(4-Aminobutyl)guanidine (BioDeep_00000001287)

 

Secondary id: BioDeep_00000400211

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


N-(Aminoiminomethyl)-1,4-butanediamine

化学式: C5H14N4 (130.1218)
中文名称: (4-氨基丁基)胍, 胍丁胺, 硫酸胍基丁胺
谱图信息: 最多检出来源 Homo sapiens(blood) 21.29%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

(4-Aminobutyl)guanidine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/(4-aminobutyl)guanidine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001287). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(CCN=C(N)N)CN
InChI: InChI=1S/C5H14N4/c6-3-1-2-4-9-5(7)8/h1-4,6H2,(H4,7,8,9)

描述信息

Agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)) is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is a putative neurotransmitter. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase. Agmatine binds to 2-adrenergic receptor and imidazoline binding sites, and blocks NMDA receptors and other cation ligand-gated channels. Agmatine inhibits nitric oxide synthase (NOS), and induces the release of some peptide hormones. Treatment with exogenous agmatine exerts neuroprotective effects in animal models of neurotrauma. -- Wikipedia; Agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)) is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is discussed as a putative neurotransmitter. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase. Agmatine binds to ?2-adrenergic receptor and imidazoline binding sites, and blocks NMDA receptors and other cation ligand-gated channels. Agmatine inhibits nitric oxide synthase (NOS), and induces the release of some peptide hormones. Agmatine is found in many foods, some of which are fruits, kohlrabi, carob, and burdock.
Agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)) is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is a putative neurotransmitter. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase. Agmatine binds to 2-adrenergic receptor and imidazoline binding sites, and blocks NMDA receptors and other cation ligand-gated channels. Agmatine inhibits nitric oxide synthase (NOS), and induces the release of some peptide hormones. Treatment with exogenous agmatine exerts neuroprotective effects in animal models of neurotrauma.

Agmatine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=306-60-5 (retrieved 2024-07-01) (CAS RN: 306-60-5). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

18 个代谢物同义名

N-(Aminoiminomethyl)-1,4-butanediamine; 1 Amino 4 guanidinobutane; 1-(4-Aminobutyl)guanidine; 1-Amino-4-guanidinobutane; N-(4-Aminobutyl)guanidine; (4-Aminobutyl) guanidine; (4-Aminobutyl)-guanidine; 4-Guanidino-1-butanamine; N-4-Aminobutylguanidine; 1-Amino-4-guanidobutane; 4-(Aminobutyl)guanidine; (4-Aminobutyl)guanidine; Agmatine sulfate salt; Agmatinium; Argmatine; Agmatine; Agmatine; (4-Aminobutyl)guanidine



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(0)

代谢反应

335 个相关的代谢反应过程信息。

Reactome(12)

BioCyc(10)

WikiPathways(0)

