Daphnetin (BioDeep_00000400386)

Main id: BioDeep_00000000272

Secondary id: BioDeep_00000863712

natural product PANOMIX_OTCML-2023


代谢物信息卡片


Daphnetin

化学式: C9H6O4 (178.0266)
中文名称: 瑞香素
谱图信息: 最多检出来源 Viridiplantae(otcml) 9.83%

分子结构信息

SMILES: C1=CC(=C(C2=C1C=CC(=O)O2)O)O
InChI: InChI=1/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H

描述信息

7,8-dihydroxy-2h-chromen-2-one, also known as daphnetin or 7,8-dihydroxycoumarin, is a member of the class of compounds known as 7,8-dihydroxycoumarins. 7,8-dihydroxycoumarins are coumarins bearing two hydroxyl groups at the C7- and C8-positions of the coumarin skeleton, respectively. 7,8-dihydroxy-2h-chromen-2-one is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). 7,8-dihydroxy-2h-chromen-2-one can be found in chickpea and watermelon, which makes 7,8-dihydroxy-2h-chromen-2-one a potential biomarker for the consumption of these food products.
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 15
INTERNAL_ID 15; CONFIDENCE Reference Standard (Level 1)
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1?, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research[1][2][3][4].
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1?, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research[1][2][3][4].
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1?, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research[1][2][3][4].
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1?, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research[1][2][3][4].

