Daphnetol (BioDeep_00000863712)
Main id: BioDeep_00000400386
PANOMIX_OTCML-2023
代谢物信息卡片
InChI=1/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12
化学式: C9H6O4 (178.0266)
中文名称: 瑞香素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C2=C1C=CC(=O)O2)O)O
InChI: InChI=1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H
描述信息
7,8-dihydroxycoumarin is a hydroxycoumarin.
Daphnetin is a natural product found in Euphorbia dracunculoides, Rhododendron lepidotum, and other organisms with data available.
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1?, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research[1][2][3][4].
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1?, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research[1][2][3][4].
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1?, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research[1][2][3][4].
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1?, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research[1][2][3][4].
同义名列表
54 个代谢物同义名
InChI=1/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12; 5-18-03-00211 (Beilstein Handbook Reference); 2H-1-Benzopyran-2-one, 7,8-dihydroxy-; 7,8-Dihydroxycoumarin, >=97\\%, powder; 7,8-dihydroxy-2H-1-benzopyran-2-one; 7,8-DIHYDROXY-2H-BENZOPYRAN-2-ONE; 7,8-Dihydroxy-2H-chromen-2-one #; 7,8-Dihydroxy-2H-chromen-2-one; 7,8-Dihydroxycoumarin, 90\\%; ATEFPOUAMCWAQS-UHFFFAOYSA-N; 7,8-DIHYDROXY-CHROMEN-2-ONE; 7,8-dihydroxychromen-2-one; COUMARIN, 7,8-DIHYDROXY-; 7,8-dihydroxy-coumarin; 1,8-Dihydroxycoumarin; 7,8-Dihydroxycoumarin; Spectrum3_000784; DAPHNETIN [INCI]; Spectrum4_001254; DAPHNETIN [MI]; Oprea1_044324; DivK1c_006960; Lopac0_000330; KBio1_001904; HSCI1_000053; Tox21_500330; KBio3_001708; Daphnetol; Daphnetin; InChI=1\C9H6O4\c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12\h1-4,10,12; 2H-1-Benzopyran-2-one, 7,8-dihydroxy- (9CI); 7,8-dihydroxy-2-chromenone; EINECS 207-632-8; NCGC00015349-01; SpecPlus_000864; 630764_ALDRICH; BSPBio_002488; KBioGR_001808; ZINC00057753; Lopac-D-5564; BRN 0009372; CHEBI:17313; D5564_SIGMA; AIDS-026334; AIDS026334; NSC 633563; EU-0100330; EU-0000106; ST5308908; NSC633563; 486-35-1; C03093; 7,8-Dihydroxycoumarin; Daphnetin
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:17313
- KEGG: C03093
- PubChem: 5280569
- ChEMBL: CHEMBL244948
- MeSH: daphnetin
- ChemIDplus: 0000486351
- chemspider: 4444191
- CAS: 486-35-1
- medchemexpress: HY-N0281
- MetaboLights: MTBLC17313
- PubChem: 5991
- KNApSAcK: C00002462
- 3DMET: B00541
- NIKKAJI: J6.008I
- KNApSAcK: 17313
分类词条
相关代谢途径
Reactome(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
27 个相关的物种来源信息
- 262982 - Artemisia apiacea: 10.1248/CPB.28.347
- 496566 - Artemisia carvifolia: 10.1248/CPB.28.347
- 1090619 - Ayapana triplinervis: 10.1016/0031-9422(71)85045-8
- 36622 - Chaenomeles Sinensis (Thouin) Koehne: -
- 29785 - Cruciata glabra: 10.1515/ZNC-1996-9-1005
- 2753872 - Daphne acutiloba: 10.1016/S0031-9422(98)00181-2
- 546994 - Daphne bholua: 10.1016/S0367-326X(99)00010-6
- 2753873 - Daphne feddei:
- 224034 - Daphne gnidium:
- 66680 - Daphne mezereum:
- 329675 - Daphne odora:
- 224035 - Daphne oleoides: 10.1016/S0031-9422(99)00305-2
- 2715869 - Daphne papyracea: 10.1248/CPB.34.595
- 885948 - Daphne tangutica:
- 1008446 - Euphorbia dracunculoides: 10.4268/CJCMM20142015
- 526193 - Euphorbia ebracteolata Hayata: -
- 212925 - Euphorbia lathyris L.: -
- 33090 - Plants: -
- 1044962 - Rhododendron lepidotum: 10.1016/J.CCLET.2009.11.015
- 217505 - Sinacalia tangutica:
- 142738 - Stellera chamaejasme:
- 169606 - Tagetes lucida: 10.1021/JF053071W
- 138038 - Vachellia pennatula: 10.1007/S10600-005-0133-8
- 33090 - 千金子: -
- 33090 - 木瓜: -
- 33090 - 芫花: -
- 33090 - 长白瑞香: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tianye Yang, Qian Pan, Rujing Yue, Guanghui Liu, Yuanyuan Zhou. Daphnetin alleviates silica-induced pulmonary inflammation and fibrosis by regulating the PI3K/AKT1 signaling pathway in mice.
