(+)-Mahanimbine (BioDeep_00000007242)
Secondary id: BioDeep_00000395594, BioDeep_00000403744
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
化学式: C23H25NO (331.1936)
中文名称: 马汉九里香碱
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 12.82%
分子结构信息
SMILES: CC(C)=CCCC1(C)C=Cc2c(c(C)cc3c2[nH]c2ccccc23)O1
InChI: InChI=1S/C23H25NO/c1-15(2)8-7-12-23(4)13-11-18-21-19(14-16(3)22(18)25-23)17-9-5-6-10-20(17)24-21/h5-6,8-11,13-14,24H,7,12H2,1-4H3
描述信息
(±)-Mahanimbine is found in herbs and spices. (±)-Mahanimbine is an alkaloid from the stem bark of Murraya koenigii (curryleaf tree
Alkaloid from the stem bark of Murraya koenigii (curryleaf tree). (±)-Mahanimbine is found in herbs and spices.
同义名列表
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:6646
- KEGG: C09220
- PubChem: 167963
- HMDB: HMDB0030318
- Metlin: METLIN67527
- ChEMBL: CHEMBL495873
- KNApSAcK: C00001745
- foodb: FDB002160
- chemspider: 146928
- CAS: 24948-14-9
- CAS: 21104-28-9
- PMhub: MS000020547
- PubChem: 11411
- 3DMET: B05337
- NIKKAJI: J15.919K
- KNApSAcK: 6646
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
- 76959 - Clausena excavata: 10.1248/CPB.45.48
- 9606 - Homo sapiens: -
- 1224773 - Murraya euchrestifolia:
- 159030 - Murraya koenigii:
- 159029 - Murraya siamensis: 10.1021/NP990570G
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yahya Hasan Hobani. Cytotoxicity of Mahanimbine from Curry Leaves in Human Breast Cancer Cells (MCF-7) via Mitochondrial Apoptosis and Anti-Angiogenesis.
Molecules (Basel, Switzerland).
2022 Feb; 27(3):. doi:
10.3390/molecules27030971. [PMID: 35164236] - Chenlin Pei, Qun He, Shuai Liang, Xuejun Gong. Mahanimbine Exerts Anticancer Effects on Human Pancreatic Cancer Cells by Triggering Cell Cycle Arrest, Apoptosis, and Modulation of AKT/Mammalian Target of Rapamycin (mTOR) and Signal Transducer and Activator of Transcription 3 (STAT3) Signalling Pathways.
Medical science monitor : international medical journal of experimental and clinical research.
2018 Oct; 24(?):6975-6983. doi:
10.12659/msm.911013. [PMID: 30273298] - Pragya Sharma, Sonali Batra, Ashwani Kumar, Anupam Sharma. In vivo antianxiety and antidepressant activity of Murraya paniculata leaf extracts.
Journal of integrative medicine.
2017 07; 15(4):320-325. doi:
10.1016/s2095-4964(17)60352-2. [PMID: 28659237] - Sneha Jagtap, Pragyanshu Khare, Priyanka Mangal, Kanthi Kiran Kondepudi, Mahendra Bishnoi, Kamlesh Kumar Bhutani. Effect of mahanimbine, an alkaloid from curry leaves, on high-fat diet-induced adiposity, insulin resistance, and inflammatory alterations.
BioFactors (Oxford, England).
2017 Mar; 43(2):220-231. doi:
10.1002/biof.1333. [PMID: 27663177] - Jyoti Dahiya, Jitender Singh, Ashwani Kumar, Anupam Sharma. Isolation, characterization and quantification of an anxiolytic constituent - mahanimbine, from Murraya koenigii Linn. Spreng Leaves.
Journal of ethnopharmacology.
2016 Dec; 193(?):706-711. doi:
10.1016/j.jep.2016.10.014. [PMID: 27737817] - Seikou Nakamura, Souichi Nakashima, Yoshimi Oda, Nami Yokota, Katsuyoshi Fujimoto, Takahiro Matsumoto, Tomoe Ohta, Keiko Ogawa, Sayuri Maeda, Shino Nishida, Hisashi Matsuda, Masayuki Yoshikawa. Alkaloids from Sri Lankan curry-leaf (Murraya koenigii) display melanogenesis inhibitory activity: structures of karapinchamines A and B.
Bioorganic & medicinal chemistry.
2013 Mar; 21(5):1043-9. doi:
10.1016/j.bmc.2013.01.012. [PMID: 23376010] - Thilahgavani Nagappan, Thirukanthan Chandra Segaran, Mohd Effendy Abdul Wahid, Perumal Ramasamy, Charles S Vairappan. Efficacy of carbazole alkaloids, essential oil and extract of Murraya koenigii in enhancing subcutaneous wound healing in rats.
Molecules (Basel, Switzerland).
2012 Dec; 17(12):14449-63. doi:
10.3390/molecules171214449. [PMID: 23519245] - Subrata Pandit, Mythies Kumar, S Ponnusankar, B C Pal, Pulok K Mukherjee. RP-HPLC-DAD for simultaneous estimation of mahanine and mahanimbine in Murraya koenigii.
Biomedical chromatography : BMC.
2011 Sep; 25(9):959-62. doi:
10.1002/bmc.1561. [PMID: 21381062] - Rahul Birari, Vishal Javia, Kamlesh Kumar Bhutani. Antiobesity and lipid lowering effects of Murraya koenigii (L.) Spreng leaves extracts and mahanimbine on high fat diet induced obese rats.
Fitoterapia.
2010 Dec; 81(8):1129-33. doi:
10.1016/j.fitote.2010.07.013. [PMID: 20655993] - J D Coonrod, R P Leach. Antigenemia in fulminant pneumococcemia.
Annals of internal medicine.
1976 May; 84(5):561-3. doi:
10.7326/0003-4819-84-5-561. [PMID: 5936]
