Questiomycin A (BioDeep_00000004860)

 

Secondary id: BioDeep_00001868452

human metabolite Endogenous blood metabolite


代谢物信息卡片


2-Acetylamino-(3H)-phenoxazin-3-one

化学式: C12H8N2O2 (212.0586)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(otcml) 31.7%

分子结构信息

SMILES: C1=CC=C2C(=C1)N=C3C=C(C(=O)C=C3O2)N
InChI: InChI=1S/C12H8N2O2/c13-7-5-9-12(6-10(7)15)16-11-4-2-1-3-8(11)14-9/h1-6H,13H2

描述信息

Questiomycin A, also known as 2-aminophenoxazin-3-one (APO), is found in mushrooms such as Calocybe gambosa (St Georges mushroom). 2-Aminophenoxazin-3-one is a benzoxazinoid metabolite. It was found excreted in the feces of rats that were fed a rye bread-based diet which makes this compound a potential fecal biomarker of whole grain intake (PMID: 23113707).

同义名列表

17 个代谢物同义名

2-Acetylamino-(3H)-phenoxazin-3-one; Acrospermum viticola toxin C; 2-Amino-3H-phenoxazin-3-one; 2-Aminophenoxazine-3-one; 2-Amino-phenoxazin-3-one; 2-Aminophenoxazin-3-one; 2-Amino-3-phenoxazone; 2-Aminophenoxazone; 3-Aminophenoxazone; 2-Aminophenoxazon; Questinomycine a; Questiomycin A; Isophenoxazine; AV toxin C; NSC 94945; PHX-3 CPD; 2-Aminophenoxazin-3-one



