Alisol A (BioDeep_00000011709)

 

Secondary id: BioDeep_00000175855, BioDeep_00000230343, BioDeep_00000230812, BioDeep_00001871111

PANOMIX_OTCML-2023


代谢物信息卡片


(5R,8S,9S,10S,11S,14R)-11-hydroxy-4,4,8,10,14-pentamethyl-17-[(4S,5R)-4,5,6-trihydroxy-6-methylheptan-2-yl]-1,2,5,6,7,9,11,12,15,16-decahydrocyclopenta[a]phenanthren-3-one

化学式: C30H50O5 (490.365805)
中文名称: 阿里索尔A, 泽泻醇 A
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 6.67%

分子结构信息

SMILES: C(CC(C(=C14)CCC1(C(C([H])2C(O)C4)(C)CCC(C(C)(C)3)([H])C(CCC3=O)2C)C)C)(C(C(C)(C)O)O)O
InChI: InChI=1S/C30H50O5/c1-17(15-21(32)25(34)27(4,5)35)18-9-13-29(7)19(18)16-20(31)24-28(6)12-11-23(33)26(2,3)22(28)10-14-30(24,29)8/h17,20-22,24-25,31-32,34-35H,9-16H2,1-8H3/t17-,20+,21+,22+,24+,25-,28+,29+,30+/m1/s1

描述信息

Alisol A is a natural product.
Alisol A is a natural product.

同义名列表

3 个代谢物同义名

Alisol A; (5R,8S,9S,10S,11S,14R)-11-hydroxy-4,4,8,10,14-pentamethyl-17-[(4S,5R)-4,5,6-trihydroxy-6-methylheptan-2-yl]-1,2,5,6,7,9,11,12,15,16-decahydrocyclopenta[a]phenanthren-3-one; Alisol-A



