nonactin (BioDeep_00000008534)
natural product
代谢物信息卡片
Upjohn 170t (high melting)
化学式: C40H64O12 (736.4397544)
中文名称: 无活菌素 来源于灰色链霉菌变种
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CC2CCC(O2)C(C(=O)OC(CC3CCC(O3)C(C(=O)OC(CC4CCC(O4)C(C(=O)OC(CC5CCC(O5)C(C(=O)O1)C)C)C)C)C)C)C
InChI: InChI=1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:7614
- KEGG: C11186
- PubChem: 72519
- PubChem: 574211
- Metlin: METLIN68901
- ChEMBL: CHEMBL415914
- ChEMBL: CHEMBL1551842
- CAS: 6833-84-7
- MoNA: CCMSLIB00000839970
- PMhub: MS000022160
- PubChem: 13367
- NIKKAJI: J9.825F
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 1908 Streptomyces globisporus: 10.1007/BF02884062
- 1911 Streptomyces griseus:
- 1908 Streptomyces globisporus: 10.1007/BF02884062
- 1911 Streptomyces griseus:
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Elina Karhu, Janne Isojärvi, Pia Vuorela, Leena Hanski, Adyary Fallarero. Identification of Privileged Antichlamydial Natural Products by a Ligand-Based Strategy.
Journal of natural products.
2017 10; 80(10):2602-2608. doi:
10.1021/acs.jnatprod.6b01052. [PMID: 29043803] - Svetlana S Efimova, Olga S Ostroumova. Effect of dipole modifiers on the magnitude of the dipole potential of sterol-containing bilayers.
Langmuir : the ACS journal of surfaces and colloids.
2012 Jul; 28(26):9908-14. doi:
10.1021/la301653s. [PMID: 22702338] - Pius S Fasinu, Patrick J Bouic, Bernd Rosenkranz. An overview of the evidence and mechanisms of herb-drug interactions.
Frontiers in pharmacology.
2012; 3(?):69. doi:
10.3389/fphar.2012.00069. [PMID: 22557968] - Tomás Rezanka, Ales Prell, Jaroslav Spízek, Karel Sigler. Pilot-plant cultivation of Streptomyces griseus producing homologues of nonactin by precursor-directed biosynthesis and their identification by LC/MS-ESI.
The Journal of antibiotics.
2010 Aug; 63(8):524-9. doi:
10.1038/ja.2010.93. [PMID: 20664602] - Jin-Man Lee, Jong-Guk Kim, Tae-Ho Kim, Do S Lee, Jae H Kim, Somi K Cho, Key Z Riu, Dong-Sun Lee, Sang-Han Lee. Nonactin hinders intracellular glycosylation in virus-infected baby hamster kidney cells.
Molecular medicine reports.
2010 Jan; 3(1):115-9. doi:
10.3892/mmr_00000227. [PMID: 21472209] - Veronica Wasserman, Pablo Kizelsztein, Olga Garbuzenko, Ron Kohen, Haim Ovadia, Rinat Tabakman, Yechezkel Barenholz. The antioxidant tempamine: in vitro antitumor and neuroprotective effects and optimization of liposomal encapsulation and release.
Langmuir : the ACS journal of surfaces and colloids.
2007 Feb; 23(4):1937-47. doi:
10.1021/la060218k. [PMID: 17279678] - Yuri Sokolov, J Ashot Kozak, Rakez Kayed, Alexandr Chanturiya, Charles Glabe, James E Hall. Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure.
The Journal of general physiology.
2006 Dec; 128(6):637-47. doi:
10.1085/jgp.200609533. [PMID: 17101816] - V Gh Shlyonsky, V S Markin, I Andreeva, S E Pedersen, S A Simon, D J Benos, I I Ismailov. Role of membrane curvature in mechanoelectrical transduction: ion carriers nonactin and valinomycin sense changes in integral bending energy.
Biochimica et biophysica acta.
