2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline (BioDeep_00000009497)
Secondary id: BioDeep_00001875129
human metabolite blood metabolite
代谢物信息卡片
6-nitro-2,3-dioxo-1H,2H,3H,4H-benzo[f]quinoxaline-7-sulfonamide
化学式: C12H8N4O6S (336.0164548)
中文名称: 二羟基喹酮
谱图信息:
最多检出来源 Homo sapiens(blood) 94.74%
分子结构信息
SMILES: C1=CC2=C3C(=CC(=C2C(=C1)S(=O)(=O)N)[N+](=O)[O-])NC(=O)C(=O)N3
InChI: InChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22)
描述信息
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
NBQX (FG9202) is a highly selective and competitive AMPA receptor antagonist. NBQX has neuroprotective and anticonvulsant activity[1].
同义名列表
8 个代谢物同义名
6-nitro-2,3-dioxo-1H,2H,3H,4H-benzo[f]quinoxaline-7-sulfonamide; 2,3-Dihydroxy-6-nitrobenzo[F]quinoxaline-7-sulphonamide; 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline; 6-Nitro-7-sulfamoylbenzo(F)quinoxaline-2,3-dione; 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; 2,3-Dioxo-6-nitro-7-sulfamoylbenzo[f]quinoxaline; nbqx; FG9202
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:31073
- KEGG: C13667
- PubChem: 3272524
- HMDB: HMDB0255485
- Metlin: METLIN69621
- ChEMBL: CHEMBL222519
- CAS: 118876-58-7
- PMhub: MS000023289
- PubChem: 586260
- PDB-CCD: E2Q
- NIKKAJI: J356.947K
- medchemexpress: HY-15068
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yuya Miyamoto, Masatoshi Nakatsuji, Takuya Yoshida, Tadayasu Ohkubo, Takashi Inui. Structural and interaction analysis of human lipocalin-type prostaglandin D synthase with the poorly water-soluble drug NBQX.
The FEBS journal.
2023 08; 290(16):3983-3996. doi:
10.1111/febs.16791. [PMID: 37021622] - Xin-Yi Man, Zao-Shang Chang, Yan-Xin Mo, Kai Liang, Le Wang, Zhi-Yong Xiao. The role of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type receptor modulators in object recognition memory reconsolidation.
Neuroreport.
2022 03; 33(4):199-203. doi:
10.1097/wnr.0000000000001769. [PMID: 35143451] - Li Jiang, Hao Zhang, Junhe Zhou, Xiaorong Tang, Le Luo, Peidong Huang, Wei Yi, Nenggui Xu, Jianhua Liu, Wenbin Fu. Involvement of Hippocampal AMPA Receptors in Electroacupuncture Attenuating Depressive-Like Behaviors and Regulating Synaptic Proteins in Rats Subjected to Chronic Unpredictable Mild Stress.
World neurosurgery.
2020 07; 139(?):e455-e462. doi:
10.1016/j.wneu.2020.04.042. [PMID: 32311563] - Young Seon Cho, Woo Seok Song, Sang Ho Yoon, Kyeong-Yeol Park, Myoung-Hwan Kim. Syringaresinol suppresses excitatory synaptic transmission and picrotoxin-induced epileptic activity in the hippocampus through presynaptic mechanisms.
Neuropharmacology.
2018 03; 131(?):68-82. doi:
10.1016/j.neuropharm.2017.12.014. [PMID: 29225041] - Panos Zanos, Mackenzie E Nelson, Jaclyn N Highland, Samuel R Krimmel, Polymnia Georgiou, Todd D Gould, Scott M Thompson. A Negative Allosteric Modulator for α5 Subunit-Containing GABA Receptors Exerts a Rapid and Persistent Antidepressant-Like Action without the Side Effects of the NMDA Receptor Antagonist Ketamine in Mice.
eNeuro.
