LS-473 (BioDeep_00000870690)
Main id: BioDeep_00000002872
代谢物信息卡片
4-12-00-00008 (Beilstein Handbook Reference)
化学式: C6H13N (99.1048)
中文名称: 环己胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CCC(CC1)N
InChI: InChI=1S/C6H13N/c7-6-4-2-1-3-5-6/h6H,1-5,7H2
描述信息
同义名列表
37 个代谢物同义名
4-12-00-00008 (Beilstein Handbook Reference); InChI=1\C6H13N\c7-6-4-2-1-3-5-6\h6H,1-5,7H; Cyclohexylamine [UN2357] [Corrosive]; Benzenamine, hexahydro-; Aminohexahydrobenzene; Hexahydrobenzenamine; Aniline, hexahydro-; 1-amino-CYCLOHEXANE; 1-Aminocyclohexane; 1-Cyclohexylamine; Cyclohexyl amine; Hexahydroaniline; Aminocyclohexane; EINECS 203-629-0; C104655_ALDRICH; CYCLOHEXYLAMINE; CyclohexanaMine; 240648_ALDRICH; NCI60_004907; BRN 0471175; AIDS-008396; 143247-75-0; CHEBI:15773; 157973-60-9; AIDS008396; CCRIS 3645; ST5213819; AI3-15323; 108-91-8; HSDB 918; UN2357; LS-473; C00571; c0690; HAI; Cyclohexylamine; Cyclohexylamine
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:15773
- KEGG: C00571
- PubChem: 7965
- ChEMBL: CHEMBL1794762
- MeSH: Cyclohexylamines
- CAS: 157973-60-9
- CAS: 108-91-8
- PubChem: 3850
- KNApSAcK: C00044142
- PDB-CCD: HAI
- 3DMET: B00135
- NIKKAJI: J2.870C
- KNApSAcK: 15773
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 2839963 - Zanthoxylum asiaticum: 10.1016/S0031-9422(97)00678-X
- 33090 - 紫苏子: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jinfu Zhou, Jianping Tang, Chenran Zhang, Guilin Li, Xinpei Lin, Sining Liao, Jinying Luo, Guangxia Yu, Fuli Zheng, Zhenkun Guo, Wenya Shao, Hong Hu, Liangpu Xu, Siying Wu, Huangyuan Li. ALKBH5 targets ACSL4 mRNA stability to modulate ferroptosis in hyperbilirubinemia-induced brain damage.
Free radical biology & medicine.
2024 Aug; 220(?):271-287. doi:
10.1016/j.freeradbiomed.2024.05.014. [PMID: 38734267] - Yi He, Xingbo Wang, Siqi Chen, Hanshen Luo, Bo Huo, Xian Guo, Rui Li, Yue Chen, Xin Yi, Xiang Wei, Ding-Sheng Jiang. SP2509 functions as a novel ferroptosis inhibitor by reducing intracellular iron level in vascular smooth muscle cells.
Free radical biology & medicine.
2024 Jul; 219(?):49-63. doi:
10.1016/j.freeradbiomed.2024.04.220. [PMID: 38608823] - Qianjie Yang, Yutong Xia, Kuangqi Chen, Yinhao Wang, Dongjie Song, Jiru Zhu, Jianping Tong, Ye Shen. Blue light induced ferroptosis via STAT3/GPX4/SLC7A11/FTH1 in conjunctiva epithelium in vivo and in vitro.
Journal of photochemistry and photobiology. B, Biology.
2024 Jun; 255(?):112908. doi:
10.1016/j.jphotobiol.2024.112908. [PMID: 38663336] - Jinshuai Lan, Li Liu, Wenjun Zhao, Zhe Li, Ruifeng Zeng, Shiyuan Fang, Lixia Chen, Yi Shen, Hai Wei, Tong Zhang, Yue Ding. Unlocking the anticancer activity of gambogic acid: a shift towards ferroptosis via a GSH/Trx dual antioxidant system.
Free radical biology & medicine.
2024 Jun; 218(?):26-40. doi:
10.1016/j.freeradbiomed.2024.03.023. [PMID: 38570172] - Bicheng Li, Minqiao Lu, Hui Wang, Siqi Sheng, Shuyuan Guo, Jia Li, Ye Tian. Macrophage Ferroptosis Promotes MMP2/9 Overexpression Induced by Hemin in Hemorrhagic Plaque.
Thrombosis and haemostasis.
2024 Jun; 124(6):568-580. doi:
10.1055/a-2173-3602. [PMID: 37696298] - Yuanyuan Chen, Zhaohua Liu, Hongmei Chen, Yi Wen, Lang Fan, Man Luo. Rhythm gene PER1 mediates ferroptosis and lipid metabolism through SREBF2/ALOX15 axis in polycystic ovary syndrome.
Biochimica et biophysica acta. Molecular basis of disease.
2024 Jun; 1870(5):167182. doi:
10.1016/j.bbadis.2024.167182. [PMID: 38653359] - Junrong Wang, Zhifang Wang, Lei Li, Man Wang, Jiaying Chang, Minghong Gao, Dongmei Wang, Chunxia Li. Ultra-small Janus nanoparticle-induced activation of ferroptosis for synergistic tumor immunotherapy.
Acta biomaterialia.
2024 Jun; 181(?):362-374. doi:
10.1016/j.actbio.2024.04.032. [PMID: 38663684] - Aomi Muramatsu, Shinsuke Nakamura, Tasuku Hirayama, Hideko Nagasawa, Akihiro Ohira, Takashi Kitaoka, Hideaki Hara, Masamitsu Shimazawa. Both hemoglobin and hemin cause damage to retinal pigment epithelium through the iron ion accumulation.
Journal of pharmacological sciences.
