geldanamycin (BioDeep_00000008549)
PANOMIX_OTCML-2023
代谢物信息卡片
Carbamic acid (6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl) ester
化学式: C29H40N2O9 (560.273367)
中文名称: 格尔德霉素
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 3.37%
分子结构信息
SMILES: CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC
InChI: InChI=1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
描述信息
A 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. it is an ansamycin antibiotic and thus shows antimicrobial activity against many gram-positive and some gram-negative bacteria.
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015853 - Cysteine Proteinase Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D000970 - Antineoplastic Agents
Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.
同义名列表
3 个代谢物同义名
geldanamycin; Carbamic acid (6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl) ester; 13R-hydroxy-8S,14S,19-trimethoxy-4,10,12S,16R-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4E,6E,10E,18-pentaen-9S-yl, carbamate
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:91381
- ChEBI: CHEBI:5292
- KEGG: C11222
- PubChem: 5288382
- PubChem: 3460
- Metlin: METLIN45547
- DrugBank: DB02424
- KNApSAcK: C00018795
- CAS: 30562-34-6
- PMhub: MS000022177
- MetaboLights: MTBLC5292
- PubChem: 13401
- PDB-CCD: GDM
- NIKKAJI: J21.396I
- RefMet: Geldanamycin
- medchemexpress: HY-15230
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 1912 Streptomyces hygroscopicus: 10.1021/NP50047A016
- 1912 Streptomyces hygroscopicus: 10.1021/NP50047A016
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jin Won Choi, Yeonhee Lee, Jaekyeong Kim, Haeun Kwon, Stephen T Deyrup, Jin Woo Lee, Dongho Lee, Hahk-Soo Kang, Hwangsoo Joo, Sang Hee Shim. Discovery of Bioactive Metabolites by Acidic Stress to a Geldanamycin Producer, Streptomyces samsunensis.
Journal of natural products.
2023 04; 86(4):947-957. doi:
10.1021/acs.jnatprod.2c01151. [PMID: 37042709] - Gustavo A Díaz-Cruz, Jingyu Liu, Kapil Tahlan, Dawn R D Bignell. Nigericin and Geldanamycin Are Phytotoxic Specialized Metabolites Produced by the Plant Pathogen Streptomyces sp. 11-1-2.
Microbiology spectrum.
2022 04; 10(2):e0231421. doi:
10.1128/spectrum.02314-21. [PMID: 35225656] - Bin Gao, Lijuan Wang, Na Zhang, Miaomiao Han, Yubo Zhang, Huancai Liu, Dongli Sun, Yifei Liu. Screening Novel Drug Candidates for Kidney Renal Clear Cell Carcinoma Treatment: A Study on Differentially Expressed Genes through the Connectivity Map Database.
Kidney & blood pressure research.
2021; 46(6):702-713. doi:
10.1159/000518437. [PMID: 34818247] - Chang Jia, Jian Zhang, Yingzhi Zhuge, Ke Xu, Jiahui Liu, Jinle Wang, Lei Li, Maoping Chu. Synergistic effects of geldanamycin with fluconazole are associated with reactive oxygen species in Candida tropicalis resistant to azoles and amphotericin B.
Free radical research.
2019 Jun; 53(6):618-628. doi:
10.1080/10715762.2019.1610563. [PMID: 31185751] - Kefan Zhang, Miaomiao Wang, Yingjiang Li, Chunping Li, Shaidi Tang, Xiuxia Qu, Ninghan Feng, Yu Wu. The PERK-EIF2α-ATF4 signaling branch regulates osteoblast differentiation and proliferation by PTH.
American journal of physiology. Endocrinology and metabolism.
2019 04; 316(4):E590-E604. doi:
10.1152/ajpendo.00371.2018. [PMID: 30668150] - Shou-Long Deng, Tie-Cheng Sun, Kun Yu, Zhi-Peng Wang, Bao-Lu Zhang, Yan Zhang, Xiu-Xia Wang, Zheng-Xing Lian, Yi-Xun Liu. Melatonin reduces oxidative damage and upregulates heat shock protein 90 expression in cryopreserved human semen.
Free radical biology & medicine.
2017 12; 113(?):347-354. doi:
10.1016/j.freeradbiomed.2017.10.342. [PMID: 29051117] - Thaddée Boudjeko, Romaric Armel Mouafo Tchinda, Mina Zitouni, Joëlle Aimée Vera Tchatchou Nana, Sylvain Lerat, Carole Beaulieu. Streptomyces cameroonensis sp. nov., a Geldanamycin Producer That Promotes Theobroma cacao Growth.
Microbes and environments.
2017 Mar; 32(1):24-31. doi:
10.1264/jsme2.me16095. [PMID: 28260703] - Romaric Armel Mouafo Tchinda, Thaddée Boudjeko, Anne-Marie Simao-Beaunoir, Sylvain Lerat, Éric Tsala, Ernest Monga, Carole Beaulieu. Morphological, Physiological, and Taxonomic Characterization of Actinobacterial Isolates Living as Endophytes of Cacao Pods and Cacao Seeds.