2017 Jan; 4(1):. doi:
10.1523/eneuro.0285-16.2017. [PMID: 28275719] - Anna E Martin, Douglas A Schober, Alexander Nikolayev, Vladimir V Tolstikov, Wesley H Anderson, Richard E Higgs, Ming-Shang Kuo, Anastasia Laksmanan, John T Catlow, Xia Li, Christian C Felder, Jeffrey M Witkin. Further Evaluation of Mechanisms Associated with the Antidepressantlike Signature of Scopolamine in Mice.
CNS & neurological disorders drug targets.
2017; 16(4):492-500. doi:
10.2174/1871527316666170309142646. [PMID: 28294051] - H Zhu, R Zhu, Z D Deng, Y C Feng, H L Shen. [Analgesic effects of ionotropic glutamate receptor antagonists MK-801 and NBQX on collagen-induced arthritis rats].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.
2016 12; 48(6):977-981. doi:
. [PMID: 27987500] - Jane E Libbey, Tyler J Hanak, Daniel J Doty, Karen S Wilcox, Robert S Fujinami. NBQX, a highly selective competitive antagonist of AMPA and KA ionotropic glutamate receptors, increases seizures and mortality following picornavirus infection.
Experimental neurology.
2016 06; 280(?):89-96. doi:
10.1016/j.expneurol.2016.04.010. [PMID: 27072529] - Jun Ho Jang, Taick Sang Nam, Jaebeom Jun, Se Jung Jung, Dong-Wook Kim, Joong Woo Leem. Peripheral NMDA Receptors Mediate Antidromic Nerve Stimulation-Induced Tactile Hypersensitivity in the Rat.
Mediators of inflammation.
2015; 2015(?):793624. doi:
10.1155/2015/793624. [PMID: 26770021] - Martín F Adrover, Jung Hoon Shin, Veronica A Alvarez. Glutamate and dopamine transmission from midbrain dopamine neurons share similar release properties but are differentially affected by cocaine.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2014 Feb; 34(9):3183-92. doi:
10.1523/jneurosci.4958-13.2014. [PMID: 24573277] - H Yamanaka, C Yokoyama, H Mizuma, S Kurai, S J Finnema, C Halldin, H Doi, H Onoe. A possible mechanism of the nucleus accumbens and ventral pallidum 5-HT1B receptors underlying the antidepressant action of ketamine: a PET study with macaques.
Translational psychiatry.
2014 Jan; 4(?):e342. doi:
10.1038/tp.2013.112. [PMID: 24399045] - Cristiane Busnardo, Fernando H F Alves, Carlos C Crestani, América A Scopinho, Leonardo B M Resstel, Fernando M A Correa. Paraventricular nucleus of the hypothalamus glutamate neurotransmission modulates autonomic, neuroendocrine and behavioral responses to acute restraint stress in rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2013 Nov; 23(11):1611-22. doi:
10.1016/j.euroneuro.2012.11.002. [PMID: 23201369] - Jelena Baranovic, Chandra S Ramanujan, Nahoko Kasai, Charles R Midgett, Dean R Madden, Keiichi Torimitsu, John F Ryan. Reconstitution of homomeric GluA2(flop) receptors in supported lipid membranes: functional and structural properties.
The Journal of biological chemistry.
2013 Mar; 288(12):8647-8657. doi:
10.1074/jbc.m112.422105. [PMID: 23382380] - Hannah J Seong, Adam G Carter. D1 receptor modulation of action potential firing in a subpopulation of layer 5 pyramidal neurons in the prefrontal cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012 Aug; 32(31):10516-21. doi:
10.1523/jneurosci.1367-12.2012. [PMID: 22855801] - Cristiane Busnardo, Carlos C Crestani, Leonardo B M Resstel, Rodrigo F Tavares, José Antunes-Rodrigues, Fernando M A Corrêa. Ionotropic glutamate receptors in hypothalamic paraventricular and supraoptic nuclei mediate vasopressin and oxytocin release in unanesthetized rats.
Endocrinology.
