6-Hydroxykaempferol (BioDeep_00000007855)

 

Secondary id: BioDeep_00000270328

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


6-Hydroxykaempferol

化学式: C15H10O7 (302.0427)
中文名称:
谱图信息: 最多检出来源 Mus musculus(not specific) 7.5%

分子结构信息

SMILES: c1(c(c(c2c(c1)oc(c(c2=O)O)c1ccc(cc1)O)O)O)O
InChI: InChI=1S/C15H10O7/c16-7-3-1-6(2-4-7)15-14(21)13(20)10-9(22-15)5-8(17)11(18)12(10)19/h1-5,16-19,21H

描述信息

同义名列表

2 个代谢物同义名

6-Hydroxykaempferol; 6-Hydroxykaempferol



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

21 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ALOX5, ANG, ANXA5, CNP, PARK7, PIK3R1, RB1, SNCA, TFDP3, TH, TYR, VEGFA
Peripheral membrane protein 2 ALOX5, ANXA5
Endoplasmic reticulum membrane 1 CYP1A2
Nucleus 9 ANG, MYB, PARK7, PIK3R1, RB1, SNCA, TFDP3, TH, VEGFA
cytosol 9 ALOX5, ANG, ANXA5, MYB, PARK7, PIK3R1, RB1, SNCA, TH
dendrite 1 TH
nucleoplasm 4 ALOX5, MYB, PARK7, RB1
RNA polymerase II transcription regulator complex 1 MYB
Cell membrane 2 PARK7, TNF
Lipid-anchor 2 CNP, PARK7
Cell projection, axon 2 SNCA, TH
Synapse 2 CNP, SNCA
cell cortex 1 SNCA
cell surface 2 TNF, VEGFA
Golgi apparatus 1 VEGFA
growth cone 2 ANG, SNCA
lysosomal membrane 1 GAA
mitochondrial inner membrane 1 CNP
neuronal cell body 3 ANG, SNCA, TNF
postsynapse 1 SNCA
sarcolemma 1 ANXA5
smooth endoplasmic reticulum 1 TH
synaptic vesicle 2 PARK7, TH
Cytoplasm, cytosol 1 ALOX5
Lysosome 3 GAA, SNCA, TYR
plasma membrane 7 BCHE, F2, GAA, PARK7, PIK3R1, SNCA, TNF
synaptic vesicle membrane 1 SNCA
terminal bouton 1 TH
Membrane 8 ANXA5, CNP, GAA, MYB, PARK7, PIK3R1, SNCA, VEGFA
axon 3 PARK7, SNCA, TH
extracellular exosome 5 ANXA5, CNP, F2, GAA, PARK7
Lysosome membrane 1 GAA
endoplasmic reticulum 2 PARK7, VEGFA
extracellular space 10 ALOX5, ANG, BCHE, CCL2, CNP, CXCL8, F2, SNCA, TNF, VEGFA
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 7 ALOX5, CNP, PARK7, PIK3R1, SNCA, TH, TYR
adherens junction 2 PARK7, VEGFA
mitochondrion 3 PARK7, SNCA, TH
protein-containing complex 1 SNCA
intracellular membrane-bounded organelle 3 CYP1A2, GAA, TYR
Microsome membrane 1 CYP1A2
Single-pass type I membrane protein 1 TYR
Secreted 8 ANG, BCHE, CCL2, CXCL8, F2, GAA, SNCA, VEGFA
extracellular region 11 ALOX5, ANG, ANXA5, BCHE, CCL2, CXCL8, F2, GAA, SNCA, TNF, VEGFA
cytoplasmic side of plasma membrane 1 TH
mitochondrial outer membrane 1 CNP
mitochondrial matrix 1 PARK7
transcription regulator complex 1 TFDP3
Nucleus membrane 1 ALOX5
nuclear membrane 1 ALOX5
external side of plasma membrane 2 ANXA5, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 2 ANG, SNCA
perikaryon 1 TH
cytoplasmic vesicle 1 TH
nucleolus 1 ANG
Melanosome membrane 2 TH, TYR
cell-cell junction 1 PIK3R1
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 2 ALOX5, TH
Membrane raft 2 PARK7, TNF
focal adhesion 1 ANXA5
microtubule 1 CNP
spindle 1 RB1
cis-Golgi network 1 PIK3R1
perinuclear endoplasmic reticulum membrane 1 PIK3R1
extracellular matrix 1 VEGFA
basement membrane 1 ANG
PML body 2 PARK7, RB1
mitochondrial intermembrane space 1 PARK7
collagen-containing extracellular matrix 2 ANXA5, F2
secretory granule 1 VEGFA
Zymogen granule membrane 1 ANXA5
neuron projection 1 TH
chromatin 3 PARK7, RB1, TFDP3
phagocytic cup 1 TNF
supramolecular fiber 1 SNCA
Chromosome 1 ANG
Nucleus, nucleolus 1 ANG
blood microparticle 2 BCHE, F2
nuclear envelope 1 ALOX5
