Zhu. MiR-134 expression and changes in inflammatory cytokines of rats with epileptic seizures.
European review for medical and pharmacological sciences.
2018 06; 22(11):3479-3484. doi:
10.26355/eurrev_201806_15174. [PMID: 29917202] - Jana Tchekalarova, Keylla da Conceição Machado, Antonio Luiz Gomes Júnior, Ana Amélia de Carvalho Melo Cavalcante, Albena Momchilova, Rumyana Tzoneva. Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice.
Seizure.
2018 Apr; 57(?):22-26. doi:
10.1016/j.seizure.2018.03.009. [PMID: 29547827] - Jing Jing, Rebekah Petroff, Sara Shum, Brenda Crouthamel, Ariel R Topletz, Kimberly S Grant, Thomas M Burbacher, Nina Isoherranen. Toxicokinetics and Physiologically Based Pharmacokinetic Modeling of the Shellfish Toxin Domoic Acid in Nonhuman Primates.
Drug metabolism and disposition: the biological fate of chemicals.
2018 02; 46(2):155-165. doi:
10.1124/dmd.117.078485. [PMID: 29150543] - Raissa Lerner, Julia M Post, Shane R Ellis, D R Naomi Vos, Ron M A Heeren, Beat Lutz, Laura Bindila. Simultaneous lipidomic and transcriptomic profiling in mouse brain punches of acute epileptic seizure model compared to controls.
Journal of lipid research.
2018 02; 59(2):283-297. doi:
10.1194/jlr.m080093. [PMID: 29208697] - Elahe Naderali, Farnaz Nikbakht, Sattar Norouzi Ofogh, Homa Rasoolijazi. The role of rosemary extract in degeneration of hippocampal neurons induced by kainic acid in the rat: A behavioral and histochemical approach.
Journal of integrative neuroscience.
2018; 17(1):19-25. doi:
10.31083/jin-170035. [PMID: 29376880] - Zhi-Hong Wang, Mei-Chin Mong, Ya-Chen Yang, Mei-Chin Yin. Asiatic acid and maslinic acid attenuated kainic acid-induced seizure through decreasing hippocampal inflammatory and oxidative stress.
Epilepsy research.
2018 01; 139(?):28-34. doi:
10.1016/j.eplepsyres.2017.11.003. [PMID: 29156327] - Gaetano Terrone, Alberto Pauletti, Alessia Salamone, Massimo Rizzi, Bianca R Villa, Luca Porcu, Mark J Sheehan, Edward Guilmette, Christopher R Butler, Justin R Piro, Tarek A Samad, Annamaria Vezzani. Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet.
Epilepsia.
2018 01; 59(1):79-91. doi:
10.1111/epi.13950. [PMID: 29171003] - Tushar Deshpande, Tingsong Li, Michel K Herde, Albert Becker, Hartmut Vatter, Martin K Schwarz, Christian Henneberger, Christian Steinhäuser, Peter Bedner. Subcellular reorganization and altered phosphorylation of the astrocytic gap junction protein connexin43 in human and experimental temporal lobe epilepsy.
Glia.
2017 11; 65(11):1809-1820. doi:
10.1002/glia.23196. [PMID: 28795432] - Jan-Øyvind Lorgen, Daniel Lawer Egbenya, Janniche Hammer, Svend Davanger. PICK1 facilitates lasting reduction in GluA2 concentration in the hippocampus during chronic epilepsy.
Epilepsy research.
2017 11; 137(?):25-32. doi:
10.1016/j.eplepsyres.2017.08.012. [PMID: 28888867] - Valeria C D'Agostino, Mariana Degrati, Viviana Sastre, Norma Santinelli, Bernd Krock, Torben Krohn, Silvana L Dans, Mónica S Hoffmeyer. Domoic acid in a marine pelagic food web: Exposure of southern right whales Eubalaena australis to domoic acid on the Península Valdés calving ground, Argentina.
Harmful algae.
2017 09; 68(?):248-257. doi:
10.1016/j.hal.2017.09.001. [PMID: 28962985] - Abdullah F U H Saeed, Sumei Ling, Jun Yuan, Shihua Wang. The Preparation and Identification of a Monoclonal Antibody against Domoic Acid and Establishment of Detection by Indirect Competitive ELISA.
Toxins.
2017 08; 9(8):. doi:
10.3390/toxins9080250. [PMID: 28817087] - Ouafa Najyb, Sonia Do Carmo, Azadeh Alikashani, Eric Rassart. Apolipoprotein D Overexpression Protects Against Kainate-Induced Neurotoxicity in Mice.