2012 May; 153(5):2323-31. doi:
10.1210/en.2011-2079. [PMID: 22396452] - Ayano Fukuhara, Hidemitsu Nakajima, Yuya Miyamoto, Katsuaki Inoue, Satoshi Kume, Young-Ho Lee, Masanori Noda, Susumu Uchiyama, Shigeru Shimamoto, Shigenori Nishimura, Tadayasu Ohkubo, Yuji Goto, Tadayoshi Takeuchi, Takashi Inui. Drug delivery system for poorly water-soluble compounds using lipocalin-type prostaglandin D synthase.
Journal of controlled release : official journal of the Controlled Release Society.
2012 Apr; 159(1):143-50. doi:
10.1016/j.jconrel.2011.12.020. [PMID: 22226778] - Liang-Wu Fu, Zhi-Ling Guo, John C Longhurst. Ionotropic glutamate receptors in the external lateral parabrachial nucleus participate in processing cardiac sympathoexcitatory reflexes.
American journal of physiology. Heart and circulatory physiology.
2012 Apr; 302(7):H1444-53. doi:
10.1152/ajpheart.00984.2011. [PMID: 22268111] - M P Kurnellas, H Li, M R Jain, S N Giraud, A B Nicot, A Ratnayake, R F Heary, S Elkabes. Reduced expression of plasma membrane calcium ATPase 2 and collapsin response mediator protein 1 promotes death of spinal cord neurons.
Cell death and differentiation.
2010 Sep; 17(9):1501-10. doi:
10.1038/cdd.2010.54. [PMID: 20489728] - Ping Wan, Yan-Ping Zhang, Jie Yan, Yu-Xia Xu, Hong-Quan Wang, Ru Yang, Cui-Qing Zhu. Glutamate enhances the surface distribution and release of Munc18 in cerebral cortical neurons.
Neuroscience bulletin.
2010 Aug; 26(4):273-81. doi:
10.1007/s12264-010-0411-8. [PMID: 20651809] - Thomas P Jensen, Lucy E Buckby, Ruth M Empson. Reduced expression of the 'fast' calcium transporter PMCA2a during homeostatic plasticity.
Molecular and cellular neurosciences.
2009 Jul; 41(3):364-72. doi:
10.1016/j.mcn.2009.04.011. [PMID: 19410650] - S M Goebel-Goody, K D Davies, R M Alvestad Linger, R K Freund, M D Browning. Phospho-regulation of synaptic and extrasynaptic N-methyl-d-aspartate receptors in adult hippocampal slices.
Neuroscience.
2009 Feb; 158(4):1446-59. doi:
10.1016/j.neuroscience.2008.11.006. [PMID: 19041929] - K Okamoto, D F Bereiter, R Thompson, A Tashiro, D A Bereiter. Estradiol replacement modifies c-fos expression at the spinomedullary junction evoked by temporomandibular joint stimulation in ovariectomized female rats.
Neuroscience.
2008 Oct; 156(3):729-36. doi:
10.1016/j.neuroscience.2008.08.003. [PMID: 18765271] - Yang-Hyun Chun, Dorie Frank, Jong-Seok Lee, Youping Zhang, Q-Schick Auh, Jin Y Ro. Peripheral AMPA receptors contribute to muscle nociception and c-fos activation.
Neuroscience research.
2008 Oct; 62(2):97-104. doi:
10.1016/j.neures.2008.06.007. [PMID: 18655811] - Rodrigo C A de Menezes, Dmitry V Zaretsky, Sumit Sarkar, Marco A P Fontes, Joseph A Dimicco. Microinjection of muscimol into the periaqueductal gray suppresses cardiovascular and neuroendocrine response to air jet stress in conscious rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2008 Sep; 295(3):R881-90. doi:
10.1152/ajpregu.00181.2008. [PMID: 18650321] - C Busnardo, R F Tavares, J Antunes-Rodrigues, F M A Corrêa. Cardiovascular effects of L-glutamate microinjection in the supraoptic nucleus of unanaesthetized rats.
Neuropharmacology.
2007 May; 52(6):1378-84. doi:
10.1016/j.neuropharm.2007.01.011. [PMID: 17367824] - Shyam D Rao, Sandra Anne Banack, Paul Alan Cox, John H Weiss. BMAA selectively injures motor neurons via AMPA/kainate receptor activation.
