Parthenolide (BioDeep_00000000069)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(1aR,4E,7aS,10aS,10bS)-1a,5-Dimethyl-8-methylene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one

化学式: C15H20O3 (248.1412)
中文名称: 小白菊内酯, 银胶菊内酯, （1aR，7aS，10aS，10bS）-1a，5-二甲基-8-亚甲基-2,3,6,7,7a，8,10a，10b-八氢氧杂环戊烯[9,10]环癸[1,2-b]呋喃-9（1aH）-酮
谱图信息: 最多检出来源 Viridiplantae(plant) 11.34%

Reviewed

Last reviewed on 2024-08-21.

Cite this Page

Parthenolide. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/parthenolide (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000069). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C/C/1=C\CC[C@@]2([C@@H](O2)[C@@H]3[C@@H](CC1)C(=C)C(=O)O3)C
InChI: InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5-

描述信息

D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
(1Ar,7aS,10aS,10bS)-1a,5-dimethyl-8-methylidene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one is a germacranolide.
Parthenolide has been used in trials studying the diagnostic of Allergic Contact Dermatitis.
(1aR,7aS,10aS,10bS)-1a,5-dimethyl-8-methylidene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one is a natural product found in Cyathocline purpurea, Tanacetum parthenium, and other organisms with data available.
Parthenolide belongs to germacranolides and derivatives class of compounds. Those are sesquiterpene lactones with a structure based on the germacranolide skeleton, characterized by a gamma lactone fused to a 1,7-dimethylcyclodec-1-ene moiety. Thus, parthenolide is considered to be an isoprenoid lipid molecule. Parthenolide is practically insoluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). Parthenolide is a bitter tasting compound found in sweet bay, which makes parthenolide a potential biomarker for the consumption of this food product. Parthenolide is a sesquiterpene lactone of the germacranolide class which occurs naturally in the plant feverfew (Tanacetum parthenium), after which it is named. It is found in highest concentration in the flowers and fruit .
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.002
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.000
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.

同义名列表

21 个代谢物同义名

Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, 2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylene-, (1aR,4E,7aS,10aS,10bR)-; Parthenolide; 4,5-alpha-Epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-oic acid gamma-lactone; (7Z)-4,8-Dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one; [1aR-(1aR*,4E,7aS*,10aS*,-10bR*)]-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one; Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, 2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylene-, (1aR,4E,7aS,10aS,10bS)-; (1aR,7aS,10aS,10bS)-1a,5-dimethyl-8-methylidene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one; (1S,2S,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.0,2,4]tetradec-7-en-13-one; (1S,2S,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one; Germacra-1(10),11(13)-dien-12-oic acid, 4,5.alpha.-epoxy-6.beta.-hydroxy-, gamma.-lactone; 4,5alpha-Epoxy-6beta-hydroxygermacra-1(10),11(13)-dien-12-oic Acid gamma-Lactone; parthenolide, (1aR-(1aR*,4E,7aS*,10aS*,10bR*))-isomer; Parthenolide ((-)-Parthenolide); KTEXNACQROZXEV-SLXBATTESA-N; (-)-Parthenolide; MEGxp0_000050; ACon1_001961; PTL; NCGC00024683-03_C15H20O3_(1aR,4E,7aS,10aS,10bS)-1a,5-Dimethyl-8-methylene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one; Parthenolide; (1aR,7aS,10aS,10bS)-1a,5-dimethyl-8-methylidene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one



数据库引用编号

64 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

83 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(82)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