International immunopharmacology.
2024 May; 133(?):112004. doi:
10.1016/j.intimp.2024.112004. [PMID: 38613881] - Tianrui Zhang, Wulin Liang, Wenjing Ou, Mingqian Zhang, Shuang Cui, Shuofeng Zhang. Daphnetin alleviates neuropathic pain in chronic constrictive injury rats via regulating the NF-κB dependent CXCL1/CXCR2 signaling pathway.
Pharmaceutical biology.
2023 Dec; 61(1):746-754. doi:
10.1080/13880209.2023.2198560. [PMID: 37177984] - Yao Wang, Liang Yang, Xiao Zhou, Ye Wang, Yijia Liang, Binshao Luo, Yuhao Dai, Zhouling Wei, Shili Li, Rong He, Wei Ding. Molecular mechanism of plant elicitor daphnetin-carboxymethyl chitosan nanoparticles against Ralstonia solanacearum by activating plant system resistance.
International journal of biological macromolecules.
2023 Jun; 241(?):124580. doi:
10.1016/j.ijbiomac.2023.124580. [PMID: 37100321] - Yujie Guo, Huiqing Zhang, Zhe Lv, Yuna Du, Dan Li, Hui Fang, Jing You, Lijun Yu, Rong Li. Up-regulated CD38 by daphnetin alleviates lipopolysaccharide-induced lung injury via inhibiting MAPK/NF-κB/NLRP3 pathway.
Cell communication and signaling : CCS.
2023 Mar; 21(1):66. doi:
10.1186/s12964-023-01041-3. [PMID: 36998049] - Bo Tian, Xin Ma, Rui Jiang. Daphnetin Mitigates Ovalbumin-Induced Allergic Rhinitis in Mice by Regulating Nrf2/HO-1 and TLR4/NF-kB Signaling.
American journal of rhinology & allergy.
2023 Jan; 37(1):19-25. doi:
10.1177/19458924221124363. [PMID: 36128844] - Yi Zhang, Lu Qu, Yun Sun, YuPing Lin, Jing Zeng, LiXia He, Xiucun Li, Wen Gu, Jian Nie, Xiaoling Yu, XiaoYun Tong, Feng Huang. Daphnetin contributes to allergen-induced Th2 cytokine expression and type 2-immune responses in atopic dermatitis and asthma.
Food & function.
2022 Nov; 13(23):12383-12399. doi:
10.1039/d2fo02518c. [PMID: 36373505] - Li Yan, Yufan Jin, Junping Pan, Xiang He, Shiqian Zhong, Rongcai Zhang, LokLam Choi, Weiwei Su, Jiaxu Chen. 7,8-Dihydroxycoumarin Alleviates Synaptic Loss by Activated PI3K-Akt-CREB-BDNF Signaling in Alzheimer's Disease Model Mice.
Journal of agricultural and food chemistry.
