Aminoadipic acid (BioDeep_00000001297)
Secondary id: BioDeep_00000227599, BioDeep_00000398048, BioDeep_00000399892, BioDeep_00000405290, BioDeep_00000408272
natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Volatile Flavor Compounds
代谢物信息卡片
(2S)-2-Azaniumyl-6-hydroxy-6-oxohexanoate
化学式: C6H11NO4 (161.0688046)
中文名称: 2-氨基己二酸水合物, L-2-氨基己二酸, DL-α-氨基己二酸, 氨基己二酸, 2-氨基己二酸, L-α-氨基己二酸
谱图信息:
最多检出来源 Viridiplantae(plant) 0.37%
Reviewed
Last reviewed on 2024-07-01.
Cite this Page
Aminoadipic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/aminoadipic_acid (retrieved
2024-11-22) (BioDeep RN: BioDeep_00000001297). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C(CC(C(=O)O)N)CC(=O)O
InChI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)
描述信息
Aminoadipic acid (CAS: 542-32-5), also known as 2-aminoadipate, is a metabolite in the principal biochemical pathway of lysine. It is an intermediate in the metabolism (i.e. breakdown or degradation) of lysine and saccharopine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor N-methyl-D-aspartate (NMDA). Aminoadipic acid has also been shown to inhibit the production of kynurenic acid, a broad spectrum excitatory amino acid receptor antagonist, in brain tissue slices (PMID: 8566117). Recent studies have shown that aminoadipic acid is elevated in prostate biopsy tissues from prostate cancer patients (PMID: 23737455). Mutations in DHTKD1 (dehydrogenase E1 and transketolase domain-containing protein 1) have been shown to cause human 2-aminoadipic aciduria and 2-oxoadipic aciduria via impaired decarboxylation of 2-oxoadipate to glutaryl-CoA, which is the last step in the lysine degradation pathway (PMID: 23141293). Aging, diabetes, sepsis, and renal failure are known to catalyze the oxidation of lysyl residues to form 2-aminoadipic acid in human skin collagen and potentially other tissues (PMID: 18448817). Proteolytic breakdown of these tissues can lead to the release of free 2-aminoadipic acid. Studies in rats indicate that aminoadipic acid (along with the three branched-chain amino acids: leucine, valine, and isoleucine) levels are elevated in the pre-diabetic phase and so aminoadipic acid may serve as a predictive biomarker for the development of diabetes (PMID: 15389298). Long-term hyperglycemia of endothelial cells can also lead to elevated levels of aminoadipate which is thought to be a sign of lysine breakdown through oxidative stress and reactive oxygen species (ROS) (PMID: 21961526). 2-Aminoadipate is a potential small-molecule marker of oxidative stress (PMID: 21647514). Therefore, depending on the circumstances aminoadipic acid can act as an acidogen, a diabetogen, an atherogen, and a metabotoxin. An acidogen is an acidic compound that induces acidosis, which has multiple adverse effects on many organ systems. A diabetogen is a compound that can lead to type 2 diabetes. An atherogen is a compound that leads to atherosclerosis and cardiovascular disease. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of aminoadipic acid are associated with at least two inborn errors of metabolism including 2-aminoadipic aciduria and 2-oxoadipic aciduria. Aminoadipic acid is an organic acid and abnormally high levels of organic acids in the blood (organic acidemia), urine (organic aciduria), the brain, and other tissues lead to general metabolic acidosis. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis, the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone (hypotonia), and lack of energy (lethargy). These can progress to heart abnormalities, kidney abnormalities, liver damage, seizures, coma, and possibly death. These are also the characteristic symptoms of the untreated IEMs mentioned above. Many affected children with organic acidemias experience intellectual disability or delayed development. In adults, acidosis or acidemia is characterized by headaches, confusion, feeling tired, tremors, sleepiness, and seizures. As a diabetogen, serum aminoadipic levels appear to regulate glucose homeostasis and have been highly predictive of individuals who later develop diabetes (PMID: 24091325). In particular, aminoadipic acid lowers fasting plasma glucose levels and enhances insulin secretion from human islets. As an atherogen, aminoadipic acid has been found to be produced at high levels via protein lysine oxidation in atherosclerotic plaques (PMID: 28069522).
A metabolite in the principal biochemical pathway of lysine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor, N-methyl-D-aspartate; (NMDA).
