N,N'-Diphenyl-p-phenylenediamine (BioDeep_00000009940)

 

Secondary id: BioDeep_00001873663

human metabolite blood metabolite


代谢物信息卡片


N,N-DIPHENYL-1,4-PHENYLENEDIAMINE

化学式: C18H16N2 (260.1313416)
中文名称: N,N’-二苯基-1,4-苯二胺, N,N-二苯基对苯二胺
谱图信息: 最多检出来源 Homo sapiens(blood) 30.77%

分子结构信息

SMILES: C1=CC=C(C=C1)NC2=CC=C(C=C2)NC3=CC=CC=C3
InChI: InChI=1S/C18H16N2/c1-3-7-15(8-4-1)19-17-11-13-18(14-12-17)20-16-9-5-2-6-10-16/h1-14,19-20H

描述信息

D020011 - Protective Agents > D000975 - Antioxidants

同义名列表

16 个代谢物同义名

N,N-DIPHENYL-1,4-PHENYLENEDIAMINE; N1,N4-diphenylbenzene-1,4-diamine; N,N-diphenyl-1,4-benzenediamine; N,N-Diphenyl-p-phenylenediamine; N,N-diphenyl-1,4-diaminobenzene; 4,4-Diphenyl-p-phenylenediamine; N,N-diphenyl-4-phenylenediamine; diphenyl-p-phenylenediamine; 1,4-Bis(phenylamino)benzene; p-Phenylaminodiphenylamine; 4-Phenylaminodiphenylamine; p-Bis(phenylamino)benzene; 1,4-Dianilinobenzene; DDPD; DFFD; DPPD



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chao Wang, Mingfang Peng, Zhipeng Gao, Qi Han, Fuhua Fu, Gaoyang Li, Donglin Su, Lvhong Huang, Jiajing Guo, Yang Shan. Untargeted Metabolomic Analyses and Antilipidemic Effects of Citrus Physiological Premature Fruit Drop. International journal of molecular sciences. 2024 Feb; 25(3):. doi: 10.3390/ijms25031876. [PMID: 38339154]
  • Su-Jin Jung, Mi-Ra Oh, Dae Young Lee, Young-Seob Lee, Geum-Soog Kim, Soo-Hyun Park, Soog-Kyoung Han, Young-Ock Kim, Sun-Jung Yoon, Soo-Wan Chae. Effect of Ginseng Extracts on the Improvement of Osteopathic and Arthritis Symptoms in Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2021 Sep; 13(10):. doi: 10.3390/nu13103352. [PMID: 34684351]
  • Ran Arieli, Soliman Khatib, Jacob Vaya. Ovine plasma dipalmitoylphosphatidylcholine does not predict decompression bubbling. Respiratory physiology & neurobiology. 2019 01; 259(?):26-29. doi: 10.1016/j.resp.2018.06.013. [PMID: 29969702]
  • Neda Dadashvand, Christina M Othon. Temperature dependent heterogeneous rotational correlation in lipids. Physical biology. 2016 11; 13(6):066004. doi: 10.1088/1478-3975/13/6/066004. [PMID: 27845924]
  • Mobin Jamal, Azhar Masood, Rosetta Belcastro, Lianet Lopez, Jun Li, Jaques Belik, Robert P Jankov, A Keith Tanswell. Lipid hydroperoxide formation regulates postnatal rat lung cell apoptosis and alveologenesis. Free radical biology & medicine. 2013 Feb; 55(?):83-92. doi: 10.1016/j.freeradbiomed.2012.11.012. [PMID: 23195685]
  • Emad A Ahmed, Hossam M Omar, Sary Kh Abd elghaffar, Sohair M M Ragb, Ahmed Y Nasser. The antioxidant activity of vitamin C, DPPD and L-cysteine against Cisplatin-induced testicular oxidative damage in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011 May; 49(5):1115-21. doi: 10.1016/j.fct.2011.02.002. [PMID: 21310208]
  • Arun Radhakrishnan. Phase separations in binary and ternary cholesterol-phospholipid mixtures. Biophysical journal. 2010 May; 98(9):L41-3. doi: 10.1016/j.bpj.2010.01.005. [PMID: 20441733]
  • J A Kotarek, M A Moss. Impact of phospholipid bilayer saturation on amyloid-beta protein aggregation intermediate growth: a quartz crystal microbalance analysis. Analytical biochemistry. 2010 Apr; 399(1):30-8. doi: 10.1016/j.ab.2009.12.016. [PMID: 20018160]
  • Hirokazu Doi, Toshiharu Horie. Salicylic acid-induced hepatotoxicity triggered by oxidative stress. Chemico-biological interactions. 2010 Feb; 183(3):363-8. doi: 10.1016/j.cbi.2009.11.024. [PMID: 19948161]