2022 Jun; 70(23):7130-7138. doi:
10.1021/acs.jafc.2c02140. [PMID: 35657168] - Abu Mohammad Syed, Sourav Kundu, Chetan Ram, Uttam Kulhari, Akhilesh Kumar, Madhav Nilakanth Mugale, Purusottam Mohapatra, Upadhyayula Suryanarayana Murty, Bidya Dhar Sahu. Up-regulation of Nrf2/HO-1 and inhibition of TGF-β1/Smad2/3 signaling axis by daphnetin alleviates transverse aortic constriction-induced cardiac remodeling in mice.
Free radical biology & medicine.
2022 06; 186(?):17-30. doi:
10.1016/j.freeradbiomed.2022.04.019. [PMID: 35513128] - Peipei Gao, Zhen Wang, Mengyao Lei, Jiaxing Che, Shuangxi Zhang, Tiantian Zhang, Yachong Hu, Le Shi, Li Cui, Jiankang Liu, Mami Noda, Yunhua Peng, Jiangang Long. Daphnetin ameliorates Aβ pathogenesis via STAT3/GFAP signaling in an APP/PS1 double-transgenic mouse model of Alzheimer's disease.
Pharmacological research.
2022 06; 180(?):106227. doi:
10.1016/j.phrs.2022.106227. [PMID: 35452800] - Tianye Yang, Xiaoli Wang, Liang Guo, Fang Zheng, Chun Meng, Yongzheng Zheng, Guanghui Liu. Daphnetin inhibits corneal inflammation and neovascularization on a mouse model of corneal alkali burn.
International immunopharmacology.
2022 Feb; 103(?):108434. doi:
10.1016/j.intimp.2021.108434. [PMID: 34920334] - Liang Yang, Zhouling Wei, Shili Li, Rui Xiao, Qinqin Xu, Yuao Ran, Wei Ding. Plant secondary metabolite, daphnetin reduces extracellular polysaccharides production and virulence factors of Ralstonia solanacearum.
Pesticide biochemistry and physiology.
2021 Nov; 179(?):104948. doi:
10.1016/j.pestbp.2021.104948. [PMID: 34802533] - Houssem Boulebd, Imene Amine Khodja. A detailed DFT-based study of the free radical scavenging activity and mechanism of daphnetin in physiological environments.
Phytochemistry.
2021 Sep; 189(?):112831. doi:
10.1016/j.phytochem.2021.112831. [PMID: 34146991] - Xiaoye Fan, Wenjing Gu, Yun Gao, Ning Ma, Changqing Fan, Xinxin Ci. Daphnetin ameliorated GM-induced renal injury through the suppression of oxidative stress and apoptosis in mice.
International immunopharmacology.
2021 Jul; 96(?):107601. doi:
10.1016/j.intimp.2021.107601. [PMID: 33812255] - Shujun Yang, Yaodong Song, Qiaofang Wang, Yanna Liu, Zhongwei Wu, Xiaojia Duan, Yan Zhang, Xiuqian Bi, Yuanzhang Geng, Sanyang Chen, Changju Zhu. Daphnetin ameliorates acute lung injury in mice with severe acute pancreatitis by inhibiting the JAK2-STAT3 pathway.
Scientific reports.
2021 06; 11(1):11491. doi:
10.1038/s41598-021-91008-6. [PMID: 34075160] - Bo-Cui Song, Meng-Meng Jiang, Shuang Zhang, Hui Ma, Min Liu, Zhong-Ren Fu, Rui Wu, Chun-Yu Tong. Immunosuppressive activity of daphnetin on the humoral immune responses in ovalbumin-sensitized BALB/c mice.
Immunopharmacology and immunotoxicology.
2021 Apr; 43(2):171-175. doi:
10.1080/08923973.2021.1872618. [PMID: 33491523] - Wenru Liu, Jun Mei, Jing Xie. Effect of locust bean gum-sodium alginate coatings incorporated with daphnetin emulsions on the quality of Scophthalmus maximus at refrigerated condition.