Nucleus envelope 1 ALOX5
microvillus 1 CNP
tertiary granule membrane 1 GAA
Melanosome 2 CNP, TYR
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
cell body 1 PARK7
pseudopodium 1 CNP
ficolin-1-rich granule lumen 1 ALOX5
secretory granule lumen 1 ALOX5
Golgi lumen 1 F2
endoplasmic reticulum lumen 2 BCHE, F2
nuclear matrix 2 ALOX5, MYB
platelet alpha granule lumen 1 VEGFA
axon terminus 1 SNCA
phosphatidylinositol 3-kinase complex 1 PIK3R1
phosphatidylinositol 3-kinase complex, class IA 1 PIK3R1
endocytic vesicle 1 ANG
azurophil granule membrane 1 GAA
SWI/SNF complex 1 RB1
Nucleus matrix 1 ALOX5
nuclear envelope lumen 2 ALOX5, BCHE
vesicle membrane 1 ANXA5
ficolin-1-rich granule membrane 1 GAA
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
angiogenin-PRI complex 1 ANG
inclusion body 1 SNCA
myelin sheath abaxonal region 1 CNP
chromatin lock complex 1 RB1
Rb-E2F complex 1 RB1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
myelin sheath adaxonal region 1 CNP
endothelial microparticle 1 ANXA5
Nucleus intermembrane space 1 ALOX5
autolysosome lumen 1 GAA
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Anil Pareek, Manish Suthar, Garvendra S Rathore, Vijay Bansal. Feverfew (Tanacetum parthenium L.): A systematic review. Pharmacognosy reviews. 2011 Jan; 5(9):103-10. doi: 10.4103/0973-7847.79105. [PMID: 22096324]
  • Wei Qu, Li Fan, Yun-chul Kim, Shizuma Ishikawa, Sanae M M Iguchi-Ariga, Xiao-Ping Pu, Hiroyoshi Ariga. Kaempferol derivatives prevent oxidative stress-induced cell death in a DJ-1-dependent manner. Journal of pharmacological sciences. 2009 Jun; 110(2):191-200. doi: 10.1254/jphs.09045fp. [PMID: 19498271]
  • Fumio Matsuda, Keiko Yonekura-Sakakibara, Rie Niida, Takashi Kuromori, Kazuo Shinozaki, Kazuki Saito. MS/MS spectral tag-based annotation of non-targeted profile of plant secondary metabolites. The Plant journal : for cell and molecular biology. 2009 Feb; 57(3):555-77. doi: 10.1111/j.1365-313x.2008.03705.x. [PMID: 18939963]
  • Hai-Jiang Zhang, Yi-Yu Cheng. An HPLC/MS method for identifying major constituents in the hypocholesterolemic extracts of Chinese medicine formula 'Xue-Fu-Zhu-Yu decoction'. Biomedical chromatography : BMC. 2006 Aug; 20(8):821-6. doi: 10.1002/bmc.607. [PMID: 16345012]
  • Joo-Heon Yoon, Seung Joon Baek. Molecular targets of dietary polyphenols with anti-inflammatory properties. Yonsei medical journal. 2005 Oct; 46(5):585-96. doi: 10.3349/ymj.2005.46.5.585. [PMID: 16259055]
  • María A Ponce, José M Scervino, Rosa Erra-Balsells, Juan A Ocampo, Alicia M Godeas. Flavonoids from shoots and roots of Trifolium repens (white clover) grown in presence or absence of the arbuscular mycorrhizal fungus Glomus intraradices. Phytochemistry. 2004 Jul; 65(13):1925-30. doi: 10.1016/j.phytochem.2004.06.005. [PMID: 15279999]
  • Christine A Williams, Jeffrey B Harborne, Jenny R Greenham, Renée J Grayer, Geoffrey C Kite, John Eagles. Variations in lipophilic and vacuolar flavonoids among European Pulicaria species. Phytochemistry. 2003 Sep; 64(1):275-83. doi: 10.1016/s0031-9422(03)00207-3. [PMID: 12946426]
  • Jenny Greenham, Jeffrey B Harborne, Christine A Williams. Identification of lipophilic flavones and flavonols by comparative HPLC, TLC and UV spectral analysis. Phytochemical analysis : PCA. 2003 Mar; 14(2):100-18. doi: 10.1002/pca.693. [PMID: 12693635]