Cudranin (BioDeep_00000870509)
Main id: BioDeep_00000230903
PANOMIX_OTCML-2023
代谢物信息卡片
1,3-Benzenediol, 4-(2-(3,5-dihydroxyphenyl)ethenyl)-, (E)-
化学式: C14H12O4 (244.0736)
中文名称: 氧化白藜芦醇, 氧化白黎芦醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1O)O)C=CC2=CC(=CC(=C2)O)O
InChI: InChI=1S/C14H12O4/c15-11-4-3-10(14(18)8-11)2-1-9-5-12(16)7-13(17)6-9/h1-8,15-18H/b2-1+
描述信息
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 μM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 μM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects[1][2][3][4].
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 μM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 μM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects[1][2][3][4].
同义名列表
23 个代谢物同义名
1,3-Benzenediol, 4-(2-(3,5-dihydroxyphenyl)ethenyl)-, (E)-; 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol; 1,3-Benzenediol, 4-(2-(3,5-dihydroxyphenyl)ethenyl)-; 4-[(E)-2-(3,5-dihydroxyphenyl)vinyl]benzene-1,3-diol; 4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol; 4-[2-(3,5-dihydroxyphenyl)vinyl]benzene-1,3-diol; 4-[2-(3,5-Dihydroxyphenyl)vinyl]-1,3-benzenediol; 4-[(E)-2-(3,5-dihydroxyphenyl)vinyl]resorcinol; 4-[2-(3,5-dihydroxyphenyl)vinyl]resorcinol; 2,4,3,5-tetrahydroxystilbene; Tetrahydroxystilbene; Oxyresveratrol; MEGxp0_001057; ACon1_001063; 29700-22-9; NSC 315550; puag-haad; 4721-07-7; NSC315550; Cudranin; C10273; trans-Oxyresveratrol; Oxyresveratrol
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:7870
- PubChem: 5281717
- ChEMBL: CHEMBL43065
- CAS: 29700-22-9
- CAS: 4721-07-7
- medchemexpress: HY-N1430
- KEGG: C10273
- PubChem: 12459
- KNApSAcK: 7870
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
27 个相关的物种来源信息
- 3488 - Artocarpus: 10.1021/NP010451C
- 709041 - Artocarpus dadah: 10.1021/NP010451C
- 1867283 - Artocarpus gomezianus: 10.1016/S0367-326X(02)00210-1
- 3489 - Artocarpus heterophyllus: 10.1021/JF800444G
- 382341 - Artocarpus lacucha: 10.1021/NP010451C
- 2675511 - Artocarpus reticulatus: 10.1007/S11418-006-0048-0
- 241862 - Bagassa guianensis: 10.1016/J.PHYTOCHEM.2010.06.020
- 46397 - Fatsia japonica: 10.1007/S10600-010-9660-Z
- 225590 - Gnetum hainanense: 10.1021/NP990382Q
- 3381 - Gnetum montanum: 10.1002/HLCA.200890007
- 3496 - Maclura pomifera:
- 164936 - Melaleuca leucadendra: 10.1248/CPB.39.3276
- 58664 - Milicia excelsa:
- 3498 - Morus alba:
- 3498 - Morus alba L.: -
- 191188 - Morus macroura:
- 229049 - Morus mongolica: 10.3987/COM-88-4771
- 33090 - Plants: -
- 3755 - Prunus dulcis: 10.1016/J.FOODCHEM.2013.10.057
- 294315 - Schoenocaulon officinale: 10.1248/CPB.50.863
- 49657 - Smilax China: -
- 241923 - Sorocea muriculata: 10.1021/NP800446G
- 1231571 - Spirotropis longifolia: 10.1016/J.PHYTOCHEM.2011.10.011
- 203092 - Veratrum grandiflorum:
- 33090 - 桑枝: -
- 33090 - 桑白皮: -
- 33090 - 菝葜: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tushar Agarwal, Suman Manandhar, Harish Kumar B, Ademola C Famurewa, Prasada Chowdari Gurram, Ramya Shri Suggala, Runali Sankhe, Jayesh Mudgal, K Sreedhara Ranganath Pai. Oxyresveratrol-β-cyclodextrin mitigates streptozotocin-induced Alzheimer's model cognitive impairment, histone deacetylase activity in rats: in silico & in vivo studies.
Scientific reports.
2024 04; 14(1):9897. doi:
10.1038/s41598-024-57188-7. [PMID: 38688962] - Guangling Yin, Chunxing Pan, Hong Liu, Changzhi Dong, Xia Chang, Wei Zhou, Shanshan Wang, Zhiyun Du. Oxyresveratrol Improves Cognitive Impairments and Episodic-like Memory through Modulating Neuroinflammation and PI3K-Akt Signaling Pathway in LPS-Induced Mice.
Molecules (Basel, Switzerland).
2024 Mar; 29(6):. doi:
10.3390/molecules29061272. [PMID: 38542908] - Waraporn Yahayo, Veerachai Pongkittiphan, Roogntawan Supabphol, Somrudee Saiyudthong. Comparative Studies of Resveratrol, Oxyresveratrol and Dihydrooxyresveratrol on Doxorubicin-Treated Lung Cancer Cells.
Asian Pacific journal of cancer prevention : APJCP.
2024 Mar; 25(3):939-949. doi:
10.31557/apjcp.2024.25.3.939. [PMID: 38546076] - Ben Niu, Yingchang Fei, Ruiling Liu, Hangjun Chen, Xiangjun Fang, Weijie Wu, Honglei Mu, Haiyan Gao. Effect of oxyresveratrol on the quality and membrane lipid metabolism of shiitake mushroom (Lentinus edodes) during storage.
Food chemistry.
