2,6-Dimethylaniline (BioDeep_00000002752)

 

Secondary id: BioDeep_00001873692

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


2-Amino-1,3-dimethylbenzene

化学式: C8H11N (121.0891446)
中文名称: 2,6-二甲基苯胺
谱图信息: 最多检出来源 Homo sapiens(blood) 2.81%

分子结构信息

SMILES: Cc(c1)c(N)c(C)cc1
InChI: InChI=1S/C8H11N/c1-6-4-3-5-7(2)8(6)9/h3-5H,9H2,1-2H3

描述信息

2,6-Dimethylaniline is a metabolite of lidocaine. Lidocaine, Xylocaine, or lignocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery. (Wikipedia)
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 73
CONFIDENCE standard compound; INTERNAL_ID 4146
CONFIDENCE standard compound; INTERNAL_ID 8824
CONFIDENCE standard compound; INTERNAL_ID 8098
KEIO_ID D178

同义名列表

14 个代谢物同义名

2-Amino-1,3-dimethylbenzene; 1-Amino-2,6-dimethylbenzene; 2,6-Xylidine hydrochloride; 2,6-Xylidine, 3H-labeled; 2,6-Dimethylphenylamine; 2,6-Dimethylbenzenamine; 2,6-Dimethylaniline; 2-Amino-1,3-xylene; 2-Amino-m-xylene; 2,6-Xylylamine; Vic-m-xylidine; 2,6-xylidine; O-Xylidine; 2,6-DMA



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

6 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(3)