Plant Reactome(311)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

18 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ARG1, AZIN2, CA1, CASP3, HMGB1, MTOR, NOS1, NOS2, ODC1, SLC9A1
Peripheral membrane protein 4 AOC1, HMGB1, MTOR, NOS1
Endoplasmic reticulum membrane 1 MTOR
Mitochondrion membrane 1 SLC22A3
Nucleus 8 ARG1, AZIN2, CASP3, HMGB1, MPO, MTOR, NOS1, NOS2
cytosol 8 ARG1, AZIN2, CA1, CASP3, MTOR, NOS1, NOS2, ODC1
dendrite 2 AZIN2, MTOR
mitochondrial membrane 1 SLC22A3
phagocytic vesicle 1 MTOR
trans-Golgi network 1 AZIN2
nucleoplasm 7 CASP3, HMGB1, MPO, MTOR, NOS1, NOS2, SLC9A1
Cell membrane 7 AOC1, HMGB1, OPRD1, SLC22A1, SLC22A3, SLC9A1, TNF
Cytoplasmic side 1 MTOR
lamellipodium 1 SLC9A1
Cytoplasmic granule 1 ARG1
Multi-pass membrane protein 5 OPRD1, SLC22A1, SLC22A2, SLC22A3, SLC9A1
Golgi apparatus membrane 1 MTOR
Synapse 1 NOS1
cell surface 3 HMGB1, SLC9A1, TNF
glutamatergic synapse 1 CASP3
Golgi membrane 2 INS, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 3 CASP3, SLC22A3, TNF
presynaptic membrane 1 OPRD1
sarcolemma 1 NOS1
Cytoplasm, cytosol 1 NOS2
Lysosome 2 MPO, MTOR
Presynapse 3 SLC22A1, SLC22A2, SLC22A3
endosome 1 HMGB1
plasma membrane 10 AOC1, HMGB1, NOS1, NOS2, OPRD1, SLC22A1, SLC22A2, SLC22A3, SLC9A1, TNF
synaptic vesicle membrane 1 OPRD1
Membrane 7 AZIN2, MTOR, OPRD1, SLC22A1, SLC22A2, SLC22A3, SLC9A1
apical plasma membrane 4 SLC22A1, SLC22A2, SLC22A3, SLC9A1
axon 1 AZIN2
basolateral plasma membrane 4 SLC22A1, SLC22A2, SLC22A3, SLC9A1
extracellular exosome 5 AOC1, CA1, MPO, SLC22A2, SLC9A1
Lysosome membrane 1 MTOR
endoplasmic reticulum 1 HMGB1
extracellular space 7 AOC1, ARG1, HMGB1, IL6, INS, MPO, TNF
perinuclear region of cytoplasm 4 AZIN2, NOS1, NOS2, SLC9A1
bicellular tight junction 1 AOC1
intercalated disc 1 SLC9A1
mitochondrion 4 AGMAT, AZIN2, NOS1, SLC9A1
protein-containing complex 1 NOS1
intracellular membrane-bounded organelle 1 MPO
Microsome membrane 1 MTOR
postsynaptic density 2 CASP3, NOS1
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 3 HMGB1, IL6, INS
extracellular region 7 AOC1, ARG1, HMGB1, IL6, INS, MPO, TNF
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
Extracellular side 2 AOC1, HMGB1
photoreceptor inner segment 1 NOS1
Nucleus membrane 1 SLC22A3
external side of plasma membrane 1 TNF
dendritic spine 1 NOS1
T-tubule 1 SLC9A1
perikaryon 1 AZIN2
cytoplasmic vesicle 1 AZIN2
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 3 SLC22A1, SLC22A2, SLC22A3
Cell membrane, sarcolemma 1 NOS1
Cytoplasm, perinuclear region 2 NOS1, NOS2
Membrane raft 3 NOS1, SLC9A1, TNF
focal adhesion 1 SLC9A1
cis-Golgi network 1 AZIN2
Peroxisome 2 AOC1, NOS2
sarcoplasmic reticulum 1 NOS1
peroxisomal matrix 1 NOS2
Cell projection, dendritic spine 1 NOS1
Nucleus, PML body 1 MTOR
PML body 1 MTOR
secretory granule 1 MPO
lateral plasma membrane 1 SLC22A1
Nucleus outer membrane 1 SLC22A3
nuclear outer membrane 1 SLC22A3
neuron projection 1 OPRD1
phagocytic cup 1 TNF
cell periphery 1 NOS1
Chromosome 1 HMGB1
cytoskeleton 1 NOS1
Secreted, extracellular space 1 AOC1
Basolateral cell membrane 4 SLC22A1, SLC22A2, SLC22A3, SLC9A1
nuclear envelope 1 MTOR
Endomembrane system 2 MTOR, SLC22A3
endosome lumen 1 INS
basal plasma membrane 3 SLC22A1, SLC22A2, SLC22A3
azurophil granule 1 MPO
ficolin-1-rich granule lumen 1 HMGB1
secretory granule lumen 2 HMGB1, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 IL6, INS
transcription repressor complex 1 HMGB1
axon terminus 1 OPRD1
specific granule lumen 2 AOC1, ARG1
transport vesicle 2 AZIN2, INS
azurophil granule lumen 2 ARG1, MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 AZIN2, INS
postsynaptic density membrane 1 OPRD1
neuronal dense core vesicle 1 OPRD1
phagocytic vesicle lumen 1 MPO
endoplasmic reticulum-Golgi intermediate compartment 2 AZIN2, HMGB1
Basal cell membrane 2 SLC22A1, SLC22A2
Lateral cell membrane 1 SLC22A1
death-inducing signaling complex 1 CASP3
dendrite membrane 1 OPRD1
Golgi apparatus, cis-Golgi network 1 AZIN2
condensed chromosome 1 HMGB1
Cytoplasmic vesicle, phagosome 1 MTOR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
interleukin-6 receptor complex 1 IL6
cation-transporting ATPase complex 1 SLC9A1
spine apparatus 1 OPRD1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
granular vesicle 1 AZIN2