Microbes and environments.
2016; 31(1):56-62. doi:
10.1264/jsme2.me15146. [PMID: 26947442] - Vidula Kolhatkar, Jose Suárez, Rohit Kolhatkar. Dendritic hexadecapeptide as a cathepsin B degradable carrier for delivery of HSP90 inhibitor.
Bioorganic & medicinal chemistry letters.
2015 Sep; 25(17):3744-7. doi:
10.1016/j.bmcl.2015.06.012. [PMID: 26159484] - Andrija Finka, Vishal Sood, Manfredo Quadroni, Paolo De Los Rios, Pierre Goloubinoff. Quantitative proteomics of heat-treated human cells show an across-the-board mild depletion of housekeeping proteins to massively accumulate few HSPs.
Cell stress & chaperones.
2015 Jul; 20(4):605-20. doi:
10.1007/s12192-015-0583-2. [PMID: 25847399] - Liudmyla Kozeko, Oleksandr Talalaiev, Volodymyr Neimash, Vasyl Povarchuk. A protective role of HSP90 chaperone in gamma-irradiated Arabidopsis thaliana seeds.
Life sciences in space research.
2015 Jul; 6(?):51-8. doi:
10.1016/j.lssr.2015.07.002. [PMID: 26256628] - Tomoaki Shigeta, Yuichi Zaizen, Yasushi Sugimoto, Yasushi Nakamura, Tomoaki Matsuo, Shigehisa Okamoto. Heat shock protein 90 acts in brassinosteroid signaling through interaction with BES1/BZR1 transcription factor.
Journal of plant physiology.
2015 Apr; 178(?):69-73. doi:
10.1016/j.jplph.2015.02.003. [PMID: 25778412] - Zhenyu Li, Lejiao Jia, Jifeng Wang, Xingkang Wu, Guowei Shi, Chunhua Lu, Yuemao Shen. Discovery of novel 17-phenylethylaminegeldanamycin derivatives as potent Hsp90 inhibitors.
Chemical biology & drug design.
2015 Feb; 85(2):181-8. doi:
10.1111/cbdd.12371. [PMID: 24903735] - Y Hao, X H Gu. Effects of heat shock protein 90 expression on pectoralis major oxidation in broilers exposed to acute heat stress.
Poultry science.
2014 Nov; 93(11):2709-17. doi:
10.3382/ps.2014-03993. [PMID: 25239533] - Despina Samakovli, Theoni Margaritopoulou, Constantinos Prassinos, Dimitra Milioni, Polydefkis Hatzopoulos. Brassinosteroid nuclear signaling recruits HSP90 activity.
The New phytologist.
2014 Aug; 203(3):743-57. doi:
10.1111/nph.12843. [PMID: 24807419] - Stefanie Trojandt, Angelika B Reske-Kunz, Matthias Bros. Geldanamycin-mediated inhibition of heat shock protein 90 partially activates dendritic cells, but interferes with their full maturation, accompanied by impaired upregulation of RelB.
Journal of experimental & clinical cancer research : CR.
2014 Feb; 33(?):16. doi:
10.1186/1756-9966-33-16. [PMID: 24524692] - Seung Yeon Park, Jung Hyun Shim, Young Sik Cho. Distinctive roles of receptor-interacting protein kinases 1 and 3 in caspase-independent cell death of L929.
Cell biochemistry and function.
2014 Jan; 32(1):62-9. doi:
10.1002/cbf.2972. [PMID: 23584955] - Sébastien Desarzens, Wan-Hui Liao, Caterina Mammi, Massimiliano Caprio, Nourdine Faresse. Hsp90 blockers inhibit adipocyte differentiation and fat mass accumulation.
PloS one.
2014; 9(4):e94127. doi:
10.1371/journal.pone.0094127. [PMID: 24705830] - L G Kozeko. [Changes in heat shock protein synthesis and thermotolerance of Arabidopsis thaliana seedlings as a result of inhibition of Hsp90 by geldanamycin].
Tsitologiia.
2014; 56(6):419-26. doi:
". [PMID: 25696978] - Shinji Masuda, Yoshihito Tokaji, Yuichi Kobayashi, Hiroyuki Ohta. Mechanisms of induction of the stress-responsive transcription factors HsfA2 and DREB2A by 12-oxo-phytodienoic acid in Arabidopsis thaliana.
Bioscience, biotechnology, and biochemistry.
2014; 78(4):647-50. doi:
10.1080/09168451.2014.891929. [PMID: 25036962] - Dixian Luo, Yiwen Bu, Jun Ma, Sandeep Rajput, Yingchun He, Guangxian Cai, Duan-Fang Liao, Deliang Cao. Heat shock protein 90-α mediates aldo-keto reductase 1B10 (AKR1B10) protein secretion through secretory lysosomes.
The Journal of biological chemistry.
