gabapentin (BioDeep_00000229721)

Main id: BioDeep_00000397520

 

human metabolite


代谢物信息卡片


gabapentin

化学式: C9H17NO2 (171.1259)
中文名称: 加巴喷丁
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCC(CC1)(CC(=O)O)CN
InChI: InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)

描述信息

D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D018692 - Antimanic Agents
N - Nervous system > N02 - Analgesics > N02B - Other analgesics and antipyretics > N02BF - Gabapentinoids
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
D002491 - Central Nervous System Agents > D000700 - Analgesics
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2561

同义名列表

2 个代谢物同义名

gabapentin; Gabapentin



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AXIN2, BCL2, CA1, CALCA, CAT, GFAP, PTGS2
Peripheral membrane protein 3 ACHE, CYP1B1, PTGS2
Endoplasmic reticulum membrane 3 BCL2, CYP1B1, PTGS2
Nucleus 4 ACHE, AXIN2, BCL2, FOS
cytosol 8 AXIN2, BCL2, CA1, CAT, FOS, GFAP, PRKCQ, SLC7A5
centrosome 1 AXIN2
nucleoplasm 2 FOS, SCNN1G
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 4 ACHE, OPRD1, SLC7A5, TNF
Multi-pass membrane protein 5 CACNA1I, NNT, OPRD1, SCNN1G, SLC7A5
Synapse 2 ACHE, TAC1
cell surface 2 ACHE, TNF
Golgi apparatus 1 ACHE
Golgi membrane 1 INS
lysosomal membrane 1 SLC7A5
mitochondrial inner membrane 1 NNT
neuromuscular junction 1 ACHE
neuronal cell body 3 CALCA, TAC1, TNF
presynaptic membrane 1 OPRD1
plasma membrane 8 ACHE, AXIN2, CACNA1I, OPRD1, PRKCQ, SCNN1G, SLC7A5, TNF
synaptic vesicle membrane 1 OPRD1
terminal bouton 1 CALCA
Membrane 8 ACHE, BCL2, CACNA1I, CAT, CYP1B1, NNT, OPRD1, SLC7A5
apical plasma membrane 2 SCNN1G, SLC7A5
axon 1 TAC1
basolateral plasma membrane 1 SLC7A5
caveola 1 PTGS2
extracellular exosome 4 CA1, CAT, SCNN1G, SLC7A5
Lysosome membrane 1 SLC7A5
endoplasmic reticulum 3 BCL2, FOS, PTGS2
extracellular space 6 ACHE, CALCA, IL10, INS, TAC1, TNF
perinuclear region of cytoplasm 1 ACHE
mitochondrion 4 BCL2, CAT, CYP1B1, NNT
protein-containing complex 3 BCL2, CAT, PTGS2
intracellular membrane-bounded organelle 3 CAT, CYP1B1, SLC7A5
Microsome membrane 2 CYP1B1, PTGS2
Secreted 4 ACHE, CALCA, IL10, INS
extracellular region 7 ACHE, CALCA, CAT, IL10, INS, TAC1, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
astrocyte end-foot 1 GFAP
hippocampal mossy fiber to CA3 synapse 1 CALCA
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
centriolar satellite 1 PRKCQ
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 SCNN1G, TNF
beta-catenin destruction complex 1 AXIN2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 2 SCNN1G, SLC7A5
Mitochondrion inner membrane 1 NNT
Matrix side 1 NNT
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 CAT
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
intermediate filament 1 GFAP
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 2 OPRD1, PTGS2
chromatin 1 FOS
cell projection 1 GFAP
phagocytic cup 1 TNF
Lipid-anchor, GPI-anchor 1 ACHE
microvillus membrane 1 SLC7A5
endosome lumen 1 INS
sodium channel complex 1 SCNN1G
respiratory chain complex 1 NNT
cell body 1 GFAP
side of membrane 1 ACHE
myelin sheath 1 BCL2
intermediate filament cytoskeleton 1 GFAP
basal plasma membrane 1 SLC7A5
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, PTGS2
nuclear matrix 1 FOS
axon terminus 1 OPRD1
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 OPRD1
immunological synapse 1 PRKCQ
neuronal dense core vesicle 2 CALCA, OPRD1
aggresome 1 PRKCQ
synaptic cleft 1 ACHE
protein-DNA complex 1 FOS
external side of apical plasma membrane 1 SLC7A5
dendrite membrane 1 OPRD1
cytoplasmic side of lysosomal membrane 1 GFAP
transcription factor AP-1 complex 1 FOS
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
amino acid transport complex 1 SLC7A5
BAD-BCL-2 complex 1 BCL2
[Isoform H]: Cell membrane 1 ACHE
spine apparatus 1 OPRD1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Radka Kodešová, Helena Švecová, Aleš Klement, Miroslav Fér, Antonín Nikodem, Ganna Fedorova, Oleksandra Rieznyk, Martin Kočárek, Alina Sadchenko, Alica Chroňáková, Roman Grabic. Contamination of water, soil, and plants by micropollutants from reclaimed wastewater and sludge from a wastewater treatment plant. The Science of the total environment. 2023 Oct; 907(?):167965. doi: 10.1016/j.scitotenv.2023.167965. [PMID: 37866592]