  • Yoshiko Kawai, Tomohiko Satoh, Daisuke Hibi, Yukihiro Ohno, Yuka Kohda, Katsuyuki Miura, Munekazu Gemba. The effect of antioxidant on development of fibrosis by cisplatin in rats. Journal of pharmacological sciences. 2009 Dec; 111(4):433-9. doi: 10.1254/jphs.09185fp. [PMID: 19966510]
  • Hyonseok Hwang. Coarse-grained molecular dynamics study of cyclic peptide nanotube insertion into a lipid bilayer. The journal of physical chemistry. A. 2009 Apr; 113(16):4780-7. doi: 10.1021/jp8080657. [PMID: 19035669]
  • Gary O Rankin, Suk-Kil Hong, Dianne K Anestis, John G Ball, Monica A Valentovic. Mechanistic aspects of 4-amino-2,6-dichlorophenol-induced in vitro nephrotoxicity. Toxicology. 2008 Mar; 245(1-2):123-9. doi: 10.1016/j.tox.2007.12.014. [PMID: 18243470]
  • Stefania Miccadei, Donato Di Venere, Angela Cardinali, Ferdinando Romano, Alessandra Durazzo, Maria Stella Foddai, Rocco Fraioli, Sohrab Mobarhan, Giuseppe Maiani. Antioxidative and apoptotic properties of polyphenolic extracts from edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells. Nutrition and cancer. 2008; 60(2):276-83. doi: 10.1080/01635580801891583. [PMID: 18444161]
  • Henrikas Nivinskas, Ausra Nemeikaite-Ceniene, Audrone Maroziene, Terese Normantiene, Narimantas Cenas. Prooxidant cytotoxicity of chromate in mammalian cells: the opposite roles of DT-diaphorase and glutathione reductase. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2006 Nov; 61(11-12):889-95. doi: . [PMID: 17294702]
  • Yuka Kohda, Yoshiko Matsunaga, Ryugo Shiota, Tomohiko Satoh, Yuko Kishi, Yoshiko Kawai, Munekazu Gemba. Involvement of Raf-1/MEK/ERK1/2 signaling pathway in zinc-induced injury in rat renal cortical slices. The Journal of toxicological sciences. 2006 Aug; 31(3):207-17. doi: 10.2131/jts.31.207. [PMID: 16960431]
  • Yoshiko Kawai, Takafumi Nakao, Naoshi Kunimura, Yuka Kohda, Munekazu Gemba. Relationship of intracellular calcium and oxygen radicals to Cisplatin-related renal cell injury. Journal of pharmacological sciences. 2006 Jan; 100(1):65-72. doi: 10.1254/jphs.fp0050661. [PMID: 16410676]
  • Ausra Nemeikaite-Ceniene, Audrone Maroziene, Audrius Pukalskas, Petras Rimantas Venskutonis, Narimantas Cenas. Redox properties of novel antioxidant 5,8-Dihydroxycoumarin: implications for its prooxidant cytotoxicity. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2005 Nov; 60(11-12):849-54. doi: 10.1515/znc-2005-11-1206. [PMID: 16402544]
  • Ausra Nemeikaite-Ceniene, Ausra Imbrasaite, Egle Sergediene, Narimantas Cenas. Quantitative structure-activity relationships in prooxidant cytotoxicity of polyphenols: role of potential of phenoxyl radical/phenol redox couple. Archives of biochemistry and biophysics. 2005 Sep; 441(2):182-90. doi: 10.1016/j.abb.2005.07.002. [PMID: 16111645]
  • Yoshiko Matsunaga, Yoshiko Kawai, Yuka Kohda, Munekazu Gemba. Involvement of activation of NADPH oxidase and extracellular signal-regulated kinase (ERK) in renal cell injury induced by zinc. The Journal of toxicological sciences. 2005 May; 30(2):135-44. doi: 10.2131/jts.30.135. [PMID: 15928461]
  • Brian S Cummings, Andrew K Gelasco, Gilbert R Kinsey, Jane McHowat, Rick G Schnellmann. Inactivation of endoplasmic reticulum bound Ca2+-independent phospholipase A2 in renal cells during oxidative stress. Journal of the American Society of Nephrology : JASN. 2004 Jun; 15(6):1441-51. doi: 10.1097/01.asn.0000127923.57438.ec. [PMID: 15153555]
  • Jonas Sarlauskas, Ausra Nemeikaite-Ceniene, Zilvinas Anusevicius, Lina Miseviciene, Marta Martinez Julvez, Milagros Medina, Carlos Gomez-Moreno, Narimantas Cenas. Flavoenzyme-catalyzed redox cycling of hydroxylamino- and amino metabolites of 2,4,6-trinitrotoluene: implications for their cytotoxicity. Archives of biochemistry and biophysics. 2004 May; 425(2):184-92. doi: 10.1016/j.abb.2004.02.043. [PMID: 15111126]