145 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 16 AKT1, ANG, BCL2, CASP3, CTNNB1, HDAC1, HSPA5, MAPK8, MTOR, NFKB1, NFKBIA, NLRP3, PTGS2, TP53, TUBB4B, VEGFA
Peripheral membrane protein 2 MTOR, PTGS2
Endoplasmic reticulum membrane 5 BCL2, HSPA5, MTOR, PTGS2, SPP1
Nucleus 16 AKT1, ANG, BCL2, CASP3, CTNNB1, HDAC1, HSPA5, JUN, MAPK8, MTOR, NFKB1, NFKBIA, NLRP3, TP53, TUBB4B, VEGFA
cytosol 14 AKT1, ANG, BCL2, CASP3, CTNNB1, HDAC1, HSPA5, MAPK8, MTOR, NFKB1, NFKBIA, NLRP3, TP53, TUBB4B
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 2 CTNNB1, TP53
nucleoplasm 10 AKT1, CASP3, CTNNB1, HDAC1, JUN, MAPK8, MTOR, NFKB1, NFKBIA, TP53
RNA polymerase II transcription regulator complex 1 JUN
Cell membrane 3 AKT1, CTNNB1, SPP1
Cytoplasmic side 1 MTOR
lamellipodium 2 AKT1, CTNNB1
Multi-pass membrane protein 1 SPP1
Golgi apparatus membrane 2 MTOR, NLRP3
Synapse 2 CTNNB1, MAPK8
cell cortex 2 AKT1, CTNNB1
cell junction 1 CTNNB1
cell surface 2 HSPA5, VEGFA
glutamatergic synapse 3 AKT1, CASP3, CTNNB1
Golgi apparatus 2 SPP1, VEGFA
Golgi membrane 2 MTOR, NLRP3
growth cone 1 ANG
lysosomal membrane 1 MTOR
neuronal cell body 3 ANG, CASP3, HDAC1
postsynapse 1 AKT1
presynaptic membrane 1 CTNNB1
Cytoplasm, cytosol 1 NLRP3
Lysosome 1 MTOR
plasma membrane 5 AKT1, CTNNB1, HSPA5, NFKBIA, SPP1
Membrane 8 AKT1, BCL2, CTNNB1, HSPA5, MTOR, NLRP3, TP53, VEGFA
axon 1 MAPK8
basolateral plasma membrane 1 CTNNB1
caveola 1 PTGS2
extracellular exosome 4 CTNNB1, HSPA5, SPP1, TUBB4B
Lysosome membrane 1 MTOR
endoplasmic reticulum 6 BCL2, HSPA5, NLRP3, PTGS2, TP53, VEGFA
extracellular space 5 ANG, CCL2, IL6, SPP1, VEGFA
perinuclear region of cytoplasm 2 CTNNB1, SPP1
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 2 CTNNB1, VEGFA
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
mitochondrion 5 BCL2, HSPA5, NFKB1, NLRP3, TP53
protein-containing complex 7 AKT1, BCL2, CTNNB1, HDAC1, HSPA5, PTGS2, TP53
intracellular membrane-bounded organelle 1 HSPA5
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 6 ANG, CCL2, IL6, NLRP3, SPP1, VEGFA
extracellular region 8 ANG, CCL2, IL6, NFKB1, NLRP3, SPP1, TUBB4B, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 4 CTNNB1, JUN, NFKB1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
Extracellular vesicle 1 TUBB4B
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
microtubule cytoskeleton 2 AKT1, TUBB4B
nucleolus 2 ANG, TP53
Wnt signalosome 1 CTNNB1
midbody 1 HSPA5
apical part of cell 1 CTNNB1
cell-cell junction 2 AKT1, CTNNB1
vesicle 1 AKT1
postsynaptic membrane 1 CTNNB1
heterochromatin 1 HDAC1
pore complex 1 BCL2
Cytoplasm, cytoskeleton 3 CTNNB1, TP53, TUBB4B
focal adhesion 2 CTNNB1, HSPA5
microtubule 1 TUBB4B
spindle 1 AKT1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
extracellular matrix 1 VEGFA
basement membrane 1 ANG
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 4 HDAC1, JUN, NFKB1, TP53
cell projection 1 SPP1
cell periphery 1 CTNNB1
mitotic spindle 1 TUBB4B
Chromosome 1 ANG
cytoskeleton 1 TUBB4B
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
Nucleus, nucleolus 1 ANG
spindle pole 1 CTNNB1
nuclear chromosome 1 JUN
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
site of double-strand break 1 TP53
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
nuclear envelope 1 MTOR
Endomembrane system 3 CTNNB1, MTOR, NLRP3
axonemal microtubule 1 TUBB4B
microtubule organizing center 1 NLRP3
Melanosome 1 HSPA5
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
euchromatin 2 CTNNB1, JUN
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
secretory granule lumen 1 NFKB1
endoplasmic reticulum lumen 4 HSPA5, IL6, PTGS2, SPP1
nuclear matrix 1 TP53
transcription repressor complex 2 HDAC1, TP53
platelet alpha granule lumen 1 VEGFA
specific granule lumen 1 NFKB1
histone deacetylase complex 1 HDAC1
endocytic vesicle 1 ANG
beta-catenin-TCF complex 1 CTNNB1
azurophil granule lumen 1 TUBB4B
NuRD complex 1 HDAC1
presynaptic active zone cytoplasmic component 1 CTNNB1
endoplasmic reticulum-Golgi intermediate compartment 1 HSPA5
[Isoform 1]: Nucleus 1 TP53
Sin3-type complex 1 HDAC1
protein-DNA complex 1 CTNNB1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CTNNB1
transcription factor AP-1 complex 1 JUN
angiogenin-PRI complex 1 ANG
interleukin-6 receptor complex 1 IL6
endoplasmic reticulum chaperone complex 1 HSPA5
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
beta-catenin-TCF7L2 complex 1 CTNNB1
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 2 NFKB1, NFKBIA
NF-kappaB p50/p65 complex 1 NFKB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1