  • Jiayu Tang, Yunchao Zhang, Chenxin Liu, Anqi Zeng, Linjiang Song. Therapeutic Strategies for Postherpetic Neuralgia: Mechanisms, Treatments, and Perspectives. Current pain and headache reports. 2023 Jul; ?(?):. doi: 10.1007/s11916-023-01146-x. [PMID: 37493871]
  • Emil Bein, Millaray Sierra Olea, Sophie Petersen, Jörg E Drewes, Uwe Hübner. Ozonation of Gabapentin in Water─Investigating Reaction Kinetics and Transformation Mechanisms of a Primary Amine Using Isotopically Labeled Ozone. Environmental science & technology. 2023 Apr; ?(?):. doi: 10.1021/acs.est.2c06709. [PMID: 37099017]
  • Zhao Liu, Ruiqian Guan, Limin Pan. Exploration of restless legs syndrome under the new concept: A review. Medicine. 2022 Dec; 101(50):e32324. doi: 10.1097/md.0000000000032324. [PMID: 36550837]
  • Vivek Jain, Ashutosh Pareek, Yashumati Ratan Bhardwaj, Saurabh Kumar Sinha, Madan Mohan Gupta, Nirmal Singh. Punicalagin and ellagic acid containing Punica granatum L. fruit rind extract prevents vincristine-induced neuropathic pain in rats: an in silico and in vivo evidence of GABAergic action and cytokine inhibition. Nutritional neuroscience. 2022 Oct; 25(10):2149-2166. doi: 10.1080/1028415x.2021.1954293. [PMID: 34369317]
  • Sijin He, Qigang Chen, Zhicong Jing, Lihua Gu, Kaixuan Luo. Avellis syndrome with ipsilateral prosopalgia, glossopharyngeal neuralgia, and central post-stroke pain: A case report and literature review. Medicine. 2022 Sep; 101(39):e30669. doi: 10.1097/md.0000000000030669. [PMID: 36181064]
  • Jonathan L Fu, Michael D Perloff. Pharmacotherapy for Spine-Related Pain in Older Adults. Drugs & aging. 2022 07; 39(7):523-550. doi: 10.1007/s40266-022-00946-x. [PMID: 35754070]
  • Lili Sadri, Deepak Shan, Luis Mejia-Sierra, QuynhDiem Lam, Jaclyn G Heilman, Divya Balchander, Kristin Noonan, Danielle M Pineda. An Enhanced Recovery After Surgery Protocol Decreases the Use of Narcotics in Infrainguinal Bypass Patients. Vascular and endovascular surgery. 2022 Jul; 56(5):465-471. doi: 10.1177/15385744221075012. [PMID: 35315304]
  • Flory T Muanda, Matthew A Weir, Fatemeh Ahmadi, Jessica M Sontrop, Andrea Cowan, Jamie L Fleet, Peter G Blake, Amit X Garg. Higher-Dose Gabapentinoids and the Risk of Adverse Events in Older Adults With CKD: A Population-Based Cohort Study. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2022 07; 80(1):98-107.e1. doi: 10.1053/j.ajkd.2021.11.007. [PMID: 34979160]
  • Ritu Lal, Aaron Ellenbogen, Barry Gidal. Interindividual Variability in the Bioavailability of Gabapentin Enacarbil Extended Release in Healthy Adults: An Analysis of Data From 6 Phase I Studies. Therapeutic drug monitoring. 2022 06; 44(3):448-454. doi: 10.1097/ftd.0000000000000935. [PMID: 34726199]
  • Tomoyuki Yamada, Satoru Mitsuboshi, Junko Makino, Kaoru Suzuki, Masami Nishihara, Masashi Neo. Risk of Pregabalin-Induced Hypoglycemia: Analysis of the Japanese Adverse Drug Event Report Database. Journal of clinical pharmacology. 2022 06; 62(6):756-761. doi: 10.1002/jcph.2009. [PMID: 34817883]
  • Matthew Gurney, Lou Gower. Randomised clinical trial evaluating the effect of a single preappointment dose of gabapentin on signs of stress in hyperthyroid cats. Journal of feline medicine and surgery. 2022 06; 24(6):e85-e89. doi: 10.1177/1098612x221091736. [PMID: 35481442]
  • Dani C Mata, John F Davis. Simultaneous quantitative analysis of 39 common toxicological drugs for increased efficiency in an ante- and postmortem laboratory. Forensic science international. 2022 May; 334(?):111246. doi: 10.1016/j.forsciint.2022.111246. [PMID: 35276541]
  • Naga Chalasani, Herbert L Bonkovsky, Jonathan G Stine, Jiezhun Gu, Huiman Barnhart, Elin Jacobsen, Einar Björnsson, Robert J Fontana, David E Kleiner, Jay H Hoofnagle. Clinical characteristics of antiepileptic-induced liver injury in patients from the DILIN prospective study. Journal of hepatology. 2022 Apr; 76(4):832-840. doi: 10.1016/j.jhep.2021.12.013. [PMID: 34953957]
  • Jing Li, Kewei Xu, Hao Ding, Qiaozhen Xi. Gabapentin Reduces Alcohol Intake in Rats by Regulating NF-κB Signaling Pathway Via PPAR γ. Alcohol and alcoholism (Oxford, Oxfordshire). 2022 Mar; 57(2):234-241. doi: 10.1093/alcalc/agab065. [PMID: 34553211]