  • Jonas Sarlauskas, Ausra Nemeikaite-Ceniene, Zilvinas Anusevicius, Lina Miseviciene, Audrone Maroziene, Arvydas Markevicius, Narimantas Cenas. Enzymatic redox properties of novel nitrotriazole explosives implications for their toxicity. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2004 May; 59(5-6):399-404. doi: 10.1515/znc-2004-5-620. [PMID: 18998409]
  • Ausra Nemeikaite-Ceniene, Jonas Sarlauskas, Zilvinas Anusevicius, Henrikas Nivinskas, Narimantas Cenas. Cytotoxicity of RH1 and related aziridinylbenzoquinones: involvement of activation by NAD(P)H:quinone oxidoreductase (NQO1) and oxidative stress. Archives of biochemistry and biophysics. 2003 Aug; 416(1):110-8. doi: 10.1016/s0003-9861(03)00281-9. [PMID: 12859987]
  • Yuka Kohda, Jun Hiramatsu, Munekazu Gemba. Involvement of MEK/ERK pathway in cephaloridine-induced injury in rat renal cortical slices. Toxicology letters. 2003 Jul; 143(2):185-94. doi: 10.1016/s0378-4274(03)00174-7. [PMID: 12749822]
  • Sung Min Park, Hyun Chul Jung, Im Soo Koak, Ha Yun Na, Jae Suk Woo, Jin Sup Jung, Yong Keun Kim. Oxidant-induced cell death in renal epithelial cells: differential effects of inorganic and organic hydroperoxides. Pharmacology & toxicology. 2003 Jan; 92(1):43-50. doi: 10.1034/j.1600-0773.2003.920108.x. [PMID: 12710597]
  • Chang Beohm Ahn, Choon Ho Song, Woo Hwan Kim, Yong Keun Kim. Effects of Juglans sinensis Dode extract and antioxidant on mercury chloride-induced acute renal failure in rabbits. Journal of ethnopharmacology. 2002 Sep; 82(1):45-9. doi: 10.1016/s0378-8741(02)00124-1. [PMID: 12169405]
  • Ausra Nemeikaite-Ceniene, Egle Sergediene, Henrikas Nivinskas, Narimantas Cenas. Cytotoxicity of natural hydroxyanthraquinones: role of oxidative stress. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2002 Sep; 57(9-10):822-7. doi: 10.1515/znc-2002-9-1012. [PMID: 12440719]
  • K Yamamoto, Y Masubuchi, S Narimatsu, S Kobayashi, T Horie. Toxicity of ethacrynic acid in isolated rat hepatocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2002 Apr; 16(2):151-8. doi: 10.1016/s0887-2333(01)00107-2. [PMID: 11869877]
  • Yong Keun Kim, Sung Keun Lee, Mi Suk Ha, Jae Suk Woo, Jin Sup Jung. Differential role of reactive oxygen species in chemical hypoxia-induced cell injury in opossum kidney cells and rabbit renal cortical slices. Experimental nephrology. 2002; 10(4):275-84. doi: 10.1159/000063702. [PMID: 12097831]
  • J R Bishop, M Shimamura, S L Hajduk. Insight into the mechanism of trypanosome lytic factor-1 killing of Trypanosoma brucei brucei. Molecular and biochemical parasitology. 2001 Nov; 118(1):33-40. doi: 10.1016/s0166-6851(01)00361-9. [PMID: 11704271]
  • N Cenas, A Nemeikaite-Ceniene, E Sergediene, H Nivinskas, Z Anusevicius, J Sarlauskas. Quantitative structure-activity relationships in enzymatic single-electron reduction of nitroaromatic explosives: implications for their cytotoxicity. Biochimica et biophysica acta. 2001 Sep; 1528(1):31-8. doi: 10.1016/s0304-4165(01)00169-6. [PMID: 11514095]
  • Y W Lee, M S Ha, Y K Kim. H2O2-induced cell death in human glioma cells: role of lipid peroxidation and PARP activation. Neurochemical research. 2001 Apr; 26(4):337-43. doi: 10.1023/a:1010993428770. [PMID: 11495343]