同义名列表

4 个代谢物同义名

Daphnetin; 7,8-Dihydroxycoumarin; 7,8-Dihydroxycoumarin; Daphnetin



数据库引用编号

71 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

76 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 BCL2, CASP3, FOXP3, KEAP1, MAPK8, MTOR, NFE2L2, NLRP3, NOS2, PIK3CA, PTGS2, STAT3, TLR4
Peripheral membrane protein 3 GORASP1, MTOR, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 4 BCL2, HMOX1, MTOR, PTGS2
Nucleus 12 BCL2, CASP3, FOXP3, HMOX1, KEAP1, MAPK8, MPO, MTOR, NFE2L2, NLRP3, NOS2, STAT3
cytosol 12 BCL2, CASP3, FOXP3, HMOX1, KEAP1, MAPK8, MTOR, NFE2L2, NLRP3, NOS2, PIK3CA, STAT3
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 1 NFE2L2
nucleoplasm 10 CASP3, FOXP3, HMOX1, KEAP1, MAPK8, MPO, MTOR, NFE2L2, NOS2, STAT3
RNA polymerase II transcription regulator complex 2 NFE2L2, STAT3
Cell membrane 2 TLR4, TNF
Cytoplasmic side 3 GORASP1, HMOX1, MTOR
lamellipodium 1 PIK3CA
Golgi apparatus membrane 3 GORASP1, MTOR, NLRP3
Synapse 1 MAPK8
cell surface 2 TLR4, TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 2 GORASP1, NFE2L2
Golgi membrane 3 GORASP1, MTOR, NLRP3
lysosomal membrane 1 MTOR
neuronal cell body 2 CASP3, TNF
Cytoplasm, cytosol 3 NFE2L2, NLRP3, NOS2
Lysosome 2 MPO, MTOR
plasma membrane 6 NFE2L2, NOS2, PIK3CA, STAT3, TLR4, TNF
Membrane 5 BCL2, HMOX1, MTOR, NLRP3, TLR4
axon 1 MAPK8
caveola 1 PTGS2
extracellular exosome 1 MPO
Lysosome membrane 1 MTOR
endoplasmic reticulum 5 BCL2, HMOX1, KEAP1, NLRP3, PTGS2
extracellular space 6 HMOX1, IL10, IL17A, IL6, MPO, TNF
perinuclear region of cytoplasm 4 HMOX1, NOS2, PIK3CA, TLR4
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, NLRP3
protein-containing complex 3 BCL2, FOXP3, PTGS2
intracellular membrane-bounded organelle 1 MPO
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TLR4
Secreted 4 IL10, IL17A, IL6, NLRP3
extracellular region 6 IL10, IL17A, IL6, MPO, NLRP3, TNF
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
transcription regulator complex 1 STAT3
centriolar satellite 1 KEAP1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 3 IL17A, TLR4, TNF
midbody 1 KEAP1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 1 TNF
pore complex 1 BCL2
cis-Golgi network 1 GORASP1
Peroxisome 1 NOS2
peroxisomal matrix 1 NOS2
Nucleus, PML body 1 MTOR
PML body 1 MTOR
secretory granule 1 MPO
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 1 PTGS2
chromatin 3 FOXP3, NFE2L2, STAT3
mediator complex 1 NFE2L2
phagocytic cup 2 TLR4, TNF
actin filament 1 KEAP1
Cul3-RING ubiquitin ligase complex 1 KEAP1
nuclear envelope 1 MTOR
Endomembrane system 2 MTOR, NLRP3
microtubule organizing center 1 NLRP3
myelin sheath 1 BCL2
azurophil granule 1 MPO
lipopolysaccharide receptor complex 1 TLR4
endoplasmic reticulum lumen 2 IL6, PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
phagocytic vesicle lumen 1 MPO
protein-DNA complex 1 NFE2L2
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
inclusion body 1 KEAP1
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Tianye Yang, Qian Pan, Rujing Yue, Guanghui Liu, Yuanyuan Zhou. Daphnetin alleviates silica-induced pulmonary inflammation and fibrosis by regulating the PI3K/AKT1 signaling pathway in mice. International immunopharmacology. 2024 May; 133(?):112004. doi: 10.1016/j.intimp.2024.112004. [PMID: 38613881]
  • Tianrui Zhang, Wulin Liang, Wenjing Ou, Mingqian Zhang, Shuang Cui, Shuofeng Zhang. Daphnetin alleviates neuropathic pain in chronic constrictive injury rats via regulating the NF-κB dependent CXCL1/CXCR2 signaling pathway. Pharmaceutical biology. 2023 Dec; 61(1):746-754. doi: 10.1080/13880209.2023.2198560. [PMID: 37177984]
  • Yao Wang, Liang Yang, Xiao Zhou, Ye Wang, Yijia Liang, Binshao Luo, Yuhao Dai, Zhouling Wei, Shili Li, Rong He, Wei Ding. Molecular mechanism of plant elicitor daphnetin-carboxymethyl chitosan nanoparticles against Ralstonia solanacearum by activating plant system resistance. International journal of biological macromolecules. 2023 Jun; 241(?):124580. doi: 10.1016/j.ijbiomac.2023.124580. [PMID: 37100321]