  • Jenifer R Gold, Tamara L Grubb, Sherry Cox, Lais Malavasi, Nicholas L Villarino. Pharmacokinetics and pharmacodynamics of repeat dosing of gabapentin in adult horses. Journal of veterinary internal medicine. 2022 Mar; 36(2):792-797. doi: 10.1111/jvim.16386. [PMID: 35150014]
  • Ananya Buapratoom, Aree Wanasuntronwong, Onrawee Khongsombat, Mayuree H Tantisira. Anti-nociceptive effects of ECa 233 a standardized extract of Centella asiatica (L.) Urban on chronic neuropathic orofacial pain in mice. Journal of ethnopharmacology. 2022 Jan; 283(?):114737. doi: 10.1016/j.jep.2021.114737. [PMID: 34648902]
  • Ke-Yu Chen, Ruo-Yang Li. Efficacy and safety of different antidepressants and anticonvulsants in central poststroke pain: A network meta-analysis and systematic review. PloS one. 2022; 17(10):e0276012. doi: 10.1371/journal.pone.0276012. [PMID: 36227855]
  • Ghazal S Daher, Ashley M Nassiri, Greg Vanichkachorn, Matthew L Carlson, Brian A Neff, Colin L W Driscoll. New onset tinnitus in the absence of hearing changes following COVID-19 infection. American journal of otolaryngology. 2022 Jan; 43(1):103208. doi: 10.1016/j.amjoto.2021.103208. [PMID: 34536917]
  • Sophie C Queler, Alexander J Towbin, Carlo Milani, Jeremy Whang, Darryl B Sneag. Parsonage-Turner Syndrome Following COVID-19 Vaccination: MR Neurography. Radiology. 2022 01; 302(1):84-87. doi: 10.1148/radiol.2021211374. [PMID: 34402669]
  • Josée Bouchard, Christopher Yates, Diane P Calello, Sophie Gosselin, Darren M Roberts, Valéry Lavergne, Robert S Hoffman, Marlies Ostermann, Ai Peng, Marc Ghannoum. Extracorporeal Treatment for Gabapentin and Pregabalin Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2022 01; 79(1):88-104. doi: 10.1053/j.ajkd.2021.06.027. [PMID: 34799138]
  • Lanying Jiang, Yadan Xiong, Jinguo Cui. Comparison of the Efficacy and Safety of Duloxetine and Gabapentin in Diabetic Peripheral Neuropathic Pain: A Meta-Analysis. Contrast media & molecular imaging. 2022; 2022(?):4084420. doi: 10.1155/2022/4084420. [PMID: 35299589]
  • Y Y Jin, C H Qin, B L Duan, Y Q Huang, K Ma. [Clinical efficacy of bulleyaconitine A combined with gabapentin on postherpetic neuralgia]. Zhonghua yi xue za zhi. 2021 Nov; 101(43):3575-3580. doi: 10.3760/cma.j.cn112137-20210817-01867. [PMID: 34808751]
  • Yao Chen, Guang-Zhi Zhang. Evaluation on curative effects of gabapentin for the prevention of chronic pain in adults following surgery: A protocol for systematic review and meta-analysis. Medicine. 2021 Oct; 100(42):e27558. doi: 10.1097/md.0000000000027558. [PMID: 34678894]
  • Chiara E Hampton, Patricia Queiroz-Williams, Montana J Oubre, Anna Martin, Andrea T Gisclair, Bruno H Pypendop. Pharmacokinetics of oral and compounded intravenous gabapentin in Duroc swine (Sus Scrofa). Journal of veterinary pharmacology and therapeutics. 2021 Sep; 44(5):776-782. doi: 10.1111/jvp.12977. [PMID: 33978255]
  • John J Mariani, Martina Pavlicova, Cale Basaraba, Agnieszka Mamczur-Fuller, Daniel J Brooks, Adam Bisaga, Kenneth M Carpenter, Edward V Nunes, Frances R Levin. Pilot randomized placebo-controlled clinical trial of high-dose gabapentin for alcohol use disorder. Alcoholism, clinical and experimental research. 2021 08; 45(8):1639-1652. doi: 10.1111/acer.14648. [PMID: 34120336]
  • Sarah J Phillips, Alison Oliveto, Michael J Mancino, Howard P Hendrickson. Development and validation of a rapid liquid chromatography/tandem mass spectrometry method to quantitate gabapentin and buprenorphine in human serum. Rapid communications in mass spectrometry : RCM. 2021 Jul; 35(14):e9104. doi: 10.1002/rcm.9104. [PMID: 33860565]
  • Jennifer E Slovak, Ana P Costa. A pilot study of transdermal gabapentin in cats. Journal of veterinary internal medicine. 2021 Jul; 35(4):1981-1987. doi: 10.1111/jvim.16137. [PMID: 34060655]
  • Marisol Contreras-Mota, Viviana Rosales-Cortés. [Hepatotoxicity probably associated with gabapentin]. Revista medica del Instituto Mexicano del Seguro Social. 2021 Jun; 59(2):157-162. doi: NULL. [PMID: 34232226]