2023 Nov; 427(?):136700. doi:
10.1016/j.foodchem.2023.136700. [PMID: 37356268] - Nisat Alam, Maidul Islam, Hasina Najnin, Sonam Shakya, Ishaat M Khan, Md Wamique Hossain, Rana Zaidi. Design and characterization of a binary CT complex of imidazole-oxyresveratrol: exploring its pharmacological and computational aspects.
Journal of biomolecular structure & dynamics.
2023 Apr; ?(?):1-17. doi:
10.1080/07391102.2023.2199088. [PMID: 37054451] - Nisat Alam, Hasina Najnin, Maidul Islam, Sonam Shakya, Ishaat M Khan, Rana Zaidi. Biochemical and histopathological analysis after sub-chronic administration of oxyresveratrol in Wistar rats.
Drug and chemical toxicology.
2023 Jan; 46(1):166-175. doi:
10.1080/01480545.2021.2015243. [PMID: 34913788] - Wuttinont Thaweesest, Visarut Buranasudja, Rianthong Phumsuay, Chawanphat Muangnoi, Opa Vajragupta, Boonchoo Sritularak, Paitoon Rashatasakhon, Pornchai Rojsitthisak. Anti-Inflammatory Activity of Oxyresveratrol Tetraacetate, an Ester Prodrug of Oxyresveratrol, on Lipopolysaccharide-Stimulated RAW264.7 Macrophage Cells.
Molecules (Basel, Switzerland).
2022 Jun; 27(12):. doi:
10.3390/molecules27123922. [PMID: 35745046] - Jiayi Wu, Xiaoge Jiang, Qiyuan Yang, Yuheng Zhang, Chenglin Wang, Ruijie Huang. Inhibition of Streptococcus mutans Biofilm Formation by the Joint Action of Oxyresveratrol and Lactobacillus casei.
Applied and environmental microbiology.
2022 05; 88(9):e0243621. doi:
10.1128/aem.02436-21. [PMID: 35416682] - Nathjanan Jongkon, Boonwiset Seaho, Ngampuk Tayana, Saisuree Prateeptongkum, Nongnaphat Duangdee, Panichakorn Jaiyong. Computational Analysis and Biological Activities of Oxyresveratrol Analogues, the Putative Cyclooxygenase-2 Inhibitors.
Molecules (Basel, Switzerland).
2022 Apr; 27(7):. doi:
10.3390/molecules27072346. [PMID: 35408774] - Feilan Zhao, Jingru Qin, Yujia Liang, Rui Zhou. Exploring anti-liver cancer targets and mechanisms of oxyresveratrol: in silico and verified findings.
Bioengineered.
2021 12; 12(2):9939-9948. doi:
10.1080/21655979.2021.1985328. [PMID: 34592904] - Murugan Thulasi Meenu, Grace Kaul, Manjulika Shukla, Kokkuvayil Vasu Radhakrishnan, Sidharth Chopra. Cudraflavone C from Artocarpus hirsutus as a Promising Inhibitor of Pathogenic, Multidrug-Resistant S. aureus, Persisters, and Biofilms: A New Insight into a Rational Explanation of Traditional Wisdom.
Journal of natural products.
2021 10; 84(10):2700-2708. doi:
10.1021/acs.jnatprod.1c00578. [PMID: 34546736] - Ting-Ann Lin, Wei-Sheng Lin, Ya-Chun Chou, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hisung Pan. Oxyresveratrol inhibits human colon cancer cell migration through regulating epithelial-mesenchymal transition and microRNA.
Food & function.
2021 Oct; 12(20):9658-9668. doi:
10.1039/d1fo01920a. [PMID: 34664597] - Tingting Liu, Min Liu, He Liu, Yongfang Ren, Yanna Zhao, Hui Yan, Qingpeng Wang, Ning Zhang, Zhuang Ding, Zhengping Wang. Co-encapsulation of (-)-epigallocatechin-3-gallate and piceatannol/oxyresveratrol in β-lactoglobulin: effect of ligand-protein binding on the antioxidant activity, stability, solubility and cytotoxicity.
Food & function.
2021 Aug; 12(16):7126-7144. doi:
10.1039/d1fo00481f. [PMID: 34180492] - Sreeja Lakshmi, Shamprasad Varija Raghu, Preetham Elumalai, Sureshkumar Sivan. Alkoxy glycerol enhanced activity of Oxyresveratrol in Alzheimer's disease by rescuing Tau protein.
Neuroscience letters.
2021 08; 759(?):135981. doi:
10.1016/j.neulet.2021.135981. [PMID: 34023407] - Matusorn Wongon, Nanteetip Limpeanchob. Artocarpus lacucha Extract and Oxyresveratrol Inhibit Glucose Transporters in Human Intestinal Caco-2 Cells.
Planta medica.
2021 Aug; 87(9):709-715. doi:
10.1055/a-1324-3570. [PMID: 33511623] - Marta Donini, Salvatore Calogero Gaglio, Carlo Laudanna, Massimiliano Perduca, Stefano Dusi. Oxyresveratrol-Loaded PLGA Nanoparticles Inhibit Oxygen Free Radical Production by Human Monocytes: Role in Nanoparticle Biocompatibility.
Molecules (Basel, Switzerland).
2021 Jul; 26(14):. doi:
10.3390/molecules26144351. [PMID: 34299623] - Kittisak Likhitwitayawuid. Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems.
Molecules (Basel, Switzerland).
2021 Jul; 26(14):. doi:
10.3390/molecules26144212. [PMID: 34299485] - Jiah Yeom, Seongho Ma, Jeong-Keun Kim, Young-Hee Lim. Oxyresveratrol Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats by Suppressing Inflammation.