文献列表

  • Karen Rodríguez-Núñez, Alejandra Cortés-Monroy, Marcela Serey, Yunus Ensari, Mehdi D Davari, Claudia Bernal, Ronny Martinez. Modulating Substrate Specificity of Rhizobium sp. Histamine Dehydrogenase through Protein Engineering for Food Quality Applications. Molecules (Basel, Switzerland). 2023 Apr; 28(9):. doi: 10.3390/molecules28093748. [PMID: 37175158]
  • Madhura P Dixit, Shivkumar S Sammeta, Mrunali D Dhokne, Shubhada Mangrulkar, Manoj A Upadhya, Milind J Umekar, Brijesh G Taksande, Nandkishor R Kotagale. Chronic agmatine treatment prevents olanzapine-induced obesity and metabolic dysregulation in female rats. Brain research bulletin. 2022 12; 191(?):69-77. doi: 10.1016/j.brainresbull.2022.10.013. [PMID: 36272666]
  • Donatella Coradduzza, Tatiana Solinas, Emanuela Azara, Nicola Culeddu, Sara Cruciani, Angelo Zinellu, Serenella Medici, Margherita Maioli, Massimo Madonia, Ciriaco Carru. Plasma Polyamine Biomarker Panels: Agmatine in Support of Prostate Cancer Diagnosis. Biomolecules. 2022 03; 12(4):. doi: 10.3390/biom12040514. [PMID: 35454104]
  • Katarina Milosevic, Ivana Stevanovic, Iva D Bozic, Ana Milosevic, Marija M Janjic, Danijela Laketa, Ivana Bjelobaba, Irena Lavrnja, Danijela Savic. Agmatine Mitigates Inflammation-Related Oxidative Stress in BV-2 Cells by Inducing a Pre-Adaptive Response. International journal of molecular sciences. 2022 Mar; 23(7):. doi: 10.3390/ijms23073561. [PMID: 35408922]
  • Dan Zhang, Jinzhao Li, Tianzhu Li. Agmatine mitigates palmitate (PA)-induced mitochondrial and metabolic dysfunction in microvascular endothelial cells. Human & experimental toxicology. 2022 Jan; 41(?):9603271221110857. doi: 10.1177/09603271221110857. [PMID: 35747990]
  • Anna Wiśniewska, Aneta Stachowicz, Katarzyna Kuś, Magdalena Ulatowska-Białas, Justyna Totoń-Żurańska, Anna Kiepura, Kamila Stachyra, Maciej Suski, Mariusz Gajda, Jacek Jawień, Rafał Olszanecki. Inhibition of Atherosclerosis and Liver Steatosis by Agmatine in Western Diet-Fed apoE-Knockout Mice Is Associated with Decrease in Hepatic De Novo Lipogenesis and Reduction in Plasma Triglyceride/High-Density Lipoprotein Cholesterol Ratio. International journal of molecular sciences. 2021 Oct; 22(19):. doi: 10.3390/ijms221910688. [PMID: 34639029]
  • Yanpei Zhang, Shuqiao Yuan, Tuanjie Che, Jinchun He. Agmatine and glycolipid metabolism. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2021 Aug; 46(8):889-893. doi: 10.11817/j.issn.1672-7347.2021.200351. [PMID: 34565735]
  • Patrick M Honore, Sebastien Redant, Keitiane Kaefer, Leonel Barreto Gutierrez, Luc Kugener, Rachid Attou, Andrea Gallerani, David De Bels. Serum Agmatine Levels Were Negatively Correlated With the Severity of Sepsis: Beware of Potential Confounders!. Critical care medicine. 2021 08; 49(8):e810-e811. doi: 10.1097/ccm.0000000000004980. [PMID: 34261941]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Nanxiang Xiong, Xiaofei Gao, Hongyang Zhao, Feng Cai, Fang-Cheng Zhang, Ye Yuan, Weichao Liu, Fangping He, Lauren G Zacharias, Hong Lin, Hieu S Vu, Chao Xing, Dong-Xiao Yao, Fei Chen, Benyan Luo, Wenzhi Sun, Ralph J DeBerardinis, Hao Xu, Woo-Ping Ge. Using arterial-venous analysis to characterize cancer metabolic consumption in patients. Nature communications. 2020 06; 11(1):3169. doi: 10.1038/s41467-020-16810-8. [PMID: 32576825]
