2-Hydroxymyristic acid (BioDeep_00000002669)

Main id: BioDeep_00000629014

 

human metabolite Endogenous natural product


代谢物信息卡片


alpha-Hydroxy-N-tetradecylic acid

化学式: C14H28O3 (244.2038)
中文名称: 2-羟基十四烷酸
谱图信息: 最多检出来源 Rattus norvegicus(feces) 15.19%

分子结构信息

SMILES: CCCCCCCCCCCCC(C(=O)O)O
InChI: InChI=1S/C14H28O3/c1-2-3-4-5-6-7-8-9-10-11-12-13(15)14(16)17/h13,15H,2-12H2,1H3,(H,16,17)

描述信息

2-Hydroxymyristic acid is an analog of myristic acid that becomes metabolically activated in cells to form 2-hydroxymyristoyl-CoA, a potent inhibitor of myristoyl-CoA:protein N-myristoyltransferase, the enzyme that catalyzes protein N-myristoylation. Treatment of T cells with 2-hydroxymyristic acid inhibits the myristoylation and alters the stability of p56lck. (PMID 8103677) [HMDB]
2-Hydroxymyristic acid is an analog of myristic acid that becomes metabolically activated in cells to form 2-hydroxymyristoyl-CoA, a potent inhibitor of myristoyl-CoA:protein N-myristoyltransferase, the enzyme that catalyzes protein N-myristoylation. Treatment of T cells with 2-hydroxymyristic acid inhibits the myristoylation and alters the stability of p56lck. (PMID 8103677).

同义名列表

25 个代谢物同义名

alpha-Hydroxy-N-tetradecylic acid; α-hydroxy myristic acid; alpha-Hydroxy-N-tetradecylate; Α-hydroxy-N-tetradecylic acid; DL-alpha-Hydroxymyristic acid; a-Hydroxy-N-tetradecylic acid; 2-hydroxy-tetradecanoic acid; 2S-Hydroxytetradecanoic acid; 2-HYDROXYTETRADECANOIC ACID; alpha-Hydroxymyristic acid; Α-hydroxy-N-tetradecylate; DL-a-Hydroxymyristic acid; DL-alpha-Hydroxymyristate; a-Hydroxy-N-tetradecylate; 2S-Hydroxytetradecanoate; 2-Hydroxytetradecanoate; 2-Hydroxy-myristic-acid; Α-hydroxymyristic acid; 2-Hydroxymyristic acid; a-Hydroxymyristic acid; alpha-Hydroxymyristate; DL-a-Hydroxymyristate; Α-hydroxymyristate; a-Hydroxymyristate; 2-Hydroxymyristate



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 CA1, CASP3, CAT, FABP1, NMT1, RAF1, SDF4, TNK1, XDH
Peripheral membrane protein 5 ACHE, CAV1, CYP1B1, NMT1, TNK1
Endosome membrane 1 CLCN5
Endoplasmic reticulum membrane 4 CAV1, CD4, CYP1B1, FA2H
Nucleus 5 ACHE, CASP3, CDCA4, FABP1, RAF1
cytosol 10 CA1, CASP3, CAT, CDCA4, CLCN5, FABP1, NMT1, RAF1, SOS2, XDH
nucleoplasm 3 CASP3, CDCA4, FABP1
Cell membrane 8 ACHE, CAV1, CD4, CLCN5, GPR132, RAF1, SDF4, TNF
Early endosome membrane 1 CAV1
Multi-pass membrane protein 3 CLCN5, FA2H, GPR132
Golgi apparatus membrane 2 CAV1, CLCN5
Synapse 1 ACHE
cell cortex 1 CAV1
cell surface 2 ACHE, TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 5 ACHE, CAV1, CLCN5, RAF1, SDF4
Golgi membrane 3 CAV1, CLCN5, INS
lysosomal membrane 1 CLCN5
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, TNF
synaptic vesicle 1 CLCN5
Cytoplasm, cytosol 1 NMT1
endosome 1 CAV1
plasma membrane 12 ACHE, CAV1, CD4, CDCA4, CLCN5, GPR132, NMT1, RAF1, SDF4, SOS2, TNF, TNK1
Membrane 10 ACHE, CAT, CAV1, CLCN5, CYP1B1, FA2H, GPR132, NMT1, SDF4, TNK1
apical plasma membrane 1 CAV1
basolateral plasma membrane 1 CAV1
caveola 1 CAV1
extracellular exosome 4 CA1, CAT, FABP1, SDF4
endoplasmic reticulum 3 CAV1, FA2H, SDF4
extracellular space 4 ACHE, INS, TNF, XDH
perinuclear region of cytoplasm 2 ACHE, CAV1
mitochondrion 3 CAT, CYP1B1, RAF1
protein-containing complex 3 CAT, CAV1, FABP1
intracellular membrane-bounded organelle 2 CAT, CYP1B1
Microsome membrane 2 CYP1B1, FA2H
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 CD4
Secreted 2 ACHE, INS
extracellular region 4 ACHE, CAT, INS, TNF
mitochondrial outer membrane 1 RAF1
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
external side of plasma membrane 2 CD4, TNF
cytoplasmic vesicle 1 CAV1
Early endosome 2 CD4, CLCN5
apical part of cell 1 CLCN5
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 3 CAV1, CD4, TNF
focal adhesion 2 CAT, CAV1
Peroxisome 2 CAT, XDH
basement membrane 1 ACHE
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, FABP1
peroxisomal membrane 1 CAT
Late endosome 1 SDF4
cilium 1 CAV1
phagocytic cup 1 TNF
[Isoform 5]: Cytoplasm 1 SDF4
Golgi apparatus, trans-Golgi network 1 CAV1
Lipid-anchor, GPI-anchor 1 ACHE
endosome lumen 1 INS
Lipid droplet 1 CAV1
Membrane, caveola 1 CAV1
side of membrane 1 ACHE
pseudopodium 1 RAF1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi apparatus lumen 1 SDF4
Golgi lumen 2 INS, SDF4
endoplasmic reticulum lumen 2 CD4, INS
endocytic vesicle membrane 1 CAV1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 1 CD4
synaptic cleft 1 ACHE
death-inducing signaling complex 1 CASP3
acrosomal membrane 1 CAV1
bleb 1 SDF4
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
catalase complex 1 CAT
apical cortex 1 FABP1
[Isoform H]: Cell membrane 1 ACHE
caveolar macromolecular signaling complex 1 CAV1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Isoform 1]: Golgi apparatus lumen 1 SDF4


文献列表

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