2006 Nov; 1758(11):1723-31. doi:
10.1016/j.bbamem.2006.09.016. [PMID: 17069752] - Sven O Hagge, Malte U Hammer, Andre Wiese, Ulrich Seydel, Thomas Gutsmann. Calcium adsorption and displacement: characterization of lipid monolayers and their interaction with membrane-active peptides/proteins.
BMC biochemistry.
2006 May; 7(?):15. doi:
10.1186/1471-2091-7-15. [PMID: 16672047] - Pei-Ji Zhao, Li-Ming Fan, Guo-Hong Li, Na Zhu, Yue-Mao Shen. Antibacterial and antitumor macrolides from Streptomyces sp. Is9131.
Archives of pharmacal research.
2005 Nov; 28(11):1228-32. doi:
10.1007/bf02978203. [PMID: 16350846] - Emine Karakuş, Sule Pekyardimci, Kiliç Esma. Urea biosensors based on PVC membrane containing palmitic acid.
Artificial cells, blood substitutes, and immobilization biotechnology.
2005; 33(3):329-41. doi:
10.1081/bio-200066632. [PMID: 16152697] - Frank Killig, Günther Stark. Photodynamic activation of ion transport through lipid membranes and its correlation with an increased dielectric constant of the membrane.
Biochimica et biophysica acta.
2002 Aug; 1564(1):207-13. doi:
10.1016/s0005-2736(02)00452-2. [PMID: 12101014] - Júlia M C S Magalhães, Adélio A S C Machado. Array of potentiometric sensors for the analysis of creatinine in urine samples.
The Analyst.
2002 Aug; 127(8):1069-75. doi:
10.1039/b201173e. [PMID: 12195948] - S Bala, M H Kombrabail, B S Prabhananda. Effect of phloretin on ionophore mediated electroneutral transmembrane translocations of H(+), K(+) and Na(+) in phospholipid vesicles.
Biochimica et biophysica acta.
2001 Feb; 1510(1-2):258-69. doi:
10.1016/s0005-2736(00)00357-6. [PMID: 11342163] - S Torralba, I B Heath. Cytoskeletal and Ca2+ regulation of hyphal tip growth and initiation.
Current topics in developmental biology.
2001; 51(?):135-87. doi:
10.1016/s0070-2153(01)51005-4. [PMID: 11236713] - Y Sokolov, W S Mailliard, N Tranngo, M Isas, H Luecke, H T Haigler, J E Hall. Annexins V and XII alter the properties of planar lipid bilayers seen by conductance probes.
The Journal of general physiology.
2000 May; 115(5):571-82. doi:
10.1085/jgp.115.5.571. [PMID: 10779315] - B J Soltys, R S Gupta. Immunoelectron microscopic localization of the 60-kDa heat shock chaperonin protein (Hsp60) in mammalian cells.
Experimental cell research.
1996 Jan; 222(1):16-27. doi:
10.1006/excr.1996.0003. [PMID: 8549659] - J G Schindler, M M Schindler, K Herna, E Reisinger, B Burk, U Kuhlmann, J Knaack, B Schmidt, H Lange. [Urea sensor for the continuous ammonium-selective enzymatic process control of the artificial kidney].
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies.
1994 Mar; 32(3):145-52. doi:
. [PMID: 8031965] - G Vareille, P Marion, J L Kraus, M Castaing. Sodium transport by an ionizable and a neutral mobile carrier: effects of membrane structure on the apparent activation energy.
Biochimica et biophysica acta.
1993 Feb; 1146(1):25-37. doi:
10.1016/0005-2736(93)90334-v. [PMID: 8443224] - H J Freisleben, D Blöcher, K Ring. Calorimetry of tetraether lipids from Thermoplasma acidophilum: incorporation of alamethicin, melittin, valinomycin, and nonactin.
Archives of biochemistry and biophysics.
1992 May; 294(2):418-26. doi:
10.1016/0003-9861(92)90706-3. [PMID: 1567197] - G J Brewer, N Matinyan. Congregation of gangliosides at the junction between two model membranes.
Biochemistry.