文献列表

  • Lei Li, Qian Zhou, Linwei Li, Tingting Ran, Weiwu Wang, Chenyang Liu, Jin Chen, Tiemin Sun, Yu Chen, Xu Feng, Feng Zhang, Shu Xu. Structural insight into subunit F of respiratory chain complex I from Xanthomonas oryzae pv. oryzae inhibition by parthenolide. Pest management science. 2024 Jun; 80(6):2679-2688. doi: 10.1002/ps.7974. [PMID: 38284296]
  • Zi-Ying Zhan, Zhi-Hong Zhang, Rong-Hui Sun, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian. A therapeutic strategy of parthenolide in improving imiquimod-induced psoriasis-like skin inflammation targeting IL-36/NETs through skin transdermal therapeutic system. International immunopharmacology. 2024 Apr; 131(?):111824. doi: 10.1016/j.intimp.2024.111824. [PMID: 38461633]
  • Jinfeng Sun, Liwei Li, Li Xiong, Fan Chen, Lingyu She, Hao Tang, Yuqing Zeng, Ying Duan, Luyao Li, Wei Wang, Gao Li, Xia Zhao, Guang Liang. Parthenolide alleviates cognitive dysfunction and neurotoxicity via regulation of AMPK/GSK3β(Ser9)/Nrf2 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 169(?):115909. doi: 10.1016/j.biopha.2023.115909. [PMID: 37992573]
  • Liru Huang, Fuhong Liu, Xukai Liu, Liyan Niu, Longhua Sun, Fang Fang, Kun Ma, Ping Hu. Parthenolide inhibits the proliferation and migration of cervical cancer cells via FAK/GSK3β pathway. Cancer chemotherapy and pharmacology. 2023 Dec; ?(?):. doi: 10.1007/s00280-023-04621-9. [PMID: 38141074]
  • Emine Toraman, Büşra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacımüftüoğlu. Role of parthenolide in paclitaxel-induced oxidative stress injury and impaired reproductive function in rat testicular tissue. Chemico-biological interactions. 2023 Nov; ?(?):110793. doi: 10.1016/j.cbi.2023.110793. [PMID: 37949423]
  • W Yao, X Wang, Y Yang, J You, J Jin, P Zeng, Q Han, X Yao, X Sun, J Zhou. [Liposome nanoparticles for targeted delivery of parthenolide induce colorectal cancer necroptosis to ameliorate tumor-infiltrating T cell exhaustion in mice]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2023 Oct; 43(10):1674-1681. doi: 10.12122/j.issn.1673-4254.2023.10.04. [PMID: 37933642]
  • María Ángeles Ávila-Gálvez, Daniela Marques, Inês Figueira, Katarina Cankar, Dirk Bosch, Maria Alexandra Brito, Cláudia Nunes Dos Santos. Costunolide and parthenolide: Novel blood-brain barrier permeable sesquiterpene lactones to improve barrier tightness. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Sep; 167(?):115413. doi: 10.1016/j.biopha.2023.115413. [PMID: 37683593]
  • Jingyuan Sun, Pei Li, Honglian Gui, Laure Rittié, David B Lombard, Katrin Rietscher, Thomas M Magin, Qing Xie, Li Liu, M Bishr Omary. Deacetylation via SIRT2 prevents keratin-mutation-associated injury and keratin aggregation. JCI insight. 2023 07; 8(14):. doi: 10.1172/jci.insight.166314. [PMID: 37485877]