International journal of biological macromolecules.
2021 Feb; 170(?):129-139. doi:
10.1016/j.ijbiomac.2020.12.089. [PMID: 33338530] - Yang-Liu Xia, Jing-Jing Wang, Shi-Yang Li, Yong Liu, Frank J Gonzalez, Ping Wang, Guang-Bo Ge. Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment.
Bioorganic & medicinal chemistry.
2021 01; 29(?):115851. doi:
10.1016/j.bmc.2020.115851. [PMID: 33218896] - Yongkui Wang, Jian Chen, Jing Chen, Chao Dong, Xu Yan, Zhongpei Zhu, Pan Lu, Zongmian Song, Hongjian Liu, Songfeng Chen. Daphnetin ameliorates glucocorticoid-induced osteoporosis via activation of Wnt/GSK-3β/β-catenin signaling.
Toxicology and applied pharmacology.
2020 12; 409(?):115333. doi:
10.1016/j.taap.2020.115333. [PMID: 33171191] - Ying Wei, Jian Yang, Meena Kishore Sakharkar, Xia Wang, Qin Liu, Jiang Du, Jing-Jie Zhang. Evaluating the inhibitory effect of eight compounds from Daphne papyracea against the NS3/4A protease of hepatitis C virus.
Natural product research.
2020 Jun; 34(11):1607-1610. doi:
10.1080/14786419.2018.1519825. [PMID: 30449158] - Jing Li, Dongliang Wang, Lei Yi, Ting Li, Miaomiao Wang, Haihui Zhu. [Daphnetin alleviates myocardial ischemia injury in rats through mediating oxidative stress and inhibiting JNK/NF-κB pathway].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2020 Jun; 36(6):513-519. doi:
. [PMID: 32696741] - Zuoxing Wu, Hailun Wu, Chen Li, Fangsheng Fu, Jiaxin Ding, Siyuan Shao, Kai Li, Xiao Yu, Yuangang Su, Jiamin Liang, Xixi Lin, Guixin Yuan, Juan Zhou, Fangming Song, Jinmin Zhao, Jiake Xu, Qian Liu, Feng Xu. Daphnetin attenuates LPS-induced osteolysis and RANKL mediated osteoclastogenesis through suppression of ERK and NFATc1 pathways.
Journal of cellular physiology.
2019 08; 234(10):17812-17823. doi:
10.1002/jcp.28408. [PMID: 30815894] - Yayun Liu, Lu Liao, Yong Chen, Fengmei Han. Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA‑treated HepG2 cells.
Molecular medicine reports.
2019 Jun; 19(6):4673-4684. doi:
10.3892/mmr.2019.10139. [PMID: 30957185] - Xiaohong Lv, Yazhen Li, Qingfei Xiao, Dan Li. Daphnetin activates the Nrf2-dependent antioxidant response to prevent arsenic-induced oxidative insult in human lung epithelial cells.
Chemico-biological interactions.
2019 Apr; 302(?):93-100. doi:
10.1016/j.cbi.2019.02.001. [PMID: 30738023] - Jin Zhi, Bin Duan, Jiwen Pei, Songdi Wu, Junli Wei. Daphnetin protects hippocampal neurons from oxygen-glucose deprivation-induced injury.
Journal of cellular biochemistry.
2019 03; 120(3):4132-4139. doi:
10.1002/jcb.27698. [PMID: 30260007] - Lina Zhang, Yue Gu, Haiwei Li, Huixia Cao, Bing Liu, Hong Zhang, Fengmin Shao. Daphnetin protects against cisplatin-induced nephrotoxicity by inhibiting inflammatory and oxidative response.
International immunopharmacology.
2018 Dec; 65(?):402-407. doi:
10.1016/j.intimp.2018.10.018. [PMID: 30380515] - Liang Yang, Lintong Wu, Xiaoyuan Yao, Shiyuan Zhao, Jiao Wang, Shili Li, Wei Ding. Hydroxycoumarins: New, effective plant-derived compounds reduce Ralstonia pseudosolanacearum populations and control tobacco bacterial wilt.