2013 Dec; 288(51):36733-40. doi:
10.1074/jbc.m113.514877. [PMID: 24217247] - Chisato Iwai, Peili Li, Yasutaka Kurata, Yoshiko Hoshikawa, Kumi Morikawa, Nani Maharani, Katsumi Higaki, Tetsuro Sasano, Tomomi Notsu, Yuko Ishido, Junichiro Miake, Yasutaka Yamamoto, Yasuaki Shirayoshi, Haruaki Ninomiya, Akira Nakai, Shigeo Murata, Akio Yoshida, Kazuhiro Yamamoto, Masayasu Hiraoka, Ichiro Hisatome. Hsp90 prevents interaction between CHIP and HERG proteins to facilitate maturation of wild-type and mutant HERG proteins.
Cardiovascular research.
2013 Dec; 100(3):520-8. doi:
10.1093/cvr/cvt200. [PMID: 23963841] - Pankaj Kumar Singh, Sweta Singh, Subramaniam Ganesh. Activation of serum/glucocorticoid-induced kinase 1 (SGK1) underlies increased glycogen levels, mTOR activation, and autophagy defects in Lafora disease.
Molecular biology of the cell.
2013 Dec; 24(24):3776-86. doi:
10.1091/mbc.e13-05-0261. [PMID: 24131995] - Liang Guo, Luke Coyle, Rory M C Abrams, Raymond Kemper, Eric T Chiao, Kyle L Kolaja. Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model.
Toxicological sciences : an official journal of the Society of Toxicology.
2013 Dec; 136(2):581-94. doi:
10.1093/toxsci/kft205. [PMID: 24052561] - Stefan Schmollinger, Miriam Schulz-Raffelt, Daniela Strenkert, Daniel Veyel, Olivier Vallon, Michael Schroda. Dissecting the heat stress response in Chlamydomonas by pharmaceutical and RNAi approaches reveals conserved and novel aspects.
Molecular plant.
2013 Nov; 6(6):1795-813. doi:
10.1093/mp/sst086. [PMID: 23713078] - Manikandadas M Madathil, Omar M Khdour, Jennifer Jaruvangsanti, Sidney M Hecht. A structurally simplified analogue of geldanamycin exhibits neuroprotective activity.
ACS medicinal chemistry letters.
2013 Oct; 4(10):953-7. doi:
10.1021/ml400207m. [PMID: 24900591] - Bertrand Gondouin, Claire Cerini, Laetitia Dou, Marion Sallée, Ariane Duval-Sabatier, Anneleen Pletinck, Raymond Calaf, Romaric Lacroix, Noémie Jourde-Chiche, Stéphane Poitevin, Laurent Arnaud, Raymond Vanholder, Philippe Brunet, Françoise Dignat-George, Stéphane Burtey. Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway.
Kidney international.
2013 Oct; 84(4):733-44. doi:
10.1038/ki.2013.133. [PMID: 23636172] - Shinpei Katou, Nobuhide Asakura, Tomoya Kojima, Ichiro Mitsuhara, Shigemi Seo. Transcriptome analysis of WIPK/SIPK-suppressed plants reveals induction by wounding of disease resistance-related genes prior to the accumulation of salicylic acid.
Plant & cell physiology.
2013 Jun; 54(6):1005-15. doi:
10.1093/pcp/pct055. [PMID: 23574699] - L E Kozeko. [Phenotypic variability of Arabidopsis thaliana seedlings as a result of inhibition of Hsp90 chaperones].
TSitologiia i genetika.
2013 Mar; 47(2):18-33. doi:
". [PMID: 23745360] - Yan-ping Li, Lin-yan Gao, Kai-tong Li, Shuai Meng, Jian-hua Zhu, Dong Li, Jie Jin, Guang-zhi Shan, Zhuo-rong Li. LC-MS/MS method for determination of geldanamycin derivative GM-AMPL in rat plasma to support preclinical development.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Jan; 912(?):43-9. doi:
10.1016/j.jchromb.2012.09.002. [PMID: 23261821] - Peter W Piper, Stefan H Millson. Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics.
Open biology.
2012 Dec; 2(12):120138. doi:
10.1098/rsob.120138. [PMID: 23271830] - Shin-Ae Kang, Hyun-Soo Cho, Jong Bok Yoon, In Kwon Chung, Seung-Taek Lee. Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells.
The Biochemical journal.
2012 Oct; 447(2):313-20. doi:
10.1042/bj20120803. [PMID: 22849407] - Jana Krtková, Aleksandra Zimmermann, Kateřina Schwarzerová, Peter Nick. Hsp90 binds microtubules and is involved in the reorganization of the microtubular network in angiosperms.
Journal of plant physiology.
2012 Sep; 169(14):1329-39. doi:
10.1016/j.jplph.2012.06.010. [PMID: 22840326] - Lianru Zhang, Yuting Yi, Qiuju Guo, Yifei Sun, Shun Ma, Shuyan Xiao, Jing Geng, Zhonghui Zheng, Siyang Song. Hsp90 interacts with AMPK and mediates acetyl-CoA carboxylase phosphorylation.