  • S M Culbertson, N A Porter. Design of unsymmetrical azo initiators to increase radical generation efficiency in low-density lipoproteins. Free radical research. 2000 Dec; 33(6):705-18. doi: 10.1080/10715760000301231. [PMID: 11237093]
  • L Tang, Y Zhang, Z Qian, X Shen. The mechanism of Fe(2+)-initiated lipid peroxidation in liposomes: the dual function of ferrous ions, the roles of the pre-existing lipid peroxides and the lipid peroxyl radical. The Biochemical journal. 2000 Nov; 352 Pt 1(?):27-36. doi: 10.1042/bj3520027. [PMID: 11062055]
  • I Rath, W Barz. The role of lipid peroxidation in aluminium toxicity in soybean cell suspension cultures. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2000 Nov; 55(11-12):957-64. doi: 10.1515/znc-2000-11-1218. [PMID: 11204202]
  • S M Colles, G M Chisolm. Lysophosphatidylcholine-induced cellular injury in cultured fibroblasts involves oxidative events. Journal of lipid research. 2000 Aug; 41(8):1188-98. doi: 10.1016/s0022-2275(20)33425-8. [PMID: 10946005]
  • K Nishino, N Noguchi, E Niki. Dynamics of action of bisphenol as radical-scavenging antioxidant against lipid peroxidation in solution and liposomal membranes. Free radical research. 1999 Dec; 31(6):535-48. doi: 10.1080/10715769900301111. [PMID: 10630678]
  • M Valentovic, M K Meadows, R C Harmon, J G Ball, S K Hong, G O Rankin. 2-Amino-5-chlorophenol toxicity in renal cortical slices from Fischer 344 rats: effect of antioxidants and sulfhydryl agents. Toxicology and applied pharmacology. 1999 Nov; 161(1):1-9. doi: 10.1006/taap.1999.8784. [PMID: 10558918]
  • K Furuno, T Suetsugu, K Shimomichi, Y Tsuruta, N Sugihara. Lipid peroxidation induced by adriamycin in linolenic acid-loaded cultured hepatocytes. Pharmacology & toxicology. 1998 Oct; 83(4):176-82. doi: 10.1111/j.1600-0773.1998.tb01465.x. [PMID: 9820879]
  • E Dickancaité, A Nemeikaitè, A Kalvelytè, N Cènas. Prooxidant character of flavonoid cytotoxicity: structure-activity relationships. Biochemistry and molecular biology international. 1998 Aug; 45(5):923-30. doi: ". [PMID: 9739457]
  • Y Minamide, T Horie, A Tomaru, S Awazu. Spontaneous chemiluminescence production, lipid peroxidation, and covalent binding in rat hepatocytes exposed to acetaminophen. Journal of pharmaceutical sciences. 1998 May; 87(5):640-6. doi: 10.1021/js9701014. [PMID: 9572917]
  • J Sarlauskas, E Dickancaite, A Nemeikaite, Z Anusevicius, H Nivinskas, J Segura-Aguilar, N Cenas. Nitrobenzimidazoles as substrates for DT-diaphorase and redox cycling compounds: their enzymatic reactions and cytotoxicity. Archives of biochemistry and biophysics. 1997 Oct; 346(2):219-29. doi: 10.1006/abbi.1997.0285. [PMID: 9343369]
  • Q Chen, M Galleano, A I Cederbaum. Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1. The Journal of biological chemistry. 1997 Jun; 272(23):14532-41. doi: 10.1074/jbc.272.23.14532. [PMID: 9169410]
  • D Banks, M R Soliman. Protective effects of antioxidants against benomyl-induced lipid peroxidation and glutathione depletion in rats. Toxicology. 1997 Jan; 116(1-3):177-81. doi: 10.1016/s0300-483x(96)03542-1. [PMID: 9020519]
  • E Niki. Mechanisms and dynamics of antioxidant action of ubiquinol. Molecular aspects of medicine. 1997; 18 Suppl(?):S63-70. doi: 10.1016/s0098-2997(97)00035-6. [PMID: 9266507]
  • J G Zhang, W E Lindup. Cisplatin-induced nephrotoxicity in vitro: increases in cytosolic calcium concentration and the inhibition of cytosolic and mitochondrial protein kinase C. Toxicology letters. 1996 Dec; 89(1):11-7. doi: 10.1016/s0378-4274(96)03776-9. [PMID: 8952706]
