Trilobacin (BioDeep_00000007797)
Secondary id: BioDeep_00000843899, BioDeep_00001869761
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
化学式: C37H66O7 (622.4808)
中文名称: 番荔枝宁VI
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 13.53%
分子结构信息
SMILES: CCCCCCCCCCC(C1CCC(O1)C2CCC(O2)C(CCCCCCCCCCC(CC3=CC(OC3=O)C)O)O)O
InChI: InChI=1S/C37H66O7/c1-3-4-5-6-7-11-14-17-20-31(39)33-22-24-35(43-33)36-25-23-34(44-36)32(40)21-18-15-12-9-8-10-13-16-19-30(38)27-29-26-28(2)42-37(29)41/h26,28,30-36,38-40H,3-25,27H2,1-2H3/t28-,30-,31+,32+,33+,34+,35+,36+/m0/s1
描述信息
Isolated from Asimina triloba (pawpaw), Annona squamosa (sugar apple), Annona purpurea (soncoya) and Rollinia mucosa (biriba). Asimicin is found in many foods, some of which are fruits, alcoholic beverages, sugar apple, and beverages.
Bullatacin is found in alcoholic beverages. Bullatacin is isolated from Rollinia mucosa (biriba), Annona squamosa (sugar apple) and Annona reticulata (custard apple).
D010575 - Pesticides > D007306 - Insecticides
D000970 - Antineoplastic Agents
D016573 - Agrochemicals
同义名列表
9 个代谢物同义名
3-(2,13-dihydroxy-13-{5-[5-(1-hydroxyundecyl)oxolan-2-yl]oxolan-2-yl}tridecyl)-5-methyl-2,5-dihydrofuran-2-one; 3-(2,13-dihydroxy-13-{5-[5-(1-hydroxyundecyl)oxolan-2-yl]oxolan-2-yl}tridecyl)-5-methyl-5H-furan-2-one; Rolliniastatin-2; annonin VI; Trilobacin; Bullatacin; Asimicin; Squamocin; Asimicin
数据库引用编号
27 个数据库交叉引用编号
- ChEBI: CHEBI:2874
- KEGG: C08467
- PubChem: 130056
- PubChem: 441555
- HMDB: HMDB0031369
- Metlin: METLIN46761
- ChEMBL: CHEMBL503360
- ChEMBL: CHEMBL61332
- KNApSAcK: C00044359
- KNApSAcK: C00044300
- foodb: FDB018174
- chemspider: 115108
- CAS: 140224-67-5
- CAS: 129212-94-8
- CAS: 102989-24-2
- CAS: 120298-30-8
- CAS: 123805-39-0
- PMhub: MS000021282
- PubChem: 10660
- KNApSAcK: C00001301
- NIKKAJI: J812.463I
- KEGG: C08545
- PubChem: 10738
- KNApSAcK: 9246
- KNApSAcK: 2874
- LOTUS: LTS0233319
- wikidata: Q730429
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
9 个相关的物种来源信息
- 49314 - Annona cherimola:
- 502529 - Annona cornifolia: 10.1016/J.FOODCHEM.2010.03.100
- 301703 - Annona glabra: 10.1584/JPESTICS.16.93
- 301699 - Annona mucosa:
- 1123437 - Annona purpurea:
- 301862 - Annona reticulata:
- 301693 - Annona squamosa:
- 137664 - Asimina parviflora: 10.1021/NP50088A012
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Claudia Azucena Durán-Ruiz, Rocío Cruz-Ortega, Alejandro Zaldívar-Riverón, Hilda Araceli Zavaleta-Mancera, Iván De-la-Cruz-Chacón, Alma Rosa González-Esquinca. Ontogenic synchronization of Bephratelloides cubensis, Annona macroprophyllata seeds and acetogenins from Annonaceae.
Journal of plant research.
2019 Jan; 132(1):81-91. doi:
10.1007/s10265-018-01078-3. [PMID: 30607643] - Jing-Fang Shi, Ping Wu, Zi-Hua Jiang, Xiao-Yi Wei. Synthesis and tumor cell growth inhibitory activity of biotinylated annonaceous acetogenins.
European journal of medicinal chemistry.
2014 Jan; 71(?):219-28. doi:
10.1016/j.ejmech.2013.11.012. [PMID: 24308999] - Yong Chen, Sha-sha Xu, Jian-wei Chen, Yu Wang, Hui-qing Xu, Nai-bing Fan, Xiang Li. Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds.
Journal of ethnopharmacology.
2012 Jul; 142(2):462-6. doi:
10.1016/j.jep.2012.05.019. [PMID: 22609808] - Yong Chen, Jian-wei Chen, Shi-jia Liu, Chun-lei Xu, Hui-qing Xu, Bao-chang Cai, Xiang Li, Wen-zheng Ju. Determination of bullatacin in rat plasma by liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 May; 897(?):94-7. doi:
10.1016/j.jchromb.2012.03.044. [PMID: 22534655] - Kirk W Pomper, Jeremiah D Lowe, Sheri B Crabtree, William Keller. Identification of annonaceous acetogenins in the ripe fruit of the North American pawpaw ( Asimina triloba ).
Journal of agricultural and food chemistry.
2009 Sep; 57(18):8339-43. doi:
10.1021/jf9018239. [PMID: 19711911] - Azucena González-Coloma, Ana Guadaño, Concepción de Inés, Rafael Martínez-Díaz, Diego Cortes. Selective action of acetogenin mitochondrial complex I inhibitors.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2002 Nov; 57(11-12):1028-34. doi:
10.1515/znc-2002-11-1213. [PMID: 12562089] - J R Tormo, M C González, D Cortes, E Estornell. Kinetic characterization of mitochondrial complex I inhibitors using annonaceous acetogenins.
Archives of biochemistry and biophysics.
1999 Sep; 369(1):119-26. doi:
10.1006/abbi.1999.1343. [PMID: 10462447] - Y Chen, D Q Yu. [Classification and NMR characteristics of the gamma-lactone and THF rings of antitumor bioactive Annonaceous acetogenins].
Yao xue xue bao = Acta pharmaceutica Sinica.
1998 Jul; 33(7):553-60. doi:
". [PMID: 12016892] - H Shimada, J B Grutzner, J F Kozlowski, J L McLaughlin. Membrane conformations and their relation to cytotoxicity of asimicin and its analogues.
Biochemistry.
1998 Jan; 37(3):854-66. doi:
10.1021/bi972348l. [PMID: 9454575] - E Estornell, J R Tormo, D Cortes. Cherimolin-1, new selective inhibitor of the first energy-coupling site of the NADH: ubiquinone oxidoreductase (complex I).
Biochemical and biophysical research communications.
1997 Nov; 240(1):234-8. doi:
10.1006/bbrc.1997.7637. [PMID: 9367916] - D J Morré, R de Cabo, C Farley, N H Oberlies, J L McLaughlin. Mode of action of bullatacin, a potent antitumor acetogenin: inhibition of NADH oxidase activity of HeLa and HL-60, but not liver, plasma membranes.
Life sciences.
1995; 56(5):343-8. doi:
10.1016/0024-3205(94)00957-0. [PMID: 7837933] - X H Li, Y H Hui, J K Rupprecht, Y M Liu, K V Wood, D L Smith, C J Chang, J L McLaughlin. Bullatacin, bullatacinone, and squamone, a new bioactive acetogenin, from the bark of Annona squamosa.
Journal of natural products.
1990 Jan; 53(1):81-6. doi:
10.1021/np50067a010. [PMID: 2348205]