Molecular neurobiology.
2017 08; 54(6):3948-3963. doi:
10.1007/s12035-016-9920-4. [PMID: 27271124] - Min Xu, Peng Sun, Ying Zhang, Ci-Hang Yang, Xin Wei, Xiao-Xia Ma, Chong-Ren Yang, Kun-Ming Ni, Ying-Jun Zhang, Xiao-Ming Li. DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy.
Scientific reports.
2017 05; 7(1):1701. doi:
10.1038/s41598-017-01734-z. [PMID: 28490750] - Priscilla Kolibea Mante, Donatus Wewura Adongo, Eric Woode. Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy.
BMC research notes.
2017 Apr; 10(1):167. doi:
10.1186/s13104-017-2488-x. [PMID: 28446201] - Kensuke Iwasa, Shinji Yamamoto, Sosuke Yagishita, Kei Maruyama, Keisuke Yoshikawa. Excitotoxicity-induced prostaglandin D2 production induces sustained microglial activation and delayed neuronal death.
Journal of lipid research.
2017 04; 58(4):649-655. doi:
10.1194/jlr.m070532. [PMID: 28174214] - Do Young Kim, Fang-Xiong Zhang, Stan T Nakanishi, Timothy Mettler, Ik-Hyun Cho, Younghee Ahn, Florian Hiess, Lina Chen, Patrick G Sullivan, S R Wayne Chen, Gerald W Zamponi, Jong M Rho. Carisbamate blockade of T-type voltage-gated calcium channels.
Epilepsia.
2017 04; 58(4):617-626. doi:
10.1111/epi.13710. [PMID: 28230232] - Chea-Ha Kim, Soo-Hyun Park, Yun-Beom Sim, Sung-Su Kim, Jun-Sub Jung, Naveen Sharma, Hong-Won Suh. Regulation of blood glucose level by kainic acid in mice: involvement of glucocorticoid system and non-NMDA receptors.
The Chinese journal of physiology.
2017 Feb; 60(1):23-31. doi:
10.4077/cjp.2017.bae397. [PMID: 28052643] - Raissa Lerner, Julia Post, Sebastian Loch, Beat Lutz, Laura Bindila. Targeting brain and peripheral plasticity of the lipidome in acute kainic acid-induced epileptic seizures in mice via quantitative mass spectrometry.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2017 Feb; 1862(2):255-267. doi:
10.1016/j.bbalip.2016.11.008. [PMID: 27871881] - Keishi Ishida, Yumi Tsuyama, Seigo Sanoh, Shigeru Ohta, Yaichiro Kotake. Perfluorooctane sulfonate induces neuronal vulnerability by decreasing GluR2 expression.
Archives of toxicology.
2017 Feb; 91(2):885-895. doi:
10.1007/s00204-016-1731-x. [PMID: 27155986] - Jennifer N Pearson, Eric Warren, Li-Ping Liang, L Jackson Roberts, Manisha Patel. Scavenging of highly reactive gamma-ketoaldehydes attenuates cognitive dysfunction associated with epileptogenesis.
Neurobiology of disease.
2017 Feb; 98(?):88-99. doi:
10.1016/j.nbd.2016.11.011. [PMID: 27932305] - Todd D Prickett, Jared J Gartner, Yardena Samuels. Genetic and Functional Analysis of GRIN2A in Tumor Samples.
Methods in molecular biology (Clifton, N.J.).
2017; 1677(?):93-116. doi:
10.1007/978-1-4939-7321-7_3. [PMID: 28986867] - Svenja Heischmann, Kevin Quinn, Charmion Cruickshank-Quinn, Li-Ping Liang, Rick Reisdorph, Nichole Reisdorph, Manisha Patel. Exploratory Metabolomics Profiling in the Kainic Acid Rat Model Reveals Depletion of 25-Hydroxyvitamin D3 during Epileptogenesis.
Scientific reports.
2016 08; 6(?):31424. doi:
10.1038/srep31424. [PMID: 27526857] - Francesco M Noé, Elisa Bellistri, Francesca Colciaghi, Barbara Cipelletti, Giorgio Battaglia, Marco de Curtis, Laura Librizzi. Kainic acid-induced albumin leak across the blood-brain barrier facilitates epileptiform hyperexcitability in limbic regions.
Epilepsia.
2016 06; 57(6):967-76. doi:
10.1111/epi.13394. [PMID: 27173148] - Bozena Kuzniewska, Karolina Nader, Michal Dabrowski, Leszek Kaczmarek, Katarzyna Kalita. Adult Deletion of SRF Increases Epileptogenesis and Decreases Activity-Induced Gene Expression.