  • Yujie Guo, Huiqing Zhang, Zhe Lv, Yuna Du, Dan Li, Hui Fang, Jing You, Lijun Yu, Rong Li. Up-regulated CD38 by daphnetin alleviates lipopolysaccharide-induced lung injury via inhibiting MAPK/NF-κB/NLRP3 pathway. Cell communication and signaling : CCS. 2023 Mar; 21(1):66. doi: 10.1186/s12964-023-01041-3. [PMID: 36998049]
  • Bo Tian, Xin Ma, Rui Jiang. Daphnetin Mitigates Ovalbumin-Induced Allergic Rhinitis in Mice by Regulating Nrf2/HO-1 and TLR4/NF-kB Signaling. American journal of rhinology & allergy. 2023 Jan; 37(1):19-25. doi: 10.1177/19458924221124363. [PMID: 36128844]
  • Yi Zhang, Lu Qu, Yun Sun, YuPing Lin, Jing Zeng, LiXia He, Xiucun Li, Wen Gu, Jian Nie, Xiaoling Yu, XiaoYun Tong, Feng Huang. Daphnetin contributes to allergen-induced Th2 cytokine expression and type 2-immune responses in atopic dermatitis and asthma. Food & function. 2022 Nov; 13(23):12383-12399. doi: 10.1039/d2fo02518c. [PMID: 36373505]
  • Li Yan, Yufan Jin, Junping Pan, Xiang He, Shiqian Zhong, Rongcai Zhang, LokLam Choi, Weiwei Su, Jiaxu Chen. 7,8-Dihydroxycoumarin Alleviates Synaptic Loss by Activated PI3K-Akt-CREB-BDNF Signaling in Alzheimer's Disease Model Mice. Journal of agricultural and food chemistry. 2022 Jun; 70(23):7130-7138. doi: 10.1021/acs.jafc.2c02140. [PMID: 35657168]
  • Abu Mohammad Syed, Sourav Kundu, Chetan Ram, Uttam Kulhari, Akhilesh Kumar, Madhav Nilakanth Mugale, Purusottam Mohapatra, Upadhyayula Suryanarayana Murty, Bidya Dhar Sahu. Up-regulation of Nrf2/HO-1 and inhibition of TGF-β1/Smad2/3 signaling axis by daphnetin alleviates transverse aortic constriction-induced cardiac remodeling in mice. Free radical biology & medicine. 2022 06; 186(?):17-30. doi: 10.1016/j.freeradbiomed.2022.04.019. [PMID: 35513128]
  • Peipei Gao, Zhen Wang, Mengyao Lei, Jiaxing Che, Shuangxi Zhang, Tiantian Zhang, Yachong Hu, Le Shi, Li Cui, Jiankang Liu, Mami Noda, Yunhua Peng, Jiangang Long. Daphnetin ameliorates Aβ pathogenesis via STAT3/GFAP signaling in an APP/PS1 double-transgenic mouse model of Alzheimer's disease. Pharmacological research. 2022 06; 180(?):106227. doi: 10.1016/j.phrs.2022.106227. [PMID: 35452800]
  • Tianye Yang, Xiaoli Wang, Liang Guo, Fang Zheng, Chun Meng, Yongzheng Zheng, Guanghui Liu. Daphnetin inhibits corneal inflammation and neovascularization on a mouse model of corneal alkali burn. International immunopharmacology. 2022 Feb; 103(?):108434. doi: 10.1016/j.intimp.2021.108434. [PMID: 34920334]
  • Liang Yang, Zhouling Wei, Shili Li, Rui Xiao, Qinqin Xu, Yuao Ran, Wei Ding. Plant secondary metabolite, daphnetin reduces extracellular polysaccharides production and virulence factors of Ralstonia solanacearum. Pesticide biochemistry and physiology. 2021 Nov; 179(?):104948. doi: 10.1016/j.pestbp.2021.104948. [PMID: 34802533]
  • Houssem Boulebd, Imene Amine Khodja. A detailed DFT-based study of the free radical scavenging activity and mechanism of daphnetin in physiological environments. Phytochemistry. 2021 Sep; 189(?):112831. doi: 10.1016/j.phytochem.2021.112831. [PMID: 34146991]
  • Xiaoye Fan, Wenjing Gu, Yun Gao, Ning Ma, Changqing Fan, Xinxin Ci. Daphnetin ameliorated GM-induced renal injury through the suppression of oxidative stress and apoptosis in mice. International immunopharmacology. 2021 Jul; 96(?):107601. doi: 10.1016/j.intimp.2021.107601. [PMID: 33812255]
  • Shujun Yang, Yaodong Song, Qiaofang Wang, Yanna Liu, Zhongwei Wu, Xiaojia Duan, Yan Zhang, Xiuqian Bi, Yuanzhang Geng, Sanyang Chen, Changju Zhu. Daphnetin ameliorates acute lung injury in mice with severe acute pancreatitis by inhibiting the JAK2-STAT3 pathway. Scientific reports. 2021 06; 11(1):11491. doi: 10.1038/s41598-021-91008-6. [PMID: 34075160]
  • Bo-Cui Song, Meng-Meng Jiang, Shuang Zhang, Hui Ma, Min Liu, Zhong-Ren Fu, Rui Wu, Chun-Yu Tong. Immunosuppressive activity of daphnetin on the humoral immune responses in ovalbumin-sensitized BALB/c mice. Immunopharmacology and immunotoxicology. 2021 Apr; 43(2):171-175. doi: 10.1080/08923973.2021.1872618. [PMID: 33491523]