L-α-Aminoadipic acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=1118-90-7 (retrieved 2024-07-01) (CAS RN: 1118-90-7). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Aminoadipic acid is an intermediate in the metabolism of lysine and saccharopine.
Aminoadipic acid is an intermediate in the metabolism of lysine and saccharopine.
同义名列表
26 个代谢物同义名
(2S)-2-Azaniumyl-6-hydroxy-6-oxohexanoate; (2S)-2-Aminohexanedioic acid; (S)-2-Aminohexanedioic acid; L-2-Aminohexanedioic acid; L-alpha-Aminoadipic acid; 2-Aminohexanedioic acid; (S)-2-Aminohexanedioate; (S)-2-Aminoadipic acid; alpha-Aminoadipic acid; L-2-Aminohexanedioate; L-2-Aminoadipic acid; L-Α-aminoadipic acid; L-alpha-Aminoadipate; L-a-Aminoadipic acid; α-Aminoadipic acid; L-Aminoadipic acid; 2-Aminoadipic acid; L-Α-aminoadipate; L-a-Aminoadipate; L-2-Aminoadipate; Aminoadipic acid; 2-Aminoadipate; a-Aminoadipate; Aminoadipate; Aminoadipic acid; L-2-Aminoadipic acid
数据库引用编号
36 个数据库交叉引用编号
- ChEBI: CHEBI:37024
- ChEBI: CHEBI:37023
- KEGG: C00956
- PubChem: 92136
- HMDB: HMDB0000510
- Metlin: METLIN3271
- ChEMBL: CHEMBL433238
- ChEMBL: CHEMBL88804
- Wikipedia: Alpha-Aminoadipic_acid
- MeSH: 2-Aminoadipic Acid
- MetaCyc: CPD-468
- KNApSAcK: C00007393
- foodb: FDB021812
- chemspider: 83182
- CAS: 1118-90-7
- MoNA: KO000169
- MoNA: KO002261
- MoNA: PR100296
- MoNA: PS063801
- MoNA: KO002259
- MoNA: KO000166
- MoNA: KO002262
- MoNA: KO000170
- MoNA: KO000168
- MoNA: KO002258
- MoNA: PS063802
- MoNA: KO000167
- MoNA: PR100729
- MoNA: KO002260
- PMhub: MS000000281
- PDB-CCD: UN1
- 3DMET: B01358
- NIKKAJI: J38.125J
- RefMet: Aminoadipic acid
- medchemexpress: HY-113328
- LOTUS: LTS0221318
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
302 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(3)
- Vitamin B6-dependent and responsive disorders:
L-lysine ⟶ Saccharopine - Cerebral organic acidurias, including diseases:
L-2-Aminoadipic acid ⟶ 2-Oxoadipic acid - Metabolic Epileptic Disorders:
P-enolpyruvate ⟶ Pyruvate
Plant Reactome(272)
- Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
2OG + L-Val ⟶ Glu + KIV - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid catabolism:
CoA + KIV + NAD ⟶ ISB-CoA + NADH + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - Amino acid metabolism:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid catabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Lysine degradation II:
H2O + NAD + allysine ⟶ NADH + alpha-aminoadipate
INOH(3)
- Lysine degradation ( Lysine degradation ):
2-Oxo-glutaric acid + L-Lysine + NADH ⟶ H2O + L-Saccharopine + NAD+ - L-2-Amino-adipic acid + 2-Oxo-glutaric acid = 2-Oxo-adipic acid + L-Glutamic acid ( Lysine degradation ):
2-Oxo-glutaric acid + L-2-Amino-adipic acid ⟶ 2-Oxo-adipic acid + L-Glutamic acid - NAD+ + L-2-Amino-adipate 6-semialdehyde + H2O = NADH + L-2-Amino-adipic acid ( Lysine degradation ):
H2O + L-2-Amino-adipate 6-semialdehyde + NAD+ ⟶ L-2-Amino-adipic acid + NADH
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(24)
- Lysine Degradation:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Glutaric Aciduria Type I:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Saccharopinuria/Hyperlysinemia II:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Hyperlysinemia I, Familial:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Hyperlysinemia II or Saccharopinuria:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Pyridoxine Dependency with Seizures:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - 2-Aminoadipic 2-Oxoadipic Aciduria:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Lysine Metabolism:
Adenosine triphosphate + Aminoadipic acid + holo-[LYS2 peptidyl-carrier-protein] ⟶ Adenosine monophosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein] + Pyrophosphate - Lysine Metabolism:
Hydrogen Ion + meso-diaminopimelate ⟶ Carbon dioxide + L-Lysine - Lysine Degradation:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - 2-Aminoadipic 2-Oxoadipic Aciduria:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Glutaric Aciduria Type I:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Saccharopinuria/Hyperlysinemia II:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Hyperlysinemia I, Familial:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Hyperlysinemia II or Saccharopinuria:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Pyridoxine Dependency with Seizures:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - 2-Aminoadipic 2-Oxoadipic Aciduria:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Lysine Degradation:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Lysine Degradation:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Glutaric Aciduria Type I:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Saccharopinuria/Hyperlysinemia II:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Hyperlysinemia I, Familial:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Hyperlysinemia II or Saccharopinuria:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water - Pyridoxine Dependency with Seizures:
L-Lysine + NADPH + Oxoglutaric acid ⟶ NADP + Saccharopine + Water
PharmGKB(0)
78 个相关的物种来源信息
- 155619 - Agaricomycetes: LTS0221318
- 4890 - Ascomycota: LTS0221318
- 2 - Bacteria: LTS0221318
- 5204 - Basidiomycota: LTS0221318
- 6237 - Caenorhabditis: LTS0221318
- 6239 - Caenorhabditis elegans: 10.1039/C3MB25539E
- 6239 - Caenorhabditis elegans: 10.1186/1471-2164-13-36
- 6239 - Caenorhabditis elegans: LTS0221318
- 415760 - Caylusea: LTS0221318
- 415761 - Caylusea abyssinica: 10.1016/S0031-9422(00)83801-7
- 415761 - Caylusea abyssinica: LTS0221318
- 7711 - Chordata: LTS0221318
- 119089 - Chromadorea: LTS0221318
- 3394 - Cycadaceae: LTS0221318
- 3296 - Cycadopsida: LTS0221318
- 3395 - Cycas: LTS0221318
- 3397 - Cycas circinalis: 10.1055/S-2006-958002
- 3397 - Cycas circinalis: LTS0221318
- 3396 - Cycas revoluta: 10.1016/S0031-9422(96)00866-7
- 3396 - Cycas revoluta: LTS0221318
- 58031 - Cycas rumphii: 10.1055/S-2006-958002
- 58031 - Cycas rumphii: LTS0221318
- 2759 - Eukaryota: LTS0221318
- 3803 - Fabaceae: LTS0221318
- 38944 - Flammulina: LTS0221318
- 38945 - Flammulina velutipes: 10.1111/J.1365-2621.1987.TB13989.X
- 38945 - Flammulina velutipes: LTS0221318
- 4751 - Fungi: LTS0221318
- 9604 - Hominidae: LTS0221318
- 9605 - Homo: LTS0221318
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-012-0464-Y
- 9606 - Homo sapiens: LTS0221318
- 3853 - Lathyrus: LTS0221318
- 3860 - Lathyrus sativus: 10.1016/0021-9673(94)00777-2
- 3860 - Lathyrus sativus: LTS0221318
- 3398 - Magnoliopsida: LTS0221318
- 40674 - Mammalia: LTS0221318
- 3879 - Medicago sativa: -
- 33208 - Metazoa: LTS0221318
- 6231 - Nematoda: LTS0221318
- 862241 - Physalacriaceae: LTS0221318
- 3887 - Pisum: LTS0221318
- 3888 - Pisum sativum: 10.3891/ACTA.CHEM.SCAND.16-0514
- 3888 - Pisum sativum: LTS0221318
- 3754 - Prunus: LTS0221318
- 3758 - Prunus domestica: 10.1021/JF00017A016
- 3758 - Prunus domestica: LTS0221318