Microbiological research.
2018 Oct; 215(?):15-21. doi:
10.1016/j.micres.2018.05.011. [PMID: 30172302] - Yangliu Xia, Chen Chen, Yong Liu, Guangbo Ge, Tongyi Dou, Ping Wang. Synthesis and Structure-Activity Relationship of Daphnetin Derivatives as Potent Antioxidant Agents.
Molecules (Basel, Switzerland).
2018 Sep; 23(10):. doi:
10.3390/molecules23102476. [PMID: 30262732] - Shinsuke Mohri, Haruya Takahashi, Maiko Sakai, Shingo Takahashi, Naoko Waki, Koichi Aizawa, Hiroyuki Suganuma, Takeshi Ara, Yasuki Matsumura, Daisuke Shibata, Tsuyoshi Goto, Teruo Kawada. Wide-range screening of anti-inflammatory compounds in tomato using LC-MS and elucidating the mechanism of their functions.
PloS one.
2018; 13(1):e0191203. doi:
10.1371/journal.pone.0191203. [PMID: 29329333] - Yi-Yi-Li-Ge-Qi Hu, Sa-Li Cao, Long-Fei Lin, Jing Fu, Xiao-Xu Dong, Chun-Jing Yang, Miao Zhang, Jian Ni. [Simultaneous determination of daphnetin, daphnoretin, daphneticin in rat plasma by LC-MS/MS and its application in pharmacokinetic study].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2017 May; 42(10):1964-1970. doi:
10.19540/j.cnki.cjcmm.20170307.003. [PMID: 29090558] - Abhishek Kumar, Priyashree Sunita, Shivesh Jha, Shakti Prasad Pattanayak. Daphnetin inhibits TNF-α and VEGF-induced angiogenesis through inhibition of the IKKs/IκBα/NF-κB, Src/FAK/ERK1/2 and Akt signalling pathways.
Clinical and experimental pharmacology & physiology.
2016 10; 43(10):939-50. doi:
10.1111/1440-1681.12608. [PMID: 27297262] - Zhengyang Han, Yuecheng Xi, Lijun Luo, Chunyang Zhou, Katsuhisa Kurogi, Yoichi Sakakibara, Masahito Suiko, Ming-Cheh Liu. Sulfate conjugation of daphnetin by the human cytosolic sulfotransferases.
Journal of ethnopharmacology.
2016 Aug; 189(?):250-2. doi:
10.1016/j.jep.2016.05.041. [PMID: 27215683] - Abhishek Kumar, S Jha, Shakti P Pattanayak. Daphnetin ameliorates 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis through Nrf-2-Keap1 and NF-κB pathways.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Aug; 82(?):439-48. doi:
10.1016/j.biopha.2016.05.028. [PMID: 27470383] - Liang Yang, Wei Ding, Yuquan Xu, Dousheng Wu, Shili Li, Juanni Chen, Bing Guo. New Insights into the Antibacterial Activity of Hydroxycoumarins against Ralstonia solanacearum.
Molecules (Basel, Switzerland).
2016 Apr; 21(4):468. doi:
10.3390/molecules21040468. [PMID: 27070570] - Hai-Yang Zhu, Hong-Wei Gao, Shu-Feng Zhang. 7,8-dihydroxycoumarin has a dual mechanism of action in hepatic ischemia reperfusion injury.
International journal of clinical and experimental pathology.
2015; 8(9):10121-9. doi:
. [PMID: 26617719] - Sridevi Duggirala, Rakesh P Nankar, Selvakumar Rajendran, Mukesh Doble. Phytochemicals as inhibitors of bacterial cell division protein FtsZ: coumarins are promising candidates.
Applied biochemistry and biotechnology.
2014 Sep; 174(1):283-96. doi:
10.1007/s12010-014-1056-2. [PMID: 25062781] - Mohamed R Mohamed, Manal A Emam, Nahla S Hassan, Abeer I Mogadem. Umbelliferone and daphnetin ameliorate carbon tetrachloride-induced hepatotoxicity in rats via nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1 expression.
