4-Hydroxy-3-methoxybenzenemethanol (BioDeep_00000000865)

 

Secondary id: BioDeep_00000419612, BioDeep_00000861607

human metabolite PANOMIX_OTCML-2023 Endogenous Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


2-Pyridinecarboxylicacid, 6-amino-3-bromo-, methyl ester

化学式: C8H10O3 (154.062991)
中文名称: 4-羟基-3-甲氧基苯甲醇, 4-羟基-3-甲氧基苄醇
谱图信息: 最多检出来源 Viridiplantae(plant) 0.78%

分子结构信息

SMILES: COC1=C(C=CC(=C1)CO)O
InChI: InChI=1S/C8H10O3/c1-11-8-4-6(5-9)2-3-7(8)10/h2-4,9-10H,5H2,1H3

描述信息

4-Hydroxy-3-methoxybenzenemethanol, also known as 4-hydroxy-3-methoxybenzyl alcohol or 3-methoxy-4-hydroxybenzyl alcohol, belongs to the class of organic compounds known as methoxyphenols. Methoxyphenols are compounds containing a methoxy group attached to the benzene ring of a phenol moiety. 4-Hydroxy-3-methoxybenzenemethanol is a drug. 4-Hydroxy-3-methoxybenzenemethanol is a sweet, anise, and balsam tasting compound. 4-hydroxy-3-methoxybenzenemethanol has been detected, but not quantified, in fruits and herbs and spices. This could make 4-hydroxy-3-methoxybenzenemethanol a potential biomarker for the consumption of these foods.
Vanillyl alcohol is a monomethoxybenzene that is 2-methoxyphenol substituted by a hydroxymethyl group at position 4. It has a role as a plant metabolite. It is a member of guaiacols and a member of benzyl alcohols.
Vanillyl alcohol has been used in trials studying the treatment of Smoking.
Vanillyl alcohol is a natural product found in Artemisia rutifolia, Euglena gracilis, and other organisms with data available.
Constituent of Capsicum subspecies; flavouring ingredient. 4-Hydroxy-3-methoxybenzenemethanol is found in herbs and spices and fruits.
A monomethoxybenzene that is 2-methoxyphenol substituted by a hydroxymethyl group at position 4.
Vanillyl alcohol (p-(Hydroxymethyl)guaiacol), derived from vanillin, is a phenolic alcohol and is used as a flavoring agent in foods and beverages[1].
Vanillyl alcohol (p-(Hydroxymethyl)guaiacol), derived from vanillin, is a phenolic alcohol and is used as a flavoring agent in foods and beverages[1].

同义名列表

37 个代谢物同义名

2-Pyridinecarboxylicacid, 6-amino-3-bromo-, methyl ester; 4-(hydroxymethyl)-2-methoxy-phenol;Vanillyl Alcohol; 4-HYDROXY-3-METHOXYBENZYLALCOHOL(VANILLICALCOHOL); 4-Hydroxy-3-methoxybenzenemethanol, 9CI; 4-Hydroxy-3-methoxybenzyl alcohol, 98\\%; Vanillyl alcohol, analytical standard; Benzenemethanol, 4-hydroxy-3-methoxy-; 4-(Hydroxymethyl)-2-methoxyphenol #; 4-Hydroxy-3-methoxy-benzenemethanol; 4-HYDROXY-3-METHOXY-BENZYL ALCOHOL; 4-Hydroxy-3-methoxybenzenemethanol; 4-Hydroxy-3-methoxyphenyl methanol; 4-(hydroxymethyl)-2-methoxy-phenol; 4-(Hydroxymethyl)-2-methoxyphenol; 4-hidroxy-3-methoxybenzyl alcohol; 4-Hydroxy-3-methoxyphenylmethanol; 3-Methoxy-4-hydroxybenzyl alcohol; 4-Hydroxy-3-methoxybenzyl alcohol; 4-Hydroxy-3-methyl benzyl alcohol; 4-hydroxymethyl-2-methoxyphenol; a,4-Dihydroxy-3-methoxytoluene; Vanillyl alcohol, >=98\\%, FG; VANILLYL ALCOHOL [FHFI]; Vanillic alcohol; Vanillyl alcohol; Vanillin alcohol; V 0018 (Alcohol); VANILLYL-ALCOHOL; UNII-X7EA1JUA6M; vanillylalcohol; Oprea1_448599; X7EA1JUA6M; AI3-24186; FEMA 3737; vanillol; p-(Hydroxymethyl)guaiacol; Vanillyl alcohol



