chrysoplenol D (BioDeep_00000000954)
Secondary id: BioDeep_00000266251, BioDeep_00001867572
human metabolite PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C18H16O8 (360.0845)
中文名称: 猫眼草酚 D, 猫眼草酚D, 猫眼草酚
谱图信息:
最多检出来源 Homo sapiens(plant) 7.48%
分子结构信息
SMILES: C1(OC)=CC2OC(C3C=C(O)C(O)=CC=3)=C(OC)C(=O)C=2C(O)=C1OC
InChI: InChI=1S/C18H16O8/c1-23-12-7-11-13(14(21)17(12)24-2)15(22)18(25-3)16(26-11)8-4-5-9(19)10(20)6-8/h4-7,19-21H,1-3H3
描述信息
3,4,5-trihydroxy-3,6,7-trimethoxyflavone is a trimethoxyflavone that is the 3,6,7-trimethyl ether derivative of quercetagetin. It has a role as an antineoplastic agent and a metabolite. It is a trihydroxyflavone and a trimethoxyflavone. It is functionally related to a quercetagetin.
Chrysosplenol D is a natural product found in Psiadia viscosa, Chrysosplenium oppositifolium, and other organisms with data available.
See also: Vitex negundo fruit (part of).
Chrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities[1][2][3][4].
Chrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities[1][2][3][4].
同义名列表
19 个代谢物同义名
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxy-; 2-(3,4-Dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-1-benzopyran-4-one; 2-(3,4-dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-chromen-4-one; 2-(3,4-dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxychromen-4-one; 5,3,4-trihydroxy 3,6,7-trimethylquercetagetin; Flavone, 3,4,5-trihydroxy-3,6,7-trimethoxy-; 3,4,5-trihydroxy-3,6,7-trimethoxyflavone; 5,3,4-Trihydroxy-3,6,7-trimethoxyflavone; Quercetagetin 3,6,7-Trimethyl ether; 3,6,7-trimethylquercetagetin; 7-METHYLAXILLARIN; UNII-GV8SR5RV6Z; Chrysosplenol D; chrysoplenol D; CHRYSOSPLENOLD; MEGxp0_000419; ACon1_001031; GV8SR5RV6Z; Chrysosplenol D
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:18016
- KEGG: C04552
- PubChem: 5280699
- HMDB: HMDB0130258
- Metlin: METLIN51410
- ChEMBL: CHEMBL491366
- LipidMAPS: LMPK12112998
- MeSH: chrysosplenol D
- ChemIDplus: 0014965209
- MetaCyc: 345-TRIHYDROXY-367-TRIMETHOXYFLAVO
- CAS: 14965-20-9
- medchemexpress: HY-N6007
- PMhub: MS000018391
- PubChem: 7157
- KNApSAcK: C00004692
- 3DMET: B00731
- NIKKAJI: J14.308A
- KNApSAcK: 18016
分类词条
相关代谢途径
Reactome(0)
BioCyc(2)
PlantCyc(2)
代谢反应
4 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(2)
- polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium):
3,6,7-trimethylquercetagetin + SAM ⟶ 3,6,7,4'-tetramethylquercetagetin + H+ + SAH - superpathway of polymethylated quercetin/quercetagetin glucoside biosynthesis (Chrysosplenium):
3,6,7-trimethylquercetagetin + SAM ⟶ 3,6,7,4'-tetramethylquercetagetin + H+ + SAH
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(2)
- polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium):
3,6,7-trimethylquercetagetin + SAM ⟶ 3,6,7,4'-tetramethylquercetagetin + H+ + SAH - superpathway of polymethylated quercetin/quercetagetin glucoside biosynthesis (Chrysosplenium):
3,6,7-trimethylquercetagetin + SAM ⟶ 3,6,7,4'-tetramethylquercetagetin + H+ + SAH
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
52 个相关的物种来源信息
- 2067805 - Abronia latifolia: 10.1080/10575639308043848
- 185140 - Acanthospermum australe: 10.1021/NP50050A054
- 282717 - Achillea ageratum: 10.1016/S0031-9422(96)00774-1
- 282727 - Achillea clusiana: 10.1016/0305-1978(96)88878-8
- 282734 - Achillea erba-rotta: 10.1016/0305-1978(96)88878-8
- 359922 - Achillea formosa: 10.1515/ZNC-1989-3-423
- 282745 - Achillea ligustica: 10.1016/0031-9422(88)80466-7
- 482479 - Achillea millefolium var. borealis: 10.1016/0305-1978(88)90071-3
- 282752 - Achillea nana: 10.1016/0305-1978(96)88878-8