- 3889 - Psophocarpus: LTS0221318
- 3891 - Psophocarpus tetragonolobus: 10.1111/J.1365-2621.1985.TB10514.X
- 3891 - Psophocarpus tetragonolobus: LTS0221318
- 26958 - Resedaceae: LTS0221318
- 6243 - Rhabditidae: LTS0221318
- 3745 - Rosaceae: LTS0221318
- 4895 - Schizosaccharomyces: LTS0221318
- 4896 - Schizosaccharomyces pombe: LTS0221318
- 4894 - Schizosaccharomycetaceae: LTS0221318
- 147554 - Schizosaccharomycetes: LTS0221318
- 1883 - Streptomyces: LTS0221318
- 1901 - Streptomyces clavuligerus: 10.1111/J.1749-6632.1996.TB40543.X
- 1901 - Streptomyces clavuligerus: 10.1128/JB.173.3.985-988.1991
- 1901 - Streptomyces clavuligerus: 10.1186/1471-2180-13-296
- 1901 - Streptomyces clavuligerus: LTS0221318
- 1901 - Streptomyces clavuligerus: NA
- 2062 - Streptomycetaceae: LTS0221318
- 35493 - Streptophyta: LTS0221318
- 9821 - Suidae: LTS0221318
- 9822 - Sus: LTS0221318
- 9823 - Sus scrofa: LTS0221318
- 9825 - Sus scrofa domesticus: 10.1007/S11306-012-0441-5
- 9825 - Sus scrofa domesticus: LTS0221318
- 415978 - Sus scrofa scrofa: 10.1007/S11306-012-0441-5
- 415978 - Sus scrofa scrofa: LTS0221318
- 58023 - Tracheophyta: LTS0221318
- 3913 - Vigna: LTS0221318
- 157791 - Vigna radiata: 10.1016/0031-9422(86)88023-2
- 157791 - Vigna radiata: LTS0221318
- 33090 - Viridiplantae: LTS0221318
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dietmar Funck, Malte Sinn, Giuseppe Forlani, Jörg S Hartig. Guanidine production by plant homoarginine-6-hydroxylases.
eLife.
2024 Apr; 12(?):. doi:
10.7554/elife.91458. [PMID: 38619227] - Mingjian Shi, Chuan Wang, Hao Mei, Marinella Temprosa, Jose C Florez, Mark Tripputi, Jordi Merino, Loren Lipworth, Xiao-Ou Shu, Robert E Gerszten, Thomas J Wang, Joshua A Beckman, Jorge L Gamboa, Jonathan D Mosley, Jane F Ferguson. Genetic Architecture of Plasma Alpha-Aminoadipic Acid Reveals a Relationship With High-Density Lipoprotein Cholesterol.
Journal of the American Heart Association.
2022 06; 11(11):e024388. doi:
10.1161/jaha.121.024388. [PMID: 35621206] - Yedi Zhou, Yu Xu, Xiang Zhang, Qian Huang, Wei Tan, Yonghui Yang, Xiaori He, Shigeo Yoshida, Peiquan Zhao, Yun Li. Plasma levels of amino acids and derivatives in retinopathy of prematurity.
International journal of medical sciences.
2021; 18(15):3581-3587. doi:
10.7150/ijms.63603. [PMID: 34522185] - Chi-Jen Lo, Yu-Shien Ko, Su-Wei Chang, Hsiang-Yu Tang, Cheng-Yu Huang, Yu-Chen Huang, Hung-Yao Ho, Chih-Ming Lin, Mei-Ling Cheng. Metabolic signatures of muscle mass loss in an elderly Taiwanese population.
Aging.
2020 12; 13(1):944-956. doi:
10.18632/aging.202209. [PMID: 33410783] - João Leandro, Tetyana Dodatko, Robert J DeVita, Hongjie Chen, Brandon Stauffer, Chunli Yu, Sander M Houten. Deletion of 2-aminoadipic semialdehyde synthase limits metabolite accumulation in cell and mouse models for glutaric aciduria type 1.
Journal of inherited metabolic disease.
2020 11; 43(6):1154-1164. doi:
10.1002/jimd.12276. [PMID: 32567100] - Matias Estaras, Fatma Z Ameur, Mario Estévez, Silvia Díaz-Velasco, Antonio Gonzalez. The lysine derivative aminoadipic acid, a biomarker of protein oxidation and diabetes-risk, induces production of reactive oxygen species and impairs trypsin secretion in mouse pancreatic acinar cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2020 Nov; 145(?):111594. doi:
10.1016/j.fct.2020.111594. [PMID: 32738373] - Juliette Bouchereau, Manuel Schiff. Inherited Disorders of Lysine Metabolism: A Review.
The Journal of nutrition.
