Pleuromulin (BioDeep_00000007211)

 

Secondary id: BioDeep_00000176464

PANOMIX_OTCML-2023


代谢物信息卡片


Pleuromutilin

化学式: C22H34O5 (378.24061140000003)
中文名称: 截短侧耳素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 3.64%

分子结构信息

SMILES: C=CC1(C)CC(OC(=O)CO)C2(C)C(C)CCC3(CCC(=O)C32)C(C)C1O
InChI: InChI=1S/C22H34O5/c1-6-20(4)11-16(27-17(25)12-23)21(5)13(2)7-9-22(14(3)19(20)26)10-8-15(24)18(21)22/h6,13-14,16,18-19,23,26H,1,7-12H2,2-5H3

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
Pleuromutilin (Drosophilin B) inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria.

同义名列表

4 个代谢物同义名

Pleuromutilin; Pleuromulin; Drosophilin B; Mutilin 14-glycolate



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Emma Stubberfield, Manal AbuOun, Roderick M Card, David Welchman, Muna F Anjum. Molecular characterization of antimicrobial resistance in Brachyspira species isolated from UK chickens: Identification of novel variants of pleuromutilin and beta-lactam resistance genes. Veterinary microbiology. 2024 Jan; 290(?):109992. doi: 10.1016/j.vetmic.2024.109992. [PMID: 38306769]
  • Xiao Wang, Rui Wang, Zhao-Sheng Zhang, Guang-Yu Zhang, Zhen Jin, Rong Shen, Dan Du, You-Zhi Tang. Semisynthetic pleuromutilin antimicrobials with therapeutic potential against methicillin-resistant Staphylococcus aureus by targeting 50S ribosomal subunit. European journal of medicinal chemistry. 2022 Jul; 237(?):114341. doi: 10.1016/j.ejmech.2022.114341. [PMID: 35430480]
  • Yunxing Fu, Chunqing Leng, Yuan Fan, Xia Ma, Xianghui Li, Xuefei Wang, Zhenghuan Guo, Xiujun Wang, Ruofeng Shang. In Vitro and In Vivo Activity of 14-O-[(4,6-Diamino-pyrimidine-2-yl) thioacetyl] Mutilin against Methicillin-Resistant Staphylococcus aureus. Molecules (Basel, Switzerland). 2021 May; 26(11):. doi: 10.3390/molecules26113277. [PMID: 34071703]
  • Guang-Yu Zhang, Zhe Zhang, Kang Li, Jie Liu, Bo Li, Zhen Jin, Ya-Hong Liu, You-Zhi Tang. Design, synthesis and biological evaluation of novel pleuromutilin derivatives containing piperazine and 1,2,3-triazole linker. Bioorganic chemistry. 2020 12; 105(?):104398. doi: 10.1016/j.bioorg.2020.104398. [PMID: 33137559]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Zhen Jin, Le Wang, Hong Gao, Ying-Hui Zhou, Ya-Hong Liu, You-Zhi Tang. Design, synthesis and biological evaluation of novel pleuromutilin derivatives possessing acetamine phenyl linker. European journal of medicinal chemistry. 2019 Nov; 181(?):111594. doi: 10.1016/j.ejmech.2019.111594. [PMID: 31419741]
  • Evijola Llabani, Robert W Hicklin, Hyang Yeon Lee, Stephen E Motika, Lisa A Crawford, Eranthie Weerapana, Paul J Hergenrother. Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis. Nature chemistry. 2019 06; 11(6):521-532. doi: 10.1038/s41557-019-0261-6. [PMID: 31086302]