PharmGKB(1)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hanieh Karimiyan, Abdusalam Uheida, Mohammadreza Hadjmohammadi, Mohammad Mahdi Moein, Mohamed Abdel-Rehim. Polyacrylonitrile / graphene oxide nanofibers for packed sorbent microextraction of drugs and their metabolites from human plasma samples. Talanta. 2019 Aug; 201(?):474-479. doi: 10.1016/j.talanta.2019.04.027. [PMID: 31122453]
  • Qian Li, Tobias Magers, Brad King, Brian J Engel, Ray Bakhtiar, Charisse Green, Ronald Shoup. Measurement of lidocaine and 2,6-dimethylaniline in minipig plasma, skin, and dermal tapes using UHPLC with electrospray MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Jun; 1087-1088(?):158-172. doi: 10.1016/j.jchromb.2018.04.030. [PMID: 29747144]
  • M M Tolba, F Belal. Two liquid chromatographic approaches for the simultaneous determination of xipamide and its degradation product (2,6-xylidine) using time-programmed fluorescence detection. Luminescence : the journal of biological and chemical luminescence. 2017 Jun; 32(4):491-501. doi: 10.1002/bio.3203. [PMID: 27562288]
  • Xue Gao, Hao Guo, Yaoyu Du, Chaokang Gu. Simultaneous Determination of Xylazine and 2,6-Xylidine in Blood and Urine by Auto Solid-Phase Extraction and Ultra High Performance Liquid Chromatography Coupled with Quadrupole-Time of Flight Mass Spectrometry. Journal of analytical toxicology. 2015 Jul; 39(6):444-50. doi: 10.1093/jat/bkv040. [PMID: 25907168]
  • Ming-Wei Chao, Pınar Erkekoglu, Chia-Yi Tseng, Wenjie Ye, Laura J Trudel, Paul L Skipper, Steven R Tannenbaum, Gerald N Wogan. Protective effects of ascorbic acid against the genetic and epigenetic alterations induced by 3,5-dimethylaminophenol in AA8 cells. Journal of applied toxicology : JAT. 2015 May; 35(5):466-77. doi: 10.1002/jat.3046. [PMID: 25178734]
  • Ron L A P Hoogenboom, Tina Zuidema, Martien Essers, Ad M van Vuuren, Piet G van Wikselaar, Jan C H van Eijkeren, Marcel J B Mengelers, Marco J Zeilmaker, Astrid S Bulder. Concentrations of dimethylaniline and other metabolites in milk and tissues of dairy cows treated with lidocaine. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2015; 32(8):1256-64. doi: 10.1080/19440049.2015.1064172. [PMID: 26118443]
  • Pinar Erkekoglu, Ming-Wei Chao, Wenjie Ye, Jing Ge, Laura J Trudel, Paul L Skipper, Belma Kocer-Gumusel, Bevin P Engelward, Gerald N Wogan, Steven R Tannenbaum. Cytoplasmic and nuclear toxicity of 3,5-dimethylaminophenol and potential protection by selenocompounds. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2014 Oct; 72(?):98-110. doi: 10.1016/j.fct.2014.06.031. [PMID: 25014158]
  • Xiaochun Zheng, Xiaoxia Mi, Sicong Li, Gang Chen. Determination of xylazine and 2,6-xylidine in animal tissues by liquid chromatography-tandem mass spectrometry. Journal of food science. 2013 Jun; 78(6):T955-9. doi: 10.1111/1750-3841.12144. [PMID: 23647632]
  • Li Tao, Billy W Day, Bibin Hu, Yong-Bing Xiang, Renwei Wang, Mariana C Stern, Manuela Gago-Dominguez, Victoria K Cortessis, David V Conti, David Van Den Berg, Malcolm C Pike, Yu-Tang Gao, Mimi C Yu, Jian-Min Yuan. Elevated 4-aminobiphenyl and 2,6-dimethylaniline hemoglobin adducts and increased risk of bladder cancer among lifelong nonsmokers--The Shanghai Bladder Cancer Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2013 May; 22(5):937-45. doi: 10.1158/1055-9965.epi-12-1447. [PMID: 23539508]
  • Nahla N Salama, Shudong Wang. Quantitative mass spectrometric analysis of ropivacaine and bupivacaine in authentic, pharmaceutical and spiked human plasma without chromatographic separation. Analytical chemistry insights. 2008 May; 4(?):11-9. doi: 10.4137/aci.s2564. [PMID: 19652756]
  • Paul L Skipper, Laura J Trudel, Thomas W Kensler, John D Groopman, Patricia A Egner, Rosa G Liberman, Gerald N Wogan, Steven R Tannenbaum. DNA adduct formation by 2,6-dimethyl-, 3,5-dimethyl-, and 3-ethylaniline in vivo in mice. Chemical research in toxicology. 2006 Aug; 19(8):1086-90. doi: 10.1021/tx060082q. [PMID: 16918249]
  • M-H Spyridaki, E Lyris, I Georgoulakis, D Kouretas, M Konstantinidou, C G Georgakopoulos. Determination of xylazine and its metabolites by GC-MS in equine urine for doping analysis. Journal of pharmaceutical and biomedical analysis. 2004 Apr; 35(1):107-16. doi: 10.1016/j.jpba.2003.12.007. [PMID: 15030885]
  • Todd M Delehant, Joseph W Denhart, W Eugene Lloyd, J D Powell. Pharmacokinetics of xylazine, 2,6-dimethylaniline, and tolazoline in tissues from yearling cattle and milk from mature dairy cows after sedation with xylazine hydrochloride and reversal with tolazoline hydrochloride. Veterinary therapeutics : research in applied veterinary medicine. 2003; 4(2):128-34. doi: NULL. [PMID: 14506588]
  • J Friskopp, G Huledal. Plasma levels of lidocaine and prilocaine after application of Oraqix, a new intrapocket anesthetic, in patients with advanced periodontitis. Journal of clinical periodontology. 2001 May; 28(5):425-9. doi: 10.1034/j.1600-051x.2001.028005425.x. [PMID: 11350505]
  • K Yasuhara, H Kobayashi, Y Shimamura, T Koujitani, H Onodera, H Takagi, M Hirose, K Mitsumori. Toxicity and blood concentrations of xylazine and its metabolite, 2,6-dimethylaniline, in rats after single or continuous oral administrations. The Journal of toxicological sciences. 2000 May; 25(2):105-13. doi: 10.2131/jts.25.105. [PMID: 10845188]
  • T Koujitani, K Yasuhara, H Kobayashi, A Shimada, H Onodera, H Takagi, M Hirose, K Mitsumori. Tumor-promoting activity of 2,6-dimethylaniline in a two-stage nasal carcinogenesis model in N-bis(2-hydroxypropyl)nitrosamine-treated rats. Cancer letters. 1999 Aug; 142(2):161-71. doi: 10.1016/s0304-3835(99)00153-6. [PMID: 10463772]
  • S W Martin, F E Bishop, B M Kerr, M Moor, M Moore, P Sheffels, M Rashed, J G Slatter, L Berthon-Cédille, F Lepage, J J Descombe, M Picard, T A Baillie, R H Levy. Pharmacokinetics and metabolism of the novel anticonvulsant agent N-(2,6-dimethylphenyl)-5-methyl-3-isoxazolecarboxamide (D2624) in rats and humans. Drug metabolism and disposition: the biological fate of chemicals. 1997 Jan; 25(1):40-6. doi: . [PMID: 9010628]
  • J V Headley, D B Maxwell, C Swyngedouw, J R Purdy. Determination of combined residues of metalaxyl and 2,6-dimethylaniline metabolites in urine by gas chromatography/mass spectrometry. Journal of AOAC International. 1996 Jan; 79(1):117-23. doi: 10.1093/jaoac/79.1.117. [PMID: 8620103]
  • D C Holland, R K Munns, J E Roybal, J A Hurlbut, A R Long. Simultaneous determination of xylazine and its major metabolite, 2,6-dimethylaniline, in bovine and swine kidney by liquid chromatography. Journal of AOAC International. 1993 Jul; 76(4):720-4. doi: . [PMID: 8374321]
  • C R Short, M L Hardy, S A Barker. The in vivo oxidative metabolism of 2,4- and 2,6-dimethylaniline in the dog and rat. Toxicology. 1989 Jul; 57(1):45-58. doi: 10.1016/0300-483x(89)90033-4. [PMID: 2749743]
  • S D Nelson, W L Nelson, W F Trager. N-Hydroxyamide metabolites of lidocaine. Synthesis, characterization, quantitation, and mutagenic potential. Journal of medicinal chemistry. 1978 Aug; 21(8):721-5. doi: 10.1021/jm00206a001. [PMID: 690997]