Experimental neurology.
2006 Sep; 201(1):244-52. doi:
10.1016/j.expneurol.2006.04.017. [PMID: 16764863] - Yukari Yoshida, Keisuke Tsuzuki, Shogo Ishiuchi, Seiji Ozawa. Serum-dependence of AMPA receptor-mediated proliferation in glioma cells.
Pathology international.
2006 May; 56(5):262-71. doi:
10.1111/j.1440-1827.2006.01954.x. [PMID: 16669875] - Wilhelm Stoffel, Rafael Körner, Dagmar Wachtmann, Bernhard U Keller. Functional analysis of glutamate transporters in excitatory synaptic transmission of GLAST1 and GLAST1/EAAC1 deficient mice.
Brain research. Molecular brain research.
2004 Sep; 128(2):170-81. doi:
10.1016/j.molbrainres.2004.06.026. [PMID: 15363892] - Hong-Jin Shu, Lawrence N Eisenman, Deepani Jinadasa, Douglas F Covey, Charles F Zorumski, Steven Mennerick. Slow actions of neuroactive steroids at GABAA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2004 Jul; 24(30):6667-75. doi:
10.1523/jneurosci.1399-04.2004. [PMID: 15282269] - Sampsa Sipilä, Kristiina Huttu, Juha Voipio, Kai Kaila. GABA uptake via GABA transporter-1 modulates GABAergic transmission in the immature hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2004 Jun; 24(26):5877-80. doi:
10.1523/jneurosci.1287-04.2004. [PMID: 15229234] - Ilona Kovács, Agnes Simon, Eva Szárics, Péter Barabás, László Héja, Lajos Nyikos, Julianna Kardos. Cyclothiazide binding to functionally active AMPA receptor reveals genuine allosteric interaction with agonist binding sites.
Neurochemistry international.
2004 Mar; 44(4):271-80. doi:
10.1016/s0197-0186(03)00137-2. [PMID: 14602090] - M Martínez-Sánchez, F Striggow, U H Schröder, S Kahlert, K G Reymann, G Reiser. Na(+) and Ca(2+) homeostasis pathways, cell death and protection after oxygen-glucose-deprivation in organotypic hippocampal slice cultures.
Neuroscience.
2004; 128(4):729-40. doi:
10.1016/j.neuroscience.2004.06.074. [PMID: 15464281] - Qing Hui Chen, Joseph R Haywood, Glenn M Toney. Sympathoexcitation by PVN-injected bicuculline requires activation of excitatory amino acid receptors.
Hypertension (Dallas, Tex. : 1979).
2003 Oct; 42(4):725-31. doi:
10.1161/01.hyp.0000085197.20043.44. [PMID: 12900439] - Attila D Kovács, Gvido Cebers, Aleta Cebere, Sture Liljequist. Loss of GABAergic neuronal phenotype in primary cerebellar cultures following blockade of glutamate reuptake.
Brain research.
2003 Jul; 977(2):209-20. doi:
10.1016/s0006-8993(03)02682-9. [PMID: 12834881] - Sandra A Filla, Mark A Winter, Kirk W Johnson, David Bleakman, Michael G Bell, Thomas J Bleisch, Ana M Castaño, Amy Clemens-Smith, Miriam del Prado, Donna K Dieckman, Esteban Dominguez, Ana Escribano, Ken H Ho, Kevin J Hudziak, Mary A Katofiasc, Jose A Martinez-Perez, Ana Mateo, Brian M Mathes, Edward L Mattiuz, Ann Marie L Ogden, Lee A Phebus, Douglas R Stack, Robert E Stratford, Paul L Ornstein. Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine.
Journal of medicinal chemistry.
2002 Sep; 45(20):4383-6. doi:
10.1021/jm025548q. [PMID: 12238915] - Xiaojun Mu, Robert D Azbill, Joe E Springer. NBQX treatment improves mitochondrial function and reduces oxidative events after spinal cord injury.