  • J G Zhang, W E Lindup. Differential effects of cisplatin on the production of NADH-dependent superoxide and the activity of antioxidant enzymes in rat renal cortical slices in vitro. Pharmacology & toxicology. 1996 Oct; 79(4):191-8. doi: 10.1111/j.1600-0773.1996.tb02087.x. [PMID: 8899860]
  • T Satoh, N Sakai, Y Enokido, Y Uchiyama, H Hatanaka. Survival factor-insensitive generation of reactive oxygen species induced by serum deprivation in neuronal cells. Brain research. 1996 Sep; 733(1):9-14. doi: 10.1016/0006-8993(96)00527-6. [PMID: 8891242]
  • K Sogabe, N F Roeser, M A Venkatachalam, J M Weinberg. Differential cytoprotection by glycine against oxidant damage to proximal tubule cells. Kidney international. 1996 Sep; 50(3):845-54. doi: 10.1038/ki.1996.384. [PMID: 8872959]
  • K Furono, T Suetsuga, N Sugihara. Effects of metal ions on lipid peroxidation in cultured rat hepatocytes loaded with alpha-linolenic acid. Journal of toxicology and environmental health. 1996 Jun; 48(2):121-9. doi: 10.1080/009841096161375. [PMID: 8642620]
  • B Van de Water, M Kruidering, J F Nagelkerke. F-actin disorganization in apoptotic cell death of cultured rat renal proximal tubular cells. The American journal of physiology. 1996 Apr; 270(4 Pt 2):F593-603. doi: 10.1152/ajprenal.1996.270.4.f593. [PMID: 8967337]
  • Z M Qian, P L Tang, E H Morgan. Effect of lipid peroxidation on transferrin-free iron uptake by rabbit reticulocytes. Biochimica et biophysica acta. 1996 Feb; 1310(3):293-302. doi: 10.1016/0167-4889(95)00175-1. [PMID: 8599607]
  • T Yamada. [Studies on the mechanisms of renal damages induced by nephrotoxic compounds]. Nihon hoigaku zasshi = The Japanese journal of legal medicine. 1995 Dec; 49(6):447-57. doi: . [PMID: 8583688]
  • K Ollinger, U T Brunk. Cellular injury induced by oxidative stress is mediated through lysosomal damage. Free radical biology & medicine. 1995 Nov; 19(5):565-74. doi: 10.1016/0891-5849(95)00062-3. [PMID: 8529915]
  • R K Tangirala, F Casanada, E Miller, J L Witztum, D Steinberg, W Palinski. Effect of the antioxidant N,N'-diphenyl 1,4-phenylenediamine (DPPD) on atherosclerosis in apoE-deficient mice. Arteriosclerosis, thrombosis, and vascular biology. 1995 Oct; 15(10):1625-30. doi: 10.1161/01.atv.15.10.1625. [PMID: 7583536]
  • N Sugihara, T Suetsugu, K Furuno. High susceptibility to paraquat-driven lipid peroxidation of cultured hepatocytes loaded with linolenic acid. The Journal of pharmacology and experimental therapeutics. 1995 Jul; 274(1):187-93. doi: NULL. [PMID: 7616398]
  • P A Glascott, E Gilfor, J L Farber. Relationship of the metabolism of vitamins C and E in cultured hepatocytes treated with tert-butyl hydroperoxide. Molecular pharmacology. 1995 Jul; 48(1):80-8. doi: ". [PMID: 7623778]
  • K Ollinger, A Brunmark. Effect of different oxygen pressures and N,N'-diphenyl-p-phenylenediamine on Adriamycin toxicity to cultured neonatal rat heart myocytes. Biochemical pharmacology. 1994 Nov; 48(9):1707-15. doi: 10.1016/0006-2952(94)90455-3. [PMID: 7980639]
  • B van de Water, J P Zoeteweij, H J de Bont, G J Mulder, J F Nagelkerke. Role of mitochondrial Ca2+ in the oxidative stress-induced dissipation of the mitochondrial membrane potential. Studies in isolated proximal tubular cells using the nephrotoxin 1,2-dichlorovinyl-L-cysteine. The Journal of biological chemistry. 1994 May; 269(20):14546-52. doi: 10.1016/s0021-9258(17)36658-9. [PMID: 8182062]