  • Wenru Liu, Jun Mei, Jing Xie. Effect of locust bean gum-sodium alginate coatings incorporated with daphnetin emulsions on the quality of Scophthalmus maximus at refrigerated condition. International journal of biological macromolecules. 2021 Feb; 170(?):129-139. doi: 10.1016/j.ijbiomac.2020.12.089. [PMID: 33338530]
  • Yang-Liu Xia, Jing-Jing Wang, Shi-Yang Li, Yong Liu, Frank J Gonzalez, Ping Wang, Guang-Bo Ge. Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment. Bioorganic & medicinal chemistry. 2021 01; 29(?):115851. doi: 10.1016/j.bmc.2020.115851. [PMID: 33218896]
  • Yongkui Wang, Jian Chen, Jing Chen, Chao Dong, Xu Yan, Zhongpei Zhu, Pan Lu, Zongmian Song, Hongjian Liu, Songfeng Chen. Daphnetin ameliorates glucocorticoid-induced osteoporosis via activation of Wnt/GSK-3β/β-catenin signaling. Toxicology and applied pharmacology. 2020 12; 409(?):115333. doi: 10.1016/j.taap.2020.115333. [PMID: 33171191]
  • Ying Wei, Jian Yang, Meena Kishore Sakharkar, Xia Wang, Qin Liu, Jiang Du, Jing-Jie Zhang. Evaluating the inhibitory effect of eight compounds from Daphne papyracea against the NS3/4A protease of hepatitis C virus. Natural product research. 2020 Jun; 34(11):1607-1610. doi: 10.1080/14786419.2018.1519825. [PMID: 30449158]
  • Jing Li, Dongliang Wang, Lei Yi, Ting Li, Miaomiao Wang, Haihui Zhu. [Daphnetin alleviates myocardial ischemia injury in rats through mediating oxidative stress and inhibiting JNK/NF-κB pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2020 Jun; 36(6):513-519. doi: . [PMID: 32696741]
  • Zuoxing Wu, Hailun Wu, Chen Li, Fangsheng Fu, Jiaxin Ding, Siyuan Shao, Kai Li, Xiao Yu, Yuangang Su, Jiamin Liang, Xixi Lin, Guixin Yuan, Juan Zhou, Fangming Song, Jinmin Zhao, Jiake Xu, Qian Liu, Feng Xu. Daphnetin attenuates LPS-induced osteolysis and RANKL mediated osteoclastogenesis through suppression of ERK and NFATc1 pathways. Journal of cellular physiology. 2019 08; 234(10):17812-17823. doi: 10.1002/jcp.28408. [PMID: 30815894]
  • Yayun Liu, Lu Liao, Yong Chen, Fengmei Han. Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA‑treated HepG2 cells. Molecular medicine reports. 2019 Jun; 19(6):4673-4684. doi: 10.3892/mmr.2019.10139. [PMID: 30957185]
  • Xiaohong Lv, Yazhen Li, Qingfei Xiao, Dan Li. Daphnetin activates the Nrf2-dependent antioxidant response to prevent arsenic-induced oxidative insult in human lung epithelial cells. Chemico-biological interactions. 2019 Apr; 302(?):93-100. doi: 10.1016/j.cbi.2019.02.001. [PMID: 30738023]
  • Jin Zhi, Bin Duan, Jiwen Pei, Songdi Wu, Junli Wei. Daphnetin protects hippocampal neurons from oxygen-glucose deprivation-induced injury. Journal of cellular biochemistry. 2019 03; 120(3):4132-4139. doi: 10.1002/jcb.27698. [PMID: 30260007]
  • Lina Zhang, Yue Gu, Haiwei Li, Huixia Cao, Bing Liu, Hong Zhang, Fengmin Shao. Daphnetin protects against cisplatin-induced nephrotoxicity by inhibiting inflammatory and oxidative response. International immunopharmacology. 2018 Dec; 65(?):402-407. doi: 10.1016/j.intimp.2018.10.018. [PMID: 30380515]
  • Liang Yang, Lintong Wu, Xiaoyuan Yao, Shiyuan Zhao, Jiao Wang, Shili Li, Wei Ding. Hydroxycoumarins: New, effective plant-derived compounds reduce Ralstonia pseudosolanacearum populations and control tobacco bacterial wilt. Microbiological research. 2018 Oct; 215(?):15-21. doi: 10.1016/j.micres.2018.05.011. [PMID: 30172302]
  • Yangliu Xia, Chen Chen, Yong Liu, Guangbo Ge, Tongyi Dou, Ping Wang. Synthesis and Structure-Activity Relationship of Daphnetin Derivatives as Potent Antioxidant Agents. Molecules (Basel, Switzerland). 2018 Sep; 23(10):. doi: 10.3390/molecules23102476. [PMID: 30262732]
  • Shinsuke Mohri, Haruya Takahashi, Maiko Sakai, Shingo Takahashi, Naoko Waki, Koichi Aizawa, Hiroyuki Suganuma, Takeshi Ara, Yasuki Matsumura, Daisuke Shibata, Tsuyoshi Goto, Teruo Kawada. Wide-range screening of anti-inflammatory compounds in tomato using LC-MS and elucidating the mechanism of their functions. PloS one. 2018; 13(1):e0191203. doi: 10.1371/journal.pone.0191203. [PMID: 29329333]
