o-Cresol (BioDeep_00000004708)

 

Secondary id: BioDeep_00000405504, BioDeep_00000863200

human metabolite blood metabolite natural product


代谢物信息卡片


2-Hydroxy-1-methylbenzene

化学式: C7H8O (108.0575)
中文名称: 邻甲酚
谱图信息: 最多检出来源 Homo sapiens(blood) 16.36%

分子结构信息

SMILES: CC1=CC=CC=C1O
InChI: InChI=1S/C7H8O/c1-6-4-2-3-5-7(6)8/h2-5,8H,1H3

描述信息

o-Cresol is a minor urinary metabolite of toluene, O-cresol is a cresol that is phenol substituted by a methyl group at position 2. It is a minor urinary metabolite of toluene. It has a role as a human xenobiotic metabolite. It is widely used chemical with neurotoxicological properties (PMID:15687000). o-Cresol is used commercially as a disinfectant. Exposure may occur by inhalation, by cutaneous adsorption or by oral ingestion. o-Cresol denature and precipitate cellular proteins and thus may rapidly cause poisoning. o-Cresol is metabolized by conjugation and oxidation. Ingestion of o-Cresol cause intense burning of mouth and throat, followed by marked abdominal pain and distress. The minimum lethal dose of cresol by mouth is about 2 g (PMID 15040915). o-Cresol is a microbial metabolite that can be found in Pseudomonas. Besides, o-Cresol is one of the chemical compounds found in castoreum. This compound is gathered from the beavers castor glands and found in the white cedar consumed by the beavers. Together with many other compounds, o-cresol is traditionally extracted from coal tar, the volatile materials obtained in the production of coke from coal. A similar source material is petroleum residues. These residue contains a few percent by weight of phenol and isomeric cresols. In addition to the materials derived from these natural sources, about two thirds of the Western worlds supply is produced by methylation of phenol using methanol.
Flavouring ingredient. 2-Methylphenol is found in many foods, some of which are yellow bell pepper, pepper (c. annuum), arabica coffee, and asparagus.

同义名列表

22 个代谢物同义名

2-Hydroxy-1-methylbenzene; 1-Methyl-2-hydroxybenzene; 1-Hydroxy-2-methylbenzene; 2-Cresol, potassium salt; 2-Cresol, ammonium salt; 2-Cresol, sodium salt; 2-Hydroxytoluene; O-Hydroxytoluene; O-Methylphenylol; O-Cresylic acid; 2-Methylphenol; O-Methylphenol; Ortho-cresol; O-Oxytoluene; O-Cresylate; Orthocresol; O-Toluol; O-Kresol; o-cresol; 2-Cresol; o-Cresol; o-Cresol



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(3)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

90 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ALB, CAT, CYP1A1, CYP2B6, CYP2C8, CYP2E1, GSTM1, HPGDS, NAT2, PPARG, PTGS2, TYR, XDH
Peripheral membrane protein 6 ACHE, CYP1A1, CYP1B1, CYP2B6, CYP2E1, PTGS2
Endoplasmic reticulum membrane 7 CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C8, CYP2E1, PTGS2
Nucleus 4 ACHE, ALB, NAT2, PPARG
cytosol 7 ALB, CAT, GSTM1, HPGDS, NAT2, PPARG, XDH
centrosome 1 ALB
nucleoplasm 3 ATP2B1, HPGDS, PPARG
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 3 ACHE, ATP2B1, NAT2
Multi-pass membrane protein 3 ATP2B1, NAT2, SLC45A2
Synapse 2 ACHE, ATP2B1
cell surface 1 ACHE
glutamatergic synapse 1 ATP2B1
Golgi apparatus 3 ACHE, ALB, ATRN
mitochondrial inner membrane 2 CYP1A1, CYP2E1
neuromuscular junction 1 ACHE
neuronal cell body 1 NAT2
presynaptic membrane 1 ATP2B1
Lysosome 1 TYR
plasma membrane 5 ACHE, ATP2B1, ATRN, CYP2C8, NAT2
synaptic vesicle membrane 1 ATP2B1
Membrane 6 ACHE, ATP2B1, CAT, CYP1B1, NAT2, SLC45A2
axon 1 NAT2
basolateral plasma membrane 2 ATP2B1, NAT2
caveola 1 PTGS2
extracellular exosome 6 ALB, ALDH2, ATP2B1, ATRN, CAT, NAT2
endoplasmic reticulum 2 ALB, PTGS2
extracellular space 4 ACHE, ALB, ATRN, XDH
perinuclear region of cytoplasm 3 ACHE, PPARG, TYR
mitochondrion 4 ALDH2, CAT, CYP1A1, CYP1B1
protein-containing complex 3 ALB, CAT, PTGS2
intracellular membrane-bounded organelle 11 ATP2B1, CAT, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C8, CYP2E1, HPGDS, PPARG, TYR
Microsome membrane 6 CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2E1, PTGS2
Single-pass type I membrane protein 2 ATRN, TYR
Secreted 2 ACHE, ALB
extracellular region 3 ACHE, ALB, CAT
[Isoform 2]: Secreted 1 ATRN
Mitochondrion matrix 1 ALDH2
mitochondrial matrix 2 ALDH2, CAT
Extracellular side 1 ACHE
anchoring junction 1 ALB
transcription regulator complex 1 NAT2
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Melanosome membrane 2 SLC45A2, TYR
Golgi-associated vesicle 1 TYR
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
focal adhesion 1 CAT
Peroxisome 2 CAT, XDH
basement membrane 1 ACHE
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
lateral plasma membrane 1 ATP2B1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 PPARG
neuron projection 1 PTGS2
ciliary basal body 1 ALB
chromatin 1 PPARG
cell projection 1 ATP2B1
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 1 ATP2B1
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 3]: Secreted 1 ATRN
intercellular bridge 1 GSTM1
Melanosome 1 TYR
Presynaptic cell membrane 1 ATP2B1
side of membrane 1 ACHE
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 2 ALB, PTGS2
platelet alpha granule lumen 1 ALB
immunological synapse 1 ATP2B1
synaptic cleft 1 ACHE
external side of apical plasma membrane 1 NAT2
[Isoform 1]: Cell membrane 1 ATRN
catalase complex 1 CAT
photoreceptor ribbon synapse 1 ATP2B1
[Isoform H]: Cell membrane 1 ACHE
NatA complex 1 NAT2
ciliary transition fiber 1 ALB


文献列表

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  • Mariya S Liyasova, Lawrence M Schopfer, Oksana Lockridge. Cresyl saligenin phosphate makes multiple adducts on free histidine, but does not form an adduct on histidine 438 of human butyrylcholinesterase. Chemico-biological interactions. 2013 Mar; 203(1):103-7. doi: 10.1016/j.cbi.2012.07.006. [PMID: 22898212]
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