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Huihong Li, Caiyun Zhang, Yangjie Zhou, Yunfei Deng, Xiaoqing Zheng, Xiehua Xue. Neurovascular protection of alisol A on cerebral ischemia mice through activating the AKT/GSK3β pathway. Aging. 2023 10; 15(20):11639-11653. doi: 10.18632/aging.205151. [PMID: 37889534]
  • Taotao Lu, Linlin Ding, Xiaoqing Zheng, Yongxu Li, Wei Wei, Weilin Liu, Jing Tao, Xiehua Xue. Alisol A Exerts Neuroprotective Effects Against HFD-Induced Pathological Brain Aging via the SIRT3-NF-κB/MAPK Pathway. Molecular neurobiology. 2023 Sep; ?(?):. doi: 10.1007/s12035-023-03592-5. [PMID: 37659035]
  • Fei Yang, Lihua Gu, Zhuzhen Han, Zhengtao Wang. Rapid screening for natural lipase inhibitors from Alisma orientale combining high-performance thin-layer chromatography-bioautography with mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Apr; 1170(?):122599. doi: 10.1016/j.jchromb.2021.122599. [PMID: 33713950]
  • Yanyan Shi, Mopei Wang, Pan Wang, Ting Zhang, Jingyi Yu, Lunyong Shi, Mo Li, Hao Wang, Qingying Zhang, Hongmei Zhao. Alisol A is potentially therapeutic in human breast cancer cells. Oncology reports. 2020 09; 44(3):1266-1274. doi: 10.3892/or.2020.7654. [PMID: 32582967]
  • Xiaomei Xu, Lisha Li, Yamin Zhang, Xuehua Lu, Wei Lin, Shuangshuang Wu, Xia Qin, Rongqing Xu, Wenjin Lin. Hypolipidemic effect of Alisma orientale (Sam.) Juzep on gut microecology and liver transcriptome in diabetic rats. PloS one. 2020; 15(10):e0240616. doi: 10.1371/journal.pone.0240616. [PMID: 33035272]
  • Chiakang Ho, Ya Gao, Danning Zheng, Yanjun Liu, Shengzhou Shan, Bin Fang, Yixuan Zhao, Dingzhong Song, Yifan Zhang, Qingfeng Li. Alisol A attenuates high-fat-diet-induced obesity and metabolic disorders via the AMPK/ACC/SREBP-1c pathway. Journal of cellular and molecular medicine. 2019 08; 23(8):5108-5118. doi: 10.1111/jcmm.14380. [PMID: 31144451]
  • Ya-Li Wang, Jian-Chao Zhao, Jia-Hao Liang, Xiang-Ge Tian, Xiao-Kui Huo, Lei Feng, Jing Ning, Chao Wang, Bao-Jing Zhang, Gang Chen, Ning Li, Cheng-Peng Sun. A bioactive new protostane-type triterpenoid from Alisma plantago-aquatica subsp. orientale (Sam.) Sam. Natural product research. 2019 Mar; 33(6):776-781. doi: 10.1080/14786419.2017.1408106. [PMID: 29183156]
  • Fei Xu, Cai Lu, Qinan Wu, Wei Gu, Jun Chen, Fang Fang, Bo Zhao, Wenjia Du, Min You. Studies on the lipid-regulating mechanism of alisol-based compounds on lipoprotein lipase. Bioorganic chemistry. 2018 10; 80(?):347-360. doi: 10.1016/j.bioorg.2018.07.001. [PMID: 29986183]
  • Maoliang Liao, Haihua Shang, Yazhuo Li, Tian Li, Miao Wang, Yanan Zheng, Wenbin Hou, Changxiao Liu. An integrated approach to uncover quality marker underlying the effects of Alisma orientale on lipid metabolism, using chemical analysis and network pharmacology. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Jun; 45(?):93-104. doi: 10.1016/j.phymed.2018.04.006. [PMID: 29705003]
  • Zhen-Peng Mai, Kun Zhou, Guang-Bo Ge, Chao Wang, Xiao-Kui Huo, Pei-Pei Dong, Sa Deng, Bao-Jing Zhang, Hou-Li Zhang, Shan-Shan Huang, Xiao-Chi Ma. Protostane Triterpenoids from the Rhizome of Alisma orientale Exhibit Inhibitory Effects on Human Carboxylesterase 2. Journal of natural products. 2015 Oct; 78(10):2372-80. doi: 10.1021/acs.jnatprod.5b00321. [PMID: 26425784]
  • Megumi Sumino, Yuko Saito, Fumio Ikegami, Takao Namiki. A simultaneous determination of principal compounds in tokishakuyakusan by high-performance liquid chromatography with diode array detector. Journal of chromatographic science. 2015 Feb; 53(2):320-4. doi: 10.1093/chromsci/bmu062. [PMID: 24981981]
  • Wen Xu, Ting Li, Jian-Fang Qiu, Shui-Sheng Wu, Ming-Qing Huang, Li-Gen Lin, Qing-Wen Zhang, Xiu-Ping Chen, Jin-Jian Lu. Anti-proliferative activities of terpenoids isolated from Alisma orientalis and their structure-activity relationships. Anti-cancer agents in medicinal chemistry. 2015; 15(2):228-35. doi: 10.2174/1871520614666140601213514. [PMID: 24893804]
  • Michael Adams, Sofia Gschwind, Stefanie Zimmermann, Marcel Kaiser, Matthias Hamburger. Renaissance remedies: Antiplasmodial protostane triterpenoids from Alisma plantago-aquatica L. (Alismataceae). Journal of ethnopharmacology. 2011 Apr; 135(1):43-7. doi: 10.1016/j.jep.2011.02.026. [PMID: 21354292]
  • Yue Yu, Qing Li, Kaishun Bi, Pu Xie, Guoguang Yang, Xiaohui Chen. A sensitive liquid chromatography-mass spectrometry method for simultaneous determination of alisol A and alisol A 24-acetate from Alisma orientale (Sam.) Juz. in rat plasma. Analytical and bioanalytical chemistry. 2011 Jan; 399(3):1363-9. doi: 10.1007/s00216-010-4426-9. [PMID: 21107819]
  • Jun-Ho Lee, Yoo-Jin Lee, Seok-Woo Kang, Yangseok Kim, Minkyu Shin, Moochang Hong, Eun-Kyoung Seo, Sung-Hoon Kim, Seung-Yeol Nah, Hyunsu Bae. Effects of protostane-type triterpenoids on the 5-HT3A receptor-mediated ion current in Xenopus oocytes. Brain research. 2010 May; 1331(?):20-7. doi: 10.1016/j.brainres.2010.03.041. [PMID: 20307506]
  • Quan Zhang, Zhi-Yong Jiang, Jie Luo, Yun-Bao Ma, Ji-Feng Liu, Rui-Hua Guo, Xue-Mei Zhang, Jun Zhou, Wei Niu, Fei-Fei Du, Li Li, Chuan Li, Ji-Jun Chen. Anti-HBV agents. Part 3: preliminary structure-activity relationships of tetra-acylalisol A derivatives as potent hepatitis B virus inhibitors. Bioorganic & medicinal chemistry letters. 2009 Dec; 19(23):6659-65. doi: 10.1016/j.bmcl.2009.10.006. [PMID: 19853440]
  • Jing Zhang, Wenyu Yang, Xingfu Chen, Weiguo Liu, Shenglun Chen, Gang Du. [Variation in yield and quality of Alisma orientalis grown under different ecological climatic regions]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 Nov; 34(22):2857-61. doi: ". [PMID: 20209945]
  • Quan Zhang, Zhi-Yong Jiang, Jie Luo, Ji-Feng Liu, Yun-Bao Ma, Rui-Hua Guo, Xue-Mei Zhang, Jun Zhou, Ji-Jun Chen. Anti-HBV agents. Part 2: synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives. Bioorganic & medicinal chemistry letters. 2009 Apr; 19(8):2148-53. doi: 10.1016/j.bmcl.2009.02.122. [PMID: 19289281]
  • Chaofeng Zhang, Aichun Zhou, Mian Zhang. [Chemical constituents of Alisma orientalis and their immunosuppressive function]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 Apr; 34(8):994-8. doi: . [PMID: 19639784]
  • Qiang Liao, Wen-Yu Yang, Xing-Fu Chen, Xiong Yao. [Effects of S-3307 on the yield and main ingredients of Alisma plantago-aquatica]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Dec; 33(24):2901-4. doi: ". [PMID: 19294845]
  • Quan Zhang, Zhi-Yong Jiang, Jie Luo, Pi Cheng, Yun-Bao Ma, Xue-Mei Zhang, Feng-Xue Zhang, Jun Zhou, Ji-Jun Chen. Anti-HBV agents. Part 1: Synthesis of alisol A derivatives: a new class of hepatitis B virus inhibitors. Bioorganic & medicinal chemistry letters. 2008 Aug; 18(16):4647-50. doi: 10.1016/j.bmcl.2008.07.012. [PMID: 18644720]