2024 Jun; 155(2):44-51. doi:
10.1016/j.jphs.2024.04.001. [PMID: 38677785] - Yanwei Wang, Jingru Qiu, Hua Yan, Nan Zhang, Shixuan Gao, Ning Xu, Cuiyan Wang, Haiyan Lou. The Bach1/HO-1 pathway regulates oxidative stress and contributes to ferroptosis in doxorubicin-induced cardiomyopathy in H9c2 cells and mice.
Archives of toxicology.
2024 Jun; 98(6):1781-1794. doi:
10.1007/s00204-024-03697-3. [PMID: 38573338] - Jia-Jia Liu, Xue Zhang, Bang-Lan Cai, Man-Man Qi, Yong-Bin Chi, Bin Peng, Deng-Hai Zhang. Ferroptosis inhibitors reduce celastrol toxicity and preserve its insulin sensitizing effects in insulin resistant HepG2 cells.
Journal of integrative medicine.
2024 May; 22(3):286-294. doi:
10.1016/j.joim.2024.03.007. [PMID: 38565435] - Xuelian Xiang, Mengtao Xu, Li Liu, Nuo Meng, Yu Lei, Yong Feng, Guodu Tang. Liproxstatin-1 attenuates acute hypertriglyceridemic pancreatitis through inhibiting ferroptosis in rats.
Scientific reports.
2024 04; 14(1):9548. doi:
10.1038/s41598-024-60159-7. [PMID: 38664508] - Lihe Lu, Yuanzhi Ye, Yajun Chen, Liyun Feng, Jiali Huang, Qingchun Liang, Zirong Lan, Qianqian Dong, Xiaoyu Liu, Yining Li, Xiuli Zhang, Jing-Song Ou, An Chen, Jianyun Yan. Oxidized phospholipid POVPC contributes to vascular calcification by triggering ferroptosis of vascular smooth muscle cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2024 Apr; 38(7):e23592. doi:
10.1096/fj.202302570r. [PMID: 38581243] - Chao Hou, Bing Zhong, Shuo Gu, Yunyan Wang, Lu Ji. Identification and validation of the biomarkers related to ferroptosis in calcium oxalate nephrolithiasis.
Aging.
2024 Mar; 16(7):5987-6007. doi:
10.18632/aging.205684. [PMID: 38536018] - Fabien Segui, Boutaina Daher, Célia Gotorbe, Jacques Pouyssegur, Vincent Picco, Milica Vucetic. Revealing the Ferroptotic Phenotype of Medulloblastoma.
Journal of visualized experiments : JoVE.
2024 Mar; ?(205):. doi:
10.3791/66645. [PMID: 38557602] - Jing Zhang, Jun Jiang, Bingqing Wang, Yue Wang, Yaoyao Qian, Jinmeng Suo, Yiming Li, Zhiyong Peng. SAP130 released by ferroptosis tubular epithelial cells promotes macrophage polarization via Mincle signaling in sepsis acute kidney injury.
International immunopharmacology.
2024 Mar; 129(?):111564. doi:
10.1016/j.intimp.2024.111564. [PMID: 38320352] - Ruijiao Lin, Zijie Jia, Hongbing Chen, Hongli Xiong, Cunhao Bian, Xin He, Bi Wei, Junfeng Fu, Minzhu Zhao, Jianbo Li. Ferrostatin‑1 alleviates liver injury via decreasing ferroptosis following ricin toxin poisoning in rat.
Toxicology.
2024 Mar; 503(?):153767. doi:
10.1016/j.tox.2024.153767. [PMID: 38437911] - Yalei Cao, Zirun Jin, Yu Xi, Jianxing Cheng, Zishui Fang, Qiancheng Zhao, Jiaming Weng, Jun Zhu, Yanlin Tang, Zhe Zhang, Hui Jiang. Roles of ferroptosis in type 1 diabetes induced spermatogenic dysfunction.
Free radical biology & medicine.
2024 Mar; 214(?):193-205. doi:
10.1016/j.freeradbiomed.2024.02.006. [PMID: 38369075] - Akane Suda, Banlanjo Abdulaziz Umaru, Yui Yamamoto, Hiroki Shima, Yuriko Saiki, Yijun Pan, Liang Jin, Jiaqi Sun, Yi Ling Clare Low, Chitose Suzuki, Takaaki Abe, Kazuhiko Igarashi, Toru Furukawa, Yuji Owada, Yoshiteru Kagawa. Polyunsaturated fatty acids-induced ferroptosis suppresses pancreatic cancer growth.
Scientific reports.
2024 02; 14(1):4409. doi:
10.1038/s41598-024-55050-4. [PMID: 38388563] - Liangzhen Xie, Zewei Zhao, Hao Xia, Shuang Su, Liwei He, Zhaohui Huang, Yongchun Li, Mingjian Gao, Jun Chen, Jian Peng, Yunjun Ruan. A novel tsRNA-5008a promotes ferroptosis in cardiomyocytes that causes atrial structural remodeling predisposed to atrial fibrillation.
Experimental cell research.
2024 Feb; 435(2):113923. doi:
10.1016/j.yexcr.2024.113923. [PMID: 38190870] - Hidenobu Kojima, Hirofumi Hirao, Kentaro Kadono, Takahiro Ito, Siyuan Yao, Taylor Torgerson, Kenneth J Dery, Hiroaki Kitajima, Takahiro Ogawa, Fady M Kaldas, Douglas G Farmer, Jerzy W Kupiec-Weglinski. Cold stress-induced ferroptosis in liver sinusoidal endothelial cells determines liver transplant injury and outcomes.
JCI insight.