Journal of neurotrauma.
2002 Aug; 19(8):917-27. doi:
10.1089/089771502320317078. [PMID: 12225652] - Makoto Ohgoh, Takahisa Hanada, Terence Smith, Toshihide Hashimoto, Masataka Ueno, Yoshiharu Yamanishi, Masahiko Watanabe, Yukio Nishizawa. Altered expression of glutamate transporters in experimental autoimmune encephalomyelitis.
Journal of neuroimmunology.
2002 Apr; 125(1-2):170-8. doi:
10.1016/s0165-5728(02)00029-2. [PMID: 11960654] - E Engidawork, F Loidl, Y Chen, C Kohlhauser, S Stoeckler, E Dell'Anna, B Lubec, G Lubec, M Goiny, J Gross, K Andersson, M Herrera-Marschitz. Comparison between hypothermia and glutamate antagonism treatments on the immediate outcome of perinatal asphyxia.
Experimental brain research.
2001 Jun; 138(3):375-83. doi:
10.1007/s002210100710. [PMID: 11460776] - S Eliasof, H B McIlvain, R E Petroski, A C Foster, J Dunlop. Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems.
Journal of neurochemistry.
2001 Apr; 77(2):550-7. doi:
10.1046/j.1471-4159.2001.00253.x. [PMID: 11299317] - R F Regan, Y Guo. Magnesium deprivation decreases cellular reduced glutathione and causes oxidative neuronal death in murine cortical cultures.
Brain research.
2001 Jan; 890(1):177-83. doi:
10.1016/s0006-8993(00)03156-5. [PMID: 11164781] - L C González, L Pinilla, M Tena-Sempere, E Aguilar. Regulation of prolactin secretion by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in male rats.
The Journal of endocrinology.
2000 Sep; 166(3):669-75. doi:
10.1677/joe.0.1660669. [PMID: 10974660] - A Görgülü, T Kiriş, F Unal, U Turkoğlu, M Küçük, S Cobanoğlu. Superoxide dismutase activity and the effects of NBQX and CPP on lipid peroxidation in experimental spinal cord injury.
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie.
2000 Apr; 199(5):285-93. doi:
10.1007/s004330050126. [PMID: 10815757] - K Kohda, Y Wang, M Yuzaki. Mutation of a glutamate receptor motif reveals its role in gating and delta2 receptor channel properties.
Nature neuroscience.
2000 Apr; 3(4):315-22. doi:
10.1038/73877. [PMID: 10725919] - B W Kristensen, J Noraberg, B Jakobsen, J B Gramsbergen, B Ebert, J Zimmer. Excitotoxic effects of non-NMDA receptor agonists in organotypic corticostriatal slice cultures.
Brain research.
1999 Sep; 841(1-2):143-59. doi:
10.1016/s0006-8993(99)01833-8. [PMID: 10546997] - L C González, L Pinilla, M Tena-Sempere, E Aguilar. Role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in the control of prolactin, growth hormone and gonadotropin secretion in prepubertal rats.
The Journal of endocrinology.
1999 Sep; 162(3):417-24. doi:
10.1677/joe.0.1620417. [PMID: 10467233] - J Jolkkonen, K Puurunen, J Koistinaho, R Kauppinen, A Haapalinna, L Nieminen, J Sivenius. Neuroprotection by the alpha2-adrenoceptor agonist, dexmedetomidine, in rat focal cerebral ischemia.
European journal of pharmacology.
1999 May; 372(1):31-6. doi:
10.1016/s0014-2999(99)00186-7. [PMID: 10374712] - L C González, L Pinilla, M Tena-Sempere, E Aguilar. Regulation of growth hormone secretion by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in infantile, prepubertal, and adult male rats.
Endocrinology.
1999 Mar; 140(3):1279-84. doi:
10.1210/endo.140.3.6568. [PMID: 10067854] - G De Sarro, M Rizzo, V A Sinopoli, R Gitto, A De Sarro, M Zappala, A Chimirri. Relationship between anticonvulsant activity and plasma level of some 2,3-benzodiazepines in genetically epilepsy-prone rats.
