5-Hydroxynorvaline-betaxanthin (BioDeep_00000009713)
Secondary id: BioDeep_00001873933
human metabolite
代谢物信息卡片
1,1-Dichloro-2-(O-chlorophenyl)-2-(p-chlorophenyl)ethylene
化学式: C14H8Cl4 (315.938)
中文名称: 2,4-滴滴伊标准溶液, 3-邻氯苯基-2-对氯苯-1,1'-二乙烯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C(=C1)C(=C(Cl)Cl)C2=CC=C(C=C2)Cl)Cl
InChI: InChI=1S/C14H8Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8H
描述信息
同义名列表
9 个代谢物同义名
1,1-Dichloro-2-(O-chlorophenyl)-2-(p-chlorophenyl)ethylene; 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethenyl]benzene; 1-Chloro-2-(2,2-dichloro-1-(4-chlorophenyl)vinyl)benzene; 2,2-(2-Chlorophenyl-4-chlorophenyl)-1,1-dichloroethene; 5-Hydroxynorvaline-betaxanthin; 2,4-DDE; O,P-DDE; 2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene; o,p'-DDE
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:34211
- KEGG: C14133
- PubChem: 246598
- HMDB: HMDB0304638
- Metlin: METLIN69824
- ChEMBL: CHEMBL1391
- chemspider: 215802
- CAS: 3424-82-6
- PMhub: MS000023524
- PubChem: 7846947
- NIKKAJI: J80.730C
- KNApSAcK: 34211
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jessica Cusato, Silvia De Francia, Sarah Allegra, Simona Carrella, Elisa Pirro, Francesca Maria Piccione, Francesca De Martino, Anna Ferrero, Fulvia Claudia Daffara, Massimo Terzolo, Alfredo Berruti, Francesco Di Carlo, Marco Tampellini, Antonio D'Avolio. Circannual variation of mitotane and its metabolites plasma levels in patients with adrenocortical carcinoma.
The Journal of pharmacy and pharmacology.
2017 Nov; 69(11):1524-1530. doi:
10.1111/jphp.12798. [PMID: 28809444] - Tawfiq M Al Antary, Mahmoud A Alawi, Hussein Estityah, Nizar Haddad. Organochlorine Pesticides Residues in Human Breast Milk from the Middle Governorates in Jordan in 2013/2014.
Bulletin of environmental contamination and toxicology.
2017 Jul; 99(1):89-92. doi:
10.1007/s00128-017-2117-3. [PMID: 28540444] - Matthias Kroiss, Dietmar Plonné, Sabine Kendl, Diana Schirmer, Cristina L Ronchi, Andreas Schirbel, Martina Zink, Constantin Lapa, Hartwig Klinker, Martin Fassnacht, Werner Heinz, Silviu Sbiera. Association of mitotane with chylomicrons and serum lipoproteins: practical implications for treatment of adrenocortical carcinoma.
European journal of endocrinology.
2016 Mar; 174(3):343-53. doi:
10.1530/eje-15-0946. [PMID: 26671975] - Rachel G Felton, Cynthia C Steiner, Barbara S Durrant, Duane H Keisler, Matthew R Milnes, Christopher W Tubbs. Identification of California Condor Estrogen Receptors 1 and 2 and Their Activation by Endocrine Disrupting Chemicals.
Endocrinology.
2015 Dec; 156(12):4448-57. doi:
10.1210/en.2015-1448. [PMID: 26372180] - Ronald J Jandacek, James E Heubi, Donna D Buckley, Jane C Khoury, Wayman E Turner, Andreas Sjödin, James R Olson, Christie Shelton, Kim Helms, Tina D Bailey, Shirley Carter, Patrick Tso, Marian Pavuk. Reduction of the body burden of PCBs and DDE by dietary intervention in a randomized trial.
The Journal of nutritional biochemistry.
2014 Apr; 25(4):483-8. doi:
10.1016/j.jnutbio.2014.01.002. [PMID: 24629911] - Ilse G Hermsen, Martin Fassnacht, Massimo Terzolo, Saskia Houterman, Jan den Hartigh, Sophie Leboulleux, Fulvia Daffara, Alfredo Berruti, Rita Chadarevian, Martin Schlumberger, Bruno Allolio, Harm R Haak, Eric Baudin. Plasma concentrations of o,p'DDD, o,p'DDA, and o,p'DDE as predictors of tumor response to mitotane in adrenocortical carcinoma: results of a retrospective ENS@T multicenter study.