Molecules (Basel, Switzerland).
2021 Apr; 26(9):. doi:
10.3390/molecules26092630. [PMID: 33946346] - Hua-Jin Zeng, Qiong-Yang Li, Jiao Ma, Ran Yang, Ling-Bo Qu. A comparative study on the effects of resveratrol and oxyresveratrol against tyrosinase activity and their inhibitory mechanism.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Apr; 251(?):119405. doi:
10.1016/j.saa.2020.119405. [PMID: 33450449] - Salvatore Calogero Gaglio, Marta Donini, Piyachat Evelyn Denbaes, Stefano Dusi, Massimiliano Perduca. Oxyresveratrol Inhibits R848-Induced Pro-Inflammatory Mediators Release by Human Dendritic Cells Even When Embedded in PLGA Nanoparticles.
Molecules (Basel, Switzerland).
2021 Apr; 26(8):. doi:
10.3390/molecules26082106. [PMID: 33916909] - Anuri Shah, Jianfei Chao, Cristina Legido-Quigley, Raymond Chuen-Chung Chang. Oxyresveratrol exerts ATF4- and Grp78-mediated neuroprotection against endoplasmic reticulum stress in experimental Parkinson's disease.
Nutritional neuroscience.
2021 Mar; 24(3):181-196. doi:
10.1080/1028415x.2019.1613764. [PMID: 31100053] - Nasa Sakamoto, Naoya Tsuno, Ryotaro Koyama, Katsuhiko Gato, Varin Titapiwatanakun, Kazuhiko Takatori, Toshiro Fukami. Four Novel Pharmaceutical Cocrystals of Oxyresveratrol, Including a 2 : 3 Cocrystal with Betaine.
Chemical & pharmaceutical bulletin.
2021; 69(10):995-1004. doi:
10.1248/cpb.c21-00375. [PMID: 34602581] - Tao Lv, Zhen Jian, Dejian Li, Rongguang Ao, Xu Zhang, Baoqing Yu. Oxyresveratrol induces apoptosis and inhibits cell viability via inhibition of the STAT3 signaling pathway in Saos‑2 cells.
Molecular medicine reports.
2020 Dec; 22(6):5191-5198. doi:
10.3892/mmr.2020.11591. [PMID: 33174060] - Adrián Matencio, M Alejandra Guerrero-Rubio, Fabrizio Caldera, Claudio Cecone, Francesco Trotta, Francisco García-Carmona, José Manuel López-Nicolás. Lifespan extension in Caenorhabditis elegans by oxyresveratrol supplementation in hyper-branched cyclodextrin-based nanosponges.
International journal of pharmaceutics.
2020 Nov; 589(?):119862. doi:
10.1016/j.ijpharm.2020.119862. [PMID: 32916214] - Passaporn Ouiyangkul, Vimon Tantishaiyakul, Namon Hirun. Exploring potential coformers for oxyresveratrol using principal component analysis.
International journal of pharmaceutics.
2020 Sep; 587(?):119630. doi:
10.1016/j.ijpharm.2020.119630. [PMID: 32652183] - Luce M Mattio, Giorgia Catinella, Andrea Pinto, Sabrina Dallavalle. Natural and nature-inspired stilbenoids as antiviral agents.
European journal of medicinal chemistry.
2020 Sep; 202(?):112541. doi:
10.1016/j.ejmech.2020.112541. [PMID: 32652408] - Phateep Hankittichai, Hua Jane Lou, Nitwara Wikan, Duncan R Smith, Saranyapin Potikanond, Wutigri Nimlamool. Oxyresveratrol Inhibits IL-1β-Induced Inflammation via Suppressing AKT and ERK1/2 Activation in Human Microglia, HMC3.
International journal of molecular sciences.
2020 Aug; 21(17):. doi:
10.3390/ijms21176054. [PMID: 32842681] - Jun Li, Zhenyu Lin, Xudong Tang, Guo Liu, Yunjiao Chen, Xiaoxiang Zhai, Qingrong Huang, Yong Cao. Oxyresveratrol extracted from Artocarpus heterophyllus Lam. inhibits tyrosinase and age pigments in vitro and in vivo.
Food & function.
2020 Jul; 11(7):6595-6607. doi:
10.1039/d0fo01193b. [PMID: 32648885] - Jiayi Wu, Qiyuan Yang, Xiaoge Jiang, Yu Fan, Yuheng Zhang, Ruijie Huang. Oxyresveratrol promotes biofilm formation, cell attachment and aggregation of Streptococcus gordonii in the presence of sucrose.
FEMS microbiology letters.
2020 06; 367(12):. doi:
10.1093/femsle/fnaa090. [PMID: 32504487] - Sarayut Radapong, Satyajit D Sarker, Kenneth J Ritchie. Oxyresveratrol Possesses DNA Damaging Activity.
Molecules (Basel, Switzerland).
2020 Jun; 25(11):. doi:
10.3390/molecules25112577. [PMID: 32492964] - Liang Wang, Hui Zhao, Liwen Wang, Yongqing Tao, Gang Du, Wenqiang Guan, Jianfu Liu, Charles Brennan, Chi-Tang Ho, Shiming Li. Effects of Selected Resveratrol Analogues on Activation and Polarization of Lipopolysaccharide-Stimulated BV-2 Microglial Cells.
Journal of agricultural and food chemistry.
2020 Mar; 68(12):3750-3757. doi:
10.1021/acs.jafc.0c00498. [PMID: 32125844] - Kei Shimoda, Naoji Kubota, Daisuke Uesugi, Yusuke Kobayashi, Hatsuyuki Hamada, Hiroki Hamada. Glycosylation of Stilbene Compounds by Cultured Plant Cells.