  • Le-Tian Huang, Tie-Jun Li, Ming-Lin Li, Han-Yong Luo, Yi-Bing Wang, Jia-He Wang. Untargeted lipidomic analysis and network pharmacology for parthenolide treated papillary thyroid carcinoma cells. BMC complementary medicine and therapies. 2023 Apr; 23(1):130. doi: 10.1186/s12906-023-03944-7. [PMID: 37095470]
  • Mehmet Enes Arslan, Hasan Türkez, Yasemin Sevim, Harun Selvitopi, Abdurrahim Kadi, Sena Öner, Adil Mardinoğlu. Costunolide and Parthenolide Ameliorate MPP+ Induced Apoptosis in the Cellular Parkinson's Disease Model. Cells. 2023 03; 12(7):. doi: 10.3390/cells12070992. [PMID: 37048065]
  • Meng Li, Qiong Luo, Xi Chen, Furong Qiu, Yanyan Tao, Xin Sun, Chenghai Liu. Screening of major hepatotoxic components of Tripterygium wilfordii based on hepatotoxic injury patterns. BMC complementary medicine and therapies. 2023 Jan; 23(1):9. doi: 10.1186/s12906-023-03836-w. [PMID: 36627617]
  • Reza Shahhoseini, Hadiseh Daneshvar. Phytochemical and physiological reactions of feverfew (Tanacetum parthenium (L.) Schultz Bip) to TiO2 nanoparticles. Plant physiology and biochemistry : PPB. 2023 Jan; 194(?):674-684. doi: 10.1016/j.plaphy.2022.12.011. [PMID: 36563573]
  • Arman Beyraghdar Kashkooli, Aalt D J van Dijk, Harro Bouwmeester, Alexander van der Krol. Individual lipid transfer proteins from Tanacetum parthenium show different specificity for extracellular accumulation of sesquiterpenes. Plant molecular biology. 2023 Jan; 111(1-2):153-166. doi: 10.1007/s11103-022-01316-2. [PMID: 36255594]
  • Li-Ping Liu, Ning Liu, Han-Ni Zhang, Ding Li. Exploring and validating the metastasis mechanism of pathenolide interfering with cutaneous melanoma through ER stress-dependent apoptosis based on the network pharmacology. Phytochemical analysis : PCA. 2022 Dec; ?(?):. doi: 10.1002/pca.3193. [PMID: 36477977]
  • Mahsa Darbahani, Mahdi Rahaie, Asa Ebrahimi, Mahmood Khosrowshahli. The effects of several abiotic elicitors on the expression of genes of key enzymes involved in the parthenolide biosynthetic pathway and its content in feverfew plant (Tanacetum parthenium L.). Natural product research. 2022 Dec; 36(23):6132-6136. doi: 10.1080/14786419.2022.2055555. [PMID: 35356827]
  • Xingchen Liu, Xiaobing Wang. Recent advances on the structural modification of parthenolide and its derivatives as anticancer agents. Chinese journal of natural medicines. 2022 Nov; 20(11):814-829. doi: 10.1016/s1875-5364(22)60238-3. [PMID: 36427916]
  • Qian Zhou, Linwei Li, Fei Liu, Jun Hu, Yan Cao, Siwei Qiao, Yuxin Zhou, Bi Wang, Yihe Jia, Yu Chen, Shu Xu, Xu Feng. Mining and characterization of oxidative stress-related binding proteins of parthenolide in Xanthomonas oryzae pv. oryzae. Pest management science. 2022 Aug; 78(8):3345-3355. doi: 10.1002/ps.6961. [PMID: 35491536]