Cellular signalling.
2012 Apr; 24(4):859-65. doi:
10.1016/j.cellsig.2011.12.001. [PMID: 22178220] - Rubul Mout, Zhi-Dong Xu, Angela K H Wolf, Vincent Jo Davisson, Gotam K Jarori. Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii.
Malaria journal.
2012 Feb; 11(?):54. doi:
10.1186/1475-2875-11-54. [PMID: 22361388] - Chun-Yu Hung, Meng-Chieh Tsai, Yi-Ping Wu, Robert Y L Wang. Identification of heat-shock protein 90 beta in Japanese encephalitis virus-induced secretion proteins.
The Journal of general virology.
2011 Dec; 92(Pt 12):2803-2809. doi:
10.1099/vir.0.033993-0. [PMID: 21813703] - Yizhe Chen, Y Chen, Pilju Youn, P Youn, Darin Y Furgeson, D Y Furgeson. Thermo-targeted drug delivery of geldanamycin to hyperthermic tumor margins with diblock elastin-based biopolymers.
Journal of controlled release : official journal of the Controlled Release Society.
2011 Oct; 155(2):175-83. doi:
10.1016/j.jconrel.2011.07.040. [PMID: 21846483] - Tae-sung Kim, Woe Yeon Kim, Sumire Fujiwara, Jeongsik Kim, Joon-Yung Cha, Jin Ho Park, Sang Yeol Lee, David E Somers. HSP90 functions in the circadian clock through stabilization of the client F-box protein ZEITLUPE.
Proceedings of the National Academy of Sciences of the United States of America.
2011 Oct; 108(40):16843-8. doi:
10.1073/pnas.1110406108. [PMID: 21949396] - N Clermont, S Lerat, C Beaulieu. Genome shuffling enhances biocontrol abilities of Streptomyces strains against two potato pathogens.
Journal of applied microbiology.
2011 Sep; 111(3):671-82. doi:
10.1111/j.1365-2672.2011.05078.x. [PMID: 21672101] - Chun-Xin Li, Guang-Zhi Shan, Bo Fan, Pei-Zhen Tao, Li-Xun Zhao, Jian-Dong Jiang, Yu-Huan Li, Zhuo-Rong Li. [Synthesis and antiviral activities of geldanamycin analog TC-GM in vitro].
Yao xue xue bao = Acta pharmaceutica Sinica.
2011 Jun; 46(6):683-7. doi:
NULL. [PMID: 21882529] - Gwanghyun Jung, Barbara Barylko, Dongmei Lu, Hongjun Shu, Helen Yin, Joseph P Albanesi. Stabilization of phosphatidylinositol 4-kinase type IIbeta by interaction with Hsp90.
The Journal of biological chemistry.
2011 Apr; 286(14):12775-84. doi:
10.1074/jbc.m110.178616. [PMID: 21330372] - O V Glushkova, T V Novoselova, M O Khrenov, S B Parfenyuk, S M Lunin, E E Fesenko, E G Novoselova. Role of heat shock protein hsp90 in formation of protective reactions in acute toxic stress.
Biochemistry. Biokhimiia.
2010 Jun; 75(6):702-7. doi:
10.1134/s0006297910060040. [PMID: 20636261] - Anna Zurawska, Jakub Urbanski, Jurgita Matuliene, Janina Baraniak, Marcin P Klejman, Slawomir Filipek, Daumantas Matulis, Pawel Bieganowski. Mutations that increase both Hsp90 ATPase activity in vitro and Hsp90 drug resistance in vivo.
Biochimica et biophysica acta.
2010 May; 1803(5):575-83. doi:
10.1016/j.bbamcr.2010.03.002. [PMID: 20226818] - Rosemary A Ndolo, M Laird Forrest, Jeffrey P Krise. The role of lysosomes in limiting drug toxicity in mice.
The Journal of pharmacology and experimental therapeutics.
2010 Apr; 333(1):120-8. doi:
10.1124/jpet.109.160226. [PMID: 20056778] - Ayako Nishizawa-Yokoi, Hitoshi Tainaka, Eriko Yoshida, Masahiro Tamoi, Yukinori Yabuta, Shigeru Shigeoka. The 26S proteasome function and Hsp90 activity involved in the regulation of HsfA2 expression in response to oxidative stress.
Plant & cell physiology.
2010 Mar; 51(3):486-96. doi:
10.1093/pcp/pcq015. [PMID: 20147301] - Taka-aki Koshimizu, Hiroyoshi Tsuchiya, Hidetoshi Tsuda, Yoko Fujiwara, Katsushi Shibata, Akira Hirasawa, Gozoh Tsujimoto, Akio Fujimura. Inhibition of heat shock protein 90 attenuates adenylate cyclase sensitization after chronic morphine treatment.
Biochemical and biophysical research communications.
2010 Feb; 392(4):603-7. doi:
10.1016/j.bbrc.2010.01.089. [PMID: 20100459] - Mark P Borgman, Omer Aras, Sandra Geyser-Stoops, Edward A Sausville, Hamidreza Ghandehari. Biodistribution of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer drug delivery.
