Nalpha-Methylhistidine (BioDeep_00000003151)

 

Secondary id: BioDeep_00000898067, BioDeep_00001869537, BioDeep_00001892683

Volatile Flavor Compounds


代谢物信息卡片


Nalpha-Methylhistidine

化学式: C7H11N3O2 (169.0851226)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 60.11%

分子结构信息

SMILES: CNC(CC1=CN=CN1)C(=O)O
InChI: InChI=1S/C7H11N3O2/c1-8-6(7(11)12)2-5-3-9-4-10-5/h3-4,6,8H,2H2,1H3,(H,9,10)(H,11,12)/t6-/m0/s1

描述信息

同义名列表

4 个代谢物同义名

Nalpha-Methylhistidine; N-Methyl-L-histidine; SCHEMBL151334; Nalpha-Methylhistidine



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • M Yusof Said, Angelica Rodriguez-Niño, Adrian Post, Joelle C Schutten, Lyanne M Kieneker, Antonio W Gomes-Neto, Marco van Londen, Maryse Cj Osté, Karin J Borgonjen-van den Berg, Ilja M Nolte, Else van den Berg, Pim de Blaauw, Jennifer van der Krogt, M Rebecca Heiner-Fokkema, Gerjan Navis, Benito A Yard, Stephan Jl Bakker. Meat intake and risk of mortality and graft failure in kidney transplant recipients. The American journal of clinical nutrition. 2021 10; 114(4):1505-1517. doi: 10.1093/ajcn/nqab185. [PMID: 34091671]
  • Wenjun Z Martini, Yong-Ming Yu, Kevin K Chung, Michael A Dubick. Muscle deteriorations become prominent within 24 hours after admission in severely burned adults. The journal of trauma and acute care surgery. 2021 08; 91(2S Suppl 2):S176-S181. doi: 10.1097/ta.0000000000003285. [PMID: 34117171]
  • Shengyuan Luo, Aditya Surapaneni, Zihe Zheng, Eugene P Rhee, Josef Coresh, Adriana M Hung, Girish N Nadkarni, Bing Yu, Eric Boerwinkle, Adrienne Tin, Dan E Arking, Inga Steinbrenner, Pascal Schlosser, Anna Köttgen, Morgan E Grams. NAT8 Variants, N-Acetylated Amino Acids, and Progression of CKD. Clinical journal of the American Society of Nephrology : CJASN. 2020 12; 16(1):37-47. doi: 10.2215/cjn.08600520. [PMID: 33380473]
  • Alexander C Razavi, Lydia A Bazzano, Jiang He, Seamus P Whelton, Casey M Rebholz, Camilo Fernandez, Marie Krousel-Wood, Changwei Li, Mengyao Shi, Jovia L Nierenberg, Shengxu Li, Jason Kinchen, Xuenan Mi, Tanika N Kelly. Race modifies the association between animal protein metabolite 1-methylhistidine and blood pressure in middle-aged adults: the Bogalusa Heart Study. Journal of hypertension. 2020 12; 38(12):2435-2442. doi: 10.1097/hjh.0000000000002571. [PMID: 32649643]
  • Yu-Hsien Lai, Ming-Che Lee, Tsung-Jen Lin, Chin-Hung Liu, Bang-Gee Hsu. Low Serum 3-Methylhistidine Levels Are Associated With First Hospitalization in Kidney Transplantation Recipients. Transplantation proceedings. 2020 Dec; 52(10):3214-3220. doi: 10.1016/j.transproceed.2020.06.036. [PMID: 32771248]
  • Ingrid V Hagen, Anita Helland, Marianne Bratlie, Øivind Midttun, Adrian McCann, Harald Sveier, Grethe Rosenlund, Gunnar Mellgren, Per Magne Ueland, Oddrun Anita Gudbrandsen. TMAO, creatine and 1-methylhistidine in serum and urine are potential biomarkers of cod and salmon intake: a randomised clinical trial in adults with overweight or obesity. European journal of nutrition. 2020 Aug; 59(5):2249-2259. doi: 10.1007/s00394-019-02076-4. [PMID: 31401679]
