herbimycin a (BioDeep_00000897217)
代谢物信息卡片
herbimycin a
化学式: C30H42N2O9 (574.289)
中文名称: 除莠霉素A
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C=C(C1OC)C2=O)C)OC)OC(=O)N)C)C)OC)OC
InChI: InChI=1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D012294 - Rifamycins
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors
同义名列表
2 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:5674
- PubChem: 5311102
- ChEMBL: CHEMBL480499
- CAS: 70563-58-5
- KEGG: C11225
- PubChem: 13404
- KNApSAcK: 5674
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 3708 - Brassica napus: 10.3389/FNUT.2022.822033
- 1912 - Streptomyces hygroscopicus:
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Immunological investigations.
1999 Mar; 28(2-3):149-63. doi:
10.3109/08820139909061144. [PMID: 10484680] - T Zakar, J E Mijovic, D Bhardwaj, D M Olson. Tyrosine kinase inhibitors block the glucocorticoid stimulation of prostaglandin endoperoxide H synthase expression in amnion cells.
Canadian journal of physiology and pharmacology.
1999 Feb; 77(2):138-42. doi:
10.1139/y98-148. [PMID: 10535705] - Z M Dong, L Jackson, J W Murphy. Mechanisms for induction of L-selectin loss from T lymphocytes by a cryptococcal polysaccharide, glucuronoxylomannan.
Infection and immunity.
1999 Jan; 67(1):220-9. doi:
10.1128/iai.67.1.220-229.1999. [PMID: 9864219] - W D Niles, A B Malik. Endocytosis and exocytosis events regulate vesicle traffic in endothelial cells.
The Journal of membrane biology.
1999 Jan; 167(1):85-101. doi:
10.1007/s002329900474. [PMID: 9878078] - Y G Ko, P Liu, R K Pathak, L C Craig, R G Anderson. Early effects of pp60(v-src) kinase activation on caveolae.
Journal of cellular biochemistry.
1998 Dec; 71(4):524-35. doi:
10.1002/(sici)1097-4644(19981215)71:4<524::aid-jcb7>3.0.co;2-b. [PMID: 9827698] - R C Muise-Helmericks, H L Grimes, A Bellacosa, S E Malstrom, P N Tsichlis, N Rosen. Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway.
The Journal of biological chemistry.
1998 Nov; 273(45):29864-72. doi:
10.1074/jbc.273.45.29864. [PMID: 9792703] - Y Murakami, H Fukazawa, S Mizuno, Y Uehara. Effect of herbimycin A on tyrosine kinase receptors and platelet derived growth factor (PDGF)-induced signal transduction.
Biological & pharmaceutical bulletin.
1998 Oct; 21(10):1030-5. doi:
10.1248/bpb.21.1030. [PMID: 9821805] - P T Bozza, W Yu, J Cassara, P F Weller. Pathways for eosinophil lipid body induction: differing signal transduction in cells from normal and hypereosinophilic subjects.
Journal of leukocyte biology.
1998 Oct; 64(4):563-9. doi:
10.1002/jlb.64.4.563. [PMID: 9766638] - M Fujihara, K Ikebuchi, T L Maekawa, S Wakamoto, C Ogiso, T Ito, T A Takahashi, T Suzuki, S Sekiguchi. Lipopolysaccharide-induced desensitization of junB gene expression in a mouse macrophage-like cell line, P388D1.
Journal of immunology (Baltimore, Md. : 1950).
1998 Oct; 161(7):3659-65. doi:
". [PMID: 9759890] - T Hiwasa, Y Nakamura, S Sakiyama. Isolation of a variant which has reduced Src activity from SH-SY5Y neuroblastoma cells.
Anticancer research.
1998 Sep; 18(5A):3311-4. doi:
NULL. [PMID: 9858901] - K Hawks, P J Higgins. Cell shape-dependent pathway of plasminogen activator inhibitor type-1 gene expression requires cytoskeletal reorganization.
Journal of cellular physiology.
1998 Aug; 176(2):293-302. doi:
10.1002/(sici)1097-4652(199808)176:2<293::aid-jcp7>3.0.co;2-j. [PMID: 9648916] - H Tsuganezawa, P A Preisig, R J Alpern. Dominant negative c-Src inhibits angiotensin II induced activation of NHE3 in OKP cells.
Kidney international.
1998 Aug; 54(2):394-8. doi:
10.1046/j.1523-1755.1998.00029.x. [PMID: 9690205] - G Imokawa, Y Yada, N Morisaki, M Kimura. Biological characterization of human fibroblast-derived mitogenic factors for human melanocytes.
The Biochemical journal.
1998 Mar; 330 ( Pt 3)(?):1235-9. doi:
10.1042/bj3301235. [PMID: 9494091] - S Naito, S Shimizu, S Maeda, J Wang, R Paul, J A Fagin. Ets-1 is an early response gene activated by ET-1 and PDGF-BB in vascular smooth muscle cells.
The American journal of physiology.
1998 02; 274(2):C472-80. doi:
10.1152/ajpcell.1998.274.2.c472. [PMID: 9486138] - T van der Bruggen, D Kanters, A T Tool, J A Raaijmakers, J W Lammers, A J Verhoeven, L Koenderman. Cytokine-induced protein tyrosine phosphorylation is essential for cytokine priming of human eosinophils.
The Journal of allergy and clinical immunology.
1998 Jan; 101(1 Pt 1):103-9. doi:
10.1016/s0091-6749(98)70200-3. [PMID: 9449508] - N W Ohan, Y Tam, P Fernando, J J Heikkila. Characterization of a novel group of basic small heat shock proteins in Xenopus laevis A6 kidney epithelial cells.