1992 Feb; 31(6):1816-20. doi:
10.1021/bi00121a033. [PMID: 1737034] - N S Matinyan, G B Melikyan, V B Arakelyan, S L Kocharov, N V Prokazova, T M Avakian. Interaction of ganglioside-containing planar bilayers with serotonin and inorganic cations.
Biochimica et biophysica acta.
1989 Sep; 984(3):313-8. doi:
10.1016/0005-2736(89)90298-8. [PMID: 2775780] - R Awiszus, G Stark. A laser-T-jump study of the adsorption of dipolar molecules to planar lipid membranes. I. 2,4-dichlorophenoxyacetic acid.
European biophysics journal : EBJ.
1988; 15(5):299-310. doi:
10.1007/bf00256481. [PMID: 3366096] - M B Sankaram, B P Shastri, K R Easwaran. Interaction of carrier ionophores with phospholipid vesicles.
Biochemistry.
1987 Aug; 26(16):4936-41. doi:
10.1021/bi00390a008. [PMID: 3117109] - M Strässle, G Stark, M Wilhelm. Effect of ionizing radiation on artificial (planar) lipid membranes. II. The ion carriers valinomycin and nonactin as probes for radiation induced structural changes of the membrane.
International journal of radiation biology and related studies in physics, chemistry, and medicine.
1987 Feb; 51(2):287-302. doi:
10.1080/09553008714550771. [PMID: 3493991] - G N Ling, M M Ochsenfeld. Membrane lipid layers vs. polarized water dominated by fixed ions: a comparative study of the effects of three macrocyclic ionophores on the K+ permeability of frog skeletal muscle, frog ovarian eggs, and human erythrocytes.
Physiological chemistry and physics and medical NMR.
1986; 18(2):109-24. doi:
. [PMID: 3492720] - J Widmer, J M Gaillard, Y Raffin, D Mouthon, R Tissot. In vitro effects of ionophores and inhibitors of main sodium and calcium movements on tyrosine and tryptophan transport by human erythrocytes.
Neuropsychobiology.
1986; 16(4):175-80. doi:
10.1159/000118322. [PMID: 3112604] - C van Dijk, R de Levie. An experimental comparison between the continuum and single jump descriptions of nonactin-mediated potassium transport through black lipid membranes.
Biophysical journal.
1985 Jul; 48(1):125-36. doi:
10.1016/s0006-3495(85)83766-8. [PMID: 3839420] - B A Sinha, P Smejtek. Effect of 3-phenylindole on lipophilic ion and carrier-mediated ion transport across bilayer lipid membranes.
The Journal of membrane biology.
1983; 71(1-2):119-30. doi:
10.1007/bf01870680. [PMID: 6687614] - O A Gracheva, A E Sokolova, A A Lev. [Phase separation in dipalmitoyl phosphatidylcholine bilayers induced by ionophores and binary electrolytes].
Biofizika.
1982 Sep; 27(5):795-9. doi:
". [PMID: 6897197] - J Y Lapointe, R Laprade. Kinetics of carrier-mediated ion transport in two new types of solvent-free lipid bilayers.
Biophysical journal.
1982 Aug; 39(2):141-50. doi:
10.1016/s0006-3495(82)84501-3. [PMID: 6896832] - R Laprade, F Grenier, J Y Lapointe, S Asselin. Effects of variation of ion and methylation of carrier on the rate constants of macrotetralide-mediated ion transport in lipid bilayers.
The Journal of membrane biology.
1982; 68(3):191-206. doi:
10.1007/bf01872264. [PMID: 6897080] - E Diaz, J Sandblom. Displacement currents in lipid bilayer membranes.
Upsala journal of medical sciences.
1982; 87(1):33-42. doi:
10.3109/03009738209178407. [PMID: 6896941] - P Smejtek, M Paulis-Illangasekare. Modification of ion transport in lipid bilayer membranes in the presence of 2,4-dichlorophenoxyacetic acid. I. Enhancement of cationic conductance and changes of the kinetics of nonactin-mediated transport of potassium.
Biophysical journal.
1979 Jun; 26(3):441-66. doi:
10.1016/s0006-3495(79)85264-9. [PMID: 263687]