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ANG, ANXA5, BIRC5, CASP3, CASP7, DDIT3, EDN1, HTT, MAPK8, MITF, NFKB1, PTGS2, TYR, XIAP
Peripheral membrane protein 2 ANXA5, PTGS2
Endosome membrane 1 HTT
Endoplasmic reticulum membrane 2 CD4, PTGS2
Nucleus 11 ANG, BIRC5, CASP3, CASP7, DDIT3, HTT, JUN, MAPK8, MITF, NFKB1, XIAP
autophagosome 1 HTT
cytosol 12 ACOX1, ANG, ANXA5, BIRC5, CASP3, CASP7, DDIT3, HTT, MAPK8, MITF, NFKB1, XIAP
dendrite 1 HTT
nucleoplasm 9 BIRC5, CASP3, CASP7, HTT, JUN, MAPK8, MITF, NFKB1, XIAP
RNA polymerase II transcription regulator complex 2 DDIT3, JUN
Cell membrane 2 CD4, HTT
Multi-pass membrane protein 1 HTT
Synapse 2 HTT, MAPK8
cell surface 1 APOH
glutamatergic synapse 1 CASP3
Golgi apparatus 1 HTT
growth cone 1 ANG
lysosomal membrane 1 MITF
neuronal cell body 2 ANG, CASP3
presynaptic membrane 1 HTT
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 CASP7
Lysosome 1 TYR
plasma membrane 3 CD4, HTT, IFNLR1
Membrane 3 ACOX1, ANXA5, IFNLR1
axon 2 HTT, MAPK8
caveola 1 PTGS2
extracellular exosome 2 ANXA5, APOH
Lysosome membrane 1 MITF
endoplasmic reticulum 2 HTT, PTGS2
extracellular space 5 ANG, APOH, CASP7, EDN1, IL4
perinuclear region of cytoplasm 2 HTT, TYR
mitochondrion 1 NFKB1
protein-containing complex 4 BIRC5, HTT, MITF, PTGS2
intracellular membrane-bounded organelle 1 TYR
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 3 CD4, IFNLR1, TYR
Secreted 4 ANG, APOH, EDN1, IL4
extracellular region 6 ANG, ANXA5, APOH, EDN1, IL4, NFKB1
basal part of cell 1 EDN1
transcription regulator complex 3 DDIT3, JUN, NFKB1
external side of plasma membrane 2 ANXA5, CD4
chylomicron 1 APOH
high-density lipoprotein particle 1 APOH
very-low-density lipoprotein particle 1 APOH
actin cytoskeleton 1 ANG
microtubule cytoskeleton 1 BIRC5
nucleolus 1 ANG
Melanosome membrane 1 TYR
midbody 1 BIRC5
Early endosome 2 CD4, HTT
Golgi-associated vesicle 1 TYR
postsynaptic membrane 1 HTT
Membrane raft 2 CD4, HTT
Cell junction, focal adhesion 1 HTT
Cytoplasm, cytoskeleton, spindle 1 BIRC5
focal adhesion 2 ANXA5, HTT
microtubule 1 BIRC5
spindle 1 BIRC5
Peroxisome 1 ACOX1
basement membrane 1 ANG
peroxisomal matrix 1 ACOX1
peroxisomal membrane 1 ACOX1
collagen-containing extracellular matrix 2 ANXA5, APOH
interphase microtubule organizing center 1 BIRC5
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 2 DDIT3, HTT
Cell projection, neuron projection 1 HTT
Zymogen granule membrane 1 ANXA5
neuron projection 2 HTT, PTGS2
chromatin 4 DDIT3, JUN, MITF, NFKB1
Chromosome 2 ANG, BIRC5
centriole 2 BIRC5, HTT
Secreted, extracellular space 1 CASP7
Nucleus, nucleolus 1 ANG
nuclear chromosome 2 BIRC5, JUN
Endomembrane system 1 HTT
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
Cytoplasmic vesicle membrane 1 HTT
Melanosome 1 TYR
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
euchromatin 1 JUN
secretory granule lumen 1 NFKB1
endoplasmic reticulum lumen 2 CD4, PTGS2
specific granule lumen 1 NFKB1
kinetochore 1 BIRC5
endocytic vesicle 1 ANG
transport vesicle 1 EDN1
chromosome, centromeric region 1 BIRC5
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 CD4
chromosome passenger complex 1 BIRC5
cytoplasmic microtubule 1 BIRC5
protein-DNA complex 1 DDIT3
spindle microtubule 1 BIRC5
survivin complex 1 BIRC5
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
postsynaptic cytosol 1 HTT
presynaptic cytosol 1 HTT
transcription factor AP-1 complex 1 JUN
T cell receptor complex 1 CD4
platelet dense granule lumen 1 APOH
angiogenin-PRI complex 1 ANG
rough endoplasmic reticulum lumen 1 EDN1
inclusion body 1 HTT
Weibel-Palade body 1 EDN1
endothelial microparticle 1 ANXA5
CHOP-C/EBP complex 1 DDIT3
CHOP-ATF3 complex 1 DDIT3
CHOP-ATF4 complex 1 DDIT3
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
serotonergic synapse 1 HTT
[Huntingtin]: Cytoplasm 1 HTT
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome 1 HTT
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Shuqi Guo, Hongbo Hu, Wei Wang, Muhammad Bilal, Xuehong Zhang. Production of Antibacterial Questiomycin A in Metabolically Engineered Pseudomonas chlororaphis HT66. Journal of agricultural and food chemistry. 2022 Jun; 70(25):7742-7750. doi: 10.1021/acs.jafc.2c03216. [PMID: 35708224]
  • Sascha Venturelli, Regina G Belz, Andreas Kämper, Alexander Berger, Kyra von Horn, André Wegner, Alexander Böcker, Gérald Zabulon, Tobias Langenecker, Oliver Kohlbacher, Fredy Barneche, Detlef Weigel, Ulrich M Lauer, Michael Bitzer, Claude Becker. Plants Release Precursors of Histone Deacetylase Inhibitors to Suppress Growth of Competitors. The Plant cell. 2015 Nov; 27(11):3175-89. doi: 10.1105/tpc.15.00585. [PMID: 26530086]
  • Hisashi Kato-Noguchi, Francisco A Macías, José M G Molinillo. Structure-activity relationship of benzoxazinones and related compounds with respect to the growth inhibition and alpha-amylase activity in cress seedlings. Journal of plant physiology. 2010 Oct; 167(15):1221-5. doi: 10.1016/j.jplph.2010.04.006. [PMID: 20605653]
  • Shusheng Zhang, Xuemei Li, Fan Zhang. CE-based simultaneous liquid-phase noncompetitive enzyme immunoassay for three tumor markers in human serum using electrochemical detection. Electrophoresis. 2007 Dec; 28(23):4427-34. doi: 10.1002/elps.200700026. [PMID: 17979157]
  • Naoko Miyano-Kurosaki, Kunihiko Kurosaki, Michiko Hayashi, Hiroshi Takaku, Masaaki Hayafune, Ken Shirato, Teruhiko Kasuga, Takahiko Endo, Akio Tomoda. 2-aminophenoxazine-3-one suppresses the growth of mouse malignant melanoma B16 cells transplanted into C57BL/6Cr Slc mice. Biological & pharmaceutical bulletin. 2006 Nov; 29(11):2197-201. doi: 10.1248/bpb.29.2197. [PMID: 17077514]
  • Stefan Martyniuk, Anna Stochmal, Francisco A Macías, David Marín, Wieslaw Oleszek. Effects of some benzoxazinoids on in vitro growth of Cephalosporium gramineum and other fungi pathogenic to cereals and on Cephalosporium stripe of winter wheat. Journal of agricultural and food chemistry. 2006 Feb; 54(4):1036-9. doi: 10.1021/jf050901x. [PMID: 16478214]
  • Mia B Gents, Susan T Nielsen, Anne G Mortensen, Carsten Christophersen, Inge S Fomsgaard. Transformation products of 2-benzoxazolinone (BOA) in soil. Chemosphere. 2005 Sep; 61(1):74-84. doi: 10.1016/j.chemosphere.2005.03.068. [PMID: 15876449]
  • Francisco A Macías, David Marín, Alberto Oliveros-Bastidas, Diego Castellano, Ana M Simonet, José M G Molinillo. Structure-Activity Relationships (SAR) studies of benzoxazinones, their degradation products and analogues. phytotoxicity on standard target species (STS). Journal of agricultural and food chemistry. 2005 Feb; 53(3):538-48. doi: 10.1021/jf0484071. [PMID: 15686399]