  • Vishal Duggal, I-Chun Thomas, Maria E Montez-Rath, Glenn M Chertow, Manjula Kurella Tamura. National Estimates of CKD Prevalence and Potential Impact of Estimating Glomerular Filtration Rate Without Race. Journal of the American Society of Nephrology : JASN. 2021 06; 32(6):1454-1463. doi: 10.1681/asn.2020121780. [PMID: 33958490]
  • M L Eckard, S G Kinsey. Gabapentin attenuates somatic signs of precipitated THC withdrawal in mice. Neuropharmacology. 2021 06; 190(?):108554. doi: 10.1016/j.neuropharm.2021.108554. [PMID: 33845073]
  • James O Meyer, Annette C Dolphin. Rab11-dependent recycling of calcium channels is mediated by auxiliary subunit α2δ-1 but not α2δ-3. Scientific reports. 2021 05; 11(1):10256. doi: 10.1038/s41598-021-89820-1. [PMID: 33986433]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Younes Valadbeigi, Vahideh Ilbeigi, Wafiullah Mamozai, Majid Soleimani. Rapid and simple determination of gabapentin in urine by ion mobility spectrometry. Journal of pharmaceutical and biomedical analysis. 2021 Apr; 197(?):113980. doi: 10.1016/j.jpba.2021.113980. [PMID: 33636645]
  • Manami Akasaka, Atsushi Kamei, Sachiko Tanifuji, Maya Asami, Jun Ito, Kanako Mizuma, Kotaro Oyama, Tomoharu Tokutomi, Kayono Yamamoto, Akimune Fukushima, Toshiki Takenouchi, Tomoko Uehara, Hisato Suzuki, Kenjiro Kosaki. GNAO1 mutation-related severe involuntary movements treated with gabapentin. Brain & development. 2021 Apr; 43(4):576-579. doi: 10.1016/j.braindev.2020.12.002. [PMID: 33358199]
  • Avery Kopacz, Cameron Ludwig, Michelle Tarbox. Atypical cutaneous and musculoskeletal manifestation of SARS-CoV-2: 'COVID-19 toes' and spasticity in a 48-year-old woman. BMJ case reports. 2021 Mar; 14(3):. doi: 10.1136/bcr-2020-241410. [PMID: 33731393]
  • Alexander Brown, Aimalohi Esechie, Bhanu Gogia, Elena Shanina. Gabapentin-Induced Myokymia: A Case Report. Clinical neuropharmacology. 2021 Mar; 44(2):75-76. doi: 10.1097/wnf.0000000000000434. [PMID: 33480615]
  • Nermeen N Welson, Remon R Rofaeil, Sabreen Mahmoud Ahmed, Shereen S Gaber, Gaber El-Saber Batiha, Mary Girgis Shahataa. Vitamin E protects against gabapentin-induced chronic hepatic and renal damage associated with the inhibition of apoptosis and tissue injury in rats. Life sciences. 2021 Feb; 267(?):118940. doi: 10.1016/j.lfs.2020.118940. [PMID: 33359747]
  • Anudeep Kaur, Lovedeep Singh, Saweta Garg, Harmanpreet Kaur, Nirmal Singh, Rajbir Bhatti. Involvement of Oxidative Stress and Nerve Growth Factor in Behavioral and Biochemical Deficits of Experimentally Induced Musculoskeletal Pain in Mice: Ameliorative Effects of Heraclin. Journal of molecular neuroscience : MN. 2021 Feb; 71(2):347-357. doi: 10.1007/s12031-020-01656-y. [PMID: 32676972]
  • Reem Odi, Valentina Franco, Emilio Perucca, Meir Bialer. Bioequivalence and switchability of generic antiseizure medications (ASMs): A re-appraisal based on analysis of generic ASM products approved in Europe. Epilepsia. 2021 02; 62(2):285-302. doi: 10.1111/epi.16802. [PMID: 33426641]
  • Youyi Peng, Qiang Zhang, William J Welsh. Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management. Journal of medicinal chemistry. 2021 01; 64(1):890-904. doi: 10.1021/acs.jmedchem.0c01964. [PMID: 33372782]
  • Daniel Brunnhoelzl, Alexander N Hanania, Alfredo Echeverria, Jan Sunde, Connie Tran, Michelle Ludwig. Paracervical blocks facilitate timely brachytherapy amidst COVID-19. Brachytherapy. 2021 Jan; 20(1):284-289. doi: 10.1016/j.brachy.2020.08.002. [PMID: 32891569]
  • Yara A Samra, Mohamed N Amin, Eman Said. Cardio-protective impact of gabapentin against doxorubicin-induced myocardial toxicity in rats; emphasis on modulation of inflammatory-apoptotic signaling. International immunopharmacology. 2021 Jan; 90(?):107125. doi: 10.1016/j.intimp.2020.107125. [PMID: 33199237]
  • Alessandro Ruggieri, Rossella Picollo, Alessandra Del Vecchio, Fabrizio Calisti, Patrizia Dragone, Alessandro Comandini, Maria T Rosignoli, Agnese Cattaneo, Frank Donath, Ralph-Steven Wedemeyer, Marina Todorova-Sanjari, André Warnke, Henning H Blume. Investigations on dose proportionality and drug-drug interaction for a fixed-dose combination of trazodone and gabapentin. International journal of clinical pharmacology and therapeutics. 2021 Jan; 59(1):71-86. doi: 10.5414/cp203845. [PMID: 33040841]