  • Wanwan Wang, Zhuoxian Yu, Jinpeng Meng, Pengyong Zhou, Ting Luo, Jin Zhang, Jun Wu, Yonggen Lou. Rice phenolamindes reduce the survival of female adults of the white-backed planthopper Sogatella furcifera. Scientific reports. 2020 04; 10(1):5778. doi: 10.1038/s41598-020-62752-y. [PMID: 32238850]
  • Dimitrios Tsikas, Alexander Bollenbach, Erik Hanff, Bibiana Beckmann, Björn Redfors. Synthesis of homoagmatine and GC-MS analysis of tissue homoagmatine and agmatine: evidence that homoagmatine but not agmatine is a metabolite of pharmacological L-homoarginine in the anesthetized rat. Amino acids. 2020 Feb; 52(2):235-245. doi: 10.1007/s00726-019-02808-0. [PMID: 31776762]
  • Takahiro Sugiura, Yasushi Hirasawa, Tohru Toyoshi, Yasuo Matsumura. Effects of Agmatine on Contrast-Induced Nephropathy in Rats and Rabbits. Biological & pharmaceutical bulletin. 2020; 43(10):1556-1561. doi: 10.1248/bpb.b20-00405. [PMID: 32999165]
  • Arisoy Ozden, Halaris Angelos, Aricioglu Feyza, Wild Elizabeth, Piletz John. Altered plasma levels of arginine metabolites in depression. Journal of psychiatric research. 2020 01; 120(?):21-28. doi: 10.1016/j.jpsychires.2019.10.004. [PMID: 31629205]
  • Xuanfei Li, Junyu Zhu, Lixing Tian, Xiaoyuan Ma, Xia Fan, Li Luo, Jing Yu, Yu Sun, Xue Yang, Wanqi Tang, Wei Ma, Jun Yan, Xiang Xu, Huaping Liang. Agmatine Protects Against the Progression of Sepsis Through the Imidazoline I2 Receptor-Ribosomal S6 Kinase 2-Nuclear Factor-κB Signaling Pathway. Critical care medicine. 2020 01; 48(1):e40-e47. doi: 10.1097/ccm.0000000000004065. [PMID: 31634234]
  • Laura Barrientos-Moreno, María Antonia Molina-Henares, Marta Pastor-García, María Isabel Ramos-González, Manuel Espinosa-Urgel. Arginine Biosynthesis Modulates Pyoverdine Production and Release in Pseudomonas putida as Part of the Mechanism of Adaptation to Oxidative Stress. Journal of bacteriology. 2019 11; 201(22):. doi: 10.1128/jb.00454-19. [PMID: 31451546]
  • Rosina Pryor, Povilas Norvaisas, Georgios Marinos, Lena Best, Louise B Thingholm, Leonor M Quintaneiro, Wouter De Haes, Daniela Esser, Silvio Waschina, Celia Lujan, Reuben L Smith, Timothy A Scott, Daniel Martinez-Martinez, Orla Woodward, Kevin Bryson, Matthias Laudes, Wolfgang Lieb, Riekelt H Houtkooper, Andre Franke, Liesbet Temmerman, Ivana Bjedov, Helena M Cochemé, Christoph Kaleta, Filipe Cabreiro. Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy. Cell. 2019 09; 178(6):1299-1312.e29. doi: 10.1016/j.cell.2019.08.003. [PMID: 31474368]