  • D L Morris, P J Kononoff. Effects of rumen-protected lysine and histidine on milk production and energy and nitrogen utilization in diets containing hydrolyzed feather meal fed to lactating Jersey cows. Journal of dairy science. 2020 Aug; 103(8):7110-7123. doi: 10.3168/jds.2020-18368. [PMID: 32505393]
  • Wataru Kume, Jun Yasuda, Takeshi Hashimoto. Acute Effect of the Timing of Resistance Exercise and Nutrient Intake on Muscle Protein Breakdown. Nutrients. 2020 Apr; 12(4):. doi: 10.3390/nu12041177. [PMID: 32331476]
  • Y Yang, H Sadri, C Prehn, J Adamski, J Rehage, S Dänicke, D von Soosten, C C Metges, M H Ghaffari, H Sauerwein. Proteasome activity and expression of mammalian target of rapamycin signaling factors in skeletal muscle of dairy cows supplemented with conjugated linoleic acids during early lactation. Journal of dairy science. 2020 Mar; 103(3):2829-2846. doi: 10.3168/jds.2019-17244. [PMID: 31954574]
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  • Li Liu, Tian-Mei Li, Xue-Ru Liu, Yi-Ping Bai, Jie Li, Ni Tang, Xiao-Bin Wang. MicroRNA-140 inhibits skeletal muscle glycolysis and atrophy in endotoxin-induced sepsis in mice via the WNT signaling pathway. American journal of physiology. Cell physiology. 2019 08; 317(2):C189-C199. doi: 10.1152/ajpcell.00419.2018. [PMID: 31042421]
  • Y Zang, L H P Silva, M Ghelichkhan, M Miura, N L Whitehouse, M L Chizzotti, A F Brito. Incremental amounts of rumen-protected histidine increase plasma and muscle histidine concentrations and milk protein yield in dairy cows fed a metabolizable protein-deficient diet. Journal of dairy science. 2019 May; 102(5):4138-4154. doi: 10.3168/jds.2018-15780. [PMID: 30852019]
  • Patricia Mitry, Nina Wawro, Sabine Rohrmann, Pieter Giesbertz, Hannelore Daniel, Jakob Linseisen. Plasma concentrations of anserine, carnosine and pi-methylhistidine as biomarkers of habitual meat consumption. European journal of clinical nutrition. 2019 05; 73(5):692-702. doi: 10.1038/s41430-018-0248-1. [PMID: 30018457]
  • Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Takeshi Arima, Kai Onishi, Kanako Sato, Norihisa Kato, Noriyuki Yanaka. Novel metabolic disturbances in marginal vitamin B6-deficient rat heart. The Journal of nutritional biochemistry. 2019 03; 65(?):26-34. doi: 10.1016/j.jnutbio.2018.11.004. [PMID: 30599394]
  • Andrea E Steuer, Kim Arnold, Dominique Kamber, Thomas Kraemer. Suitability evaluation of new endogenous biomarkers for the identification of nitrite-based urine adulteration in mass spectrometry methods. Drug testing and analysis. 2019 Feb; 11(2):230-239. doi: 10.1002/dta.2481. [PMID: 30118186]
  • Nadezda V Khodorova, Douglas N Rutledge, Marion Oberli, David Mathiron, Paulo Marcelo, Robert Benamouzig, Daniel Tomé, Claire Gaudichon, Serge Pilard. Urinary Metabolomics Profiles Associated to Bovine Meat Ingestion in Humans. Molecular nutrition & food research. 2019 01; 63(1):e1700834. doi: 10.1002/mnfr.201700834. [PMID: 29468821]
  • Zhenzhao Wang, Rui Xu, Guiping Shen, Jianghua Feng. Metabolic Response in Rabbit Urine to Occurrence and Relief of Unilateral Ureteral Obstruction. Journal of proteome research. 2018 09; 17(9):3184-3194. doi: 10.1021/acs.jproteome.8b00304. [PMID: 30024170]