2024 Feb; 9(3):. doi:
10.1172/jci.insight.174354. [PMID: 38329125] - Si Chen, Jian-Jun Gao, Yu-Jia Liu, Zhi-Wei Mo, Fang-Yuan Wu, Zuo-Jun Hu, Yue-Ming Peng, Xiao-Qin Zhang, Zhen-Sheng Ma, Ze-Long Liu, Jian-Yun Yan, Zhi-Jun Ou, Yan Li, Jing-Song Ou. The oxidized phospholipid PGPC impairs endothelial function by promoting endothelial cell ferroptosis via FABP3.
Journal of lipid research.
2024 02; 65(2):100499. doi:
10.1016/j.jlr.2024.100499. [PMID: 38218337] - Fengping Chen, Jiexia Lu, Biaolin Zheng, Nan Yi, Chunxiao Xie, Feiran Chen, Dafu Wei, Haixing Jiang, Shanyu Qin. Artesunate Inhibits the Growth of Insulinoma Cells via SLC7A11/ GPX4-mediated Ferroptosis.
Current pharmaceutical design.
2024; 30(3):230-239. doi:
10.2174/0113816128289372240105041038. [PMID: 38243946] - Mengran Wang, Tingting Xuan, Haining Li, Jing An, Tianhui Hao, Jiang Cheng. Protective effect of FXN overexpression on ferroptosis in L-Glu-induced SH-SY5Y cells.
Acta histochemica.
2024 Jan; 126(1):152135. doi:
10.1016/j.acthis.2024.152135. [PMID: 38266318] - Camilla Scarpellini, Greta Klejborowska, Caroline Lanthier, Behrouz Hassannia, Tom Vanden Berghe, Koen Augustyns. Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors.
Trends in pharmacological sciences.
2023 12; 44(12):902-916. doi:
10.1016/j.tips.2023.08.012. [PMID: 37770317] - Jiawei Song, Yihang Chen, Yufei Chen, Siyuan Wang, Zhaojie Dong, Xinming Liu, Xueting Li, Zhenzhou Zhang, Lanlan Sun, Jiuchang Zhong. Ferrostatin-1 Blunts Right Ventricular Hypertrophy and Dysfunction in Pulmonary Arterial Hypertension by Suppressing the HMOX1/GSH Signaling.
Journal of cardiovascular translational research.
2023 Aug; ?(?):. doi:
10.1007/s12265-023-10423-4. [PMID: 37603208] - Dorian M Cheff, Chuying Huang, Karoline C Scholzen, Radosveta Gencheva, Michael H Ronzetti, Qing Cheng, Matthew D Hall, Elias S J Arnér. The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1.
Redox biology.
2023 06; 62(?):102703. doi:
10.1016/j.redox.2023.102703. [PMID: 37087975] - Yanxiu Zhao, Binhua Jiang, Dinghui Huang, Juxiang Lou, Guoshun Li, Jianqi Liu, Fuhui Duan, Yuan Yuan, Xiaoyan Su. Ferrostatin-1 post-treatment attenuates acute kidney injury in mice by inhibiting ferritin production and regulating iron uptake-related proteins.
PeerJ.
2023; 11(?):e15786. doi:
10.7717/peerj.15786. [PMID: 37701828] - Sheng Zhang, Shuai Cao, Heng Zhou, Limin Li, Qing Hu, Xiuhong Mao, Shen Ji. Realgar-induced nephrotoxicity via ferroptosis in mice.
Journal of applied toxicology : JAT.
2022 11; 42(11):1843-1853. doi:
10.1002/jat.4362. [PMID: 35803278] - Kailin Yang, Liuting Zeng, Xiao Yuan, Shanshan Wang, Anqi Ge, Hao Xu, Jinsong Zeng, Jinwen Ge. The mechanism of ferroptosis regulating oxidative stress in ischemic stroke and the regulation mechanism of natural pharmacological active components.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Oct; 154(?):113611. doi:
10.1016/j.biopha.2022.113611. [PMID: 36081288] - Jinna Xie, Zehua Ye, Lei Li, Yuqi Xia, Run Yuan, Yuan Ruan, Xiangjun Zhou. Ferrostatin‑1 alleviates oxalate‑induced renal tubular epithelial cell injury, fibrosis and calcium oxalate stone formation by inhibiting ferroptosis.
Molecular medicine reports.
2022 08; 26(2):. doi:
10.3892/mmr.2022.12772. [PMID: 35703358] - Lucía Martín-Saiz, Juan Guerrero-Mauvecin, Diego Martín-Sanchez, Olatz Fresnedo, Manuel J Gómez, Susana Carrasco, Pablo Cannata-Ortiz, Alberto Ortiz, José A Fernandez, Ana B Sanz. Ferrostatin-1 modulates dysregulated kidney lipids in acute kidney injury.
The Journal of pathology.
2022 07; 257(3):285-299. doi:
10.1002/path.5882. [PMID: 35152438] - Ross P Martini, Dominic Siler, Justin Cetas, Nabil J Alkayed, Elyse Allen, Miriam M Treggiari. A Double-Blind, Randomized, Placebo-Controlled Trial of Soluble Epoxide Hydrolase Inhibition in Patients with Aneurysmal Subarachnoid Hemorrhage.
Neurocritical care.
2022 06; 36(3):905-915. doi:
10.1007/s12028-021-01398-8. [PMID: 34873674] - Shan-Shan Xie, Yan Deng, Sheng-Lan Guo, Jia-Quan Li, Ying-Chuan Zhou, Juan Liao, Dan-Dan Wu, Wei-Fang Lan. Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation.
Scientific reports.
2022 02; 12(1):3056. doi:
10.1038/s41598-022-06848-7. [PMID: 35197507] - Mona Mashayekhi, Celestine N Wanjalla, Christian M Warren, Joshua D Simmons, Kakali Ghoshal, Mark Pilkinton, Samuel S Bailin, Curtis L Gabriel, Ambra Pozzi, John R Koethe, Nancy J Brown, Spyros A Kalams, J Matthew Luther. The soluble epoxide hydrolase inhibitor GSK2256294 decreases the proportion of adipose pro-inflammatory T cells.