The Journal of clinical endocrinology and metabolism.
2011 Jun; 96(6):1844-51. doi:
10.1210/jc.2010-2676. [PMID: 21470991] - Pilar F Valerón, José J Pestano, Octavio P Luzardo, Manuel L Zumbado, Maira Almeida, Luis D Boada. Differential effects exerted on human mammary epithelial cells by environmentally relevant organochlorine pesticides either individually or in combination.
Chemico-biological interactions.
2009 Aug; 180(3):485-91. doi:
10.1016/j.cbi.2009.04.010. [PMID: 19422813] - Lori K Davis, Nancy Visitacion, Larry G Riley, Naoshi Hiramatsu, Craig V Sullivan, Tetsuya Hirano, E Gordon Grau. Effects of o,p'-DDE, heptachlor, and 17beta-estradiol on vitellogenin gene expression and the growth hormone/insulin-like growth factor-I axis in the tilapia, Oreochromis mossambicus.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2009 May; 149(4):507-14. doi:
10.1016/j.cbpc.2008.11.007. [PMID: 19101654] - Dai B Yang, Ya Q Wang, Wen X Liu, Shu Tao. A novel pretreatment approach for fast determination of organochlorine pesticides in biotic samples.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2008 May; 43(4):307-13. doi:
10.1080/03601230801941642. [PMID: 18437618] - Peter Thomas, Jing Dong. Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption.
The Journal of steroid biochemistry and molecular biology.
2006 Dec; 102(1-5):175-9. doi:
10.1016/j.jsbmb.2006.09.017. [PMID: 17088055] - Anna A Kasperlik-Zaluska, Andrzej Cichocki. Clinical role of determination of plasma mitotane and its metabolites levels in patients with adrenal cancer: results of a long-term follow-up.
Journal of experimental therapeutics & oncology.
2005; 5(2):125-32. doi:
. [PMID: 16471038] - Ruth H Milston, Martin S Fitzpatrick, Anthony T Vella, Shaun Clements, Deke Gundersen, Grant Feist, Tawni L Crippen, Joann Leong, Carl B Schreck. Short-term exposure of Chinook salmon (Oncoryhnchus tshawytscha) to o,p-DDE or DMSO during early life-history stages causes long-term humoral immunosuppression.
Environmental health perspectives.
2003 Oct; 111(13):1601-7. doi:
10.1289/ehp.6171. [PMID: 14551037] - Hong Fang, Weida Tong, William S Branham, Carrie L Moland, Stacy L Dial, Huixiao Hong, Qian Xie, Roger Perkins, William Owens, Daniel M Sheehan. Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.
Chemical research in toxicology.
2003 Oct; 16(10):1338-58. doi:
10.1021/tx030011g. [PMID: 14565775] - Gabriele E Ackermann, Eva Brombacher, Karl Fent. Development of a fish reporter gene system for the assessment of estrogenic compounds and sewage treatment plant effluents.
Environmental toxicology and chemistry.
2002 Sep; 21(9):1864-75. doi:
. [PMID: 12206426] - J Matthews, T Celius, R Halgren, T Zacharewski. Differential estrogen receptor binding of estrogenic substances: a species comparison.
The Journal of steroid biochemistry and molecular biology.
2000 Nov; 74(4):223-34. doi:
10.1016/s0960-0760(00)00126-6. [PMID: 11162928] - A Andersen, A A Kasperlik-Zaluska, D J Warren. Determination of mitotane (o,p-DDD) and its metabolites o,p-DDA and o,p-DDE in plasma by high-performance liquid chromatography.
Therapeutic drug monitoring.
1999 Jun; 21(3):355-9. doi:
10.1097/00007691-199906000-00020. [PMID: 10365653] - R Benecke, E Keller, B Vetter, R A de Zeeuw. Plasma level monitoring of mitotane (o,p'-DDD) and its metabolite (o,p'-DDE) during long-term treatment of Cushing's disease with low doses.
European journal of clinical pharmacology.
1991; 41(3):259-61. doi:
10.1007/bf00315440. [PMID: 1748144] - M Inouye, T Mio, K Sumino. Use of GC/MS/SIM for rapid determination of plasma levels of o,p'-DDD, o,p'-DDE and o,p'-DDA.
Clinica chimica acta; international journal of clinical chemistry.
1987 Dec; 170(2-3):305-14. doi:
10.1016/0009-8981(87)90141-0. [PMID: 3436064]