Pharmacology, biochemistry, and behavior.
1998 Nov; 61(3):215-20. doi:
10.1016/s0091-3057(98)00036-7. [PMID: 9768555] - A P Kozikowski, D Steensma, G L Araldi, W Tückmantel, S Wang, S Pshenichkin, E Surina, J T Wroblewski. Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.
Journal of medicinal chemistry.
1998 May; 41(10):1641-50. doi:
10.1021/jm970719q. [PMID: 9572889] - M A Varney, S P Rao, C Jachec, C Deal, S D Hess, L P Daggett, F Lin, E C Johnson, G Veliçelebi. Pharmacological characterization of the human ionotropic glutamate receptor subtype GluR3 stably expressed in mammalian cells.
The Journal of pharmacology and experimental therapeutics.
1998 Apr; 285(1):358-70. doi:
. [PMID: 9536032] - W A Baumgartner, M Redmond, M Brock, E Tseng, M E Blue, J C Troncoso, M V Johnston. Pathophysiology of cerebral injury and future management.
Journal of cardiac surgery.
1997 Mar; 12(2 Suppl):300-10; discussion 310. doi:
NULL. [PMID: 9271760] - R Bleakman, D D Schoepp, B Ballyk, H Bufton, E F Sharpe, K Thomas, P L Ornstein, R K Kamboj. Pharmacological discrimination of GluR5 and GluR6 kainate receptor subtypes by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahyd roisdoquinoline-3 carboxylic-acid.
Molecular pharmacology.
1996 Apr; 49(4):581-5. doi:
. [PMID: 8609884] - P Nilsson, H Laursen, L Hillered, A J Hansen. Calcium movements in traumatic brain injury: the role of glutamate receptor-operated ion channels.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
1996 Mar; 16(2):262-70. doi:
10.1097/00004647-199603000-00011. [PMID: 8594058] - J C Pelletier, D P Hesson, K A Jones, A M Costa. Substituted 1,2-dihydrophthalazines: potent, selective, and noncompetitive inhibitors of the AMPA receptor.
Journal of medicinal chemistry.
1996 Jan; 39(2):343-6. doi:
10.1021/jm950740w. [PMID: 8558499] - J Y Koh, B J Gwag, D Lobner, D W Choi. Potentiated necrosis of cultured cortical neurons by neurotrophins.
Science (New York, N.Y.).
1995 Apr; 268(5210):573-5. doi:
10.1126/science.7725105. [PMID: 7725105] - C K Tygesen, M Jørgensen, P H Andersen. The importance of two specific domains in ligand binding to the AMPA/kainate glutamate receptors GluR2 and GluR6.
FEBS letters.
1995 Apr; 363(1-2):184-8. doi:
10.1016/0014-5793(95)00315-z. [PMID: 7537225] - C Thomsen, A Bau, P Faarup, C Foged, A Kanstrup, P D Suzdak. Effects of bromohomoibotenate on metabotropic glutamate receptors.
Neuroreport.
1994 Dec; 5(18):2417-20. doi:
10.1097/00001756-199412000-00003. [PMID: 7696571] - G De Sarro, S Renne, F Nava, A De Sarro. Fenbufen pretreatment potentiates the anticonvulsant activity of CPPene and NBQX in DBA/2 mice.
The Journal of pharmacy and pharmacology.
1994 Dec; 46(12):1017-22. doi:
10.1111/j.2042-7158.1994.tb03259.x. [PMID: 7714713] - E J Wagner, K E Moore, K J Lookingland. Non-NMDA receptor-mediated regulation of hypothalamic dopaminergic neurons in the rat.
European journal of pharmacology.