Prostaglandins & other lipid mediators.
2022 02; 158(?):106604. doi:
10.1016/j.prostaglandins.2021.106604. [PMID: 34922004] - Hongfei Ge, Xingsen Xue, Jishu Xian, Linbo Yuan, Long Wang, Yongjie Zou, Jun Zhong, Zhouyang Jiang, Jiantao Shi, Tunan Chen, Hong Su, Hua Feng, Shengli Hu. Ferrostatin-1 Alleviates White Matter Injury Via Decreasing Ferroptosis Following Spinal Cord Injury.
Molecular neurobiology.
2022 Jan; 59(1):161-176. doi:
10.1007/s12035-021-02571-y. [PMID: 34635980] - Nan Yang, Yunxiao Shang. Ferrostatin-1 and 3-Methyladenine Ameliorate Ferroptosis in OVA-Induced Asthma Model and in IL-13-Challenged BEAS-2B Cells.
Oxidative medicine and cellular longevity.
2022; 2022(?):9657933. doi:
10.1155/2022/9657933. [PMID: 35154576] - Zheng Xiao, Bin Kong, Jin Fang, Tianyou Qin, Chang Dai, Wei Shuai, He Huang. Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction.
Bioengineered.
2021 12; 12(2):9367-9376. doi:
10.1080/21655979.2021.2001913. [PMID: 34787054] - Yun Tang, Haojun Luo, Qiong Xiao, Li Li, Xiang Zhong, Jiong Zhang, Fang Wang, Guisen Li, Li Wang, Yi Li. Isoliquiritigenin attenuates septic acute kidney injury by regulating ferritinophagy-mediated ferroptosis.
Renal failure.
2021 Dec; 43(1):1551-1560. doi:
10.1080/0886022x.2021.2003208. [PMID: 34791966] - Xiaoyan Meng, Wenjing Huang, Weiwei Mo, Tingting Shu, Haoqiang Yang, Haibo Ning. ADAMTS-13-regulated nuclear factor E2-related factor 2 signaling inhibits ferroptosis to ameliorate cisplatin-induced acute kidney injuy.
Bioengineered.
2021 12; 12(2):11610-11621. doi:
10.1080/21655979.2021.1994707. [PMID: 34666603] - Xiaoqin Zhang, Linda Xiaoyan Li, Hao Ding, Vicente E Torres, Chen Yu, Xiaogang Li. Ferroptosis Promotes Cyst Growth in Autosomal Dominant Polycystic Kidney Disease Mouse Models.
Journal of the American Society of Nephrology : JASN.
2021 11; 32(11):2759-2776. doi:
10.1681/asn.2021040460. [PMID: 34716241] - Zhijun Meng, Hongping Liang, Jianli Zhao, Jia Gao, Caihong Liu, Xinliang Ma, Jing Liu, Bin Liang, Xiangying Jiao, Jimin Cao, Yajing Wang. HMOX1 upregulation promotes ferroptosis in diabetic atherosclerosis.
Life sciences.
2021 Nov; 284(?):119935. doi:
10.1016/j.lfs.2021.119935. [PMID: 34508760] - Junxuan Xu, Si Liu, Zilu Cui, Xingyu Wang, Tingting Ning, Tiange Wang, Nan Zhang, Sian Xie, Li Min, Shutian Zhang, Chunnan Liang, Shengtao Zhu. Ferrostatin-1 alleviated TNBS induced colitis via the inhibition of ferroptosis.
Biochemical and biophysical research communications.
2021 10; 573(?):48-54. doi:
10.1016/j.bbrc.2021.08.018. [PMID: 34388454] - Kaibo Guo, Peipei Wang, Leyin Zhang, Yiwen Zhou, Xinyang Dai, Yici Yan, Yuxuan Chen, Harpreet S Wasan, Jieru Yu, Shanming Ruan, Leitao Sun. Transcription factor POU4F2 promotes colorectal cancer cell migration and invasion through hedgehog-mediated epithelial-mesenchymal transition.
Cancer science.
2021 Oct; 112(10):4176-4186. doi:
10.1111/cas.15089. [PMID: 34327778] - James M Luther, Justina Ray, Dawei Wei, John R Koethe, Latoya Hannah, Anthony DeMatteo, Robert Manning, Andrew S Terker, Dungeng Peng, Hui Nian, Chang Yu, Mona Mashayekhi, Jorge Gamboa, Nancy J Brown. GSK2256294 Decreases sEH (Soluble Epoxide Hydrolase) Activity in Plasma, Muscle, and Adipose and Reduces F2-Isoprostanes but Does Not Alter Insulin Sensitivity in Humans.
Hypertension (Dallas, Tex. : 1979).
2021 09; 78(4):1092-1102. doi:
10.1161/hypertensionaha.121.17659. [PMID: 34455816] - Xuming Tang, Skyler Uhl, Tuo Zhang, Dongxiang Xue, Bo Li, J Jeya Vandana, Joshua A Acklin, Lori L Bonnycastle, Narisu Narisu, Michael R Erdos, Yaron Bram, Vasuretha Chandar, Angie Chi Nok Chong, Lauretta A Lacko, Zaw Min, Jean K Lim, Alain C Borczuk, Jenny Xiang, Ali Naji, Francis S Collins, Todd Evans, Chengyang Liu, Benjamin R tenOever, Robert E Schwartz, Shuibing Chen. SARS-CoV-2 infection induces beta cell transdifferentiation.
Cell metabolism.