Environmental toxicology and pharmacology.
2014 Sep; 38(2):531-41. doi:
10.1016/j.etap.2014.08.004. [PMID: 25170823] - Wen Zhang, Liu-qing Di, Jun-Song Li, Jin-jun Shan, An Kang, Shuai Qian, Le-tian Chen. The effects of Glycyrrhizae uralenis and its major bioactive components on pharmacokinetics of daphnetin in Cortex daphnes in rats.
Journal of ethnopharmacology.
2014 Jul; 154(3):584-92. doi:
10.1016/j.jep.2014.03.047. [PMID: 24704595] - Zhi-Yong Liu, Jiao Liu, Kai-Liang Zhao, Li-Kun Wang, Qiao Shi, Teng Zuo, Tian-Yi Liu, Liang Zhao, Wei-Xing Wang. Protective effects of daphnetin on sodium taurocholate‑induced severe acute pancreatitis in rats.
Molecular medicine reports.
2014 May; 9(5):1709-14. doi:
10.3892/mmr.2014.1995. [PMID: 24584301] - Aline Witaicenis, Leonardo Noboru Seito, Alexandre da Silveira Chagas, Luiz Domingues de Almeida, Ana Carolina Luchini, Patrícia Rodrigues-Orsi, Silvia Helena Cestari, Luiz Claudio Di Stasi. Antioxidant and intestinal anti-inflammatory effects of plant-derived coumarin derivatives.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2014 Feb; 21(3):240-6. doi:
10.1016/j.phymed.2013.09.001. [PMID: 24176844] - Bocui Song, Zhenning Wang, Yan Liu, Sisi Xu, Guoren Huang, Ying Xiong, Shuang Zhang, Linli Xu, Xuming Deng, Shuang Guan. Immunosuppressive activity of daphnetin, one of coumarin derivatives, is mediated through suppression of NF-κB and NFAT signaling pathways in mouse T cells.
PloS one.
2014; 9(5):e96502. doi:
10.1371/journal.pone.0096502. [PMID: 24800925] - Lina Tu, Sha Li, Yingyuan Fu, Rongfeng Yao, Zhiqin Zhang, Shulong Yang, Xiaoping Zeng, Nanzhen Kuang. The therapeutic effects of daphnetin in collagen-induced arthritis involve its regulation of Th17 cells.
International immunopharmacology.
2012 Aug; 13(4):417-23. doi:
10.1016/j.intimp.2012.04.001. [PMID: 22554834] - Ipek Süntar, Esra Küpeli Akkol, Hikmet Keles, Erdem Yesilada, Satyajit D Sarker, Randolph Arroo, Turhan Baykal. Efficacy of Daphne oleoides subsp. kurdica used for wound healing: identification of active compounds through bioassay guided isolation technique.
Journal of ethnopharmacology.
2012 Jun; 141(3):1058-70. doi:
10.1016/j.jep.2012.04.001. [PMID: 22521733] - Hyun Ah Jung, Jin Ju Park, Md Nurul Islam, Seung Eun Jin, Byung-Sun Min, Je-Hyun Lee, Hee Sook Sohn, Jae Sue Choi. Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation.
Archives of pharmacal research.
2012 Jun; 35(6):1021-35. doi:
10.1007/s12272-012-0610-0. [PMID: 22870812] - Rongfeng Yao, Yingyuan Fu, Sha Li, Lina Tu, Xiaoping Zeng, Nanzhen Kuang. Regulatory effect of daphnetin, a coumarin extracted from Daphne odora, on the balance of Treg and Th17 in collagen-induced arthritis.
European journal of pharmacology.
2011 Nov; 670(1):286-94. doi:
10.1016/j.ejphar.2011.08.019. [PMID: 21914445] - Jing Peng, Yanying Yu, Wen Xiong, Chunpeng Wan, Shuwen Cao. [Chemical constituents of Daphne odora var. margirmta].
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