FUSARENON X (BioDeep_00000002629)

 

Secondary id: BioDeep_00000412875


代谢物信息卡片


Trichothec-9-en-8-one, 12,13-epoxy-3alpha,4beta,7beta,15-tetrahydroxy-, 4-acetate

化学式: C17H22O8 (354.1314612)
中文名称: 镰刀菌烯酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)OC1C(O)C2OC3C=C(C)C(=O)C(O)C3(CO)C1(C)C21CO1
InChI: InChI=1S/C17H22O8/c1-7-4-9-16(5-18,12(22)10(7)20)15(3)13(24-8(2)19)11(21)14(25-9)17(15)6-23-17/h4,9,11-14,18,21-22H,5-6H2,1-3H3

描述信息

D009676 - Noxae > D011042 - Poisons > D014255 - Trichothecenes
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins

同义名列表

5 个代谢物同义名

Trichothec-9-en-8-one, 12,13-epoxy-3alpha,4beta,7beta,15-tetrahydroxy-, 4-acetate; CID 12309986; Fusarenone X; FUSARENON X; Fusarenon-X



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Beatriz Arce-López, Lydia Alvarez-Erviti, Barbara De Santis, María Izco, Silvia López-Calvo, Maria Eugenia Marzo-Sola, Francesca Debegnach, Elena Lizarraga, Adela López de Cerain, Elena González-Peñas, Ariane Vettorazzi. Biomonitoring of Mycotoxins in Plasma of Patients with Alzheimer's and Parkinson's Disease. Toxins. 2021 07; 13(7):. doi: 10.3390/toxins13070477. [PMID: 34357949]
  • Wanchalerm Phruksawan, Saranya Poapolathep, Mario Giorgi, Kanjana Imsilp, Chainarong Sakulthaew, Helen Owen, Amnart Poapolathep. Toxicokinetic profile of fusarenon-X and its metabolite nivalenol in the goat (Capra hircus). Toxicon : official journal of the International Society on Toxinology. 2018 Oct; 153(?):78-84. doi: 10.1016/j.toxicon.2018.08.015. [PMID: 30172791]
  • Imourana Alassane-Kpembi, Juliana Rubira Gerez, Anne-Marie Cossalter, Manon Neves, Joëlle Laffitte, Claire Naylies, Yannick Lippi, Martine Kolf-Clauw, Ana Paula L Bracarense, Philippe Pinton, Isabelle P Oswald. Intestinal toxicity of the type B trichothecene mycotoxin fusarenon-X: whole transcriptome profiling reveals new signaling pathways. Scientific reports. 2017 08; 7(1):7530. doi: 10.1038/s41598-017-07155-2. [PMID: 28790326]
  • Sawinee Aupanun, Saranya Poapolathep, Kanjana Imsilp, Teerasak Prapong, Amnart Poapolathep. Oral exposure of fusarenon-X induced apoptosis in Peyer's patches, thymus, and spleen of mice. Research in veterinary science. 2015 Oct; 102(?):217-22. doi: 10.1016/j.rvsc.2015.08.012. [PMID: 26412547]
  • Wenda Wu, Hui-Ren Zhou, Kaiyu He, Xiao Pan, Yoshiko Sugita-Konishi, Maiko Watanabe, Haibin Zhang, James J Pestka. Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. Toxicological sciences : an official journal of the Society of Toxicology. 2014 Apr; 138(2):278-89. doi: 10.1093/toxsci/kft335. [PMID: 24385417]
  • Thanit Saengtienchai, Saranya Poapolathep, Supaporn Isariyodom, Yoshinori Ikenaka, Mayumi Ishizuka, Amnart Poapolathep. Toxicokinetics and tissue depletion of Fusarenon-X and its metabolite nivalenol in piglets. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2014 Apr; 66(?):307-12. doi: 10.1016/j.fct.2014.01.053. [PMID: 24508584]
  • Huali Xue, Yang Bi, Jinmei Wei, Yamei Tang, Ying Zhao, Yi Wang. New method for the simultaneous analysis of types A and B trichothecenes by ultrahigh-performance liquid chromatography coupled with tandem mass spectrometry in potato tubers inoculated with Fusarium sulphureum. Journal of agricultural and food chemistry. 2013 Oct; 61(39):9333-8. doi: 10.1021/jf402997t. [PMID: 24010413]
  • Margit Schollenberger, Hans-Martin Müller, Katrin Ernst, Sarah Sondermann, Melanie Liebscher, Claudia Schlecker, Gerald Wischer, Winfried Drochner, Karin Hartung, Hans-Peter Piepho. Occurrence and distribution of 13 trichothecene toxins in naturally contaminated maize plants in Germany. Toxins. 2012 10; 4(10):778-87. doi: 10.3390/toxins4100778. [PMID: 23162697]
  • Zheng Han, Xuesong Liu, Yiping Ren, Lianjun Luan, Yongjiang Wu. A rapid method with ultra-high-performance liquid chromatography-tandem mass spectrometry for simultaneous determination of five type B trichothecenes in traditional Chinese medicines. Journal of separation science. 2010 Jul; 33(13):1923-32. doi: 10.1002/jssc.201000094. [PMID: 20533344]
  • A Poapolathep, S Poapolathep, Y Sugita-Konishi, K Imsilp, T Tassanawat, C Sinthusing, Y Itoh, S Kumagai. Fate of fusarenon-X in broilers and ducks. Poultry science. 2008 Aug; 87(8):1510-5. doi: 10.3382/ps.2008-00008. [PMID: 18648042]
  • Amnart Poapolathep, Yoshiko Sugita-Konishi, Tulayakul Phitsanu, Kunio Doi, Susumu Kumagai. Placental and milk transmission of trichothecene mycotoxins, nivalenol and fusarenon-X, in mice. Toxicon : official journal of the International Society on Toxinology. 2004 Jul; 44(1):111-3. doi: 10.1016/j.toxicon.2004.04.005. [PMID: 15225570]
  • Amnart Poapolathep, Yoshiko Sugita-Konishi, Kunio Doi, Susumu Kumagai. The fates of trichothecene mycotoxins, nivalenol and fusarenon-X, in mice. Toxicon : official journal of the International Society on Toxinology. 2003 Jun; 41(8):1047-54. doi: 10.1016/s0041-0101(03)00089-8. [PMID: 12875880]
  • S Kumagai, T Shimizu. Effects of fusarenon-X and T-2 toxin on intestinal absorption of monosaccharide in rats. Archives of toxicology. 1988; 61(6):489-95. doi: 10.1007/bf00293696. [PMID: 3190447]
  • Y Matsuoka, K Kubota. Studies on mechanisms of diarrhea induced by fusarenon-X, a trichothecene mycotoxin from Fusarium species: fusarenon-X-induced diarrhea is not mediated by cyclic nucleotides. Toxicology and applied pharmacology. 1987 Dec; 91(3):326-32. doi: 10.1016/0041-008x(87)90055-x. [PMID: 2827346]