  • Francisco Madrid-Gambin, Carl Brunius, Mar Garcia-Aloy, Sheila Estruel-Amades, Rikard Landberg, Cristina Andres-Lacueva. Untargeted 1H NMR-Based Metabolomics Analysis of Urine and Serum Profiles after Consumption of Lentils, Chickpeas, and Beans: An Extended Meal Study To Discover Dietary Biomarkers of Pulses. Journal of agricultural and food chemistry. 2018 Jul; 66(27):6997-7005. doi: 10.1021/acs.jafc.8b00047. [PMID: 29920085]
  • Bastian Kochlik, Christiana Gerbracht, Tilman Grune, Daniela Weber. The Influence of Dietary Habits and Meat Consumption on Plasma 3-Methylhistidine-A Potential Marker for Muscle Protein Turnover. Molecular nutrition & food research. 2018 05; 62(9):e1701062. doi: 10.1002/mnfr.201701062. [PMID: 29573154]
  • Brenna S Fullerton, Eric A Sparks, Faraz A Khan, Jeremy G Fisher, Rocco Anzaldi, Michael R Scoville, Yong-Ming Yu, David A Wagner, Tom Jaksic, Nilesh M Mehta. Whole Body Protein Turnover and Net Protein Balance After Pediatric Thoracic Surgery: A Noninvasive Single-Dose 15 N Glycine Stable Isotope Protocol With End-Product Enrichment. JPEN. Journal of parenteral and enteral nutrition. 2018 02; 42(2):361-370. doi: 10.1177/0148607116678831. [PMID: 29443397]
  • Mariarita Brancaccio, Giuseppe D'Argenio, Vincenzo Lembo, Anna Palumbo, Immacolata Castellano. Antifibrotic Effect of Marine Ovothiol in an In Vivo Model of Liver Fibrosis. Oxidative medicine and cellular longevity. 2018; 2018(?):5045734. doi: 10.1155/2018/5045734. [PMID: 30647809]
  • T Saneyasu, N Tsuchii, Y Nakano, A Kitashiro, T Tsuchihashi, H Shindo, K Honda, H Kamisoyama. Effects of short-term fasting on the Akt-mediated pathway involved in protein metabolism in chicken skeletal muscle. Domestic animal endocrinology. 2017 10; 61(?):54-61. doi: 10.1016/j.domaniend.2017.06.002. [PMID: 28710921]
  • Xiaofei Yin, Helena Gibbons, Milena Rundle, Gary Frost, Breige A McNulty, Anne P Nugent, Janette Walton, Albert Flynn, Michael J Gibney, Lorraine Brennan. Estimation of Chicken Intake by Adults Using Metabolomics-Derived Markers. The Journal of nutrition. 2017 Oct; 147(10):1850-1857. doi: 10.3945/jn.117.252197. [PMID: 28794208]
  • Mariola Olkowicz, Janusz Debski, Patrycja Jablonska, Michal Dadlez, Ryszard T Smolenski. Application of a new procedure for liquid chromatography/mass spectrometry profiling of plasma amino acid-related metabolites and untargeted shotgun proteomics to identify mechanisms and biomarkers of calcific aortic stenosis. Journal of chromatography. A. 2017 Sep; 1517(?):66-78. doi: 10.1016/j.chroma.2017.08.024. [PMID: 28851525]
  • John P Loftus, Sharon A Center, John M Lucy, Julie A Stanton, Sean P McDonough, Jeanine Peters-Kennedy, Kenneth A Arceneaux, Molly A Bechtold, Courtney L Bennett, Christina A Bradbury, Martha G Cline, Deborah L Hall-Fonte, Julie F Hammer-Landrum, Janice L Huntingford, Jennifer Marshall, Kristopher S Sharpe, Jessica L Redin, Samuel T Selva, Tomasina A Lucia. Characterization of aminoaciduria and hypoaminoacidemia in dogs with hepatocutaneous syndrome. American journal of veterinary research. 2017 Jun; 78(6):735-744. doi: 10.2460/ajvr.78.6.735. [PMID: 28541155]