Biochemistry and cell biology = Biochimie et biologie cellulaire.
1998; 76(4):665-71. doi:
10.1139/bcb-76-4-665. [PMID: 10099789] - M Sato, N Kojima, M Miura, K Imai, H Senoo. Induction of cellular processes containing collagenase and retinoid by integrin-binding to interstitial collagen in hepatic stellate cell culture.
Cell biology international.
1998; 22(2):115-25. doi:
10.1006/cbir.1998.0234. [PMID: 9878098] - F Khechai, V Ollivier, F Bridey, M Amar, J Hakim, D de Prost. Effect of advanced glycation end product-modified albumin on tissue factor expression by monocytes. Role of oxidant stress and protein tyrosine kinase activation.
Arteriosclerosis, thrombosis, and vascular biology.
1997 Nov; 17(11):2885-90. doi:
10.1161/01.atv.17.11.2885. [PMID: 9409271] - P W Tsao, M S Forsythe, S A Mousa. Dissociation between the anti-aggregatory & anti-secretory effects of platelet integrin alpha IIb beta 3 (GPIIb/IIIa) antagonists, c7E3 and DMP728.
Thrombosis research.
1997 Oct; 88(2):137-46. doi:
10.1016/s0049-3848(97)00225-9. [PMID: 9361367] - V Lafont, T Fischer, R Zumbihl, S Faure, C Hivroz, B Rouot, J Favero. Evidence for a CD4-associated calcium influx independent of the phosphoinositide transduction pathway in human T cells.
European journal of immunology.
1997 Sep; 27(9):2261-8. doi:
10.1002/eji.1830270921. [PMID: 9341768] - W M Billis, B A White. Effects of the protein tyrosine kinase inhibitor, herbimycin A, on prolactin gene expression in GH3 and 235-1 pituitary tumor cells.
Biochimica et biophysica acta.
1997 Aug; 1358(1):31-8. doi:
10.1016/s0167-4889(97)00053-0. [PMID: 9296518] - E A Fisher, M Zhou, D M Mitchell, X Wu, S Omura, H Wang, A L Goldberg, H N Ginsberg. The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70.
The Journal of biological chemistry.
1997 Aug; 272(33):20427-34. doi:
10.1074/jbc.272.33.20427. [PMID: 9252351] - P Buckhaults, L Chen, N Fregien, M Pierce. Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogene.
The Journal of biological chemistry.
1997 Aug; 272(31):19575-81. doi:
10.1074/jbc.272.31.19575. [PMID: 9235963] - W N Campbell, M Fitzpatrick, X Ding, M Jett, P Gemski, S E Goldblum. SEB is cytotoxic and alters EC barrier function through protein tyrosine phosphorylation in vitro.
The American journal of physiology.
1997 Jul; 273(1 Pt 1):L31-9. doi:
10.1152/ajplung.1997.273.1.l31. [PMID: 9252537] - D D Bannerman, S E Goldblum. Endotoxin induces endothelial barrier dysfunction through protein tyrosine phosphorylation.
The American journal of physiology.
1997 Jul; 273(1 Pt 1):L217-26. doi:
10.1152/ajplung.1997.273.1.l217. [PMID: 9252559] - H Hagar, N Ueda, S V Shah. Tyrosine phosphorylation in DNA damage and cell death in hypoxic injury to LLC-PK1 cells.
Kidney international.
1997 Jun; 51(6):1747-53. doi:
10.1038/ki.1997.240. [PMID: 9186862] - L Padmore, S An, R H Gunby, K Kelly, G K Radda, K A Knox. CD40-triggered protein tyrosine phosphorylation on Vav and on phosphatidylinositol 3-kinase correlates with survival of the Ramos-Burkitt lymphoma B cell line.
Cellular immunology.
1997 May; 177(2):119-28. doi:
10.1006/cimm.1997.1102. [PMID: 9178638] - T Ogawa, A Ozaki, H Shimauchi, H Uchida. Hyporesponsiveness of inflamed human gingival fibroblasts from patients with chronic periodontal diseases against cell surface components of Porphyromonas gingivalis.
FEMS immunology and medical microbiology.
1997 May; 18(1):17-30. doi:
10.1111/j.1574-695x.1997.tb01023.x. [PMID: 9215583] - P D Prasad, V Torres-Zamorano, R Kekuda, F H Leibach, V Ganapathy. Functional link between tyrosine phosphorylation and human serotonin transporter gene expression.
European journal of pharmacology.
1997 Apr; 325(1):85-92. doi:
10.1016/s0014-2999(97)00100-3. [PMID: 9151943] - S Araki, M Haneda, M Togawa, R Kikkawa. Endothelin-1 activates c-Jun NH2-terminal kinase in mesangial cells.
Kidney international.
1997 Mar; 51(3):631-9. doi:
10.1038/ki.1997.92. [PMID: 9067893] - Y Uehara. [Protein kinase inhibitors--screening of new molecular target therapeutics].
Gan to kagaku ryoho. Cancer & chemotherapy.
1997 Jan; 24(2):136-44. doi:
NULL. [PMID: 9030224] - D Briant, N Ohan, J J Heikkila. Effect of herbimycin A on hsp30 and hsp70 heat shock protein gene expression in Xenopus cultured cells.
Biochemistry and cell biology = Biochimie et biologie cellulaire.
1997; 75(6):777-82. doi:
NULL. [PMID: 9599667]