  • David H Bergin, Yu Jing, Gail Williams, Bruce G Mockett, Hu Zhang, Wickliffe C Abraham, Ping Liu. Safety and neurochemical profiles of acute and sub-chronic oral treatment with agmatine sulfate. Scientific reports. 2019 09; 9(1):12669. doi: 10.1038/s41598-019-49078-0. [PMID: 31481723]
  • Daqing Xu, Lirong Zhang. Increasing Agmatine Production in Escherichia coli through Metabolic Engineering. Journal of agricultural and food chemistry. 2019 Jul; 67(28):7908-7915. doi: 10.1021/acs.jafc.9b03038. [PMID: 31268314]
  • Emine Yılmaz, M Ramazan Şekeroğlu, Ekrem Yılmaz, Erdem Çokluk. Evaluation of plasma agmatine level and its metabolic pathway in patients with bipolar disorder during manic episode and remission period. International journal of psychiatry in clinical practice. 2019 Jun; 23(2):128-133. doi: 10.1080/13651501.2019.1569237. [PMID: 31081413]
  • Beyazit Garip, Hakan Kayir, Ozcan Uzun. l-Arginine metabolism before and after 10 weeks of antipsychotic treatment in first-episode psychotic patients. Schizophrenia research. 2019 04; 206(?):58-66. doi: 10.1016/j.schres.2018.12.015. [PMID: 30587428]
  • V Selakovic, Lj Arsenijevic, M Jovanovic, S Sivcev, N Jovanovic, M Leontijevic, M Stojanovic, M Radenkovic, P Andjus, L Radenovic. Functional and pharmacological analysis of agmatine administration in different cerebral ischemia animal models. Brain research bulletin. 2019 03; 146(?):201-212. doi: 10.1016/j.brainresbull.2019.01.005. [PMID: 30641119]
  • E K El-Sayed, Aae Ahmed, Em El Morsy, S Nofal. Neuroprotective effect of agmatine (decarboxylated l-arginine) against oxidative stress and neuroinflammation in rotenone model of Parkinson's disease. Human & experimental toxicology. 2019 Feb; 38(2):173-184. doi: 10.1177/0960327118788139. [PMID: 30001633]
  • Nishat Ahmed, Naif Aljuhani, Hind S Al-Hujaili, Manar A Al-Hujaili, Mohamed A Elkablawy, Magdy M Noah, Hany Abo-Haded, Dina S El-Agamy. Agmatine protects against sodium valproate-induced hepatic injury in mice via modulation of nuclear factor-κB/inducible nitric oxide synthetase pathway. Journal of biochemical and molecular toxicology. 2018 Dec; 32(12):e22227. doi: 10.1002/jbt.22227. [PMID: 30273971]
  • Ana C Guerra de Souza, Cinara L Gonçalves, Viviane de Souza, Juliana M Hartwig, Marcelo Farina, Rui D Prediger. Agmatine attenuates depressive-like behavior and hippocampal oxidative stress following amyloid β (Aβ1-40) administration in mice. Behavioural brain research. 2018 11; 353(?):51-56. doi: 10.1016/j.bbr.2018.06.032. [PMID: 29964071]
  • Lusliany J Rondón, M C Farges, N Davin, B Sion, A M Privat, M P Vasson, A Eschalier, C Courteix. L-Arginine supplementation prevents allodynia and hyperalgesia in painful diabetic neuropathic rats by normalizing plasma nitric oxide concentration and increasing plasma agmatine concentration. European journal of nutrition. 2018 Oct; 57(7):2353-2363. doi: 10.1007/s00394-017-1508-x. [PMID: 28725942]
  • Maha H Sharawy, Rehab S Abdelrahman, Dalia H El-Kashef. Agmatine attenuates rhabdomyolysis-induced acute kidney injury in rats in a dose dependent manner. Life sciences. 2018 Sep; 208(?):79-86. doi: 10.1016/j.lfs.2018.07.019. [PMID: 30009822]