2020 10; 150(Suppl 1):2556S-2560S. doi:
10.1093/jn/nxaa112. [PMID: 33000154] - Cristina Razquin, Miguel Ruiz-Canela, Clary B Clish, Jun Li, Estefania Toledo, Courtney Dennis, Liming Liang, Albert Salas-Huetos, Kerry A Pierce, Marta Guasch-Ferré, Dolores Corella, Emilio Ros, Ramon Estruch, Enrique Gómez-Gracia, Montse Fitó, Jose Lapetra, Dora Romaguera, Angel Alonso-Gómez, Lluis Serra-Majem, Jordi Salas-Salvadó, Frank B Hu, Miguel A Martínez-González. Lysine pathway metabolites and the risk of type 2 diabetes and cardiovascular disease in the PREDIMED study: results from two case-cohort studies.
Cardiovascular diabetology.
2019 11; 18(1):151. doi:
10.1186/s12933-019-0958-2. [PMID: 31722714] - Wang-Yang Xu, Yan Shen, Houbao Zhu, Junhui Gao, Chen Zhang, Lingyun Tang, Shun-Yuan Lu, Chun-Ling Shen, Hong-Xin Zhang, Ziwei Li, Peng Meng, Ying-Han Wan, Jian Fei, Zhu-Gang Wang. 2-Aminoadipic acid protects against obesity and diabetes.
The Journal of endocrinology.
2019 11; 243(2):111-123. doi:
10.1530/joe-19-0157. [PMID: 31454789] - Mario Estévez, Patricia Padilla, Leila Carvalho, Lourdes Martín, Ana Carrapiso, Josué Delgado. Malondialdehyde interferes with the formation and detection of primary carbonyls in oxidized proteins.
Redox biology.
2019 09; 26(?):101277. doi:
10.1016/j.redox.2019.101277. [PMID: 31352127] - Jiao Xue, Junjuan Wang, Pan Gong, Minhang Wu, Wenshuang Yang, Shiju Jiang, Ye Wu, Yuwu Jiang, Yuehua Zhang, Tatiana Yuzyuk, Hong Li, Zhixian Yang. Simultaneous quantification of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate, pipecolic acid and alpha-aminoadipic acid in pyridoxine-dependent epilepsy.
Scientific reports.
2019 08; 9(1):11371. doi:
10.1038/s41598-019-47882-2. [PMID: 31388081] - Ganesh V Halade, Vasundhara Kain, Bochra Tourki, Jeevan Kumar Jadapalli. Lipoxygenase drives lipidomic and metabolic reprogramming in ischemic heart failure.
Metabolism: clinical and experimental.
2019 07; 96(?):22-32. doi:
10.1016/j.metabol.2019.04.011. [PMID: 30999004] - Charles R Evans, Alla Karnovsky, Michael A Puskarich, George Michailidis, Alan E Jones, Kathleen A Stringer. Untargeted Metabolomics Differentiates l-Carnitine Treated Septic Shock 1-Year Survivors and Nonsurvivors.
Journal of proteome research.
2019 05; 18(5):2004-2011. doi:
10.1021/acs.jproteome.8b00774. [PMID: 30895797] - Suat Ekin, Murat Dogan, Fazilet Gok, Yağmur Karakus. Assessment of antioxidant enzymes, total sialic acid, lipid bound sialic acid, vitamins and selected amino acids in children with phenylketonuria.
Pediatric research.
2018 12; 84(6):821-828. doi:
10.1038/s41390-018-0137-2. [PMID: 30135593] - Christoph U Schräder, Andrea Heinz, Petra Majovsky, Berin Karaman Mayack, Jürgen Brinckmann, Wolfgang Sippl, Christian E H Schmelzer. Elastin is heterogeneously cross-linked.
The Journal of biological chemistry.
2018 09; 293(39):15107-15119. doi:
10.1074/jbc.ra118.004322. [PMID: 30108173] - Wang-Yang Xu, Houbao Zhu, Yan Shen, Ying-Han Wan, Xiao-Die Tu, Wen-Ting Wu, Lingyun Tang, Hong-Xin Zhang, Shun-Yuan Lu, Xiao-Long Jin, Jian Fei, Zhu-Gang Wang. DHTKD1 Deficiency Causes Charcot-Marie-Tooth Disease in Mice.
Molecular and cellular biology.
2018 07; 38(13):. doi:
10.1128/mcb.00085-18. [PMID: 29661920] - Juraj Koska, Aramesh Saremi, Scott Howell, Gideon Bahn, Barbora De Courten, Henry Ginsberg, Paul J Beisswenger, Peter D Reaven. Advanced Glycation End Products, Oxidation Products, and Incident Cardiovascular Events in Patients With Type 2 Diabetes.