Molecular pharmaceutics.
2009 Nov; 6(6):1836-47. doi:
10.1021/mp900134c. [PMID: 19743884] - Joon-Yung Cha, Min Hee Jung, Netty Ermawati, Mukhamad Su'udi, Gyu-Jin Rho, Chang-Deok Han, Kon Ho Lee, Daeyoung Son. Functional characterization of orchardgrass endoplasmic reticulum-resident Hsp90 (DgHsp90) as a chaperone and an ATPase.
Plant physiology and biochemistry : PPB.
2009 Oct; 47(10):859-66. doi:
10.1016/j.plaphy.2009.06.008. [PMID: 19625192] - Juliann G Kiang, Joan T Smith, Neil G Agravante. Geldanamycin analog 17-DMAG inhibits iNOS and caspases in gamma-irradiated human T cells.
Radiation research.
2009 Sep; 172(3):321-30. doi:
10.1667/rr1585.1. [PMID: 19708781] - June Chunqiu Hou, Dumaine Williams, Jérôme Vicogne, Jeffrey E Pessin. The glucose transporter 2 undergoes plasma membrane endocytosis and lysosomal degradation in a secretagogue-dependent manner.
Endocrinology.
2009 Sep; 150(9):4056-64. doi:
10.1210/en.2008-1685. [PMID: 19477941] - Sanae Ben Mkaddem, Catherine Werts, Jean-Michel Goujon, Marcelle Bens, Eric Pedruzzi, Eric Ogier-Denis, Alain Vandewalle. Heat shock protein gp96 interacts with protein phosphatase 5 and controls toll-like receptor 2 (TLR2)-mediated activation of extracellular signal-regulated kinase (ERK) 1/2 in post-hypoxic kidney cells.
The Journal of biological chemistry.
2009 May; 284(18):12541-9. doi:
10.1074/jbc.m808376200. [PMID: 19265198] - Karen Lundgren, Hong Zhang, John Brekken, Nanni Huser, Rachel E Powell, Noel Timple, David J Busch, Laura Neely, John L Sensintaffar, Yong-ching Yang, Andres McKenzie, Jessica Friedman, Robert Scannevin, Adeela Kamal, Kevin Hong, Srinivas R Kasibhatla, Marcus F Boehm, Francis J Burrows. BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.
Molecular cancer therapeutics.
2009 Apr; 8(4):921-9. doi:
10.1158/1535-7163.mct-08-0758. [PMID: 19372565] - Keri A Barksdale, Gautam N Bijur. The basal flux of Akt in the mitochondria is mediated by heat shock protein 90.
Journal of neurochemistry.
2009 Mar; 108(5):1289-99. doi:
10.1111/j.1471-4159.2009.05878.x. [PMID: 19187436] - Xianhua Cao, Guang Jia, Tao Zhang, Ming Yang, Bing Wang, Peter A Wassenaar, Hao Cheng, Michael V Knopp, Duxin Sun. Non-invasive MRI tumor imaging and synergistic anticancer effect of HSP90 inhibitor and glycolysis inhibitor in RIP1-Tag2 transgenic pancreatic tumor model.
Cancer chemotherapy and pharmacology.
2008 Nov; 62(6):985-94. doi:
10.1007/s00280-008-0688-8. [PMID: 18253734] - Ewen M Harrison, Eva Sharpe, Christopher O Bellamy, Stephen J McNally, Luke Devey, O James Garden, James A Ross, Stephen J Wigmore. Heat shock protein 90-binding agents protect renal cells from oxidative stress and reduce kidney ischemia-reperfusion injury.
American journal of physiology. Renal physiology.
2008 Aug; 295(2):F397-405. doi:
10.1152/ajprenal.00361.2007. [PMID: 18562631] - Larissa Belova, Deanna R Brickley, Betty Ky, Sanjay K Sharma, Suzanne D Conzen. Hsp90 regulates the phosphorylation and activity of serum- and glucocorticoid-regulated kinase-1.
The Journal of biological chemistry.
2008 Jul; 283(27):18821-31. doi:
10.1074/jbc.m803289200. [PMID: 18456663] - Lanyan Fang, Duxin Sun. Predictive physiologically based pharmacokinetic model for antibody-directed enzyme prodrug therapy.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jun; 36(6):1153-65. doi:
10.1124/dmd.107.019182. [PMID: 18356268] - Nina Marie Pedersen, Inger Helene Madshus, Camilla Haslekås, Espen Stang. Geldanamycin-induced down-regulation of ErbB2 from the plasma membrane is clathrin dependent but proteasomal activity independent.
Molecular cancer research : MCR.
2008 Mar; 6(3):491-500. doi:
10.1158/1541-7786.mcr-07-0191. [PMID: 18337455] - Carmel T Chan, Ramasamy Paulmurugan, Olivier S Gheysens, Joungnam Kim, Gabriela Chiosis, Sanjiv Sam Gambhir. Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects.