  • Jinbo Li, Kaixuan Zhang, Yu Meng, Jianping Hu, Mengqi Ding, Jiahui Bian, Mingli Yan, Jianming Han, Meiliang Zhou. Jasmonic acid/ethylene signaling coordinates hydroxycinnamic acid amides biosynthesis through ORA59 transcription factor. The Plant journal : for cell and molecular biology. 2018 08; 95(3):444-457. doi: 10.1111/tpj.13960. [PMID: 29752755]
  • Yusuke Kitada, Koji Muramatsu, Hirokazu Toju, Ryoko Kibe, Yoshimi Benno, Shin Kurihara, Mitsuharu Matsumoto. Bioactive polyamine production by a novel hybrid system comprising multiple indigenous gut bacterial strategies. Science advances. 2018 06; 4(6):eaat0062. doi: 10.1126/sciadv.aat0062. [PMID: 29963630]
  • Erman Esnafoglu, İlhan İrende. Decreased plasma agmatine levels in autistic subjects. Journal of neural transmission (Vienna, Austria : 1996). 2018 04; 125(4):735-740. doi: 10.1007/s00702-017-1836-2. [PMID: 29302750]
  • S Tommasi, D J Elliot, M Da Boit, S R Gray, B C Lewis, A A Mangoni. Homoarginine and inhibition of human arginase activity: kinetic characterization and biological relevance. Scientific reports. 2018 02; 8(1):3697. doi: 10.1038/s41598-018-22099-x. [PMID: 29487337]
  • Inci Turan, Hale Sayan Ozacmak, V Haktan Ozacmak, Figen Barut, Mehmet Araslı. Agmatine attenuates intestinal ischemia and reperfusion injury by reducing oxidative stress and inflammatory reaction in rats. Life sciences. 2017 Nov; 189(?):23-28. doi: 10.1016/j.lfs.2017.08.032. [PMID: 28893640]
  • Mohammed S El-Awady, Manar A Nader, Maha H Sharawy. The inhibition of inducible nitric oxide synthase and oxidative stress by agmatine attenuates vascular dysfunction in rat acute endotoxemic model. Environmental toxicology and pharmacology. 2017 Oct; 55(?):74-80. doi: 10.1016/j.etap.2017.08.009. [PMID: 28837867]
  • Anna Wiśniewska, Rafał Olszanecki, Justyna Totoń-Żurańska, Katarzyna Kuś, Aneta Stachowicz, Maciej Suski, Anna Gębska, Mariusz Gajda, Jacek Jawień, Ryszard Korbut. Anti-Atherosclerotic Action of Agmatine in ApoE-Knockout Mice. International journal of molecular sciences. 2017 Aug; 18(8):. doi: 10.3390/ijms18081706. [PMID: 28777310]
  • Nitin B Gawali, Vipin D Bulani, Malvika S Gursahani, Padmini S Deshpande, Pankaj S Kothavade, Archana R Juvekar. Agmatine attenuates chronic unpredictable mild stress-induced anxiety, depression-like behaviours and cognitive impairment by modulating nitrergic signalling pathway. Brain research. 2017 05; 1663(?):66-77. doi: 10.1016/j.brainres.2017.03.004. [PMID: 28302445]
  • Fatemeh Yarmohmmadi, Nastaran Rahimi, Hedyeh Faghir-Ghanesefat, Nina Javadian, Alireza Abdollahi, Parvin Pasalar, Farahnaz Jazayeri, Shahram Ejtemaeemehr, Ahmad Reza Dehpour. Protective effects of agmatine on doxorubicin-induced chronic cardiotoxicity in rat. European journal of pharmacology. 2017 Feb; 796(?):39-44. doi: 10.1016/j.ejphar.2016.12.022. [PMID: 27993640]
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