  • M Parola, M Pinzani, A Casini, E Albano, G Poli, A Gentilini, P Gentilini, M U Dianzani. Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen alpha 1 (I) gene expression in human liver fat-storing cells. Biochemical and biophysical research communications. 1993 Aug; 194(3):1044-50. doi: 10.1006/bbrc.1993.1927. [PMID: 8352762]
  • L Mikkelsen, H S Hansen, N Grunnet, J Dich. Inhibition of fatty acid synthesis in rat hepatocytes by exogenous polyunsaturated fatty acids is caused by lipid peroxidation. Biochimica et biophysica acta. 1993 Feb; 1166(1):99-104. doi: 10.1016/0005-2760(93)90289-l. [PMID: 8431498]
  • R Carini, M Parola, M U Dianzani, E Albano. Lipid peroxidation and hepatocyte death investigation of a possible mechanism of oxidative cell injury. Annals of the New York Academy of Sciences. 1992 Nov; 663(?):444-6. doi: 10.1111/j.1749-6632.1992.tb38696.x. [PMID: 1482081]
  • T Onodera, G Takemura, T Oguro, M Ashraf. Effect of exogenous hydrogen peroxide on myocardial function and structure in isolated rat heart. The Canadian journal of cardiology. 1992 Nov; 8(9):989-97. doi: . [PMID: 1486549]
  • K Asakura, H Ikeda, M Gemba. In vitro oxygenation injury to slices prepared from ischemic kidney in rats. Japanese journal of pharmacology. 1992 Oct; 60(2):149-51. doi: 10.1254/jjp.60.149. [PMID: 1479743]
  • T W Petry, G H Wolfgang, R A Jolly, R Ochoa, W J Donarski. Antioxidant-dependent inhibition of diquat-induced toxicity in vivo. Toxicology. 1992 Aug; 74(1):33-43. doi: 10.1016/0300-483x(92)90041-c. [PMID: 1514186]
  • C P Sparrow, T W Doebber, J Olszewski, M S Wu, J Ventre, K A Stevens, Y S Chao. Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N'-diphenyl-phenylenediamine. The Journal of clinical investigation. 1992 Jun; 89(6):1885-91. doi: 10.1172/jci115793. [PMID: 1601995]
  • M L Hu, A L Tappel. Glutathione and antioxidants protect microsomes against lipid peroxidation and enzyme inactivation. Lipids. 1992 Jan; 27(1):42-5. doi: 10.1007/bf02537057. [PMID: 1608302]
  • G F Rush, G D Ponsler. Cephaloridine-induced biochemical changes and cytotoxicity in suspensions of rabbit isolated proximal tubules. Toxicology and applied pharmacology. 1991 Jun; 109(2):314-26. doi: 10.1016/0041-008x(91)90178-h. [PMID: 2068729]
  • J B Kirkland. Lipid peroxidation, protein thiol oxidation and DNA damage in hydrogen peroxide-induced injury to endothelial cells: role of activation of poly(ADP-ribose)polymerase. Biochimica et biophysica acta. 1991 May; 1092(3):319-25. doi: 10.1016/s0167-4889(97)90007-0. [PMID: 1904775]
  • R L Thies, A P Autor. Reactive oxygen injury to cultured pulmonary artery endothelial cells: mediation by poly(ADP-ribose) polymerase activation causing NAD depletion and altered energy balance. Archives of biochemistry and biophysics. 1991 May; 286(2):353-63. doi: 10.1016/0003-9861(91)90051-j. [PMID: 1654786]
  • G H Wolfgang, R A Jolly, W J Donarski, T W Petry. Inhibition of diquat-induced lipid peroxidation and toxicity in precision-cut rat liver slices by novel antioxidants. Toxicology and applied pharmacology. 1991 Apr; 108(2):321-9. doi: 10.1016/0041-008x(91)90121-t. [PMID: 2017757]
  • R J Ruch, S Bandyopadhyay, P Somani, J E Klaunig. Evaluation of amiodarone free radical toxicity in rat hepatocytes. Toxicology letters. 1991 Apr; 56(1-2):117-26. doi: 10.1016/0378-4274(91)90097-p. [PMID: 2017769]
  • J Hannemann, J Duwe, K Baumann. Iron- and ascorbic acid-induced lipid peroxidation in renal microsomes isolated from rats treated with platinum compounds. Cancer chemotherapy and pharmacology. 1991; 28(6):427-33. doi: 10.1007/bf00685818. [PMID: 1934247]