2021 08; 33(8):1577-1591.e7. doi:
10.1016/j.cmet.2021.05.015. [PMID: 34081913] - Thomas Gicquel, Camille Richeval, Vadim Mesli, Alexandr Gish, Florian Hakim, Romain Pelletier, Raphael Cornez, Axelle Balgairies, Delphine Allorge, Jean-Michel Gaulier. Fatal intoxication related to two new arylcyclohexylamine derivatives (2F-DCK and 3-MeO-PCE).
Forensic science international.
2021 Jul; 324(?):110852. doi:
10.1016/j.forsciint.2021.110852. [PMID: 34049075] - Junting Xiao, Shanshan Zhang, Baijie Tu, Xuejun Jiang, Shuqun Cheng, Qianghu Tang, Jun Zhang, Xia Qin, Bin Wang, Zhen Zou, Chengzhi Chen. Arsenite induces ferroptosis in the neuronal cells via activation of ferritinophagy.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 May; 151(?):112114. doi:
10.1016/j.fct.2021.112114. [PMID: 33722599] - Jingjing Du, Lishuang Wang, Xiaoming Huang, Na Zhang, Ze Long, You Yang, Fangfang Zhong, Bowen Zheng, Wenjian Lan, Wanjun Lin, Wenzhe Ma. Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 May; 85(?):153551. doi:
10.1016/j.phymed.2021.153551. [PMID: 33827043] - Jumpei Ito, Shigemiki Omiya, Mara-Camelia Rusu, Hiromichi Ueda, Tomokazu Murakawa, Yohei Tanada, Hajime Abe, Kazuki Nakahara, Michio Asahi, Manabu Taneike, Kazuhiko Nishida, Ajay M Shah, Kinya Otsu. Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice.
eLife.
2021 02; 10(?):. doi:
10.7554/elife.62174. [PMID: 33526170] - Lulu Sun, Hongliang Dong, Weiqun Zhang, Nan Wang, Na Ni, Xuelian Bai, Naiguo Liu. Lipid Peroxidation, GSH Depletion, and SLC7A11 Inhibition Are Common Causes of EMT and Ferroptosis in A549 Cells, but Different in Specific Mechanisms.
DNA and cell biology.
2021 Feb; 40(2):172-183. doi:
10.1089/dna.2020.5730. [PMID: 33351681] - Xiaohong Zhang, Mengxin Tian, Xin Li, Chunyan Zheng, Ailian Wang, Jundong Feng, Xiaodan Hu, Shuquan Chang, Haiqian Zhang. Hematopoietic protection and mechanisms of ferrostatin-1 on hematopoietic acute radiation syndrome of mice.
International journal of radiation biology.
2021; 97(4):464-473. doi:
10.1080/09553002.2021.1876956. [PMID: 33464146] - Helen M Deeks, Rebecca K Walters, Jonathan Barnoud, David R Glowacki, Adrian J Mulholland. Interactive Molecular Dynamics in Virtual Reality Is an Effective Tool for Flexible Substrate and Inhibitor Docking to the SARS-CoV-2 Main Protease.
Journal of chemical information and modeling.
2020 12; 60(12):5803-5814. doi:
10.1021/acs.jcim.0c01030. [PMID: 33174415] - Bing Hu, Yunsheng Liu, Xiaozhu Chen, Jianjun Zhao, Jinghong Han, Hongsong Dong, Qingyin Zheng, Guohui Nie. Ferrostatin-1 protects auditory hair cells from cisplatin-induced ototoxicity in vitro and in vivo.
Biochemical and biophysical research communications.
2020 12; 533(4):1442-1448. doi:
10.1016/j.bbrc.2020.10.019. [PMID: 33109343] - Priya Jhelum, Eva Santos-Nogueira, Wulin Teo, Alice Haumont, Isadora Lenoël, Peter K Stys, Samuel David. Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2020 11; 40(48):9327-9341. doi:
10.1523/jneurosci.1749-20.2020. [PMID: 33106352] - Yuan Zhong, Fei Tian, Huanxin Ma, Huihan Wang, Wei Yang, Zhuogang Liu, Aijun Liao. FTY720 induces ferroptosis and autophagy via PP2A/AMPK pathway in multiple myeloma cells.
Life sciences.
2020 Nov; 260(?):118077. doi:
10.1016/j.lfs.2020.118077. [PMID: 32810509] - Yiran Sun, Libo He, Taoyu Wang, Wan Hua, Huan Qin, Jingjin Wang, Li Wang, Wanqin Gu, Tingting Li, Na Li, Xinanbei Liu, Fang Chen, Lin Tang. Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells.
Molecular neurobiology.
2020 Nov; 57(11):4628-4641. doi:
10.1007/s12035-020-02049-3. [PMID: 32770451] - Jingjing Lu, Feng Xu, Hong Lu. LncRNA PVT1 regulates ferroptosis through miR-214-mediated TFR1 and p53.
Life sciences.
2020 Nov; 260(?):118305. doi:
10.1016/j.lfs.2020.118305. [PMID: 32827544] - Kyu Min Kim, Sam Seok Cho, Sung Hwan Ki. Emerging roles of ferroptosis in liver pathophysiology.
Archives of pharmacal research.
2020 Oct; 43(10):985-996. doi:
10.1007/s12272-020-01273-8. [PMID: 33079307] - Honglin Mei, Liping Zhao, Wen Li, Zhiwei Zheng, Dongmei Tang, Xiaoling Lu, Yingzi He. Inhibition of ferroptosis protects House Ear Institute-Organ of Corti 1 cells and cochlear hair cells from cisplatin-induced ototoxicity.
Journal of cellular and molecular medicine.