Cancer research.
2008 Jan; 68(1):216-26. doi:
10.1158/0008-5472.can-07-2268. [PMID: 18172314] - Kenji Yamada, Yoichiro Fukao, Makoto Hayashi, Mitsue Fukazawa, Iku Suzuki, Mikio Nishimura. Cytosolic HSP90 regulates the heat shock response that is responsible for heat acclimation in Arabidopsis thaliana.
The Journal of biological chemistry.
2007 Dec; 282(52):37794-804. doi:
10.1074/jbc.m707168200. [PMID: 17965410] - Fang He, Zhuan-Hong Qiao, Jian Cai, William Pierce, Da-Cheng He, Zhao-Hui Song. Involvement of the 90-kDa heat shock protein (Hsp-90) in CB2 cannabinoid receptor-mediated cell migration: a new role of Hsp-90 in migration signaling of a G protein-coupled receptor.
Molecular pharmacology.
2007 Nov; 72(5):1289-300. doi:
10.1124/mol.107.036566. [PMID: 17698952] - Chen Lu, Dan Chen, Zhengping Zhang, Fang Fang, Yifan Wu, Lan Luo, Zhimin Yin. Heat Shock Protein 90 regulates the stability of c-Jun in HEK293 Cells.
Molecules and cells.
2007 Oct; 24(2):210-4. doi:
NULL. [PMID: 17978573] - Fang Xu, Somshuvra Mukhopadhyay, Pravin B Sehgal. Live cell imaging of interleukin-6-induced targeting of 'transcription factor' STAT3 to sequestering endosomes in the cytoplasm.
American journal of physiology. Cell physiology.
2007 Oct; 293(4):C1374-82. doi:
10.1152/ajpcell.00220.2007. [PMID: 17670892] - Mads Lerdrup, Silas Bruun, Michael V Grandal, Kirstine Roepstorff, Malene M Kristensen, Anette M Hommelgaard, Bo van Deurs. Endocytic down-regulation of ErbB2 is stimulated by cleavage of its C-terminus.
Molecular biology of the cell.
2007 Sep; 18(9):3656-66. doi:
10.1091/mbc.e07-01-0025. [PMID: 17626164] - F Roviezzo, S Cuzzocrea, A Di Lorenzo, V Brancaleone, E Mazzon, R Di Paola, M Bucci, G Cirino. Protective role of PI3-kinase-Akt-eNOS signalling pathway in intestinal injury associated with splanchnic artery occlusion shock.
British journal of pharmacology.
2007 Jun; 151(3):377-83. doi:
10.1038/sj.bjp.0707233. [PMID: 17450173] - Michael Burkitt, Conor Magee, David O'Connor, Fiona Campbell, Philip Cornford, William Greenhalf. Potentiation of chemotherapeutics by the Hsp90 antagonist geldanamycin requires a steady serum condition.
Molecular carcinogenesis.
2007 Jun; 46(6):466-75. doi:
10.1002/mc.20296. [PMID: 17219417] - Aparajita Dey, Arthur I Cederbaum. Geldanamycin, an inhibitor of Hsp90 increases cytochrome P450 2E1 mediated toxicity in HepG2 cells through sustained activation of the p38MAPK pathway.
Archives of biochemistry and biophysics.
2007 May; 461(2):275-86. doi:
10.1016/j.abb.2007.02.014. [PMID: 17382893] - Ye Chen, Michael P Schnetz, Carlos E Irarrazabal, Rong-Fong Shen, Chester K Williams, Maurice B Burg, Joan D Ferraris. Proteomic identification of proteins associated with the osmoregulatory transcription factor TonEBP/OREBP: functional effects of Hsp90 and PARP-1.
American journal of physiology. Renal physiology.
2007 Mar; 292(3):F981-92. doi:
10.1152/ajprenal.00493.2005. [PMID: 17148781] - Shin-ichiro Nakagawa, Takuya Umehara, Chiho Matsuda, Shusuke Kuge, Masayuki Sudoh, Michinori Kohara. Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver mice.
Biochemical and biophysical research communications.
2007 Feb; 353(4):882-8. doi:
10.1016/j.bbrc.2006.12.117. [PMID: 17196931] - Suryakant K Niture, Chinavenmani S Velu, Quentin R Smith, G Jayarama Bhat, Kalkunte S Srivenugopal. Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.
Carcinogenesis.
2007 Feb; 28(2):378-89. doi:
10.1093/carcin/bgl155. [PMID: 16950796] - Sujin Park, Bin Dong, Fumio Matsumura. Rapid activation of c-Src kinase by dioxin is mediated by the Cdc37-HSP90 complex as part of Ah receptor signaling in MCF10A cells.
Biochemistry.
2007 Jan; 46(3):899-908. doi:
10.1021/bi061925f. [PMID: 17223712] - Colleen Fearns, Qilin Pan, John C Mathison, Tsung-Hsien Chuang. Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding.