  • G H Wolfgang, R A Jolly, T W Petry. Diquat-induced oxidative damage in hepatic microsomes: effects of antioxidants. Free radical biology & medicine. 1991; 10(6):403-11. doi: 10.1016/0891-5849(91)90049-9. [PMID: 1654289]
  • Q Chen, T W Jones, P C Brown, J L Stevens. The mechanism of cysteine conjugate cytotoxicity in renal epithelial cells. Covalent binding leads to thiol depletion and lipid peroxidation. The Journal of biological chemistry. 1990 Dec; 265(35):21603-11. doi: . [PMID: 2254317]
  • Y Masuda, Y Nakamura. Effects of oxygen deficiency and calcium omission on carbon tetrachloride hepatotoxicity in isolated perfused livers from phenobarbital-pretreated rats. Biochemical pharmacology. 1990 Oct; 40(8):1865-76. doi: 10.1016/0006-2952(90)90368-u. [PMID: 2242020]
  • G H Wolfgang, W J Donarski, T W Petry. Effects of novel antioxidants on carbon tetrachloride-induced lipid peroxidation and toxicity in precision-cut rat liver slices. Toxicology and applied pharmacology. 1990 Oct; 106(1):63-70. doi: 10.1016/0041-008x(90)90106-5. [PMID: 2251684]
  • J B Coleman, A F Casini, A Serroni, J L Farber. Evidence for the participation of activated oxygen species and the resulting peroxidation of lipids in the killing of cultured hepatocytes by aryl halides. Toxicology and applied pharmacology. 1990 Sep; 105(3):393-402. doi: 10.1016/0041-008x(90)90143-i. [PMID: 2237914]
  • M E Kyle, I Sakaida, A Serroni, J L Farber. Metabolism of acetaminophen by cultured rat hepatocytes. Depletion of protein thiol groups without any loss of viability. Biochemical pharmacology. 1990 Sep; 40(6):1211-8. doi: 10.1016/0006-2952(90)90385-x. [PMID: 2403376]
  • A K Ghoshal, T H Rushmore, P Buc-Calderon, M Roberfroid, E Farber. Prevention by free radical scavenger AD5 of prooxidant effects of choline deficiency. Free radical biology & medicine. 1990; 8(1):3-7. doi: 10.1016/0891-5849(90)90137-8. [PMID: 2323581]
  • G H Wolfgang, R A Jolly, W J Donarski, R Ochoa, T W Petry. Inhibition of carbon tetrachloride-induced lipid peroxidation by novel antioxidants in rat hepatic microsomes: dissociation from hepatoprotective effects in vivo. Journal of biochemical toxicology. 1990; 5(3):167-74. doi: 10.1002/jbt.2570050306. [PMID: 2283667]
  • N Susa, S Ueno, Y Furukawa, N Michiba, S Minoura. Induction of lipid peroxidation in mice by hexavalent chromium and its relation to the toxicity. Nihon juigaku zasshi. The Japanese journal of veterinary science. 1989 Dec; 51(6):1103-10. doi: 10.1292/jvms1939.51.1103. [PMID: 2601225]
  • M E Kyle, D Nakae, S Sakaida, A Serroni, J L Farber. Protein thiol depletion and the killing of cultured hepatocytes by hydrogen peroxide. Biochemical pharmacology. 1989 Nov; 38(21):3797-805. doi: 10.1016/0006-2952(89)90588-1. [PMID: 2597173]
  • V Kefalas, N H Stacey. Potentiation of carbon tetrachloride-induced lipid peroxidation by trichloroethylene in isolated rat hepatocytes: no role in enhanced toxicity. Toxicology and applied pharmacology. 1989 Oct; 101(1):158-69. doi: 10.1016/0041-008x(89)90221-4. [PMID: 2799814]
  • N Masaki, M E Kyle, A Serroni, J L Farber. Mitochondrial damage as a mechanism of cell injury in the killing of cultured hepatocytes by tert-butyl hydroperoxide. Archives of biochemistry and biophysics. 1989 May; 270(2):672-80. doi: 10.1016/0003-9861(89)90550-x. [PMID: 2705785]
  • R Hasegawa, S Fukushima, A Hagiwara, T Masui, A Masuda, N Ito. Long-term feeding study of N,N'-diphenyl-p-phenylenediamine in F344 rats. Toxicology. 1989 Jan; 54(1):69-78. doi: 10.1016/0300-483x(89)90079-6. [PMID: 2916243]