2020 10; 24(20):12065-12081. doi:
10.1111/jcmm.15839. [PMID: 32929878] - Dan Li, Chunjie Jiang, Guibin Mei, Ying Zhao, Li Chen, Jingjing Liu, Yuhan Tang, Chao Gao, Ping Yao. Quercetin Alleviates Ferroptosis of Pancreatic β Cells in Type 2 Diabetes.
Nutrients.
2020 Sep; 12(10):. doi:
10.3390/nu12102954. [PMID: 32992479] - Rushdia Zareen Yusuf, Borja Saez, Azeem Sharda, Nick van Gastel, Vionnie W C Yu, Ninib Baryawno, Elizabeth W Scadden, Sanket Acharya, Shrikanta Chattophadhyay, Cherrie Huang, Vasanthi Viswanathan, Dana S'aulis, Julien Cobert, David B Sykes, Mark A Keibler, Sudeshna Das, John N Hutchinson, Michael Churchill, Siddhartha Mukherjee, Dongjun Lee, Francois Mercier, John Doench, Lars Bullinger, David J Logan, Stuart Schreiber, Gregory Stephanopoulos, William B Rizzo, David T Scadden. Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
Blood.
2020 09; 136(11):1303-1316. doi:
10.1182/blood.2019001808. [PMID: 32458004] - Yingying Yu, Li Jiang, Hao Wang, Zhe Shen, Qi Cheng, Pan Zhang, Jiaming Wang, Qian Wu, Xuexian Fang, Lingyan Duan, Shufen Wang, Kai Wang, Peng An, Tuo Shao, Raymond T Chung, Shusen Zheng, Junxia Min, Fudi Wang. Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis.
Blood.
2020 08; 136(6):726-739. doi:
10.1182/blood.2019002907. [PMID: 32374849] - Chun-Yu Liu, Min Wang, Hong-Min Yu, Fang-Xuan Han, Qiong-Shi Wu, Xing-Jun Cai, Hiroshi Kurihara, Yong-Xing Chen, Yi-Fang Li, Rong-Rong He. Ferroptosis is involved in alcohol-induced cell death in vivo and in vitro.
Bioscience, biotechnology, and biochemistry.
2020 Aug; 84(8):1621-1628. doi:
10.1080/09168451.2020.1763155. [PMID: 32419644] - Xuexian Fang, Zhaoxian Cai, Hao Wang, Dan Han, Qi Cheng, Pan Zhang, Feng Gao, Yingying Yu, Zijun Song, Qian Wu, Peng An, Sicong Huang, Jianwei Pan, Hou-Zao Chen, Jinghai Chen, Andreas Linkermann, Junxia Min, Fudi Wang. Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis.
Circulation research.
2020 07; 127(4):486-501. doi:
10.1161/circresaha.120.316509. [PMID: 32349646] - Martina Maria Capelletti, Hana Manceau, Hervé Puy, Katell Peoc'h. Ferroptosis in Liver Diseases: An Overview.
International journal of molecular sciences.
2020 Jul; 21(14):. doi:
10.3390/ijms21144908. [PMID: 32664576] - Tianshu Wu, Xue Liang, Xi Liu, Yimeng Li, Yutong Wang, Lu Kong, Meng Tang. Induction of ferroptosis in response to graphene quantum dots through mitochondrial oxidative stress in microglia.
Particle and fibre toxicology.
2020 07; 17(1):30. doi:
10.1186/s12989-020-00363-1. [PMID: 32652997] - Pan Meng, Shanshan Zhang, Xuejun Jiang, Shuqun Cheng, Jun Zhang, Xianqing Cao, Xia Qin, Zhen Zou, Chengzhi Chen. Arsenite induces testicular oxidative stress in vivo and in vitro leading to ferroptosis.
Ecotoxicology and environmental safety.
2020 May; 194(?):110360. doi:
10.1016/j.ecoenv.2020.110360. [PMID: 32151864] - Anderson Luiz Oenning, Letícia Birk, Sarah Eller, Tiago Franco de Oliveira, Josias Merib, Eduardo Carasek. A green and low-cost method employing switchable hydrophilicity solvent for the simultaneous determination of antidepressants in human urine by gas chromatography - mass spectrometry detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Apr; 1143(?):122069. doi:
10.1016/j.jchromb.2020.122069. [PMID: 32213465] - Ting Zhou, Pei Wang, Zhenxin Gu, Meng Ma, Runqiang Yang. Spermidine improves antioxidant activity and energy metabolism in mung bean sprouts.
Food chemistry.
2020 Mar; 309(?):125759. doi:
10.1016/j.foodchem.2019.125759. [PMID: 31706672] - Ariunaa Sampilvanjil, Tadayoshi Karasawa, Naoya Yamada, Takanori Komada, Tsunehito Higashi, Chintogtokh Baatarjav, Sachiko Watanabe, Ryo Kamata, Nobuhiko Ohno, Masafumi Takahashi. Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells.
American journal of physiology. Heart and circulatory physiology.
2020 03; 318(3):H508-H518. doi:
10.1152/ajpheart.00559.2019. [PMID: 31975626] - Naoya Yamada, Tadayoshi Karasawa, Hiroaki Kimura, Sachiko Watanabe, Takanori Komada, Ryo Kamata, Ariunaa Sampilvanjil, Junya Ito, Kiyotaka Nakagawa, Hiroshi Kuwata, Shuntaro Hara, Koichi Mizuta, Yasunaru Sakuma, Naohiro Sata, Masafumi Takahashi. Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure.
Cell death & disease.
2020 02; 11(2):144. doi:
10.1038/s41419-020-2334-2. [PMID: 32094346] - Hyemin Lee, Fereshteh Zandkarimi, Yilei Zhang, Jitendra Kumar Meena, Jongchan Kim, Li Zhuang, Siddhartha Tyagi, Li Ma, Thomas F Westbrook, Gregory R Steinberg, Daisuke Nakada, Brent R Stockwell, Boyi Gan. Energy-stress-mediated AMPK activation inhibits ferroptosis.