  • Ibrahim A Naguib, Nesma A Ali, Fadwa A Elroby, Mohamed R El Ghobashy, Fatma F Abdallah. US FDA-validated green GC-MS method for analysis of gabapentin, tramadol and/or amitriptyline mixtures in biological fluids. Bioanalysis. 2020 Nov; 12(21):1521-1533. doi: 10.4155/bio-2020-0217. [PMID: 33118848]
  • S Mohammadi Kebar, A Sharghi, M Ghorghani, S Hoseininia. Comparison of gabapentin and hydroxyzine in the treatment of pruritus in patients on dialysis. Clinical and experimental dermatology. 2020 Oct; 45(7):866-871. doi: 10.1111/ced.14270. [PMID: 32363638]
  • Fatma Duygu Kaya-Yertutanol, İ Tayfun Uzbay, Burcu Çevreli, Hayrunnisa Bolay-Belen. Effect of gabapentin on sleep-deprivation-induced disruption of prepulse inhibition. Psychopharmacology. 2020 Oct; 237(10):2993-3006. doi: 10.1007/s00213-020-05587-9. [PMID: 32594186]
  • Jiwoon Ra, Hoonsik Yoom, Heejong Son, Yunho Lee. Occurrence and transformation of gabapentin in urban water quality engineering: Rapid formation of nitrile from amine during drinking water chlorination. Water research. 2020 Oct; 184(?):116123. doi: 10.1016/j.watres.2020.116123. [PMID: 32698090]
  • Feyzullah Aksan, Eric Andrew Nelson, Kristin A Swedish. A COVID-19 patient with intense burning pain. Journal of neurovirology. 2020 10; 26(5):800-801. doi: 10.1007/s13365-020-00887-4. [PMID: 32779108]
  • Sindhuja Korem, Haresh Gandhi, Decerie Baculi Dayag. Guillain-Barré syndrome associated with COVID-19 disease. BMJ case reports. 2020 Sep; 13(9):. doi: 10.1136/bcr-2020-237215. [PMID: 32958554]
  • Rajkumar Chinnadurai, Smeeta Sinha, Aoife C Lowney, Mary Miller. Pain management in patients with end-stage renal disease and calciphylaxis- a survey of clinical practices among physicians. BMC nephrology. 2020 09; 21(1):403. doi: 10.1186/s12882-020-02067-2. [PMID: 32948131]
  • Aaron J Trachtenberg, David Collister, Claudio Rigatto. Recent advances in the treatment of uremic pruritus. Current opinion in nephrology and hypertension. 2020 09; 29(5):465-470. doi: 10.1097/mnh.0000000000000625. [PMID: 32740217]
  • Terese Monette O Aquino, Karla Angela C Luchangco, Elizabeth V Sanchez, Vermen M Verallo-Rowell. A randomized controlled study of 6\% gabapentin topical formulation for chronic kidney disease-associated pruritus. International journal of dermatology. 2020 Aug; 59(8):955-961. doi: 10.1111/ijd.14953. [PMID: 32459016]
  • Ana Carolina Conchon Costa, Priscila Akemi Yamamoto, Gabriela Rocha Lauretti, Jhohann Richard de Lima Benzi, Cleslei Fernando Zanelli, Vivien Barz, Giuliano Ciarimboli, Natália Valadares de Moraes. Cetirizine Reduces Gabapentin Plasma Concentrations and Effect: Role of Renal Drug Transporters for Organic Cations. Journal of clinical pharmacology. 2020 08; 60(8):1076-1086. doi: 10.1002/jcph.1603. [PMID: 32149389]
  • Jennifer A Felsted, Alice Meng, Dominique Ameroso, Maribel Rios. Sex-specific Effects of α2δ-1 in the Ventromedial Hypothalamus of Female Mice Controlling Glucose and Lipid Balance. Endocrinology. 2020 07; 161(7):. doi: 10.1210/endocr/bqaa068. [PMID: 32337532]
  • Saleh Ghiasy, Ali Tayebi-Azar, Amin Alinezhad, Morteza Fallah-Karkan, Hojat Salimi, Seyyed Ali Hojjati, Jalil Hosseini. The Effect Of Preoperative Gabapentin on Pain Severity After Posterior Urethral Surgery: A Randomized, Double-Blind, Placebo-Controlled Study. Urology journal. 2020 Jun; 17(6):626-630. doi: 10.22037/uj.v0i0.5598. [PMID: 32654111]
  • Chandan Vangala, Jingbo Niu, Maria E Montez-Rath, Jingyin Yan, Sankar D Navaneethan, Aanand D Naik, Wolfgang C Winkelmayer. Hip Fracture Risk among Hemodialysis-Dependent Patients Prescribed Opioids and Gabapentinoids. Journal of the American Society of Nephrology : JASN. 2020 06; 31(6):1325-1334. doi: 10.1681/asn.2019090904. [PMID: 32371535]
  • Patrick O Mills, Cassandra O Tansey, Sarah C Genzer, Matthew R Mauldin, Rex A Howard, Chantal A Kling, Felix R Jackson, Audrey M Matheny, Dawn M Boothe, George W Lathrop, Nathaniel Powell, Nadia Gallardo-Romero. Pharmacokinetic Profiles of Gabapentin after Oral and Subcutaneous Administration in Black-tailed Prairie Dogs (Cynomys ludovicianus). Journal of the American Association for Laboratory Animal Science : JAALAS. 2020 05; 59(3):305-309. doi: 10.30802/aalas-jaalas-19-000150. [PMID: 32213233]