Molecules (Basel, Switzerland).
2020 Mar; 25(6):. doi:
10.3390/molecules25061437. [PMID: 32235774] - Damu Sunilkumar, G Drishya, Aneesh Chandrasekharan, Sanu K Shaji, Chinchu Bose, Jennifer Jossart, J Jefferson P Perry, Nandita Mishra, Geetha B Kumar, Bipin G Nair. Oxyresveratrol drives caspase-independent apoptosis-like cell death in MDA-MB-231 breast cancer cells through the induction of ROS.
Biochemical pharmacology.
2020 03; 173(?):113724. doi:
10.1016/j.bcp.2019.113724. [PMID: 31756327] - Adrián Matencio, Nilesh Kumar Dhakar, Federica Bessone, Giorgia Musso, Roberta Cavalli, Chiara Dianzani, Francisco García-Carmona, José Manuel López-Nicolás, Francesco Trotta. Study of oxyresveratrol complexes with insoluble cyclodextrin based nanosponges: Developing a novel way to obtain their complexation constants and application in an anticancer study.
Carbohydrate polymers.
2020 Mar; 231(?):115763. doi:
10.1016/j.carbpol.2019.115763. [PMID: 31888848] - Phateep Hankittichai, Pensiri Buacheen, Pornsiri Pitchakarn, Mingkwan Na Takuathung, Nitwara Wikan, Duncan R Smith, Saranyapin Potikanond, Wutigri Nimlamool. Artocarpus lakoocha Extract Inhibits LPS-Induced Inflammatory Response in RAW 264.7 Macrophage Cells.
International journal of molecular sciences.
2020 02; 21(4):. doi:
10.3390/ijms21041355. [PMID: 32079307] - Jiayi Wu, Yu Fan, Xinyue Wang, Xiaoge Jiang, Jing Zou, Ruijie Huang. Effects of the natural compound, oxyresveratrol, on the growth of Streptococcus mutans, and on biofilm formation, acid production, and virulence gene expression.
European journal of oral sciences.
2020 02; 128(1):18-26. doi:
10.1111/eos.12667. [PMID: 31970819] - Rong Li, Yingqi Song, Zhenni Ji, Li Li, Liming Zhou. Pharmacological biotargets and the molecular mechanisms of oxyresveratrol treating colorectal cancer: Network and experimental analyses.
BioFactors (Oxford, England).
2020 Jan; 46(1):158-167. doi:
10.1002/biof.1583. [PMID: 31647596] - Min Liu, Tingting Liu, Yabo Shi, Yanna Zhao, Hui Yan, Bin Sun, Qingpeng Wang, Zhengping Wang, Jun Han. Comparative study on the interaction of oxyresveratrol and piceatannol with trypsin and lysozyme: binding ability, activity and stability.
Food & function.
2019 Dec; 10(12):8182-8194. doi:
10.1039/c9fo01888c. [PMID: 31696185] - Nongnaphat Duangdee, Natawadee Chamboonchu, Sumet Kongkiatpaiboon, Saisuree Prateeptongkum. Quantitative 1 HNMR spectroscopy for the determination of oxyresveratrol in Artocarpus lacucha heartwood.
Phytochemical analysis : PCA.
2019 Nov; 30(6):617-622. doi:
10.1002/pca.2834. [PMID: 31020748] - Weixin Wang, Rui Yang, Huan Yao, Yun Wu, Weidong Pan, Ai-Qun Jia. Inhibiting the formation of advanced glycation end-products by three stilbenes and the identification of their adducts.
Food chemistry.
2019 Oct; 295(?):10-15. doi:
10.1016/j.foodchem.2019.02.137. [PMID: 31174737] - Jukrapun Komaikul, Tharita Kitisripanya, Kittisak Likhitwitayawuid, Boonchoo Sritularak, Hiroyuki Tanaka, Waraporn Putalun. Improvement of stilbenoid production by 2-hydroxypropyl-β-cyclodextrin in white mulberry (Morus alba L.) callus cultures.
Natural product research.
2019 Oct; 33(19):2762-2769. doi:
10.1080/14786419.2018.1499643. [PMID: 30470133] - Dhirarin Junsaeng, Tosapol Anukunwithaya, Phanit Songvut, Boonchoo Sritularak, Kittisak Likhitwitayawuid, Phisit Khemawoot. Comparative pharmacokinetics of oxyresveratrol alone and in combination with piperine as a bioenhancer in rats.
BMC complementary and alternative medicine.
2019 Sep; 19(1):235. doi:
10.1186/s12906-019-2653-y. [PMID: 31477089] - Jin-Hyung Lee, Yong-Guy Kim, Chaitany Jayprakash Raorane, Shi Yong Ryu, Jae-Jin Shim, Jintae Lee. The anti-biofilm and anti-virulence activities of trans-resveratrol and oxyresveratrol against uropathogenic Escherichia coli.
Biofouling.
2019 08; 35(7):758-767. doi:
10.1080/08927014.2019.1657418. [PMID: 31505984] - Yanbin Su, Chengyu Sun, Yan Chen, Shichang Liu, Ning Jing, Shuxin Li. Toxic trans-crotonaldehyde in mitochondria intercepted by oxyresveratrol contributing to anticancer.
IUBMB life.
2019 07; 71(7):1014-1020. doi:
10.1002/iub.2051. [PMID: 31012998] - Annick D van den Brand, Judith Villevoye, Sandra M Nijmeijer, Martin van den Berg, Majorie B M van Duursen. Anti-tumor properties of methoxylated analogues of resveratrol in malignant MCF-7 but not in non-tumorigenic MCF-10A mammary epithelial cell lines.
Toxicology.