The Journal of biological chemistry.
2006 Nov; 281(45):34592-600. doi:
10.1074/jbc.m604019200. [PMID: 16968706] - Edward G Mimnaugh, Wanping Xu, Michele Vos, Xitong Yuan, Len Neckers. Endoplasmic reticulum vacuolization and valosin-containing protein relocalization result from simultaneous hsp90 inhibition by geldanamycin and proteasome inhibition by velcade.
Molecular cancer research : MCR.
2006 Sep; 4(9):667-81. doi:
10.1158/1541-7786.mcr-06-0019. [PMID: 16966435] - Chunsik Lee, Johan Dixelius, Asa Thulin, Harukiyo Kawamura, Lena Claesson-Welsh, Anna-Karin Olsson. Signal transduction in endothelial cells by the angiogenesis inhibitor histidine-rich glycoprotein targets focal adhesions.
Experimental cell research.
2006 Aug; 312(13):2547-56. doi:
10.1016/j.yexcr.2006.04.022. [PMID: 16769050] - Juliann G Kiang, Phillip D Bowman, Xinyue Lu, Yansong Li, Xuan Z Ding, Baiteng Zhao, Yuang-Taung Juang, James L Atkins, George C Tsokos. Geldanamycin prevents hemorrhage-induced ATP loss by overexpressing inducible HSP70 and activating pyruvate dehydrogenase.
American journal of physiology. Gastrointestinal and liver physiology.
2006 Jul; 291(1):G117-27. doi:
10.1152/ajpgi.00397.2005. [PMID: 16565416] - Aparajita Dey, Arthur I Cederbaum. Geldanamycin, an inhibitor of Hsp90, potentiates cytochrome P4502E1-mediated toxicity in HepG2 cells.
The Journal of pharmacology and experimental therapeutics.
2006 Jun; 317(3):1391-9. doi:
10.1124/jpet.106.101808. [PMID: 16513847] - Alexandre Hinzpeter, Joanna Lipecka, Franck Brouillard, Maryvonne Baudoin-Legros, Michal Dadlez, Aleksander Edelman, Janine Fritsch. Association between Hsp90 and the ClC-2 chloride channel upregulates channel function.
American journal of physiology. Cell physiology.
2006 Jan; 290(1):C45-56. doi:
10.1152/ajpcell.00209.2005. [PMID: 16049054] - Mads Lerdrup, Anette M Hommelgaard, Michael Grandal, Bo van Deurs. Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.
Journal of cell science.
2006 Jan; 119(Pt 1):85-95. doi:
10.1242/jcs.02707. [PMID: 16352662] - Elizabeth R Glaze, Amy L Lambert, Adaline C Smith, John G Page, William D Johnson, David L McCormick, Alan P Brown, Barry S Levine, Joseph M Covey, Merrill J Egorin, Julie L Eiseman, Julianne L Holleran, Edward A Sausville, Joseph E Tomaszewski. Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance.
Cancer chemotherapy and pharmacology.
2005 Dec; 56(6):637-47. doi:
10.1007/s00280-005-1000-9. [PMID: 15986212] - Virginia L Vega, Antonio De Maio. Increase in phagocytosis after geldanamycin treatment or heat shock: role of heat shock proteins.
Journal of immunology (Baltimore, Md. : 1950).
2005 Oct; 175(8):5280-7. doi:
10.4049/jimmunol.175.8.5280. [PMID: 16210633] - Patrick F Finn, Nicholas T Mesires, Michaela Vine, J Fred Dice. Effects of small molecules on chaperone-mediated autophagy.
Autophagy.
2005 Oct; 1(3):141-5. doi:
10.4161/auto.1.3.2000. [PMID: 16874031] - Andrea M Skantar, Keli Agama, Susan L F Meyer, Lynn K Carta, Bryan T Vinyard. Effects of geldanamycin on hatching and juvenile motility in Caenorhabditis elegans and Heterodera glycines.
Journal of chemical ecology.
2005 Oct; 31(10):2481-91. doi:
10.1007/s10886-005-7114-z. [PMID: 16195856] - Eran Barzilay, Nathalie Ben-Califa, Mika Shahar, Yoel Kashman, Drorit Neumann. Generation of a novel anti-geldanamycin antibody.
Biochemical and biophysical research communications.
2005 May; 330(2):561-4. doi:
10.1016/j.bbrc.2005.03.014. [PMID: 15796919] - Phuong A Vo, Bhavini Lad, James A P Tomlinson, Stephanie Francis, Amrita Ahluwalia. autoregulatory role of endothelium-derived nitric oxide (NO) on Lipopolysaccharide-induced vascular inducible NO synthase expression and function.
The Journal of biological chemistry.
2005 Feb; 280(8):7236-43. doi:
10.1074/jbc.m411317200. [PMID: 15583003] - N F Smith, A Hayes, B P Nutley, F I Raynaud, P Workman. Evaluation of the cassette dosing approach for assessing the pharmacokinetics of geldanamycin analogues in mice.