  • Thierry P I J M Canisius, J W P Hans Soons, Pauline Verschuure, Emmeke A Wammes-van der Heijden, Rob P W Rouhl, H J Marian Majoie. Therapeutic drug monitoring of anti-epileptic drugs - a clinical verification of volumetric absorptive micro sampling. Clinical chemistry and laboratory medicine. 2020 04; 58(5):828-835. doi: 10.1515/cclm-2019-0784. [PMID: 32045349]
  • Shaza Deeb, Fiona M Wylie, Hazel J Torrance, Karen S Scott. An Insight into Gabapentin and Pregabalin in Scottish Prisoners. Journal of analytical toxicology. 2020 Apr; 44(5):504-513. doi: 10.1093/jat/bkz105. [PMID: 31897471]
  • Kathleen May V Eusebio-Alpapara, Rochelle L Castillo, Belen L Dofitas. Gabapentin for uremic pruritus: a systematic review of randomized controlled trials. International journal of dermatology. 2020 Apr; 59(4):412-422. doi: 10.1111/ijd.14708. [PMID: 31777066]
  • Jenifer R Gold, Tamara L Grubb, Stephen Green, Sherry Cox, Nicolas F Villarino. Plasma disposition of gabapentin after the intragastric administration of escalating doses to adult horses. Journal of veterinary internal medicine. 2020 Mar; 34(2):933-940. doi: 10.1111/jvim.15724. [PMID: 32034928]
  • David Wiercigroch, Hasan Sheikh, Jennifer Hulme. A rapid access to addiction medicine clinic facilitates treatment of substance use disorder and reduces substance use. Substance abuse treatment, prevention, and policy. 2020 01; 15(1):4. doi: 10.1186/s13011-019-0250-1. [PMID: 31931831]
  • Ana Celia Muñoz-Muñoz, Teresa Pekol, Dana Schubring, Robin Hyland, Charlene Johnson, Lawrence Andrade. Characterization of an Amphetamine Interference from Gabapentin in an LC-HRMS Method. Journal of analytical toxicology. 2020 Jan; 44(1):36-40. doi: 10.1093/jat/bkz046. [PMID: 31263895]
  • Ayako Furugen. [Transfer Mechanisms of Compounds between Mother and Fetus/Infant Aimed for Optimized Medication during Pregnancy and Breastfeeding]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2020; 140(10):1199-1206. doi: 10.1248/yakushi.20-00140. [PMID: 32999198]
  • Salina P Waddy, Adan Z Becerra, Julia B Ward, Kevin E Chan, Chyng-Wen Fwu, Paul W Eggers, Kevin C Abbott, Paul L Kimmel. Concomitant Use of Gabapentinoids with Opioids Is Associated with Increased Mortality and Morbidity among Dialysis Patients. American journal of nephrology. 2020; 51(6):424-432. doi: 10.1159/000507725. [PMID: 32428902]
  • Somayeh Iravani, Amir Hooman Kazemi Motlagh, Seyede Zahra Emami Razavi, Farhad Shahi, Jing Wang, Li Hou, Wenjun Sun, Mohammad Reza Afshari Fard, Mahdi Aghili, Mehrdad Karimi, Hossein Rezaeizadeh, Baixiao Zhao. Effectiveness of Acupuncture Treatment on Chemotherapy-Induced Peripheral Neuropathy: A Pilot, Randomized, Assessor-Blinded, Controlled Trial. Pain research & management. 2020; 2020(?):2504674. doi: 10.1155/2020/2504674. [PMID: 32676134]
  • Ahmed Yeddi, Omeralfaroug Adam, Mowyad Khalid, Sindhuri Benjaram, Ahmad Abu-Heija, Mohamed A Abdallah, Pranav Shah. Myoclonus and Altered Mental Status Induced by Single Dose of Gabapentin in a Patient With End-Stage Renal Disease: A Case Report and Literature Review. American journal of therapeutics. 2019 Nov; 26(6):e768-e770. doi: 10.1097/mjt.0000000000000942. [PMID: 30839320]
  • Katarzyna Socała, Elżbieta Wyska, Małgorzata Szafarz, Dorota Nieoczym, Piotr Wlaź. Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies. Neuropharmacology. 2019 11; 158(?):107733. doi: 10.1016/j.neuropharm.2019.107733. [PMID: 31377197]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Tianle Gao, Tiansheng Shi, Zsuzsanna Wiesenfeld-Hallin, Tao Li, Jian-Dong Jiang, Xiao-Jun Xu. Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain. European journal of pharmacology. 2019 Jul; 854(?):101-108. doi: 10.1016/j.ejphar.2019.03.061. [PMID: 30954565]
  • Griet Van Lancker, Luc Van Bortel, Brant Delafontaine, Koen Boussery, Eleonora Swart, Abdel Chahbouni, Jan Van Bocxlaer, Pieter Colin. Switchability of Gabapentin Formulations: A Randomized Trial to Assess Bioequivalence Between Neurontin and Gabasandoz on the Individual Subject Level. Clinical pharmacology and therapeutics. 2019 07; 106(1):195-203. doi: 10.1002/cpt.1353. [PMID: 30636281]
