Pimozide (BioDeep_00000002076)

 

Secondary id: BioDeep_00000408933

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one

化学式: C28H29F2N3O (461.2279)
中文名称: 匹莫齐特
谱图信息: 最多检出来源 Mentha canadensis(plant) 10.22%

分子结构信息

SMILES: c1ccc2c(c1)[nH]c(=O)n2C1CCN(CCCC(c2ccc(cc2)F)c2ccc(cc2)F)CC1
InChI: InChI=1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)

描述信息

A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AG - Diphenylbutylpiperidine derivatives
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.

同义名列表

16 个代谢物同义名

1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one; Pharmascience brand OF pimozide; ASTA medica brand OF pimozide; Janssen brand OF pimozide; Neoperidole; Orap forte; Pimozidum; Halomonth; Pimozida; pimozide; Antalon; Opiran; Orap; R6238; Pimozide; Pimozide



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ABCB1, AKT1, ATG5, CYP2D6, CYP3A4, HTT, MTOR, PRL, STAT3, STAT5A
Peripheral membrane protein 2 ATG5, MTOR
Endosome membrane 2 FLT3, HTT
Endoplasmic reticulum membrane 4 CYP2D6, CYP3A4, DRD1, MTOR
Nucleus 8 AKT1, DRD1, HTT, MTOR, PRL, STAT3, STAT5A, USP1
autophagosome 2 ATG5, HTT
cytosol 7 AKT1, ATG5, HTT, MTOR, STAT3, STAT5A, USP1
dendrite 4 DRD2, HTR7, HTT, MTOR
phagocytic vesicle 1 MTOR
nucleoplasm 7 AKT1, HTT, MTOR, PRL, STAT3, STAT5A, USP1
RNA polymerase II transcription regulator complex 3 PRL, STAT3, STAT5A
Cell membrane 7 ABCB1, AKT1, DRD1, DRD2, HTR7, HTT, KCNH2
Cytoplasmic side 1 MTOR
lamellipodium 1 AKT1
Multi-pass membrane protein 7 ABCB1, CACNA1I, DRD1, DRD2, HTR7, HTT, KCNH2
Golgi apparatus membrane 2 DRD2, MTOR
Synapse 4 CRH, DRD2, HTR7, HTT
cell cortex 1 AKT1
cell surface 2 ABCB1, KCNH2
glutamatergic synapse 4 AKT1, ATG5, DRD1, DRD2
Golgi apparatus 1 HTT
Golgi membrane 3 DRD2, INS, MTOR
lysosomal membrane 1 MTOR
postsynapse 2 AKT1, ATG5
presynaptic membrane 3 DRD1, DRD2, HTT
Lysosome 1 MTOR
acrosomal vesicle 1 DRD2
plasma membrane 10 ABCB1, AKT1, CACNA1I, DRD1, DRD2, FLT3, HTR7, HTT, KCNH2, STAT3
synaptic vesicle membrane 1 DRD2
Membrane 9 ABCB1, AKT1, ATG5, CACNA1I, CYP2D6, CYP3A4, FLT3, KCNH2, MTOR
apical plasma membrane 1 ABCB1
axon 3 ATG5, DRD2, HTT
extracellular exosome 1 ABCB1
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 CYP2D6, FLT3, HTT
extracellular space 4 CRH, GNRH1, INS, PRL
perinuclear region of cytoplasm 2 HTT, KCNH2
Schaffer collateral - CA1 synapse 1 ATG5
mitochondrion 1 CYP2D6
protein-containing complex 3 AKT1, ATG5, HTT
intracellular membrane-bounded organelle 2 CYP2D6, CYP3A4
Microsome membrane 3 CYP2D6, CYP3A4, MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 FLT3
Secreted 3 CRH, INS, PRL
extracellular region 4 CRH, GNRH1, INS, PRL
Mitochondrion outer membrane 1 MTOR
Single-pass membrane protein 1 CYP2D6
mitochondrial outer membrane 1 MTOR
transcription regulator complex 1 STAT3
ciliary membrane 2 DRD1, DRD2
varicosity 1 CRH
dendritic spine 2 DRD1, DRD2
neuronal dense core vesicle lumen 1 CRH
perikaryon 2 CRH, DRD2
microtubule cytoskeleton 1 AKT1
Early endosome 1 HTT
cell-cell junction 1 AKT1
vesicle 1 AKT1
postsynaptic membrane 3 DRD1, DRD2, HTT
Apical cell membrane 1 ABCB1
Membrane raft 1 HTT
Cell junction, focal adhesion 1 HTT
focal adhesion 1 HTT
spindle 1 AKT1
GABA-ergic synapse 2 DRD1, DRD2
Cell projection, dendritic spine 1 DRD1
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
lateral plasma membrane 1 DRD2
axoneme 1 ATG5
Late endosome 1 HTT
receptor complex 1 FLT3
Cell projection, neuron projection 1 HTT
neuron projection 1 HTT
ciliary basal body 1 AKT1
cilium 2 DRD1, DRD2
chromatin 3 PRL, STAT3, STAT5A
phagocytic vesicle membrane 1 ATG5
centriole 1 HTT
non-motile cilium 2 DRD1, DRD2
sperm flagellum 1 DRD2
nuclear envelope 1 MTOR
Endomembrane system 2 HTT, MTOR
endosome lumen 2 INS, PRL
monoatomic ion channel complex 1 KCNH2
Preautophagosomal structure membrane 1 ATG5
Atg12-Atg5-Atg16 complex 1 ATG5
mitochondria-associated endoplasmic reticulum membrane contact site 1 ATG5
phagophore assembly site membrane 1 ATG5
Cytoplasmic vesicle membrane 1 HTT
Cell projection, dendrite 1 DRD1
inward rectifier potassium channel complex 1 KCNH2
voltage-gated potassium channel complex 1 KCNH2
trans-Golgi network membrane 1 HTR7
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 FLT3, INS
axon terminus 1 DRD2
voltage-gated calcium channel complex 1 CACNA1I
endocytic vesicle 1 DRD2
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
external side of apical plasma membrane 1 ABCB1
dopaminergic synapse 1 DRD2
postsynaptic cytosol 1 HTT
Cytoplasmic vesicle, phagosome 1 MTOR
Cell projection, cilium membrane 1 DRD1
presynaptic cytosol 1 HTT
transferase complex 1 ATG5
inclusion body 1 HTT
G protein-coupled receptor complex 2 DRD1, DRD2
serotonergic synapse 1 HTT
[Huntingtin]: Cytoplasm 1 HTT
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome 1 HTT
phagophore 1 ATG5


文献列表

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