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

16 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yousun Lee, Sujin Lee, Sungjun Kim, Dogyeong Lee, Keehoon Won. Solvent-free enzymatic synthesis and evaluation of vanillyl propionate as an effective and biocompatible preservative. Bioprocess and biosystems engineering. 2023 Sep; ?(?):. doi: 10.1007/s00449-023-02921-1. [PMID: 37682355]
  • Ruijian Li, Sang Jae Rhee, Soochan Bae, Shi Su, Chang-Sun Kang, Qingen Ke, Ye Eun Koo, Chloe Ryu, Chul Gyu Song, Dongwon Lee, Peter M Kang. H2O2-Responsive Antioxidant Nanoparticle Attenuates Whole Body Ischemia/Reperfusion-Induced Multi-Organ Damages. Journal of cardiovascular pharmacology and therapeutics. 2021 05; 26(3):279-288. doi: 10.1177/1074248420969571. [PMID: 33111565]
  • Yoshiyuki Tanaka, Takaya Asano, Yorika Kanemitsu, Tanjuro Goto, Yuichi Yoshida, Kenichiro Yasuba, Yuki Misawa, Sachie Nakatani, Kenji Kobata. Positional differences of intronic transposons in pAMT affect the pungency level in chili pepper through altered splicing efficiency. The Plant journal : for cell and molecular biology. 2019 11; 100(4):693-705. doi: 10.1111/tpj.14462. [PMID: 31323150]
  • Juan Antonio Méndez-Líter, Isabel Tundidor, Manuel Nieto-Domínguez, Beatriz Fernández de Toro, Andrés González Santana, Laura Isabel de Eugenio, Alicia Prieto, Juan Luis Asensio, Francisco Javier Cañada, Cristina Sánchez, María Jesús Martínez. Transglycosylation products generated by Talaromyces amestolkiae GH3 β-glucosidases: effect of hydroxytyrosol, vanillin and its glucosides on breast cancer cells. Microbial cell factories. 2019 May; 18(1):97. doi: 10.1186/s12934-019-1147-4. [PMID: 31151435]
  • Jovana Trbojević Ivić, Nenad Milosavić, Aleksandra Dimitrijević, Marija Gavrović Jankulović, Dejan Bezbradica, Dušan Kolarski, Dušan Veličković. Synthesis of medium-chain length capsinoids from coconut oil catalyzed by Candida rugosa lipases. Food chemistry. 2017 Mar; 218(?):505-508. doi: 10.1016/j.foodchem.2016.09.049. [PMID: 27719942]
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  • Kenji Kobata, Mai Sugawara, Makoto Mimura, Susumu Yazawa, Tatsuo Watanabe. Potent production of capsaicinoids and capsinoids by Capsicum peppers. Journal of agricultural and food chemistry. 2013 Nov; 61(46):11127-32. doi: 10.1021/jf403553w. [PMID: 24147886]
  • William J Hunter, Daniel K Manter, Daniel van der Lelie. Biotransformation of ferulic acid to 4-vinylguaiacol by Enterobacter soli and E. aerogenes. Current microbiology. 2012 Dec; 65(6):752-7. doi: 10.1007/s00284-012-0222-4. [PMID: 22986816]
  • Daisuke Sato, Yuki Eshita, Hisashi Katsuragi, Hiroki Hamada, Kei Shimoda, Naoji Kubota. Glycosylation of vanillin and 8-nordihydrocapsaicin by cultured Eucalyptus perriniana cells. Molecules (Basel, Switzerland). 2012 May; 17(5):5013-20. doi: 10.3390/molecules17055013. [PMID: 22552154]
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  • Kiki L Larsen, Søren Barsberg. Environmental effects on the lignin model monomer, vanillyl alcohol, studied by Raman spectroscopy. The journal of physical chemistry. B. 2011 Oct; 115(39):11470-80. doi: 10.1021/jp203910h. [PMID: 21830768]
  • Betty Mbatia, Shiva Shanker Kaki, Bo Mattiasson, Francis Mulaa, Patrick Adlercreutz. Enzymatic synthesis of lipophilic rutin and vanillyl esters from fish byproducts. Journal of agricultural and food chemistry. 2011 Jul; 59(13):7021-7. doi: 10.1021/jf200867r. [PMID: 21630661]
  • E-J Shin, J-H Bach, T-T L Nguyen, X-K T Nguyen, B-D Jung, K-W Oh, M J Kim, S K Ko, C G Jang, S F Ali, H-C Kim. Gastrodia elata bl attenuates methamphetamine-induced dopaminergic toxicity via inhibiting oxidative burdens. Current neuropharmacology. 2011 Mar; 9(1):118-21. doi: 10.2174/157015911795016967. [PMID: 21886575]
  • Kunduru K Reddy, Thumu Ravinder, Rachapudi B N Prasad, Sanjit Kanjilal. Evaluation of the antioxidant activity of capsiate analogues in polar, nonpolar, and micellar media. Journal of agricultural and food chemistry. 2011 Jan; 59(2):564-9. doi: 10.1021/jf104244m. [PMID: 21166418]