2019 06; 422(?):35-43. doi:
10.1016/j.tox.2019.04.009. [PMID: 31004704] - Xin Hu, Yuanyuan Liang, Bo Zhao, Yongyi Wang. Oxyresveratrol protects human lens epithelial cells against hydrogen peroxide-induced oxidative stress and apoptosis by activation of Akt/HO-1 pathway.
Journal of pharmacological sciences.
2019 Mar; 139(3):166-173. doi:
10.1016/j.jphs.2019.01.003. [PMID: 30709701] - Rao Salman Aziz, Arfah Siddiqua, Muhammad Shahzad, Arham Shabbir, Nadia Naseem. Oxyresveratrol ameliorates ethanol-induced gastric ulcer via downregulation of IL-6, TNF-α, NF-ĸB, and COX-2 levels, and upregulation of TFF-2 levels.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Feb; 110(?):554-560. doi:
10.1016/j.biopha.2018.12.002. [PMID: 30530291] - Yumena Suzuki, Chawanphat Muangnoi, Wuttinont Thaweesest, Polsak Teerawonganan, Pahweenvaj Ratnatilaka Na Bhuket, Varin Titapiwatanakun, Mika Yoshimura-Fujii, Boonchoo Sritularak, Kittisak Likhitwitayawuid, Pornchai Rojsitthisak, Toshiro Fukami. Exploring Novel Cocrystalline Forms of Oxyresveratrol to Enhance Aqueous Solubility and Permeability across a Cell Monolayer.
Biological & pharmaceutical bulletin.
2019; 42(6):1004-1012. doi:
10.1248/bpb.b19-00048. [PMID: 31155574] - Chadathorn Inyai, Panitch Boonsnongcheep, Jukrapun Komaikul, Boonchoo Sritularak, Hiroyuki Tanaka, Waraporn Putalun. Alginate immobilization of Morus alba L. cell suspension cultures improved the accumulation and secretion of stilbenoids.
Bioprocess and biosystems engineering.
2019 Jan; 42(1):131-141. doi:
10.1007/s00449-018-2021-1. [PMID: 30284036] - Jin Hee Choi, No-Joon Song, A Reum Lee, Dong Ho Lee, Min-Ju Seo, Suji Kim, Seo-Hyuk Chang, Dong Kwon Yang, Yu-Jin Hwang, Kyung-A Hwang, Tal Soo Ha, Ui Jeong Yun, Kye Won Park. Oxyresveratrol Increases Energy Expenditure through Foxo3a-Mediated Ucp1 Induction in High-Fat-Diet-Induced Obese Mice.
International journal of molecular sciences.
2018 Dec; 20(1):. doi:
10.3390/ijms20010026. [PMID: 30577593] - Zhuoheng Zhong, Wei Zhu, Shengzhi Liu, Qijie Guan, Xi Chen, Wei Huang, Tantan Wang, Bingxian Yang, Jingkui Tian. Molecular Characterization of a Geranyl Diphosphate-Specific Prenyltransferase Catalyzing Stilbenoid Prenylation from Morus alba.
Plant & cell physiology.
2018 Nov; 59(11):2214-2227. doi:
10.1093/pcp/pcy138. [PMID: 30020500] - Suhyun Kim, Dong Gun Lee. Oxyresveratrol-induced DNA cleavage triggers apoptotic response in Candida albicans.
Microbiology (Reading, England).
2018 09; 164(9):1112-1121. doi:
10.1099/mic.0.000696. [PMID: 30024372] - Dahyun Hwang, HyunA Jo, Seong-Ho Ma, Young-Hee Lim. Oxyresveratrol stimulates mucin production in an NAD+-dependent manner in human intestinal goblet cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2018 Aug; 118(?):880-888. doi:
10.1016/j.fct.2018.06.039. [PMID: 29935245] - Kyung Taek Heo, Byeongsan Lee, Sangkeun Son, Jong Seog Ahn, Jae-Hyuk Jang, Young-Soo Hong. Production of Bioactive 3'-Hydroxystilbene Compounds Using the Flavin-Dependent Monooxygenase Sam5.
Journal of microbiology and biotechnology.
2018 Jul; 28(7):1105-1111. doi:
10.4014/jmb.1804.04007. [PMID: 30021423] - Yaowaporn Sangsen, Thongchai Sooksawate, Kittisak Likhitwitayawuid, Boonchoo Sritularak, Ruedeekorn Wiwattanapatapee. A Self-Microemulsifying Formulation of Oxyresveratrol Prevents Amyloid Beta Protein-Induced Neurodegeneration in Mice.
Planta medica.
2018 Jul; 84(11):820-828. doi:
10.1055/s-0043-125337. [PMID: 29301146] - Ju-Hee Lee, Su Youn Baek, Eun Jeong Jang, Sae Kwang Ku, Kyu Min Kim, Sung Hwan Ki, Chang-Eop Kim, Kwang Il Park, Sang Chan Kim, Young Woo Kim. Oxyresveratrol ameliorates nonalcoholic fatty liver disease by regulating hepatic lipogenesis and fatty acid oxidation through liver kinase B1 and AMP-activated protein kinase.
Chemico-biological interactions.
2018 Jun; 289(?):68-74. doi:
10.1016/j.cbi.2018.04.023. [PMID: 29702089] - Hongmei Du, Lili Ma, Guangdong Chen, Shan Li. The effects of oxyresveratrol abrogates inflammation and oxidative stress in rat model of spinal cord injury.
Molecular medicine reports.
2018 03; 17(3):4067-4073. doi:
10.3892/mmr.2017.8294. [PMID: 29257323] - Ya-Nan Jia, Hai-Peng Lu, Ya-Lin Peng, Bao-Shun Zhang, Xiao-Bao Gong, Jun Su, You Zhou, Min-Hui Pan, Li Xu. Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
International immunopharmacology.