  • Yiting Shi, Tianyu Dong, Boxuan Zeng, Mingdong Yao, Ying Wang, Zexiong Xie, Wenhai Xiao, Yingjin Yuan. Production of Plant Sesquiterpene Lactone Parthenolide in the Yeast Cell Factory. ACS synthetic biology. 2022 07; 11(7):2473-2483. doi: 10.1021/acssynbio.2c00132. [PMID: 35723427]
  • Anshuo Li, Wenbin Gao, Xuwu Zhang, Yuwei Deng, Yuhui Zhu, Hao Gu, Jin Wen, Xinquan Jiang. A dual-responsive 'Yin-Yang' photothermal delivery system to accelerate Parthenolide anti-tumor efficacy. Biomaterials advances. 2022 Jul; 138(?):212935. doi: 10.1016/j.bioadv.2022.212935. [PMID: 35913256]
  • Ricardo A Leitão, Carlos A Fontes-Ribeiro, Ana Paula Silva. The effect of parthenolide on methamphetamine-induced blood-brain barrier and astrocyte alterations. European journal of clinical investigation. 2022 Apr; 52(4):e13694. doi: 10.1111/eci.13694. [PMID: 34694635]
  • Tao An, Huanhuan Yin, Yanting Lu, Feng Liu. The Emerging Potential of Parthenolide Nanoformulations in Tumor Therapy. Drug design, development and therapy. 2022; 16(?):1255-1272. doi: 10.2147/dddt.s355059. [PMID: 35517982]
  • Yubo Dong, Xuanjin Qian, Jian Li. Sesquiterpene Lactones and Cancer: New Insight into Antitumor and Anti-inflammatory Effects of Parthenolide-Derived Dimethylaminomicheliolide and Micheliolide. Computational and mathematical methods in medicine. 2022; 2022(?):3744837. doi: 10.1155/2022/3744837. [PMID: 35898475]
  • Mingxian Lan, Xi Gao, Xiuan Duan, Hongmei Li, Hang Yu, Jinliang Li, Yueqin Zhao, Xiaojiang Hao, Yuhan Zhao, Xiao Ding, Guoxing Wu. Nematicidal activity of tirotundin and parthenolide isolated from Tithonia diversifolia and Chrysanthemum parthenium. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2022; 57(1):54-61. doi: 10.1080/03601234.2021.2022945. [PMID: 34983315]
  • Zhen-Yu Cui, Ge Wang, Jing Zhang, Jian Song, Yu-Chen Jiang, Jia-Yi Dou, Li-Hua Lian, Ji-Xing Nan, Yan-Ling Wu. Parthenolide, bioactive compound of Chrysanthemum parthenium L., ameliorates fibrogenesis and inflammation in hepatic fibrosis via regulating the crosstalk of TLR4 and STAT3 signaling pathway. Phytotherapy research : PTR. 2021 Oct; 35(10):5680-5693. doi: 10.1002/ptr.7214. [PMID: 34250656]
  • Louna Karam, Soumaiah Abou Staiteieh, Rady Chaaban, Berthe Hayar, Bassel Ismail, Frank Neipel, Nadine Darwiche, Raghida Abou Merhi. Anticancer activities of parthenolide in primary effusion lymphoma preclinical models. Molecular carcinogenesis. 2021 08; 60(8):567-581. doi: 10.1002/mc.23324. [PMID: 34101920]
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  • Weihong Wang, Yukai He, Qiuli Liu. Parthenolide plays a protective role in the liver of mice with metabolic dysfunction‑associated fatty liver disease through the activation of the HIPPO pathway. Molecular medicine reports. 2021 07; 24(1):. doi: 10.3892/mmr.2021.12126. [PMID: 33955510]
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