Nature cell biology.
2020 02; 22(2):225-234. doi:
10.1038/s41556-020-0461-8. [PMID: 32029897] - Matthew Lovatt, Khadijah Adnan, Viridiana Kocaba, Martin Dirisamer, Gary S L Peh, Jodhbir S Mehta. Peroxiredoxin-1 regulates lipid peroxidation in corneal endothelial cells.
Redox biology.
2020 02; 30(?):101417. doi:
10.1016/j.redox.2019.101417. [PMID: 31901729] - Zhaoxin Hu, Hao Zhang, Bin Yi, Shikun Yang, Jun Liu, Jing Hu, Jianwen Wang, Ke Cao, Wei Zhang. VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis.
Cell death & disease.
2020 01; 11(1):73. doi:
10.1038/s41419-020-2256-z. [PMID: 31996668] - Jasmin Dächert, Vanessa Ehrenfeld, Karoline Habermann, Nadezda Dolgikh, Simone Fulda. Targeting ferroptosis in rhabdomyosarcoma cells.
International journal of cancer.
2020 01; 146(2):510-520. doi:
10.1002/ijc.32496. [PMID: 31173656] - Zhuanzhuan Qiang, Hui Dong, Yangyang Xia, Dongdong Chai, Rong Hu, Hong Jiang. Nrf2 and STAT3 Alleviates Ferroptosis-Mediated IIR-ALI by Regulating SLC7A11.
Oxidative medicine and cellular longevity.
2020; 2020(?):5146982. doi:
10.1155/2020/5146982. [PMID: 33014271] - Xia Qin, Qianghu Tang, Xuejun Jiang, Jun Zhang, Bin Wang, Xuemei Liu, Yandan Zhang, Zhen Zou, Chengzhi Chen. Zinc Oxide Nanoparticles Induce Ferroptotic Neuronal Cell Death in vitro and in vivo.
International journal of nanomedicine.
2020; 15(?):5299-5315. doi:
10.2147/ijn.s250367. [PMID: 32884256] - Dalma Scheffer, Gyula Kulcsár, György Nagyéri, Marianna Kiss-Merki, Zoltán Rékási, Magnus Maloy, Tamás Czömpöly. Active mixture of serum-circulating small molecules selectively inhibits proliferation and triggers apoptosis in cancer cells via induction of ER stress.
Cellular signalling.
2020 01; 65(?):109426. doi:
10.1016/j.cellsig.2019.109426. [PMID: 31669205] - Giovanni Miotto, Monica Rossetto, Maria Luisa Di Paolo, Laura Orian, Rina Venerando, Antonella Roveri, Ana-Marija Vučković, Valentina Bosello Travain, Mattia Zaccarin, Lucio Zennaro, Matilde Maiorino, Stefano Toppo, Fulvio Ursini, Giorgio Cozza. Insight into the mechanism of ferroptosis inhibition by ferrostatin-1.
Redox biology.
2020 01; 28(?):101328. doi:
10.1016/j.redox.2019.101328. [PMID: 31574461] - Xue Li, Yu Zou, Jia Xing, Yuan-Yuan Fu, Kai-Yue Wang, Peng-Zhi Wan, Xiao-Yue Zhai. Pretreatment with Roxadustat (FG-4592) Attenuates Folic Acid-Induced Kidney Injury through Antiferroptosis via Akt/GSK-3β/Nrf2 Pathway.
Oxidative medicine and cellular longevity.
2020; 2020(?):6286984. doi:
10.1155/2020/6286984. [PMID: 32051732] - Pengfei Liu, Yetong Feng, Hanwei Li, Xin Chen, Guangsuo Wang, Shiyuan Xu, Yalan Li, Lei Zhao. Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis.
Cellular & molecular biology letters.
2020; 25(?):10. doi:
10.1186/s11658-020-00205-0. [PMID: 32161620] - Ruizhu Liu, Xuefeng Li, Guoqing Zhao. Beclin1-mediated ferroptosis activation is associated with isoflurane-induced toxicity in SH-SY5Y neuroblastoma cells.
Acta biochimica et biophysica Sinica.
2019 Nov; 51(11):1134-1141. doi:
10.1093/abbs/gmz104. [PMID: 31650158] - Yan Wang, Meng Tang. PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance.
Environmental pollution (Barking, Essex : 1987).
2019 Nov; 254(Pt A):112937. doi:
10.1016/j.envpol.2019.07.105. [PMID: 31401526] - Fei Deng, Isha Sharma, Yingbo Dai, Ming Yang, Yashpal S Kanwar. Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule.
The Journal of clinical investigation.
2019 11; 129(11):5033-5049. doi:
10.1172/jci129903. [PMID: 31437128] - Isabel Gomila, Maria Ángeles Leciñena, Miguel Ángel Elorza, Yolanda Pastor, Laura Sahuquillo, Miguel Servera, Jordi Puiguriguer, Bernardino Barcelo. Detectability of Dissociative Psychoactive Substances in Urine by Five Commercial Phencyclidine Immunoassays.
Journal of analytical toxicology.
2019 Jul; 43(6):497-503. doi:
10.1093/jat/bkz026. [PMID: 31329888] - Min Wu, Ye Feng, Guo-Xin Ye, Yu-Chen Han, Si-Si Wang, Hai-Feng Ni, Feng-Mei Wang, Min Gao, Lin-Li Lv, Bi-Cheng Liu. Calcium-sensing receptor activation attenuates collagen expression in renal proximal tubular epithelial cells.
American journal of physiology. Renal physiology.