1994 Mar; 254(1-2):105-12. doi:
10.1016/0014-2999(94)90376-x. [PMID: 7515817] - D Xue, Z G Huang, K Barnes, H J Lesiuk, K E Smith, A M Buchan. Delayed treatment with AMPA, but not NMDA, antagonists reduces neocortical infarction.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
1994 Mar; 14(2):251-61. doi:
10.1038/jcbfm.1994.32. [PMID: 7509339] - L Dalgaard, R K Hjortkjaer, B Regnier, L Nordholm. Pharmacokinetics of the neuroprotective glutamate antagonist NBQX (6-nitro-7-sulfamoyl-benzo(f)quinoxaline-2,3-dione) in mice, rats, and dogs. Interactions with probenecid.
Drug metabolism and disposition: the biological fate of chemicals.
1994 Mar; 22(2):289-93. doi:
. [PMID: 7912178] - B B Johansson, I Westergren. Pharmacological reduction of brain edema induced by intracarotid infusion of protamine sulphate: a comparison between a free radical scavenger and an AMPA receptor antagonist.
Acta neurochirurgica. Supplementum.
1994; 60(?):128-31. doi:
10.1007/978-3-7091-9334-1_34. [PMID: 7976524] - T Zarnowski, Z Kleinrok, W A Turski, S J Czuczwar. 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline enhances the protective activity of common antiepileptic drugs against maximal electroshock-induced seizures in mice.
Neuropharmacology.
1993 Sep; 32(9):895-900. doi:
10.1016/0028-3908(93)90145-s. [PMID: 7694171] - V Dall, U Orntoft, A Schmidt, L Nordholm. Interaction of the competitive AMPA receptor antagonist NBQX with hexobarbital.
Pharmacology, biochemistry, and behavior.
1993 Sep; 46(1):73-6. doi:
10.1016/0091-3057(93)90319-o. [PMID: 8255925] - C Thomsen, E R Mulvihill, B Haldeman, D S Pickering, D R Hampson, P D Suzdak. A pharmacological characterization of the mGluR1 alpha subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line.
Brain research.
1993 Aug; 619(1-2):22-8. doi:
10.1016/0006-8993(93)91592-g. [PMID: 7690672] - K S Pai, S K Shankar, V Ravindranath. Billion-fold difference in the toxic potencies of two excitatory plant amino acids, L-BOAA and L-BMAA: biochemical and morphological studies using mouse brain slices.
Neuroscience research.
1993 Aug; 17(3):241-8. doi:
10.1016/0168-0102(93)90051-q. [PMID: 7901822] - S H Ingwersen. Combined reversed phase and anion exchange solid phase extraction for the assay of the neuroprotectant NBQX in human plasma and urine.
Biomedical chromatography : BMC.
1993 May; 7(3):166-71. doi:
10.1002/bmc.1130070314. [PMID: 8318836] - C McFarlane, D S Warner, M M Todd, L Nordholm. AMPA receptor competitive antagonism reduces halothane MAC in rats.
Anesthesiology.
1992 Dec; 77(6):1165-70. doi:
10.1097/00000542-199212000-00018. [PMID: 1334638] - R Gill, L Nordholm, D Lodge. The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) in a rat focal ischaemia model.
Brain research.
1992 May; 580(1-2):35-43. doi:
10.1016/0006-8993(92)90924-x. [PMID: 1504814] - W E Hoffman, D Pelligrino, C Werner, E Kochs, R F Albrecht, J Schulte am Esch. Ketamine decreases plasma catecholamines and improves outcome from incomplete cerebral ischemia in rats.
Anesthesiology.
1992 May; 76(5):755-62. doi:
10.1097/00000542-199205000-00014. [PMID: 1575344] - I Westergren, B B Johansson. NBQX, an AMPA antagonist, reduces glutamate-mediated brain edema.
Brain research.
1992 Feb; 573(2):324-6. doi:
10.1016/0006-8993(92)90781-4. [PMID: 1354550] - L Nordholm. Determination of the neuroprotective agent 6-nitro-7-sulphamoylbenzo[f]quinoxaline-2,3-dione in plasma using high-performance liquid chromatography.
Journal of chromatography.
1991 Aug; 568(2):481-6. doi:
10.1016/0378-4347(91)80187-h. [PMID: 1783654]