  • Yi-Yi-Li-Ge-Qi Hu, Sa-Li Cao, Long-Fei Lin, Jing Fu, Xiao-Xu Dong, Chun-Jing Yang, Miao Zhang, Jian Ni. [Simultaneous determination of daphnetin, daphnoretin, daphneticin in rat plasma by LC-MS/MS and its application in pharmacokinetic study]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2017 May; 42(10):1964-1970. doi: 10.19540/j.cnki.cjcmm.20170307.003. [PMID: 29090558]
  • Abhishek Kumar, Priyashree Sunita, Shivesh Jha, Shakti Prasad Pattanayak. Daphnetin inhibits TNF-α and VEGF-induced angiogenesis through inhibition of the IKKs/IκBα/NF-κB, Src/FAK/ERK1/2 and Akt signalling pathways. Clinical and experimental pharmacology & physiology. 2016 10; 43(10):939-50. doi: 10.1111/1440-1681.12608. [PMID: 27297262]
  • Zhengyang Han, Yuecheng Xi, Lijun Luo, Chunyang Zhou, Katsuhisa Kurogi, Yoichi Sakakibara, Masahito Suiko, Ming-Cheh Liu. Sulfate conjugation of daphnetin by the human cytosolic sulfotransferases. Journal of ethnopharmacology. 2016 Aug; 189(?):250-2. doi: 10.1016/j.jep.2016.05.041. [PMID: 27215683]
  • Abhishek Kumar, S Jha, Shakti P Pattanayak. Daphnetin ameliorates 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis through Nrf-2-Keap1 and NF-κB pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2016 Aug; 82(?):439-48. doi: 10.1016/j.biopha.2016.05.028. [PMID: 27470383]
  • Liang Yang, Wei Ding, Yuquan Xu, Dousheng Wu, Shili Li, Juanni Chen, Bing Guo. New Insights into the Antibacterial Activity of Hydroxycoumarins against Ralstonia solanacearum. Molecules (Basel, Switzerland). 2016 Apr; 21(4):468. doi: 10.3390/molecules21040468. [PMID: 27070570]
  • Hai-Yang Zhu, Hong-Wei Gao, Shu-Feng Zhang. 7,8-dihydroxycoumarin has a dual mechanism of action in hepatic ischemia reperfusion injury. International journal of clinical and experimental pathology. 2015; 8(9):10121-9. doi: . [PMID: 26617719]
  • Sridevi Duggirala, Rakesh P Nankar, Selvakumar Rajendran, Mukesh Doble. Phytochemicals as inhibitors of bacterial cell division protein FtsZ: coumarins are promising candidates. Applied biochemistry and biotechnology. 2014 Sep; 174(1):283-96. doi: 10.1007/s12010-014-1056-2. [PMID: 25062781]
  • Mohamed R Mohamed, Manal A Emam, Nahla S Hassan, Abeer I Mogadem. Umbelliferone and daphnetin ameliorate carbon tetrachloride-induced hepatotoxicity in rats via nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1 expression. Environmental toxicology and pharmacology. 2014 Sep; 38(2):531-41. doi: 10.1016/j.etap.2014.08.004. [PMID: 25170823]
  • Wen Zhang, Liu-qing Di, Jun-Song Li, Jin-jun Shan, An Kang, Shuai Qian, Le-tian Chen. The effects of Glycyrrhizae uralenis and its major bioactive components on pharmacokinetics of daphnetin in Cortex daphnes in rats. Journal of ethnopharmacology. 2014 Jul; 154(3):584-92. doi: 10.1016/j.jep.2014.03.047. [PMID: 24704595]
  • Zhi-Yong Liu, Jiao Liu, Kai-Liang Zhao, Li-Kun Wang, Qiao Shi, Teng Zuo, Tian-Yi Liu, Liang Zhao, Wei-Xing Wang. Protective effects of daphnetin on sodium taurocholate‑induced severe acute pancreatitis in rats. Molecular medicine reports. 2014 May; 9(5):1709-14. doi: 10.3892/mmr.2014.1995. [PMID: 24584301]
  • Aline Witaicenis, Leonardo Noboru Seito, Alexandre da Silveira Chagas, Luiz Domingues de Almeida, Ana Carolina Luchini, Patrícia Rodrigues-Orsi, Silvia Helena Cestari, Luiz Claudio Di Stasi. Antioxidant and intestinal anti-inflammatory effects of plant-derived coumarin derivatives. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Feb; 21(3):240-6. doi: 10.1016/j.phymed.2013.09.001. [PMID: 24176844]
  • Bocui Song, Zhenning Wang, Yan Liu, Sisi Xu, Guoren Huang, Ying Xiong, Shuang Zhang, Linli Xu, Xuming Deng, Shuang Guan. Immunosuppressive activity of daphnetin, one of coumarin derivatives, is mediated through suppression of NF-κB and NFAT signaling pathways in mouse T cells. PloS one. 2014; 9(5):e96502. doi: 10.1371/journal.pone.0096502. [PMID: 24800925]
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