Cancer chemotherapy and pharmacology.
2004 Dec; 54(6):475-86. doi:
10.1007/s00280-004-0853-7. [PMID: 15526201] - Nao Kagawa. A drastic reduction in the basal level of heat-shock protein 90 in the brain of goldfish (Carassius auratus) after administration of geldanamycin.
Zoological science.
2004 Nov; 21(11):1085-9. doi:
10.2108/zsj.21.1085. [PMID: 15572859] - Sanjay Kansra, Stefan W Stoll, Jessica L Johnson, James T Elder. Autocrine extracellular signal-regulated kinase (ERK) activation in normal human keratinocytes: metalloproteinase-mediated release of amphiregulin triggers signaling from ErbB1 to ERK.
Molecular biology of the cell.
2004 Sep; 15(9):4299-309. doi:
10.1091/mbc.e04-03-0233. [PMID: 15254267] - Jie Zhou, Tobias Schmid, Ronald Frank, Bernhard Brüne. PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation.
The Journal of biological chemistry.
2004 Apr; 279(14):13506-13. doi:
10.1074/jbc.m310164200. [PMID: 14726529] - Aaron P Jansen, Corinne E Camalier, Cristi Stark, Nancy H Colburn. Characterization of programmed cell death 4 in multiple human cancers reveals a novel enhancer of drug sensitivity.
Molecular cancer therapeutics.
2004 Feb; 3(2):103-10. doi:
NULL. [PMID: 14985450] - T R Uhrenholt, J Schjerning, P B Hansen, R Nørregaard, B L Jensen, G L Sorensen, O Skøtt. Rapid inhibition of vasoconstriction in renal afferent arterioles by aldosterone.
Circulation research.
2003 Dec; 93(12):1258-66. doi:
10.1161/01.res.0000106135.02935.e1. [PMID: 14615288] - Elena Adinolfi, Miran Kim, Mark T Young, Francesco Di Virgilio, Annmarie Surprenant. Tyrosine phosphorylation of HSP90 within the P2X7 receptor complex negatively regulates P2X7 receptors.
The Journal of biological chemistry.
2003 Sep; 278(39):37344-51. doi:
10.1074/jbc.m301508200. [PMID: 12869560] - S Agbessi, J Beauséjour, C Déry, C Beaulieu. Antagonistic properties of two recombinant strains of Streptomyces melanosporofaciens obtained by intraspecific protoplast fusion.
Applied microbiology and biotechnology.
2003 Aug; 62(2-3):233-8. doi:
10.1007/s00253-003-1256-0. [PMID: 12883869] - Konstanze F Winklhofer, Ulrich Heller, Anja Reintjes, Jörg Tatzelt. Inhibition of complex glycosylation increases the formation of PrPsc.
Traffic (Copenhagen, Denmark).
2003 May; 4(5):313-22. doi:
10.1034/j.1600-0854.2003.00088.x. [PMID: 12713659] - Noriko Sato, Tetsuya Yamamoto, Yuichi Sekine, Taro Yumioka, Akira Junicho, Hideki Fuse, Tadashi Matsuda. Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.
Biochemical and biophysical research communications.
2003 Jan; 300(4):847-52. doi:
10.1016/s0006-291x(02)02941-8. [PMID: 12559950] - Mehul Shah, Kirit Patel, Victor A Fried, Pravin B Sehgal. Interactions of STAT3 with caveolin-1 and heat shock protein 90 in plasma membrane raft and cytosolic complexes. Preservation of cytokine signaling during fever.
The Journal of biological chemistry.
2002 Nov; 277(47):45662-9. doi:
10.1074/jbc.m205935200. [PMID: 12235142] - Abdul A Waheed, Teresa L Z Jones. Hsp90 interactions and acylation target the G protein Galpha 12 but not Galpha 13 to lipid rafts.
The Journal of biological chemistry.
2002 Sep; 277(36):32409-12. doi:
10.1074/jbc.c200383200. [PMID: 12117999] - Peter M Haggie, Bruce A Stanton, A S Verkman. Diffusional mobility of the cystic fibrosis transmembrane conductance regulator mutant, delta F508-CFTR, in the endoplasmic reticulum measured by photobleaching of GFP-CFTR chimeras.
The Journal of biological chemistry.
2002 May; 277(19):16419-25. doi:
10.1074/jbc.m112361200. [PMID: 11877404] - Sergio Dias, Sergey V Shmelkov, George Lam, Shahin Rafii. VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition.
Blood.
2002 Apr; 99(7):2532-40. doi:
10.1182/blood.v99.7.2532. [PMID: 11895790] - Wanping Xu, Edward G Mimnaugh, Jung-Sik Kim, Jane B Trepel, Leonard M Neckers. Hsp90, not Grp94, regulates the intracellular trafficking and stability of nascent ErbB2.
Cell stress & chaperones.
2002 Jan; 7(1):91-6. doi:
10.1379/1466-1268(2002)007<0091:hngrti>2.0.co;2. [PMID: 11892991]