2018 Mar; 56(?):105-112. doi:
10.1016/j.intimp.2018.01.014. [PMID: 29414639] - Yuanqi Liu, Wei Ren, Yang Bai, Lihong Wan, Xiaodong Sun, Yin Liu, Wenbi Xiong, Yuan-Yuan Zhang, Liming Zhou. Oxyresveratrol prevents murine H22 hepatocellular carcinoma growth and lymph node metastasis via inhibiting tumor angiogenesis and lymphangiogenesis.
Journal of natural medicines.
2018 Mar; 72(2):481-492. doi:
10.1007/s11418-018-1173-2. [PMID: 29350326] - Mounir Maafi, Mohammed Ahmed Al-Qarni. Φ-order spectrophotokinetic characterisation and quantification of trans-cis oxyresveratrol reactivity, photodegradation and actinometry.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2018 Jan; 188(?):64-71. doi:
10.1016/j.saa.2017.06.067. [PMID: 28692869] - Yan Wang, Mi-Mi Hao, Ying Sun, Li-Feng Wang, Hao Wang, Yan-Jun Zhang, Hong-Yan Li, Peng-Wei Zhuang, Zhen Yang. Synergistic Promotion on Tyrosinase Inhibition by Antioxidants.
Molecules (Basel, Switzerland).
2018 Jan; 23(1):. doi:
10.3390/molecules23010106. [PMID: 29300356] - Hai-Peng Lu, Ya-Nan Jia, Ya-Lin Peng, Yan Yu, Si-Long Sun, Meng-Ting Yue, Min-Hui Pan, Ling-Shu Zeng, Li Xu. Oxyresveratrol, a Stilbene Compound from Morus alba L. Twig Extract Active Against Trichophyton rubrum.
Phytotherapy research : PTR.
2017 Dec; 31(12):1842-1848. doi:
10.1002/ptr.5926. [PMID: 29024160] - Jianfei He, Zong-Ping Zheng, Qin Zhu, Fengxian Guo, Jie Chen. Encapsulation Mechanism of Oxyresveratrol by β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin and Computational Analysis.
Molecules (Basel, Switzerland).
2017 Oct; 22(11):. doi:
10.3390/molecules22111801. [PMID: 29088059] - HyunA Jo, Dahyun Hwang, Jeong-Keun Kim, Young-Hee Lim. Oxyresveratrol improves tight junction integrity through the PKC and MAPK signaling pathways in Caco-2 cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2017 Oct; 108(Pt A):203-213. doi:
10.1016/j.fct.2017.08.002. [PMID: 28780155] - Jing Wei, Jing-Rui Chen, Eva Maria Arriero Pais, Tai-Yi Wang, Lin Miao, Lan Li, Ling-Yan Li, Feng Qiu, Li-Min Hu, Xiu-Mei Gao, Guan-Wei Fan. Oxyresveratrol Is a Phytoestrogen Exerting Anti-inflammatory Effects Through NF-κB and Estrogen Receptor Signaling.
Inflammation.
2017 Aug; 40(4):1285-1296. doi:
10.1007/s10753-017-0572-y. [PMID: 28484893] - Tharita Kitisripanya, Chadathorn Inyai, Supaluk Krittanai, Kittisak Likhitwitayawuid, Boonchoo Sritularak, Poonsakdi Ploypradith, Hiroyuki Tanaka, Satoshi Morimoto, Waraporn Putalun. A monoclonal antibody-based immunoassay for the determination of oxyresveratrol from Artocarpus lacucha Buch.-Ham.
Journal of natural medicines.
2017 Jul; 71(3):523-530. doi:
10.1007/s11418-017-1083-8. [PMID: 28364228] - Hui Yuan Tan, Iris Mei Ying Tse, Edmund Tsze Shing Li, Mingfu Wang. Oxyresveratrol Supplementation to C57bl/6 Mice Fed with a High-Fat Diet Ameliorates Obesity-Associated Symptoms.
Nutrients.
2017 Feb; 9(2):. doi:
10.3390/nu9020147. [PMID: 28212343] - Md Ataur Rahman, Kausik Bishayee, Ali Sadra, Sung-Oh Huh. Oxyresveratrol activates parallel apoptotic and autophagic cell death pathways in neuroblastoma cells.
Biochimica et biophysica acta. General subjects.
2017 Feb; 1861(2):23-36. doi:
10.1016/j.bbagen.2016.10.025. [PMID: 27815218] - Dahyun Hwang, HyunA Jo, Seonwook Hwang, Jeong-Keun Kim, In-Ho Kim, Young-Hee Lim. Conditioned medium from LS 174T goblet cells treated with oxyresveratrol strengthens tight junctions in Caco-2 cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Jan; 85(?):280-286. doi:
10.1016/j.biopha.2016.11.022. [PMID: 27876210] - Jianfei He, Qin Zhu, Xue Dong, Hongyang Pan, Jie Chen, Zong-Ping Zheng. Oxyresveratrol and ascorbic acid O/W microemulsion: Preparation, characterization, anti-isomerization and potential application as antibrowning agent on fresh-cut lotus root slices.
Food chemistry.
2017 Jan; 214(?):269-276. doi:
10.1016/j.foodchem.2016.07.095. [PMID: 27507475] - Yun-Chong Zheng, Hao He, Xing Wei, Sheng Ge, Yan-Hua Lu. Comparison of Regulation Mechanisms of Five Mulberry Ingredients on Insulin Secretion under Oxidative Stress.
Journal of agricultural and food chemistry.