  • Kenji Kobata, Makoto Mimura, Mai Sugawara, Tatsuo Watanabe. Synthesis of stable isotope-labeled precursors for the biosyntheses of capsaicinoids, capsinoids, and capsiconinoids. Bioscience, biotechnology, and biochemistry. 2011; 75(8):1611-4. doi: 10.1271/bbb.110187. [PMID: 21821932]
  • Akihiro Tai, Takeshi Sawano, Futoshi Yazama. Antioxidant properties of ethyl vanillin in vitro and in vivo. Bioscience, biotechnology, and biochemistry. 2011; 75(12):2346-50. doi: 10.1271/bbb.110524. [PMID: 22146718]
  • Andrea R Josse, Scott S Sherriffs, Andrew M Holwerda, Richard Andrews, Aaron W Staples, Stuart M Phillips. Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise. Nutrition & metabolism. 2010 Aug; 7(?):65. doi: 10.1186/1743-7075-7-65. [PMID: 20682072]
  • Yuka Koike, Motonori Fukumura, Yasuaki Hirai, Yumiko Hori, Shiho Usui, Toshiyuki Atsumi, Kazuo Toriizuka. Novel phenolic glycosides, adenophorasides A-E, from Adenophora roots. Journal of natural medicines. 2010 Jul; 64(3):245-51. doi: 10.1007/s11418-010-0398-5. [PMID: 20229365]
  • Yoshiaki Shirai, Satoko Ueno, Akira Nakayama, Kiyoko Ikeuchi, Kazuyuki Ubukata, Ryuichi Mihara, Bruce K Bernard. Studies of the toxicological potential of capsinoids, XII: pharmacokinetic study of capsinoid-containing CH-19 Sweet extract in rats. International journal of toxicology. 2010 Mar; 29(2 Suppl):15S-21S. doi: 10.1177/1091581809359427. [PMID: 20388820]
  • Bruce K Bernard, Kazuyuki Ubukata, Ryuichi Mihara, Yoshiaki Sato, Hiroyuki Nemoto. Studies of the toxicological potential of capsinoids, XI: pharmacokinetic and tissue distribution study of 14C-dihydrocapsiate and metabolites in rats. International journal of toxicology. 2010 Mar; 29(2 Suppl):3S-14S. doi: 10.1177/1091581809357082. [PMID: 20388819]
  • Young Woon Jang, Ji Yun Lee, Chang Jong Kim. Anti-asthmatic activity of phenolic compounds from the roots of Gastrodia elata Bl. International immunopharmacology. 2010 Feb; 10(2):147-54. doi: 10.1016/j.intimp.2009.10.009. [PMID: 19874915]
  • Yaqin Lang, Hiroaki Kisaka, Ryuji Sugiyama, Kenzo Nomura, Akihito Morita, Tatsuo Watanabe, Yoshiyuki Tanaka, Susumu Yazawa, Tetsuya Miwa. Functional loss of pAMT results in biosynthesis of capsinoids, capsaicinoid analogs, in Capsicum annuum cv. CH-19 Sweet. The Plant journal : for cell and molecular biology. 2009 Sep; 59(6):953-61. doi: 10.1111/j.1365-313x.2009.03921.x. [PMID: 19473323]
  • Kriengsak Lirdprapamongkol, Jan-Peter Kramb, Tuangporn Suthiphongchai, Rudee Surarit, Chantragan Srisomsap, Gerd Dannhardt, Jisnuson Svasti. Vanillin suppresses metastatic potential of human cancer cells through PI3K inhibition and decreases angiogenesis in vivo. Journal of agricultural and food chemistry. 2009 Apr; 57(8):3055-63. doi: 10.1021/jf803366f. [PMID: 19368348]
  • Antonella Rosa, Angela Atzeri, Monica Deiana, M Paola Melis, Alessandra Incani, Giulia Corona, Debora Loru, Giovanni Appendino, M Assunta Dessì. Protective effect of vanilloids against tert-butyl hydroperoxide-induced oxidative stress in vero cells culture. Journal of agricultural and food chemistry. 2008 May; 56(10):3546-53. doi: 10.1021/jf073448t. [PMID: 18439017]
  • Chin Chye Teo, Swee Ngin Tan, Jean Wan Hong Yong, Choy Sin Hew, Eng Shi Ong. Evaluation of the extraction efficiency of thermally labile bioactive compounds in Gastrodia elata Blume by pressurized hot water extraction and microwave-assisted extraction. Journal of chromatography. A. 2008 Feb; 1182(1):34-40. doi: 10.1016/j.chroma.2008.01.011. [PMID: 18206897]
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  • Tae-Young Jung, Seong-Il Suh, Hyung Lee, In-Soo Kim, Hyun-Joo Kim, Ho-Sang Yoo, Seong-Ryong Lee. Protective effects of several components of Gastrodia elata on lipid peroxidation in gerbil brain homogenates. Phytotherapy research : PTR. 2007 Oct; 21(10):960-4. doi: 10.1002/ptr.2193. [PMID: 17604371]
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