Molecular neurobiology.
2016 Apr; 53(3):1478-1493. doi:
10.1007/s12035-014-9089-7. [PMID: 25636686] - Malk Eun Pak, Yu Ri Kim, Ha Neui Kim, Sung Min Ahn, Hwa Kyoung Shin, Jin Ung Baek, Byung Tae Choi. Studies on medicinal herbs for cognitive enhancement based on the text mining of Dongeuibogam and preliminary evaluation of its effects.
Journal of ethnopharmacology.
2016 Feb; 179(?):383-90. doi:
10.1016/j.jep.2016.01.006. [PMID: 26773844] - Yi Chang, Cheng Wei Lu, Tzu Yu Lin, Shu Kuei Huang, Su Jane Wang. Baicalein, a Constituent of Scutellaria baicalensis, Reduces Glutamate Release and Protects Neuronal Cell Against Kainic Acid-Induced Excitotoxicity in Rats.
The American journal of Chinese medicine.
2016; 44(5):943-62. doi:
10.1142/s0192415x1650052x. [PMID: 27430911] - Marlyn P Langford, Thomas B Redens, Chanping Liang, A Scott Kavanaugh, Donald E Texada. EAAT and Xc⁻ Exchanger Inhibition Depletes Glutathione in the Transformed Human Lens Epithelial Cell Line SRA 01/04.
Current eye research.
2016; 41(3):357-66. doi:
10.3109/02713683.2015.1017651. [PMID: 25897760] - Yiping Zhang, Dawei Chen, Zhuan Hong. A Rapid LC-HRMS Method for the Determination of Domoic Acid in Urine Using a Self-Assembly Pipette Tip Solid-Phase Extraction.
Toxins.
2015 Dec; 8(1):. doi:
10.3390/toxins8010010. [PMID: 26729165] - Noriko Yutsudo, Hiroshi Kitagawa. Involvement of chondroitin 6-sulfation in temporal lobe epilepsy.
Experimental neurology.
2015 Dec; 274(Pt B):126-33. doi:
10.1016/j.expneurol.2015.07.009. [PMID: 26231575] - Hai-Ying Shen, Erwin A van Vliet, Kerry-Ann Bright, Marissa Hanthorn, Nikki K Lytle, Jan Gorter, Eleonora Aronica, Detlev Boison. Glycine transporter 1 is a target for the treatment of epilepsy.
Neuropharmacology.
2015 Dec; 99(?):554-65. doi:
10.1016/j.neuropharm.2015.08.031. [PMID: 26302655] - Morgayn I Read, Dominic M McCann, Rebecca N Millen, Joanne C Harrison, D Steven Kerr, Ivan A Sammut. Progressive development of cardiomyopathy following altered autonomic activity in status epilepticus.
American journal of physiology. Heart and circulatory physiology.
2015 Nov; 309(9):H1554-64. doi:
10.1152/ajpheart.00256.2015. [PMID: 26342065] - Christiana Wittmaack, Garet P Lahvis, Edward O Keith, Caryn Self-Sullivan. Diagnosing domoic acid toxicosis in the California sea lion (Zalophus californianus) using behavioral criteria: A novel approach.
Zoo biology.
2015 Jul; 34(4):314-20. doi:
10.1002/zoo.21217. [PMID: 25962475] - Eun-Joo Shin, Ji Hoon Jeong, Chun Kee Chung, Dae-Joong Kim, Myung-Bok Wie, Eon Sub Park, Yoon Hee Chung, Yunsung Nam, The-Vinh Tran, Sung Youl Lee, Hwa-Jung Kim, Wei-Yi Ong, Hyoung-Chun Kim. Ceruloplasmin is an endogenous protectant against kainate neurotoxicity.
Free radical biology & medicine.
2015 Jul; 84(?):355-372. doi:
10.1016/j.freeradbiomed.2015.03.031. [PMID: 25843655] - Xiaoqian Wang, Tie Gao, Zhuan Hong, Feng Qu. [Affinity capillary electrophoresis for screening proteins interacting with domoic acid].
Se pu = Chinese journal of chromatography.
2015 Jul; 33(7):673-7. doi:
10.3724/sp.j.1123.2015.03026. [PMID: 26672193] - Ying-Hao Ho, Yu-Te Lin, Chih-Wei J Wu, Yung-Mei Chao, Alice Y W Chang, Julie Y H Chan. Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus.
Journal of biomedical science.
2015 Jun; 22(?):46. doi:
10.1186/s12929-015-0157-8. [PMID: 26100815]