Guanfacine (BioDeep_00000001997)
Secondary id: BioDeep_00001868045
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide
化学式: C9H9Cl2N3O (245.0123)
中文名称: 氯酰胍
谱图信息:
最多检出来源 Homo sapiens(blood) 12.25%
分子结构信息
SMILES: C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl
InChI: InChI=1S/C9H9Cl2N3O/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13/h1-3H,4H2,(H4,12,13,14,15)
描述信息
A centrally acting antihypertensive agent. The drug lowers both systolic and diastolic blood pressure by activating the central nervous system alpha-2 adrenoreceptors, which results in reduced sympathetic outflow leading to reduced vascular tone. Its adverse reactions include dry mouth, sedation, and constipation. [PubChem]
C - Cardiovascular system > C02 - Antihypertensives > C02A - Antiadrenergic agents, centrally acting > C02AC - Imidazoline receptor agonists
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:5558
- KEGG: C07037
- KEGGdrug: D08031
- PubChem: 3519
- HMDB: HMDB0015153
- Metlin: METLIN4060
- DrugBank: DB01018
- ChEMBL: CHEMBL862
- Wikipedia: Guanfacine
- MeSH: Guanfacine
- chemspider: 3399
- CAS: 29110-47-2
- PMhub: MS000001618
- PubChem: 9249
- NIKKAJI: J21.225C
- RefMet: Guanfacine
- KNApSAcK: 5558
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhiyuan Hou, Difu Shi, Jianing Lin, Xiangcheng Zhao, Hailong Zhang, Jinsong Ding. Effect of ion pair strategy on transdermal delivery of guanfacine: Which factor dominates drug permeation?.
International journal of pharmaceutics.
2024 Jan; 652(?):123835. doi:
10.1016/j.ijpharm.2024.123835. [PMID: 38262582] - Yuki Takahashi, Katsunaka Mikami, Keitaro Kimoto, Yuichi Onishi, Kenji Yamamoto, Hideo Matsumoto. A Case of Nocturnal Enuresis Associated with Attention-deficit/hyperactivity Disorder Successfully Treated with Guanfacine Monotherapy.
The Tokai journal of experimental and clinical medicine.
2022 Jul; 47(2):72-74. doi:
. [PMID: 35801551] - Christopher Wohkittel, Oliver Scherf-Clavel, Stefanie Fekete, Marcel Romanos, Petra Högger, Manfred Gerlach. Determination of Guanfacine in Oral Fluid and Serum of Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: A Short Communication.
Therapeutic drug monitoring.
2022 04; 44(2):340-344. doi:
10.1097/ftd.0000000000000917. [PMID: 34334681] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Kouji Fukuyama, Tomosuke Nakano, Takashi Shiroyama, Motohiro Okada. Chronic Administrations of Guanfacine on Mesocortical Catecholaminergic and Thalamocortical Glutamatergic Transmissions.
International journal of molecular sciences.
2021 Apr; 22(8):. doi:
10.3390/ijms22084122. [PMID: 33923533] - John W Downs, Brandon K Wills, Kirk L Cumpston, Carl E Wolf, S Rutherfoord Rose. Pediatric Guanfacine Toxicity with Severely Elevated Plasma Concentration.
Journal of child and adolescent psychopharmacology.
2020 09; 30(7):473-474. doi:
10.1089/cap.2020.0033. [PMID: 32667829] - Yelizaveta Sher, Beatrice Rabkin, José R Maldonado, Paul Mohabir. COVID-19-Associated Hyperactive Intensive Care Unit Delirium With Proposed Pathophysiology and Treatment: A Case Report.
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2020 Sep; 61(5):544-550. doi:
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Drug metabolism and pharmacokinetics.
2019 Dec; 34(6):365-371. doi:
10.1016/j.dmpk.2019.07.001. [PMID: 31563330] - Yuji Inoue, Hirotoshi Morita, Kohei Nozawa, Takushi Kanazu. Metabolite profiling of guanfacine in plasma and urine of healthy Japanese subjects after oral administration of guanfacine extended-release tablets.
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