  • E G Carder, W P Weiss. Short- and longer-term effects of feeding increased metabolizable protein with or without an altered amino acid profile to dairy cows immediately postpartum. Journal of dairy science. 2017 Jun; 100(6):4528-4538. doi: 10.3168/jds.2016-12362. [PMID: 28434720]
  • Gustavo Provensi, Roberta Fabbri, Leonardo Munari, Alessia Costa, Elisabetta Baldi, Corrado Bucherelli, Patrizio Blandina, Maria Beatrice Passani. Histaminergic Neurotransmission as a Gateway for the Cognitive Effect of Oleoylethanolamide in Contextual Fear Conditioning. The international journal of neuropsychopharmacology. 2017 05; 20(5):392-399. doi: 10.1093/ijnp/pyw110. [PMID: 28339575]
  • Liufeng Zheng, Fangrui Zuo, Shengjun Zhao, Pingli He, Hongkui Wei, Quanhang Xiang, Jiaman Pang, Jian Peng. Dietary supplementation of branched-chain amino acids increases muscle net amino acid fluxes through elevating their substrate availability and intramuscular catabolism in young pigs. The British journal of nutrition. 2017 Apr; 117(7):911-922. doi: 10.1017/s0007114517000757. [PMID: 28446262]
  • Zheng Zhou, Mario Vailati-Riboni, Daniel N Luchini, Juan J Loor. Methionine and Choline Supply during the Periparturient Period Alter Plasma Amino Acid and One-Carbon Metabolism Profiles to Various Extents: Potential Role in Hepatic Metabolism and Antioxidant Status. Nutrients. 2016 Dec; 9(1):. doi: 10.3390/nu9010010. [PMID: 28036059]
  • Yuki Iida, Takenori Yamazaki, Hajime Arima, Tsutomu Kawabe, Sumio Yamada. Predictors of surgery-induced muscle proteolysis in patients undergoing cardiac surgery. Journal of cardiology. 2016 12; 68(6):536-541. doi: 10.1016/j.jjcc.2015.11.011. [PMID: 26777625]
  • Yiyi Zhang, Elena Blasco-Colmenares, Amy C Harms, Barry London, Indrani Halder, Madhurmeet Singh, Samuel C Dudley, Rebecca Gutmann, Eliseo Guallar, Thomas Hankemeier, Gordon F Tomaselli, Alan Cheng. Serum amine-based metabolites and their association with outcomes in primary prevention implantable cardioverter-defibrillator patients. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2016 Sep; 18(9):1383-90. doi: 10.1093/europace/euv342. [PMID: 26498162]
  • Saki Shimamoto, Daichi Ijiri, Kazuki Nakashima, Mana Kawaguchi, Yoshitaka Ishimaru, Airi Furukawa, Akira Ohtsuka. Clenbuterol changes phosphorylated FOXO1 localization and decreases protein degradation in the sartorius muscle of neonatal chicks. Bioscience, biotechnology, and biochemistry. 2016 Aug; 80(8):1499-504. doi: 10.1080/09168451.2016.1158629. [PMID: 27055887]
  • Mette Schmedes, Eli Kristin Aadland, Ulrik Kraemer Sundekilde, Hélène Jacques, Charles Lavigne, Ingvild Eide Graff, Øyvin Eng, Asle Holthe, Gunnar Mellgren, Jette Feveile Young, Hanne Christine Bertram, Bjørn Liaset, Morten Rahr Clausen. Lean-seafood intake decreases urinary markers of mitochondrial lipid and energy metabolism in healthy subjects: Metabolomics results from a randomized crossover intervention study. Molecular nutrition & food research. 2016 07; 60(7):1661-72. doi: 10.1002/mnfr.201500785. [PMID: 26873789]