2019 05; 316(5):F1006-F1015. doi:
10.1152/ajprenal.00413.2018. [PMID: 30838870] - Elizabeth G Bromfield, Jessica L H Walters, Shenae L Cafe, Ilana R Bernstein, Simone J Stanger, Amanda L Anderson, R John Aitken, Eileen A McLaughlin, Matthew D Dun, Barend M Gadella, Brett Nixon. Differential cell death decisions in the testis: evidence for an exclusive window of ferroptosis in round spermatids.
Molecular human reproduction.
2019 05; 25(5):241-256. doi:
10.1093/molehr/gaz015. [PMID: 30865280] - Bao-Shu Xie, Yi-Qin Wang, Yong Lin, Qing Mao, Jun-Feng Feng, Guo-Yi Gao, Ji-Yao Jiang. Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice.
CNS neuroscience & therapeutics.
2019 04; 25(4):465-475. doi:
10.1111/cns.13069. [PMID: 30264934] - Takara Ohto, Manami Konishi, Hiroki Tanaka, Koji Onomoto, Mitsutoshi Yoneyama, Yuta Nakai, Kota Tange, Hiroki Yoshioka, Hidetaka Akita. Inhibition of the Inflammatory Pathway Enhances Both the in Vitro and in Vivo Transfection Activity of Exogenous in Vitro-Transcribed mRNAs Delivered by Lipid Nanoparticles.
Biological & pharmaceutical bulletin.
2019; 42(2):299-302. doi:
10.1248/bpb.b18-00783. [PMID: 30713260] - Sarmina Dangol, Yafei Chen, Byung Kook Hwang, Nam-Soo Jwa. Iron- and Reactive Oxygen Species-Dependent Ferroptotic Cell Death in Rice-Magnaporthe oryzae Interactions.
The Plant cell.
2019 01; 31(1):189-209. doi:
10.1105/tpc.18.00535. [PMID: 30563847] - Gyu-Tae Shin, Hwa Joung Lee, Ji Eun Park. Growth arrest and DNA damage 45γ is required for caspase-dependent renal tubular cell apoptosis.
PloS one.
2019; 14(2):e0212818. doi:
10.1371/journal.pone.0212818. [PMID: 30794682] - Péter Hajdinák, Ádám Czobor, András Szarka. The potential role of acrolein in plant ferroptosis-like cell death.
PloS one.
2019; 14(12):e0227278. doi:
10.1371/journal.pone.0227278. [PMID: 31887216] - Giulia Costa, Marcello Serra, Nicholas Pintori, Maria Antonietta Casu, Mary Tresa Zanda, Daniela Murtas, Maria Antonietta De Luca, Nicola Simola, Liana Fattore. The novel psychoactive substance methoxetamine induces persistent behavioral abnormalities and neurotoxicity in rats.
Neuropharmacology.
2019 01; 144(?):219-232. doi:
10.1016/j.neuropharm.2018.10.031. [PMID: 30366005] - Mahboubeh Hosseini-Kharat, Davit Zargarian, Ali Mohammad Alizadeh, Kazem Karami, Maryam Saeidifar, Solmaz Khalighfard, Laurent Dubrulle, Mostafa Zakariazadeh, Jean-Philippe Cloutier, Zahra Sohrabijam. In vitro and in vivo antiproliferative activity of organo-nickel SCS-pincer complexes on estrogen responsive MCF7 and MC4L2 breast cancer cells. Effects of amine fragment substitutions on BSA binding and cytotoxicity.
Dalton transactions (Cambridge, England : 2003).
2018 Dec; 47(47):16944-16957. doi:
10.1039/c8dt03079k. [PMID: 30450497] - Lars Devisscher, Samya Van Coillie, Sam Hofmans, Dries Van Rompaey, Kenneth Goossens, Eline Meul, Louis Maes, Hans De Winter, Pieter Van Der Veken, Peter Vandenabeele, Tom Vanden Berghe, Koen Augustyns. Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy.
Journal of medicinal chemistry.
2018 11; 61(22):10126-10140. doi:
10.1021/acs.jmedchem.8b01299. [PMID: 30354101] - Xingan Cheng, Jingmin Ye, Huiqing He, Zhanmei Liu, Chunbao Charles Xu, Bo Wu, Xialing Xiong, Xugang Shu, Xuhong Jiang, Xiangjing Qin. Synthesis, characterization and in vitro biological evaluation of two matrine derivatives.
Scientific reports.
2018 10; 8(1):15686. doi:
10.1038/s41598-018-33908-8. [PMID: 30356148] - Silvia Codenotti, Maura Poli, Michela Asperti, Daniela Zizioli, Francesco Marampon, Alessandro Fanzani. Cell growth potential drives ferroptosis susceptibility in rhabdomyosarcoma and myoblast cell lines.
Journal of cancer research and clinical oncology.
2018 Sep; 144(9):1717-1730. doi:
10.1007/s00432-018-2699-0. [PMID: 29971532] - Somanathapura K NaveenKumar, Bidare N SharathBabu, Mahadevappa Hemshekhar, Kempaiah Kemparaju, Kesturu S Girish, Govindasamy Mugesh. The Role of Reactive Oxygen Species and Ferroptosis in Heme-Mediated Activation of Human Platelets.
ACS chemical biology.
2018 08; 13(8):1996-2002. doi:
10.1021/acschembio.8b00458. [PMID: 29869870] - Meiying Luo, Longfei Wu, Kexin Zhang, Hong Wang, Tian Zhang, Lucas Gutierrez, Douglas O'Connell, Peng Zhang, Yu Li, Tongtong Gao, Wenyan Ren, Yongfei Yang. miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma.
Cell death and differentiation.
2018 08; 25(8):1457-1472. doi:
10.1038/s41418-017-0053-8. [PMID: 29348676]