  • Mohammad Shamsul Ola, Abdullah S Alhomida, Kathryn F LaNoue. Gabapentin Attenuates Oxidative Stress and Apoptosis in the Diabetic Rat Retina. Neurotoxicity research. 2019 Jul; 36(1):81-90. doi: 10.1007/s12640-019-00018-w. [PMID: 30830678]
  • Sara N Davison. Clinical Pharmacology Considerations in Pain Management in Patients with Advanced Kidney Failure. Clinical journal of the American Society of Nephrology : CJASN. 2019 06; 14(6):917-931. doi: 10.2215/cjn.05180418. [PMID: 30833302]
  • Margrete Larsen Burns, Einar Kinge, Mimi Stokke Opdal, Svein I Johannessen, Cecilie Johannessen Landmark. Therapeutic drug monitoring of gabapentin in various indications. Acta neurologica Scandinavica. 2019 May; 139(5):446-454. doi: 10.1111/ane.13075. [PMID: 30710348]
  • Sriram Sriperumbuduri, Swapnil Hiremath. The case for cautious consumption: NSAIDs in chronic kidney disease. Current opinion in nephrology and hypertension. 2019 03; 28(2):163-170. doi: 10.1097/mnh.0000000000000473. [PMID: 30531470]
  • Priscila A Yamamoto, Jhohann R L Benzi, Francine J Azeredo, Fabíola Dach, Edgar Ianhez Júnior, Cleslei F Zanelli, Natália V de Moraes. Pharmacogenetics-based population pharmacokinetic analysis of gabapentin in patients with chronic pain: Effect of OCT2 and OCTN1 gene polymorphisms. Basic & clinical pharmacology & toxicology. 2019 Mar; 124(3):266-272. doi: 10.1111/bcpt.13126. [PMID: 30192429]
  • Bing Chun Yan, Jie Wang, Yanggang Rui, Jianwen Cao, Pei Xu, Dan Jiang, Xiaolu Zhu, Moo-Ho Won, Ping Bo, Peiqing Su. Neuroprotective Effects of Gabapentin Against Cerebral Ischemia Reperfusion-Induced Neuronal Autophagic Injury via Regulation of the PI3K/Akt/mTOR Signaling Pathways. Journal of neuropathology and experimental neurology. 2019 02; 78(2):157-171. doi: 10.1093/jnen/nly119. [PMID: 30597043]
  • Ai-Ling Li, Xiaoyan Lin, Amey S Dhopeshwarkar, Ana Carla Thomaz, Lawrence M Carey, Yingpeng Liu, Spyros P Nikas, Alexandros Makriyannis, Ken Mackie, Andrea G Hohmann. Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal. Molecular pharmacology. 2019 02; 95(2):155-168. doi: 10.1124/mol.118.113233. [PMID: 30504240]
  • Y Aman, T Pitcher, C Ballard, M Malcangio. Impaired chronic pain-like behaviour and altered opioidergic system in the TASTPM mouse model of Alzheimer's disease. European journal of pain (London, England). 2019 01; 23(1):91-106. doi: 10.1002/ejp.1288. [PMID: 29987897]
  • Stephen Merrigan, Kamisha L Johnson-Davis. Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method to Quantify Gabapentin and Pregabalin in Urine. Methods in molecular biology (Clifton, N.J.). 2019; 1872(?):119-127. doi: 10.1007/978-1-4939-8823-5_12. [PMID: 30350285]
  • Derek Adrian, Mark G Papich, Ronald Baynes, Emma Stafford, B Duncan X Lascelles. The pharmacokinetics of gabapentin in cats. Journal of veterinary internal medicine. 2018 Nov; 32(6):1996-2002. doi: 10.1111/jvim.15313. [PMID: 30307652]
  • Rahul Lauhan, Alan Hsu, Al Alam, Kristin Beizai. Tianeptine Abuse and Dependence: Case Report and Literature Review. Psychosomatics. 2018 11; 59(6):547-553. doi: 10.1016/j.psym.2018.07.006. [PMID: 30149933]
  • Yunfeng Jiang, Junhong Li, Huasheng Lin, Qiaotong Huang, Tongbiao Wang, Shijie Zhang, Qing Zhang, Zheng Rong, Jun Xiong. The efficacy of gabapentin in reducing pain intensity and morphine consumption after breast cancer surgery: A meta-analysis. Medicine. 2018 Sep; 97(38):e11581. doi: 10.1097/md.0000000000011581. [PMID: 30235654]
  • Geoffrey R Browning, James W Carpenter, Geraldine C Magnin, Butch KuKanich. PHARMACOKINETICS OF ORAL GABAPENTIN IN CARIBBEAN FLAMINGOS ( PHOENICOPTERUS RUBER RUBER). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2018 Sep; 49(3):609-616. doi: 10.1638/2017-0245.1. [PMID: 30212356]
  • Peter M Sinclair. Interventions for chronic kidney disease-associated restless legs syndrome. International journal of evidence-based healthcare. 2018 09; 16(3):182-184. doi: 10.1097/xeb.0000000000000137. [PMID: 29517509]
  • Michal Behuliak, Michal Bencze, Kamila Polgárová, Jaroslav Kuneš, Ivana Vaněčková, Josef Zicha. Hemodynamic Response to Gabapentin in Conscious Spontaneously Hypertensive Rats. Hypertension (Dallas, Tex. : 1979). 2018 09; 72(3):676-685. doi: 10.1161/hypertensionaha.118.09909. [PMID: 30354755]