2016 Nov; 64(46):8763-8772. doi:
10.1021/acs.jafc.6b03845. [PMID: 27802600] - Jiyun Lee, Gayeung Kwon, Jieun Park, Jeong-Keun Kim, Young-Hee Lim. Brief Communication: SIR-2.1-dependent lifespan extension of Caenorhabditis elegans by oxyresveratrol and resveratrol.
Experimental biology and medicine (Maywood, N.J.).
2016 10; 241(16):1757-63. doi:
10.1177/1535370216650054. [PMID: 27190265] - Jiyun Lee, Gayeung Kwon, Jieun Park, Jeong-Keun Kim, Soo Young Choe, Yoonhee Seo, Young-Hee Lim. An ethanol extract of Ramulus mori improves blood circulation by inhibiting platelet aggregation.
Bioscience, biotechnology, and biochemistry.
2016 Jul; 80(7):1410-5. doi:
10.1080/09168451.2016.1156479. [PMID: 26967156] - Nutputsorn Chatsumpun, Taksina Chuanasa, Boonchoo Sritularak, Vimolmas Lipipun, Vichien Jongbunprasert, Somsak Ruchirawat, Poonsakdi Ploypradith, Kittisak Likhitwitayawuid. Oxyresveratrol: Structural Modification and Evaluation of Biological Activities.
Molecules (Basel, Switzerland).
2016 Apr; 21(4):489. doi:
10.3390/molecules21040489. [PMID: 27104505] - Hao He, Wan-Guo Yu, Jun-Peng Yang, Sheng Ge, Yan-Hua Lu. Multiple Comparisons of Glucokinase Activation Mechanisms of Five Mulberry Bioactive Ingredients in Hepatocyte.
Journal of agricultural and food chemistry.
2016 Mar; 64(12):2475-84. doi:
10.1021/acs.jafc.5b02823. [PMID: 26292150] - Yaowaporn Sangsen, Kamonthip Wiwattanawongsa, Kittisak Likhitwitayawuid, Boonchoo Sritularak, Potchanapond Graidist, Ruedeekorn Wiwattanapatapee. Influence of surfactants in self-microemulsifying formulations on enhancing oral bioavailability of oxyresveratrol: Studies in Caco-2 cells and in vivo.
International journal of pharmaceutics.
2016 Feb; 498(1-2):294-303. doi:
10.1016/j.ijpharm.2015.12.002. [PMID: 26680318] - Hee Yoon Choi, Ju-Hee Lee, Kyung Hwan Jegal, Il Je Cho, Young Woo Kim, Sang Chan Kim. Oxyresveratrol abrogates oxidative stress by activating ERK-Nrf2 pathway in the liver.
Chemico-biological interactions.
2016 Feb; 245(?):110-21. doi:
10.1016/j.cbi.2015.06.024. [PMID: 26102008] - Narin Preyavichyapugdee, Manaw Sangfuang, Saowapark Chaiyapum, Suwatcharaporn Sriburin, Yupa Pootaeng-on, Phiraphol Chusongsang, Wannee Jiraungkoorskul, Mananya Preyavichyapugdee, Prasert Sobhon. SCHISTOSOMICIDAL ACTIVITY OF THE CRUDE EXTRACT OF ARTOCARPUS LAKOOCHA.
The Southeast Asian journal of tropical medicine and public health.
2016 Jan; 47(1):1-15. doi:
. [PMID: 27086420] - Muhammad Imran Ashraf, Muhammad Shahzad, Arham Shabbir. Oxyresveratrol ameliorates allergic airway inflammation via attenuation of IL-4, IL-5, and IL-13 expression levels.
Cytokine.
2015 Dec; 76(2):375-381. doi:
10.1016/j.cyto.2015.09.013. [PMID: 26431781] - Ji-Yang Sheng, Tong-Tong Chen, Xiao-Juan Tan, Ting Chen, Ai-Qun Jia. The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship.
Bioorganic & medicinal chemistry letters.
2015 Nov; 25(22):5217-20. doi:
10.1016/j.bmcl.2015.09.064. [PMID: 26453007] - Carmen Vanessa Ortiz-Ruiz, Manuel Ballesta de Los Santos, Jose Berna, Jose Fenoll, Pedro Antonio Garcia-Ruiz, Jose Tudela, Francisco Garcia-Canovas. Kinetic characterization of oxyresveratrol as a tyrosinase substrate.
IUBMB life.
2015 Nov; 67(11):828-36. doi:
10.1002/iub.1439. [PMID: 26450473] - H S Lee, D H Kim, J E Hong, J-Y Lee, E J Kim. Oxyresveratrol suppresses lipopolysaccharide-induced inflammatory responses in murine macrophages.
Human & experimental toxicology.
2015 Aug; 34(8):808-18. doi:
10.1177/0960327114559989. [PMID: 25425548] - Yaowaporn Sangsen, Kamonthip Wiwattanawongsa, Kittisak Likhitwitayawuid, Boonchoo Sritularak, Ruedeekorn Wiwattanapatapee. Modification of oral absorption of oxyresveratrol using lipid based nanoparticles.
Colloids and surfaces. B, Biointerfaces.
2015 Jul; 131(?):182-90. doi:
10.1016/j.colsurfb.2015.04.055. [PMID: 25988282] - Dae-Ki Joung, Sung-Hoon Choi, Ok-Hwa Kang, Sung-Bae Kim, Su-Hyun Mun, Yun-Soo Seo, Da-Hye Kang, Ryong Gong, Dong-Won Shin, Youn-Chul Kim, Dong-Yeul Kwon. Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus.
Molecular medicine reports.