Diabetes care.
2018 03; 41(3):570-576. doi:
10.2337/dc17-1740. [PMID: 29208654] - Janaína Camacho da Silva, Alexandre Umpierrez Amaral, Cristiane Cecatto, Alessandro Wajner, Kálita Dos Santos Godoy, Rafael Teixeira Ribeiro, Aline de Mello Gonçalves, Ângela Zanatta, Mateus Struecker da Rosa, Samanta Oliveira Loureiro, Carmen Regla Vargas, Guilhian Leipnitz, Diogo Onofre Gomes de Souza, Moacir Wajner. α-Ketoadipic Acid and α-Aminoadipic Acid Cause Disturbance of Glutamatergic Neurotransmission and Induction of Oxidative Stress In Vitro in Brain of Adolescent Rats.
Neurotoxicity research.
2017 Aug; 32(2):276-290. doi:
10.1007/s12640-017-9735-8. [PMID: 28429309] - Amal Al Teneiji, Theodora U J Bruun, Dawn Cordeiro, Jaina Patel, Michal Inbar-Feigenberg, Shelly Weiss, Eduard Struys, Saadet Mercimek-Mahmutoglu. Phenotype, biochemical features, genotype and treatment outcome of pyridoxine-dependent epilepsy.
Metabolic brain disease.
2017 04; 32(2):443-451. doi:
10.1007/s11011-016-9933-8. [PMID: 27882480] - Nematallah Mansour, Véronique Dumulon-Perreault, Samia Ait-Mohand, Michel Paquette, Roger Lecomte, Brigitte Guérin. Impact of dianionic and dicationic linkers on tumor uptake and biodistribution of [64 Cu]Cu/NOTA peptide-based gastrin-releasing peptide receptors antagonists.
Journal of labelled compounds & radiopharmaceuticals.
2017 04; 60(4):200-212. doi:
10.1002/jlcr.3491. [PMID: 28129446] - Zhipeng A Wang, Yu Zeng, Yadagiri Kurra, Xin Wang, Jeffery M Tharp, Erol C Vatansever, Willie W Hsu, Susie Dai, Xinqiang Fang, Wenshe R Liu. A Genetically Encoded Allysine for the Synthesis of Proteins with Site-Specific Lysine Dimethylation.
Angewandte Chemie (International ed. in English).
2017 01; 56(1):212-216. doi:
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Biochimica et biophysica acta. Molecular basis of disease.
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2016 Apr; 1017-1018(?):145-152. doi:
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The Journal of nutrition.
2015 Nov; 145(11):2456-63. doi:
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Journal of inherited metabolic disease.
2015 Sep; 38(5):873-9. doi:
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Nutritional neuroscience.
2015 Aug; 18(6):256-64. doi:
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Animal science journal = Nihon chikusan Gakkaiho.
2015 Apr; 86(4):435-42. doi:
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NMR in biomedicine.
2015 Mar; 28(3):317-26. doi:
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Meat science.
2014 Mar; 96(3):1250-7. doi:
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Meat science.
2014 Feb; 96(2 Pt A):812-20. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Jan; 944(?):141-3. doi:
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The Chinese journal of physiology.
2013 Dec; 56(6):309-17. doi:
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Plant signaling & behavior.
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The Journal of clinical investigation.
2013 Oct; 123(10):4309-17. doi:
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American journal of human genetics.
2012 Dec; 91(6):1082-7. doi:
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Meat science.
2012 Dec; 92(4):596-603. doi:
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Meat science.
2012 Dec; 92(4):451-7. doi:
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Molecular genetics and metabolism.
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Journal of inherited metabolic disease.
2012 Nov; 35(6):1031-6. doi:
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Molecular bioSystems.
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2012 Oct; 17(4):371-3. doi:
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Journal of inherited metabolic disease.
2012 Sep; 35(5):909-16. doi:
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Journal of agricultural and food chemistry.
2012 Aug; 60(32):8002-11. doi:
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The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques.
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Journal of agricultural and food chemistry.
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Molecular genetics and metabolism.
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Journal of the science of food and agriculture.
2011 Oct; 91(13):2500-4. doi:
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2011 Sep; 118(5):796-805. doi:
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Chemico-biological interactions.
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Cancer cell international.
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Brain : a journal of neurology.
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International journal of biological sciences.
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Brain : a journal of neurology.
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BMC plant biology.
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