  • Khaled G Abdel-Wahhab, Eitedal M Daoud, Aliaa El Gendy, Hagar H Mourad, Fathia A Mannaa, Maha M Saber. Efficiencies of Low-Level Laser Therapy (LLLT) and Gabapentin in the Management of Peripheral Neuropathy: Diabetic Neuropathy. Applied biochemistry and biotechnology. 2018 Sep; 186(1):161-173. doi: 10.1007/s12010-018-2729-z. [PMID: 29527628]
  • Anna Skogh, Anna Lesniak, Christian Sköld, Maria Karlgren, Fabienne Z Gaugaz, Richard Svensson, Shanti Diwakarla, Anna Jonsson, Rebecca Fransson, Fred Nyberg, Mathias Hallberg, Anja Sandström. An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice. Bioorganic & medicinal chemistry letters. 2018 08; 28(14):2446-2450. doi: 10.1016/j.bmcl.2018.06.009. [PMID: 29929882]
  • Mariele Gobo-Oliveira, Vitória G Pigari, Matheus Sp Ogata, Hélio A Miot, Daniela Ponce, Luciana Pf Abbade. Gabapentin versus dexchlorpheniramine as treatment for uremic pruritus: a randomised controlled trial. European journal of dermatology : EJD. 2018 Aug; 28(4):488-495. doi: 10.1684/ejd.2018.3356. [PMID: 29976533]
  • Michael J Palte, Sankha S Basu, Jameson L Dahlin, Ralitsa Gencheva, Donald Mason, Petr Jarolim, Athena K Petrides. Development and Validation of an Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Method for the Concurrent Measurement of Gabapentin, Lamotrigine, Levetiracetam, Monohydroxy Derivative of Oxcarbazepine, and Zonisamide Concentrations in Serum in a Clinical Setting. Therapeutic drug monitoring. 2018 08; 40(4):469-476. doi: 10.1097/ftd.0000000000000516. [PMID: 29994986]
  • Radomir Reszke, Jacek C Szepietowski. End-Stage Renal Disease Chronic Itch and Its Management. Dermatologic clinics. 2018 Jul; 36(3):277-292. doi: 10.1016/j.det.2018.02.007. [PMID: 29929599]
  • Konstantinos C Fragkos, John Barragry, Charisma Shahi Fernando, Marco Novelli, Joanna Begent, Natalia Zárate-Lopez. Severe eosinophilic colitis caused by neuropathic agents in a patient with chronic fatigue syndrome and functional abdominal pain: case report and review of the literature. Zeitschrift fur Gastroenterologie. 2018 06; 56(6):573-577. doi: 10.1055/a-0596-7981. [PMID: 29890559]
  • Jhohann Richard de Lima Benzi, Priscila Akemi Yamamoto, Jessica Hanna Stevens, Amanda Martins Baviera, Natália Valadares de Moraes. The role of organic cation transporter 2 inhibitor cimetidine, experimental diabetes mellitus and metformin on gabapentin pharmacokinetics in rats. Life sciences. 2018 May; 200(?):63-68. doi: 10.1016/j.lfs.2018.03.012. [PMID: 29551575]
  • Dennis Swearingen, Gerald M Aronoff, Sabrina Ciric, Ritu Lal. Pharmacokinetics of immediate release, extended release, and gastric retentive gabapentin formulations in healthy adults
. International journal of clinical pharmacology and therapeutics. 2018 May; 56(5):231-238. doi: 10.5414/cp203166. [PMID: 29633699]
  • Michael E Chua, Manuel C See, Ednalyn B Esmeňa, Jaime C Balingit, Marcelino L Morales. Efficacy and Safety of Gabapentin in Comparison to Solifenacin Succinate in Adult Overactive Bladder Treatment. Lower urinary tract symptoms. 2018 May; 10(2):135-142. doi: 10.1111/luts.12152. [PMID: 28150436]
  • Ezgi Erkılıç, Elvin Kesimci, Duygu Sahin, Bülent Bektaşer, Nadir Yalçın, Süleyman Ellik, Aylin Sepici-Dinçel. Does preemptive gabapentin modulate cytokine response in total knee arthroplasty? A placebo controlled study. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2018 Apr; 27(4):487-491. doi: 10.17219/acem/68630. [PMID: 29943522]
  • Robab Maghsoudi, Saeed Farhadi-Niaki, Masoud Etemadian, Amir H Kashi, Pejman Shadpour, Asemaneh Shirani, Rana Samadinezhad-Khoshbaf-Sorkhabi, Meghdad Tabatabaei. Comparing the Efficacy of Tolterodine and Gabapentin Versus Placebo in Catheter Related Bladder Discomfort After Percutaneous Nephrolithotomy: A Randomized Clinical Trial. Journal of endourology. 2018 02; 32(2):168-174. doi: 10.1089/end.2017.0563. [PMID: 29278929]
  • Jing Miao, Doreen E Aboagye, Boris Chulpayev, Lin Liu, Gary Ishkanian, Bangaruraju Kolanuvada, Dariush Alaie, Richard L Petrillo. Importance of Regular and Maintenance Therapy Adherence in Neuromyelitis Optica (NMO): Lessons from a Repeating Relapse Case. The American journal of case reports. 2018 Jan; 19(?):41-46. doi: 10.12659/ajcr.906150. [PMID: 29321467]