- 282753 - Achillea nobilis: 10.1016/0305-1978(88)90033-6
- 282770 - Achillea virescens: 10.1016/0305-1978(88)90033-6
- 63345 - Achlys triphylla: 10.1016/0031-9422(91)83058-S
- 99024 - Ajania fruticulosa: 10.1007/BF00565848
- 4045 - Apium graveolens: -
- 35608 - Artemisia annua:
- 35608 - Artemisia Annua L.: -
- 262982 - Artemisia apiacea: 10.1016/S0305-1978(02)00178-3
- 1287600 - Artemisia australis: 10.1016/S0305-1978(02)00178-3
- 496566 - Artemisia carvifolia: 10.1016/S0305-1978(02)00178-3
- 72329 - Artemisia herba-alba: 10.1016/0031-9422(88)80018-9
- 1227629 - Artemisia lindleyana: 10.1021/NP50043A027
- 72345 - Artemisia lucentica: 10.1016/0031-9422(88)80018-9
- 669133 - Artemisia mongolica: 10.1016/S0305-1978(02)00178-3
- 72350 - Artemisia reptans:
- 557631 - Chiliadenus candicans: 10.3109/13880208809053916
- 1458965 - Chiliadenus montanus: 10.1016/0031-9422(89)80084-6
- 80774 - Chrysosplenium alternifolium: 10.1007/S10600-009-9422-Y
- 61245 - Chrysosplenium grayanum: 10.1021/NP50075A029
- 1155259 - Chrysosplenium oppositifolium: 10.1248/CPB.16.2310
- 61239 - Chrysosplenium tosaense: 10.1248/CPB.16.2310
- 204214 - Coleus cylindraceus: 10.1021/NP000124P
- 664351 - Cyanostegia microphylla: 10.1071/CH9671049
- 9606 - Homo sapiens: -
- 301871 - Leucocyclus formosus: 10.1515/ZNC-1989-3-423
- 149445 - Madia sativa: 10.1016/0031-9422(92)80273-H
- 119176 - Pentanema britannicum: 10.1016/0031-9422(91)83681-A
- 176562 - Perityle emoryi: 10.1016/0305-1978(88)90007-5
- 2784686 - Perityle rupestris: 10.1016/0305-1978(88)90007-5
- 2784726 - Perityle vaseyi:
- 33090 - Plants: -
- 2171725 - Plectranthus montanus: 10.1021/NP000124P
- 175519 - Pluchea sagittalis: 10.1016/S0031-9422(00)84421-0
- 1077900 - Psiadia viscosa: 10.1016/S0031-9422(00)97976-7
- 119185 - Pulicaria arabica: 10.3109/13880208809053916
- 313942 - Tessaria integrifolia: 10.3136/FSTR.6.106
- 54477 - Vitex agnus-castus: 10.1016/S0031-9422(99)00181-8
- 361442 - Vitex negundo: 10.3390/MOLECULES15118469
- 223431 - Vitex negundo var. cannabifolia: 10.3390/MOLECULES15118469
- 413484 - Vitex rotundifolia:
- 204215 - Vitex trifolia:
- 204215 - Vitex trifolia L.: -
- 204215 - Vitex trifolia l.var.simplicifolia Cham.: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chunqing Fu, Keyu Zhang, Manyuan Wang, Feng Qiu. Casticin and chrysosplenol D from Artemisia annua L. induce apoptosis by inhibiting topoisomerase IIα in human non-small-cell lung cancer cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jun; 100(?):154095. doi:
10.1016/j.phymed.2022.154095. [PMID: 35398735] - Sophia J Lang, Michael Schmiech, Susanne Hafner, Christian Paetz, Carmen Steinborn, Roman Huber, Menna El Gaafary, Katharina Werner, Christoph Q Schmidt, Tatiana Syrovets, Thomas Simmet. Antitumor activity of an Artemisia annua herbal preparation and identification of active ingredients.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Sep; 62(?):152962. doi:
10.1016/j.phymed.2019.152962. [PMID: 31132755] - Musarat Amina, Perwez Alam, Mohammad K Parvez, Nawal M Al-Musayeib, Samerah A Al-Hwaity, Nada S Al-Rashidi, Mohammed S Al-Dosari. Isolation and validated HPTLC analysis of four cytotoxic compounds, including a new sesquiterpene from aerial parts of Plectranthus cylindraceus.
Natural product research.
2018 Apr; 32(7):804-809. doi:
10.1080/14786419.2017.1363750. [PMID: 28783981] - Joseph Skaf, Omar Hamarsheh, Michael Berninger, Srikkanth Balasubramanian, Tobias A Oelschlaeger, Ulrike Holzgrabe. Improving anti-trypanosomal activity of alkamides isolated from Achillea fragrantissima.
Fitoterapia.
2018 Mar; 125(?):191-198. doi:
10.1016/j.fitote.2017.11.001. [PMID: 29108932]
