Swerchirin (BioDeep_00000007870)

 

Secondary id: BioDeep_00000866239

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


1,8-dihydroxy-3,5-dimethoxy-9H-xanthen-9-one

化学式: C15H12O6 (288.06338519999997)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 66.67%

分子结构信息

SMILES: c1(cc(c2c(c1)oc1c(c2=O)c(ccc1OC)O)O)OC
InChI: InChI=1S/C15H12O6/c1-19-7-5-9(17)12-11(6-7)21-15-10(20-2)4-3-8(16)13(15)14(12)18/h3-6,16-17H,1-2H3

描述信息

同义名列表

9 个代谢物同义名

1,8-dihydroxy-3,5-dimethoxy-9H-xanthen-9-one; 1,8-Dihydroxy-3,5-dimethoxy-xanthenone; 1,8-Dihydroxy-3,5-dimethoxyxanthenone; 1,8-Dihydroxy-2,6-dimethoxyxanthone; 1,8-Dihydroxy-3,5-dimethoxyxanthone; 3,5-Dimethoxy-1,8-dihydroxyxanthone; 5-O-Methylbellidifolin; Methylbellidifolin; Swerchirin



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

95 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lan Luo, Haibo Zhao, Qian Luo. Swerchirin exerts anticancer activity on SKOV3 human ovarian cancer cells via induction of mitochondrial apoptosis, G2/M cell cycle arrest and inhibition of Raf/MEK/ERK cascade. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2018 Jan; 23(1):111-116. doi: . [PMID: 29552769]
  • Susanna Phoboo, Marcia Da Silva Pinto, Ana Cristina Lopes Barbosa, Dipayan Sarkar, Prasanta C Bhowmik, Pramod Kumar Jha, Kalidas Shetty. Phenolic-linked biochemical rationale for the anti-diabetic properties of Swertia chirayita (Roxb. ex Flem.) Karst. Phytotherapy research : PTR. 2013 Feb; 27(2):227-35. doi: 10.1002/ptr.4714. [PMID: 22523004]
  • Jing Jia, Tao Chen, Ping Wang, Guichen Chen, Jinmao You, Yongjun Liu, Yulin Li. Preparative separation of methylswertianin, swerchirin and decussatin from the Tibetan medicinal plant Swertia mussotii using high-speed counter-current chromatography. Phytochemical analysis : PCA. 2012 Jul; 23(4):332-6. doi: 10.1002/pca.1362. [PMID: 22052665]
  • Yi Yuan, Baosong Cui, Ying Zhang, Shuai Li. [Xanthones of Comastoma pedunlulatum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Jun; 35(12):1577-9. doi: 10.4268/cjcmm20101216. [PMID: 20815211]
  • Jin Zhang, Mi-Jeong Ahn, Qi Shi Sun, Ki-Yoon Kim, Yun Ha Hwang, Jei Man Ryu, Jinwoong Kim. Inhibitors of bone resorption from Halenia corniculata. Archives of pharmacal research. 2008 Jul; 31(7):850-5. doi: 10.1007/s12272-001-1237-y. [PMID: 18704326]
  • Homa Hajimehdipoor, Zhina Sadeghi, Sara Elmi, Azadeh Elmi, Mahmoud Ghazi-Khansari, Yaghoub Amanzadeh, Seyyed-Esmaeal Sadat-Ebrahimi. Protective effects of Swertia longifolia Boiss. and its active compound, swerchirin, on paracetamol-induced hepatotoxicity in mice. The Journal of pharmacy and pharmacology. 2006 Feb; 58(2):277-80. doi: 10.1211/jpp.58.2.0017. [PMID: 16451758]
  • Huiling Yang, Chenxu Ding, Yuanwen Duan, Jianquan Liu. Variation of active constituents of an important Tibet folk medicine Swertia mussotii Franch. (Gentianaceae) between artificially cultivated and naturally distributed. Journal of ethnopharmacology. 2005 Apr; 98(1-2):31-5. doi: 10.1016/j.jep.2004.12.015. [PMID: 15763361]
  • B Q Ya, L C Nian, C Li, X P Gen. Protective effect of swerchirin on hematopoiesis in 60Co-irradiated mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 1999 May; 6(2):85-8. doi: 10.1016/s0944-7113(99)80040-3. [PMID: 10374245]
  • A M Saxena, M B Bajpai, P S Murthy, S K Mukherjee. Mechanism of blood sugar lowering by a swerchirin-containing hexane fraction (SWI) of Swertia chirayita. Indian journal of experimental biology. 1993 Feb; 31(2):178-81. doi: . [PMID: 8500831]
  • M B Bajpai, R K Asthana, N K Sharma, S K Chatterjee, S K Mukherjee. Hypoglycemic effect of swerchirin from the hexane fraction of Swertia chirayita. Planta medica. 1991 Apr; 57(2):102-4. doi: 10.1055/s-2006-960041. [PMID: 1891489]
  • I Agata, H Sekizaki, A Sakushima, S Nishibe, S Hisada, K Kimura. [Studies on the constituents of medicinal plants in Hokkaido. I. On the whole herb of Swertia tetrapetala Pall. (1) (author's transl)]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1981 Nov; 101(11):1067-71. doi: 10.1248/yakushi1947.101.11_1067. [PMID: 7343662]