2015 Jul; 12(1):663-7. doi:
10.3892/mmr.2015.3345. [PMID: 25683461] - Ji Yeon Jeong, Yang Hee Jo, Seon Beom Kim, Qing Liu, Jin Woo Lee, Eun Jin Mo, Ki Yong Lee, Bang Yeon Hwang, Mi Kyeong Lee. Pancreatic lipase inhibitory constituents from Morus alba leaves and optimization for extraction conditions.
Bioorganic & medicinal chemistry letters.
2015 Jun; 25(11):2269-74. doi:
10.1016/j.bmcl.2015.04.045. [PMID: 25935644] - Wen-fang Yi, Jia-bing Peng, Gang Ren, Wei Jiang, Jian Liang, Wen-jun Yuan. [Chemical Constitutes from Root of Artocarpus styracifolius].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2015 May; 38(5):972-4. doi:
. [PMID: 26767289] - Shuting Hu, Feng Chen, Mingfu Wang. Photoprotective effects of oxyresveratrol and Kuwanon O on DNA damage induced by UVA in human epidermal keratinocytes.
Chemical research in toxicology.
2015 Mar; 28(3):541-8. doi:
10.1021/tx500497u. [PMID: 25588103] - Jiaa Park, Joon Heum Park, Hwa-Jin Suh, In Chul Lee, Jaesook Koh, Yong Chool Boo. Effects of resveratrol, oxyresveratrol, and their acetylated derivatives on cellular melanogenesis.
Archives of dermatological research.
2014 Jul; 306(5):475-87. doi:
10.1007/s00403-014-1440-3. [PMID: 24414332] - So-Ra Yoon, Seung-Hwan Yang, Joo-Won Suh, Soon-Mi Shim. Fermentation of Smilax china root by Aspergillus usami and Saccharomyces cerevisiae promoted concentration of resveratrol and oxyresveratrol and the free-radical scavenging activity.
Journal of the science of food and agriculture.
2014 Jul; 94(9):1822-6. doi:
10.1002/jsfa.6499. [PMID: 24919869] - Sung-Pil Jo, Jeong-Keun Kim, Young-Hee Lim. Antihyperlipidemic effects of stilbenoids isolated from Morus alba in rats fed a high-cholesterol diet.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2014 Mar; 65(?):213-8. doi:
10.1016/j.fct.2013.12.040. [PMID: 24407019] - Diana C Rueda, Angela Schöffmann, Maria De Mieri, Melanie Raith, Evelyn A Jähne, Steffen Hering, Matthias Hamburger. Identification of dihydrostilbenes in Pholidota chinensis as a new scaffold for GABAA receptor modulators.
Bioorganic & medicinal chemistry.
2014 Feb; 22(4):1276-84. doi:
10.1016/j.bmc.2014.01.008. [PMID: 24462176] - Nan Hu, Mei Mei, Jianqing Ruan, Wenjin Wu, Yitao Wang, Ru Yan. Regioselective glucuronidation of oxyresveratrol, a natural hydroxystilbene, by human liver and intestinal microsomes and recombinant UGTs.
Drug metabolism and pharmacokinetics.
2014; 29(3):229-36. doi:
10.2133/dmpk.dmpk-13-rg-102. [PMID: 24256624] - Ghada M Abbas, Fatma M Abdel Bar, Hany N Baraka, Ahmed A Gohar, Mohammed-Farid Lahloub. A new antioxidant stilbene and other constituents from the stem bark of Morus nigra L.
Natural product research.
2014; 28(13):952-9. doi:
10.1080/14786419.2014.900770. [PMID: 24673367] - Wei-Xin Wang, Jing-Yi Qian, Xiao-Jing Wang, Ai-Ping Jiang, Ai-Qun Jia. Anti-HIV-1 activities of extracts and phenolics from Smilax china L.
Pakistan journal of pharmaceutical sciences.
2014 Jan; 27(1):147-51. doi:
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Journal of investigative and clinical dentistry.
2013 Nov; 4(4):219-24. doi:
10.1111/jicd.12056. [PMID: 23857911] - Peng Zhao, Shang-Ke Chen, Ying-Hong Cai, Xiao Lu, Zhe Li, Yuen-Kit Cheng, Cuixian Zhang, Xiaopeng Hu, Xixin He, Hai-Bin Luo. The molecular basis for the inhibition of phosphodiesterase-4D by three natural resveratrol analogs. Isolation, molecular docking, molecular dynamics simulations, binding free energy, and bioassay.
Biochimica et biophysica acta.
2013 Oct; 1834(10):2089-96. doi:
10.1016/j.bbapap.2013.07.004. [PMID: 23871879] - J Hur, S Kim, P Lee, Y M Lee, S Y Choi. The protective effects of oxyresveratrol imine derivative against hydrogen peroxide-induced cell death in PC12 cells.
Free radical research.
2013 Mar; 47(3):212-8. doi:
10.3109/10715762.2012.762769. [PMID: 23298159] - Yi-Ching Chen, Yin-Jing Tien, Chun-Houh Chen, Francesca N Beltran, Evangeline C Amor, Ran-Juh Wang, Den-Jen Wu, Clément Mettling, Yea-Lih Lin, Wen-Chin Yang. Morus alba and active compound oxyresveratrol exert anti-inflammatory activity via inhibition of leukocyte migration involving MEK/ERK signaling.
BMC complementary and alternative medicine.
2013 Feb; 13(?):45. doi:
10.1186/1472-6882-13-45. [PMID: 23433072] - Jin Zhou, Shun-xiang Li, Wei Wang, Xiao-yi Guo, Xiang-Yang Lu, Xin-pei Yan, Dan Huang, Bao-yang Wei, Liang Cao. Variations in the levels of mulberroside A, oxyresveratrol, and resveratrol in mulberries in different seasons and during growth.
TheScientificWorldJournal.
2013; 2013(?):380692. doi:
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