Xanomeline tartrate (BioDeep_00000008856)

 

Secondary id: BioDeep_00000015356

human metabolite blood metabolite


代谢物信息卡片


5-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1-methyl-1,2,3,6-tetrahydropyridine

化学式: C14H23N3OS (281.1561748)
中文名称: 占诺美林
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCOC1=NSN=C1C1=CCCN(C)C1
InChI: InChI=1S/C14H23N3OS/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3

描述信息

Same as: D06330
Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia[1][2].

同义名列表

7 个代谢物同义名

5-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1-methyl-1,2,3,6-tetrahydropyridine; 3-(3-O-Hexyl-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine; (3-O-Hexyloxy)-TZTP; Xanomeline tartrate; XANOMELINE; LY 246708; LY-246708



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dongxue Wang, Yunjin Yao, Shiqi Wang, Yifei Hou, Lanxue Zhao, Hao Wang, Hongzhuan Chen, Jianrong Xu. Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between Gαq and β-Arrestin through BRET Assays and Molecular Docking. International journal of molecular sciences. 2023 Apr; 24(8):. doi: 10.3390/ijms24087356. [PMID: 37108518]
  • Joshua D Vardigan, Christopher E Cannon, Vanita Puri, Mandy Dancho, AmyJo Koser, Marion Wittmann, Scott D Kuduk, John J Renger, Jason M Uslaner. Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey. Psychopharmacology. 2015 Jun; 232(11):1859-66. doi: 10.1007/s00213-014-3813-x. [PMID: 25491927]
  • Mauricio Rosas-Ballina, Sergio I Valdés-Ferrer, Meghan E Dancho, Mahendar Ochani, David Katz, Kai Fan Cheng, Peder S Olofsson, Sangeeta S Chavan, Yousef Al-Abed, Kevin J Tracey, Valentin A Pavlov. Xanomeline suppresses excessive pro-inflammatory cytokine responses through neural signal-mediated pathways and improves survival in lethal inflammation. Brain, behavior, and immunity. 2015 Feb; 44(?):19-27. doi: 10.1016/j.bbi.2014.07.010. [PMID: 25063706]
  • Laurence Desrues, Thomas Lefebvre, Céline Lecointre, Marie-Thérèse Schouft, Jérôme Leprince, Vincent Compère, Fabrice Morin, François Proust, Pierrick Gandolfo, Marie-Christine Tonon, Hélène Castel. Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity. PloS one. 2012; 7(5):e36319. doi: 10.1371/journal.pone.0036319. [PMID: 22563490]
  • Scott D Kuduk, Ronald K Chang, Christina N Di Marco, Daniel R Pitts, Thomas J Greshock, Lei Ma, Marion Wittmann, Matthew A Seager, Kenneth A Koeplinger, Charles D Thompson, George D Hartman, Mark T Bilodeau, William J Ray. Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold. Journal of medicinal chemistry. 2011 Jul; 54(13):4773-80. doi: 10.1021/jm200400m. [PMID: 21682298]
  • Jan Jakubík, Stanislav Tucek, Esam E El-Fakahany. Role of receptor protein and membrane lipids in xanomeline wash-resistant binding to muscarinic M1 receptors. The Journal of pharmacology and experimental therapeutics. 2004 Jan; 308(1):105-10. doi: 10.1124/jpet.103.058594. [PMID: 14569060]
  • B J Ring, S A Wrighton, S L Aldridge, K Hansen, B Haehner, L A Shipley. Flavin-containing monooxygenase-mediated N-oxidation of the M(1)-muscarinic agonist xanomeline. Drug metabolism and disposition: the biological fate of chemicals. 1999 Oct; 27(10):1099-103. doi: . [PMID: 10497134]
  • A Medina, N Bodick, A L Goldberger, M Mac Mahon, L A Lipsitz. Effects of central muscarinic-1 receptor stimulation on blood pressure regulation. Hypertension (Dallas, Tex. : 1979). 1997 Mar; 29(3):828-34. doi: 10.1161/01.hyp.29.3.828. [PMID: 9052903]
  • S C Kasper, P L Bonate, A F DeLong. High-performance liquid chromatographic assay for xanomeline, a specific M-1 agonist, and its metabolite in human plasma. Journal of chromatography. B, Biomedical applications. 1995 Jul; 669(2):397-403. doi: 10.1016/0378-4347(95)00124-2. [PMID: 7581918]
  • A T Murphy, S C Kasper, T A Gillespie, A F Delong. Determination of xanomeline and active metabolite, N-desmethylxanomeline, in human plasma by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. Journal of chromatography. B, Biomedical applications. 1995 Jun; 668(2):273-80. doi: 10.1016/0378-4347(95)00080-3. [PMID: 7581862]
  • T J Brown, L A Shipley. Determination of xanomeline (LY246708 tartrate), an investigational agent for the treatment of Alzheimer's disease, in rat and monkey plasma by capillary gas chromatography with nitrogen-phosphorus detection. Journal of chromatography. B, Biomedical applications. 1995 Mar; 665(2):337-44. doi: 10.1016/0378-4347(94)00538-g. [PMID: 7795813]
  • J J Sramek, N R Cutler, D J Hurley, R D Seifert. The utility of salivary amylase as an evaluation of M3 muscarinic agonist activity in Alzheimer's disease. Progress in neuro-psychopharmacology & biological psychiatry. 1995 Jan; 19(1):85-91. doi: 10.1016/0278-5846(94)00107-s. [PMID: 7535938]
  • A T Murphy, P L Bonate, S C Kasper, T A Gillespie, A F DeLong. Determination of xanomeline in human plasma by ion-spray tandem mass spectrometry. Biological mass spectrometry. 1994 Oct; 23(10):621-5. doi: 10.1002/bms.1200231004. [PMID: 7986832]
  • C L Hamilton, J A Kirkwood, G Carter, R S Williams. Sensitive liquid chromatographic method for the determination of a specific M1 agonist, LY246708, an investigational agent with potential for the treatment of Alzheimer's disease, in human plasma. Journal of chromatography. 1993 Apr; 613(2):365-70. doi: 10.1016/0378-4347(93)80156-x. [PMID: 8491827]