  • Kyohei Furukawa, Motoi Kikusato, Tomomi Kamizono, Masaaki Toyomizu. Time-course changes in muscle protein degradation in heat-stressed chickens: Possible involvement of corticosterone and mitochondrial reactive oxygen species generation in induction of the ubiquitin-proteasome system. General and comparative endocrinology. 2016 Mar; 228(?):105-110. doi: 10.1016/j.ygcen.2016.02.007. [PMID: 26883687]
  • Gary E Fraser, Karen Jaceldo-Siegl, Susanne M Henning, Jing Fan, Synnove F Knutsen, Ella H Haddad, Joan Sabaté, W Lawrence Beeson, Hannelore Bennett. Biomarkers of Dietary Intake Are Correlated with Corresponding Measures from Repeated Dietary Recalls and Food-Frequency Questionnaires in the Adventist Health Study-2. The Journal of nutrition. 2016 Mar; 146(3):586-94. doi: 10.3945/jn.115.225508. [PMID: 26843587]
  • K Nichols, J J M Kim, M Carson, J A Metcalf, J P Cant, J Doelman. Glucose supplementation stimulates peripheral branched-chain amino acid catabolism in lactating dairy cows during essential amino acid infusions. Journal of dairy science. 2016 Feb; 99(2):1145-1160. doi: 10.3168/jds.2015-9912. [PMID: 26627857]
  • Murat Gulsun, Taner Oznur, Emre Aydemir, Fatih Ozcelik, Murat Erdem, Serkan Zincir, Ozgur Akgul, Yasemin Kurt. Possible relationship between amino acids, aggression and psychopathy. International journal of psychiatry in clinical practice. 2016; 20(2):91-100. doi: 10.3109/13651501.2016.1144771. [PMID: 26982638]
  • E D Batista, E Detmann, E C Titgemeyer, S C Valadares Filho, R F D Valadares, L L Prates, L N Rennó, M F Paulino. Effects of varying ruminally undegradable protein supplementation on forage digestion, nitrogen metabolism, and urea kinetics in Nellore cattle fed low-quality tropical forage. Journal of animal science. 2016 Jan; 94(1):201-16. doi: 10.2527/jas.2015-9493. [PMID: 26812327]
  • Jeremy G Fisher, Eric A Sparks, Faraz A Khan, Jamin L Alexander, Lisa A Asaro, David Wypij, Michael Gaies, Biren P Modi, Christopher Duggan, Michael S D Agus, Yong-Ming Yu, Tom Jaksic. Tight Glycemic Control With Insulin Does Not Affect Skeletal Muscle Degradation During the Early Postoperative Period Following Pediatric Cardiac Surgery. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2015 Jul; 16(6):515-21. doi: 10.1097/pcc.0000000000000413. [PMID: 25850865]
  • F Giallongo, A N Hristov, J Oh, T Frederick, H Weeks, J Werner, H Lapierre, R A Patton, A Gehman, C Parys. Effects of slow-release urea and rumen-protected methionine and histidine on performance of dairy cows. Journal of dairy science. 2015 May; 98(5):3292-308. doi: 10.3168/jds.2014-8791. [PMID: 25726096]
  • Saskia G A van der Drift, Martin Houweling, Marina Bouman, Ad P Koets, Aloysius G M Tielens, Mirjam Nielen, Ruurd Jorritsma. Effects of a single glucocorticoid injection on propylene glycol-treated cows with clinical ketosis. Veterinary journal (London, England : 1997). 2015 May; 204(2):144-9. doi: 10.1016/j.tvjl.2015.01.016. [PMID: 25841896]
  • Ole Lamp, Michael Derno, Winfried Otten, Manfred Mielenz, Gerd Nürnberg, Björn Kuhla. Metabolic Heat Stress Adaption in Transition Cows: Differences in Macronutrient Oxidation between Late-Gestating and Early-Lactating German Holstein Dairy Cows. PloS one. 2015; 10(5):e0125264. doi: 10.1371/journal.pone.0125264. [PMID: 25938406]
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