  • Robert T Jacobs, Christopher S Lunde, Yvonne R Freund, Vincent Hernandez, Xianfeng Li, Yi Xia, David S Carter, Pamela W Berry, Jason Halladay, Fernando Rock, Rianna Stefanakis, Eric Easom, Jacob J Plattner, Louise Ford, Kelly L Johnston, Darren A N Cook, Rachel Clare, Andrew Cassidy, Laura Myhill, Hayley Tyrer, Joanne Gamble, Ana F Guimaraes, Andrew Steven, Franziska Lenz, Alexandra Ehrens, Stefan J Frohberger, Marianne Koschel, Achim Hoerauf, Marc P Hübner, Case W McNamara, Malina A Bakowski, Joseph D Turner, Mark J Taylor, Stephen A Ward. Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis. Journal of medicinal chemistry. 2019 03; 62(5):2521-2540. doi: 10.1021/acs.jmedchem.8b01854. [PMID: 30730745]
  • Ruofeng Shang, Chao Zhang, Yunpeng Yi, Yu Liu, Wanxia Pu. Determination of a New Pleuromutilin Derivative in Broiler Chicken Plasma by RP-HPLC-UV and Its Application to a Pharmacokinetic Study. Journal of chromatographic science. 2018 Aug; 56(7):604-610. doi: 10.1093/chromsci/bmy033. [PMID: 29668863]
  • Susanne Paukner, Astrid Gruss, Jørgen Skov Jensen. In Vitro Activity of Lefamulin against Sexually Transmitted Bacterial Pathogens. Antimicrobial agents and chemotherapy. 2018 05; 62(5):. doi: 10.1128/aac.02380-17. [PMID: 29530863]
  • Jessica Joerling, Stefanie A Barth, Karen Schlez, Hermann Willems, Werner Herbst, Christa Ewers. Phylogenetic diversity, antimicrobial susceptibility and virulence gene profiles of Brachyspira hyodysenteriae isolates from pigs in Germany. PloS one. 2018; 13(1):e0190928. doi: 10.1371/journal.pone.0190928. [PMID: 29324785]
  • Ken B Waites, Donna M Crabb, Lynn B Duffy, Jorgen S Jensen, Yang Liu, Susanne Paukner. In Vitro Activities of Lefamulin and Other Antimicrobial Agents against Macrolide-Susceptible and Macrolide-Resistant Mycoplasma pneumoniae from the United States, Europe, and China. Antimicrobial agents and chemotherapy. 2017 02; 61(2):. doi: 10.1128/aac.02008-16. [PMID: 27855075]
  • M Zeitlinger, R Schwameis, A Burian, B Burian, P Matzneller, M Müller, W W Wicha, D B Strickmann, W Prince. Simultaneous assessment of the pharmacokinetics of a pleuromutilin, lefamulin, in plasma, soft tissues and pulmonary epithelial lining fluid. The Journal of antimicrobial chemotherapy. 2016 Apr; 71(4):1022-6. doi: 10.1093/jac/dkv442. [PMID: 26747098]
  • Chao Zhang, Yunpeng Yi, Jiongran Chen, Rensheng Xin, Zhen Yang, Zhiting Guo, Jianping Liang, Ruofeng Shang. In vivo efficacy and toxicity studies of a novel antibacterial agent: 14-o-[(2-amino-1,3,4-thiadiazol-5-yl)thioacetyl] mutilin. Molecules (Basel, Switzerland). 2015 Mar; 20(4):5299-312. doi: 10.3390/molecules20045299. [PMID: 25812151]
  • Ruofeng Shang, Shengyu Wang, Ximing Xu, Yunpeng Yi, Wenzhu Guo, Yuliu, Jianping Liang. Chemical synthesis and biological activities of novel pleuromutilin derivatives with substituted amino moiety. PloS one. 2013; 8(12):e82595. doi: 10.1371/journal.pone.0082595. [PMID: 24376551]
  • Claire J Knight, Andy M Bailey, Gary D Foster. Investigating Agrobacterium-mediated transformation of Verticillium albo-atrum on plant surfaces. PloS one. 2010 Oct; 5(10):e13684. doi: 10.1371/journal.pone.0013684. [PMID: 21060684]
  • W A Clyde, L Thomas. Tropism of Mycoplasma gallisepticum for arterial walls. Proceedings of the National Academy of Sciences of the United States of America. 1973 May; 70(5):1545-9. doi: 10.1073/pnas.70.5.1545. [PMID: 4576023]