  • M T Williams, L Simonet. In vivo suppression of stearyl CoA desaturase activity by griseofulvin: evidence against the involvement of lipid peroxidation. Toxicology and applied pharmacology. 1988 Dec; 96(3):541-9. doi: 10.1016/0041-008x(88)90013-0. [PMID: 2905086]
  • J L Farber, T B Leonard, M E Kyle, D Nakae, A Serroni, S A Rogers. Peroxidation-dependent and peroxidation-independent mechanisms by which acetaminophen kills cultured rat hepatocytes. Archives of biochemistry and biophysics. 1988 Dec; 267(2):640-50. doi: 10.1016/0003-9861(88)90072-0. [PMID: 3214174]
  • J Hannemann, K Baumann. Cisplatin-induced lipid peroxidation and decrease of gluconeogenesis in rat kidney cortex: different effects of antioxidants and radical scavengers. Toxicology. 1988 Oct; 51(2-3):119-32. doi: 10.1016/0300-483x(88)90143-6. [PMID: 3176025]
  • S Miccadei, D Nakae, M E Kyle, D Gilfor, J L Farber. Oxidative cell injury in the killing of cultured hepatocytes by allyl alcohol. Archives of biochemistry and biophysics. 1988 Sep; 265(2):302-10. doi: 10.1016/0003-9861(88)90132-4. [PMID: 3421708]
  • S Ueno, N Susa, Y Furukawa, K Aikawa, I Itagaki, T Komiyama, Y Takashima. The relationship between the development of toxicity and lipid peroxidation induced by chromium compounds in rats. The Kitasato archives of experimental medicine. 1988 Sep; 61(2-3):137-47. doi: NULL. [PMID: 3210555]
  • M S Sandy, D Di Monte, M T Smith. Relationships between intracellular vitamin E, lipid peroxidation, and chemical toxicity in hepatocytes. Toxicology and applied pharmacology. 1988 Apr; 93(2):288-97. doi: 10.1016/0041-008x(88)90129-9. [PMID: 3258679]
  • Q G Jiang, P Moldéus. Effect of the antioxidant N,N1-diphenyl-p-phenylenediamine (DPPD) on bromobenzene metabolism and toxicity in isolated hepatocytes. Pharmacology & toxicology. 1988 Feb; 62(2):104-6. doi: 10.1111/j.1600-0773.1988.tb01855.x. [PMID: 3353350]
  • M Gemba, N Fukuishi, S Nakano. Effect of N-N'-diphenyl-p-phenylenediamine pretreatment on urinary enzyme excretion in cisplatin nephrotoxicity in rats. Japanese journal of pharmacology. 1988 Jan; 46(1):90-2. doi: 10.1254/jjp.46.90. [PMID: 2896807]
  • D A Donnelly, C S Boyer, D R Petersen, D Ross. Cocaine-induced biochemical changes and cytotoxicity in hepatocytes isolated from both mice and rats. Chemico-biological interactions. 1988; 67(1-2):95-104. doi: 10.1016/0009-2797(88)90089-0. [PMID: 3168084]
  • M S Sandy, D Di Monte, P Cohen, M T Smith. Role of active oxygen in paraquat and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) cytotoxicity. Basic life sciences. 1988; 49(?):795-801. doi: 10.1007/978-1-4684-5568-7_127. [PMID: 3266922]
  • G F Rush, P F Smith, D W Alberts, C K Mirabelli, R M Snyder, S T Crooke, J Sowinski, H B Jones, P J Bugelski. The mechanism of acute cytotoxicity of triethylphosphine gold(I) complexes. I. Characterization of triethylphosphine gold chloride-induced biochemical and morphological changes in isolated hepatocytes. Toxicology and applied pharmacology. 1987 Sep; 90(3):377-90. doi: 10.1016/0041-008x(87)90130-x. [PMID: 3660408]
  • K Sugihara, S Nakano, M Gemba. Effect of cisplatin on in vitro production of lipid peroxides in rat kidney cortex. Japanese journal of pharmacology. 1987 May; 44(1):71-6. doi: 10.1254/jjp.44.71. [PMID: 3114524]
  • K Sugihara, S Nakano, M Koda, K Tanaka, N Fukuishi, M Gemba. Stimulatory effect of cisplatin on production of lipid peroxidation in renal tissues. Japanese journal of pharmacology. 1987 Mar; 43(3):247-52. doi: 10.1254/jjp.43.247. [PMID: 3586414]