Maclurin (BioDeep_00000000914)

   

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


(3,4-Dihydroxyphenyl)(2,4,6-trihydroxyphenyl)methanone, 9CI

化学式: C13H10O6 (262.047736)
中文名称: 2,3,4,4,6-五羟基二苯甲酮, 2,3,4,4,6-五羥二苯基酮, 2,3',4,4',6-五羟基二苯甲酮
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 20.37%

分子结构信息

SMILES: C1=CC(=C(C=C1C(=O)C2=C(C=C(C=C2O)O)O)O)O
InChI: InChI=1S/C13H10O6/c14-7-4-10(17)12(11(18)5-7)13(19)6-1-2-8(15)9(16)3-6/h1-5,14-18H

描述信息

Maclurin is a member of benzophenones.
Maclurin is a natural product found in Garcinia multiflora, Garcinia assugu, and other organisms with data available.
Maclurin is found in fruits. Extract from heartwood of Garcinia mangostana (mangosteen). Also from Morus alba (white mulberry
D007155 - Immunologic Factors > D000373 - Agglutinins > D037121 - Plant Lectins
D007155 - Immunologic Factors > D000373 - Agglutinins > D037102 - Lectins
Macurin is a xanthone that can be isolated from Garcinia lancilimba[1].
Macurin is a xanthone that can be isolated from Garcinia lancilimba[1].

同义名列表

31 个代谢物同义名

(3,4-Dihydroxyphenyl)(2,4,6-trihydroxyphenyl)methanone, 9CI; Methanone, (3,4-dihydroxyphenyl)(2,4,6-trihydroxyphenyl)-; (3,4-dihydroxyphenyl)(2,4,6-trihydroxyphenyl)-Methanone; (3,4-dihydroxyphenyl)-(2,4,6-trihydroxyphenyl)methanone; (3,4-Dihydroxyphenyl)(2,4,6-trihydroxyphenyl)methanone; Methanone,4-dihydroxyphenyl)(2,4,6-trihydroxyphenyl)-; 2-[(3,4-dihydroxyphenyl)carbonyl]benzene-1,3,5-triol; Benzophenone, 2,3,4,4,6-pentahydroxy- (8CI); 2-(3,4-dihydroxybenzoyl)benzene-1,3,5-triol; Benzophenone, 2,3,4,4,6-pentahydroxy-; 2,3,4,4, 6-Pentahydroxybenzophenone; 2,3,4,4,6-Pentahydroxy-Benzophenone; 2,3,4,4,6-Pentahydroxybenzophenone; Benzophenone,3,4,4,6-pentahydroxy-; (3,4,6-trihydroxyphenyl)methanone; 2,4,4,6-Pentahydroxybenzophenone; maclura pomifera lectin; Moringerbic acid; Morintannic acid; UNII-27KFF3PMTU; Moritannic acid; Fustic extract; Patent Fustin; MACLURIN [MI]; Kino-yellow; 27KFF3PMTU; Laguncurin; Maklurin; Maclurin; Macurin; BP_29



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dong Joon Lee, Sang Yeol Lee, Young-Su Yi. Maclurin inhibits caspase-11 non-canonical inflammasome in macrophages and ameliorates acute lethal sepsis in mice. International immunopharmacology. 2024 Mar; 129(?):111615. doi: 10.1016/j.intimp.2024.111615. [PMID: 38330799]
  • Jiechen Kong, Xianxi Zhou, Jianghua Lu, Qianting Han, Xiyan Ouyang, Dongfeng Chen, Aijun Liu. Maclurin Promotes the Chondrogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by Regulating miR-203a-3p/Smad1. Cellular reprogramming. 2022 02; 24(1):9-20. doi: 10.1089/cell.2021.0122. [PMID: 35180001]
  • Yu Jin Lee, Sang Yeol Lee. Maclurin exerts anti-cancer effects in human osteosarcoma cells via prooxidative activity and modulations of PARP, p38, and ERK signaling. IUBMB life. 2021 08; 73(8):1060-1072. doi: 10.1002/iub.2506. [PMID: 34003554]
  • Young Sun Hwang, Sae Woong Oh, See-Hyoung Park, Jienny Lee, Ju Ah Yoo, Kitae Kwon, Se Jung Park, Jangsoon Kim, Eunbi Yu, Jae Youl Cho, Jongsung Lee. Melanogenic Effects of Maclurin Are Mediated through the Activation of cAMP/PKA/CREB and p38 MAPK/CREB Signaling Pathways. Oxidative medicine and cellular longevity. 2019; 2019(?):9827519. doi: 10.1155/2019/9827519. [PMID: 31949887]
  • Yu Jin Lee, Okkeun Jung, Jongsung Lee, Juhyeon Son, Jae Youl Cho, Chongsuk Ryou, Sang Yeol Lee. Maclurin exerts anti-cancer effects on PC3 human prostate cancer cells via activation of p38 and inhibitions of JNK, FAK, AKT, and c-Myc signaling pathways. Nutrition research (New York, N.Y.). 2018 10; 58(?):62-71. doi: 10.1016/j.nutres.2018.07.003. [PMID: 30340816]
  • Min Jung Ku, Ji Hyun Kim, Jongsung Lee, Jae Youl Cho, Taehoon Chun, Sang Yeol Lee. Maclurin suppresses migration and invasion of human non-small-cell lung cancer cells via anti-oxidative activity and inhibition of the Src/FAK-ERK-β-catenin pathway. Molecular and cellular biochemistry. 2015 Apr; 402(1-2):243-52. doi: 10.1007/s11010-015-2331-4. [PMID: 25630491]
  • Theresa Beelders, D Jacobus Brand, Dalene de Beer, Christiaan J Malherbe, Sithandiwe E Mazibuko, Christo J F Muller, Elizabeth Joubert. Benzophenone C- and O-glucosides from Cyclopia genistoides (Honeybush) inhibit mammalian α-glucosidase. Journal of natural products. 2014 Dec; 77(12):2694-9. doi: 10.1021/np5007247. [PMID: 25419864]
  • Xican Li, Yaoxiang Gao, Fei Li, Aifeng Liang, Zhiming Xu, Ye Bai, Wenqiong Mai, Lu Han, Dongfeng Chen. Maclurin protects against hydroxyl radical-induced damages to mesenchymal stem cells: antioxidant evaluation and mechanistic insight. Chemico-biological interactions. 2014 Aug; 219(?):221-8. doi: 10.1016/j.cbi.2014.06.014. [PMID: 24973644]
  • Adam Kokotkiewicz, Maria Luczkiewicz, Justyna Pawlowska, Piotr Luczkiewicz, Pawel Sowinski, Jacek Witkowski, Ewa Bryl, Adam Bucinski. Isolation of xanthone and benzophenone derivatives from Cyclopia genistoides (L.) Vent. (honeybush) and their pro-apoptotic activity on synoviocytes from patients with rheumatoid arthritis. Fitoterapia. 2013 Oct; 90(?):199-208. doi: 10.1016/j.fitote.2013.07.020. [PMID: 23916580]
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