Betavulgarin (BioDeep_00000007934)

 

Secondary id: BioDeep_00000269988

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


7-(2-hydroxyphenyl)-9-methoxy-2H,8H-[1,3]dioxolo[4,5-g]chromen-8-one

化学式: C17H12O6 (312.0634)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 93.75%

分子结构信息

SMILES: c12c(c(c3c(c1)occ(c3=O)c1c(cccc1)O)OC)OCO2
InChI: InChI=1S/C17H12O6/c1-20-17-14-12(6-13-16(17)23-8-22-13)21-7-10(15(14)19)9-4-2-3-5-11(9)18/h2-7,18H,8H2,1H3

描述信息

Betavulgarin, also known as 2-hydroxy-5-methoxy-6,7-methylenedioxyisoflavone, is a member of the class of compounds known as isoflavones. Isoflavones are polycyclic compounds containing a 2-isoflavene skeleton which bears a ketone group at the C4 carbon atom. Thus, betavulgarin is considered to be a flavonoid lipid molecule. Betavulgarin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Betavulgarin can be found in chickpea, common beet, and red beetroot, which makes betavulgarin a potential biomarker for the consumption of these food products.

同义名列表

5 个代谢物同义名

7-(2-hydroxyphenyl)-9-methoxy-2H,8H-[1,3]dioxolo[4,5-g]chromen-8-one; 7-(2-Hydroxyphenyl)-9-methoxy-8H-(1,3)dioxolo(4,5-g)chromen-8-one; 2-Hydroxy-5-methoxy-6,7-methylenedioxyisoflavone; Betavulgarin; Betavulgarin



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

49 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 AKT1, MAPK14, MYC, NOS2, PPARG, PTGS1, PTGS2, RELA, SOX2, SRY, STAT3
Peripheral membrane protein 2 PTGS1, PTGS2
Endoplasmic reticulum membrane 2 PTGS1, PTGS2
Nucleus 11 AKT1, MAPK14, MMP2, MYC, NANOG, NOS2, PPARG, RELA, SOX2, SRY, STAT3
cytosol 9 AKT1, CD44, IL1B, MAPK14, NOS2, PPARG, RELA, SOX2, STAT3
nucleoplasm 10 AKT1, MAPK14, MYC, NANOG, NOS2, PPARG, RELA, SOX2, SRY, STAT3
RNA polymerase II transcription regulator complex 2 PPARG, STAT3
Cell membrane 4 AKT1, CD44, HTR3A, TNF
Cleavage furrow 1 HTR3A
lamellipodium 1 AKT1
Multi-pass membrane protein 1 HTR3A
Synapse 1 HTR3A
cell cortex 1 AKT1
cell surface 3 CD24, CD44, TNF
glutamatergic synapse 3 AKT1, MAPK14, RELA
Golgi apparatus 2 CD44, PTGS1
neuronal cell body 1 TNF
postsynapse 2 AKT1, HTR3A
Cytoplasm, cytosol 2 IL1B, NOS2
Lysosome 1 IL1B
plasma membrane 7 AKT1, CD44, HTR3A, MMP2, NOS2, STAT3, TNF
Membrane 5 AKT1, CD24, CD44, HTR3A, MYC
apical plasma membrane 1 CD44
basolateral plasma membrane 1 CD44
caveola 1 PTGS2
extracellular exosome 3 CD44, MMP9, PTGS1
endoplasmic reticulum 1 PTGS2
extracellular space 5 IL17A, IL1B, MMP2, MMP9, TNF
perinuclear region of cytoplasm 2 NOS2, PPARG
mitochondrion 2 MAPK14, MMP2
protein-containing complex 3 AKT1, MYC, PTGS2
intracellular membrane-bounded organelle 4 CD24, NANOG, PPARG, PTGS1
Microsome membrane 2 PTGS1, PTGS2
Single-pass type I membrane protein 1 CD44
Secreted 3 CD44, IL17A, IL1B
extracellular region 7 CD44, IL17A, IL1B, MAPK14, MMP2, MMP9, TNF
Single-pass membrane protein 1 CD44
transcription regulator complex 3 RELA, SOX2, STAT3
photoreceptor outer segment 1 PTGS1
external side of plasma membrane 3 CD24, IL17A, TNF
Secreted, extracellular space, extracellular matrix 1 MMP9
microtubule cytoskeleton 1 AKT1
nucleolus 2 MYC, NANOG
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
postsynaptic membrane 1 HTR3A
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 2 CD24, TNF
focal adhesion 1 CD44
spindle 1 AKT1
extracellular matrix 1 MMP2
Peroxisome 1 NOS2
peroxisomal matrix 1 NOS2
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 2 MMP2, MMP9
secretory granule 1 IL1B
nuclear speck 3 MAPK14, SOX2, SRY
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Postsynaptic cell membrane 1 HTR3A
sarcomere 1 MMP2
receptor complex 1 PPARG
neuron projection 3 HTR3A, PTGS1, PTGS2
ciliary basal body 1 AKT1
chromatin 7 MYC, NANOG, PPARG, RELA, SOX2, SRY, STAT3
cell projection 1 CD44
phagocytic cup 1 TNF
Nucleus, nucleolus 1 MYC
spindle pole 1 MAPK14
serotonin-activated cation-selective channel complex 1 HTR3A
transmembrane transporter complex 1 HTR3A
nuclear envelope 1 MYC
Endomembrane system 1 PTGS1
microvillus 1 CD44
Cell projection, microvillus 1 CD44
Nucleus, nucleoplasm 1 MYC
Nucleus speckle 2 SOX2, SRY
ficolin-1-rich granule lumen 2 MAPK14, MMP9
secretory granule lumen 1 MAPK14
secretory granule membrane 1 CD44
endoplasmic reticulum lumen 1 PTGS2
tertiary granule lumen 1 MMP9
[Isoform 1]: Secreted, extracellular space, extracellular matrix 1 MMP2
RNA polymerase II transcription repressor complex 1 MYC
Secreted, extracellular exosome 1 IL1B
Rough endoplasmic reticulum 1 MYC
lamellipodium membrane 1 CD44
Myc-Max complex 1 MYC
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
macrophage migration inhibitory factor receptor complex 1 CD44
NF-kappaB p50/p65 complex 1 RELA
NF-kappaB complex 1 RELA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
nucleoplasmic reticulum 1 MYC


文献列表

  • Ren Liu, Hack Sun Choi, Xing Zhen, Su-Lim Kim, Ji-Hyang Kim, Yu-Chan Ko, Bong-Sik Yun, Dong-Sun Lee. Betavulgarin Isolated from Sugar Beet (Beta vulgaris) Suppresses Breast Cancer Stem Cells through Stat3 Signaling. Molecules (Basel, Switzerland). 2020 Jun; 25(13):. doi: 10.3390/molecules25132999. [PMID: 32630026]
  • Muhammad Iqbal Choudhary, Sumaira Hareem, Hina Siddiqui, Shazia Anjum, Shamsher Ali, Atta-Ur-Rahman, Mudassir Israr Zaidi. A benzil and isoflavone from Iris tenuifolia. Phytochemistry. 2008 Jun; 69(9):1880-5. doi: 10.1016/j.phytochem.2008.03.011. [PMID: 18472117]