DL-Lysine (BioDeep_00000684908)
Main id: BioDeep_00000001375
PANOMIX_OTCML-2023
代谢物信息卡片
Lysine, DL-
化学式: C6H14N2O2 (146.1055)
中文名称: DL-赖氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CCN)CC(C(=O)O)N
InChI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)
描述信息
DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins[1].
同义名列表
4 个代谢物同义名
Lysine, DL-; DL-Lysine; (±)-2,6-Diaminocaproic acid; DL-Lysine
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:132486
- ChEBI: CHEBI:25094
- PubChem: 866
- ChEMBL: CHEMBL28328
- CAS: 70-54-2
- medchemexpress: HY-B2236
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kinga Skrzyniarz, Samuel Takvor-Mena, Karolina Lach, Małgorzata Łysek-Gładysińska, Óscar Barrios-Gumiel, Jesús Cano, Karol Ciepluch. Molecular mechanism of action of imidazolium carbosilane dendrimers on the outer bacterial membrane - From membrane damage to permeability to antimicrobial endolysin.
Journal of colloid and interface science.
2024 Jul; 665(?):814-824. doi:
10.1016/j.jcis.2024.03.130. [PMID: 38555749] - Shruti O Kushwaha, Santosh Kumar Sahu, Virendra Kumar Yadav, Mayuri C Rathod, Dhaval Patel, Dipak Kumar Sahoo, Ashish Patel. Bacteriophages as a potential substitute for antibiotics: A comprehensive review.
Cell biochemistry and function.
2024 Apr; 42(3):e4022. doi:
10.1002/cbf.4022. [PMID: 38655589] - Jeongik Cho, Hye-Won Hong, Kyungah Park, Heejoon Myung, Hyunjin Yoon. Unveiling the mechanism of bactericidal activity of a cecropin A-fused endolysin LNT113.
International journal of biological macromolecules.
2024 Mar; 260(Pt 1):129493. doi:
10.1016/j.ijbiomac.2024.129493. [PMID: 38224804] - Hazel M Sisson, Robert D Fagerlund, Simon A Jackson, Yves Briers, Suzanne L Warring, Peter C Fineran. Antibacterial synergy between a phage endolysin and citric acid against the Gram-negative kiwifruit pathogen Pseudomonas syringae pv. actinidiae.
Applied and environmental microbiology.
2024 Feb; ?(?):e0184623. doi:
10.1128/aem.01846-23. [PMID: 38319087] - Vahideh Rafiei, Yasaman Najafi, Heriberto Vélëz, Georgios Tzelepis. Investigating the role of a putative endolysin-like candidate effector protein in Verticillium longisporum virulence.
Biochemical and biophysical research communications.
2022 11; 629(?):6-11. doi:
10.1016/j.bbrc.2022.08.086. [PMID: 36088806] - Luca G Valente, Ngoc Dung Le, Melissa Pitton, Gabriele Chiffi, Denis Grandgirard, Stephan M Jakob, David R Cameron, Grégory Resch, Yok-Ai Que, Stephen L Leib. Efficacy assessment of a novel endolysin PlyAZ3aT for the treatment of ceftriaxone-resistant pneumococcal meningitis in an infant rat model.
PloS one.
2022; 17(4):e0266928. doi:
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Carbohydrate polymers.
2021 Dec; 273(?):118605. doi:
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Viruses.
2021 09; 13(10):. doi:
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Viruses.
2021 04; 13(4):. doi:
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PloS one.
2021; 16(10):e0256817. doi:
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Cell host & microbe.
2020 09; 28(3):380-389.e9. doi:
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BMC biotechnology.
2019 12; 19(1):101. doi:
10.1186/s12896-019-0594-7. [PMID: 31864319] - Md Reyazul Islam, Namil Son, Junho Lee, Dong Wook Lee, Eun-Ju Sohn, Inhwan Hwang. Production of bacteriophage-encoded endolysin, LysP11, in Nicotiana benthamiana and its activity as a potent antimicrobial agent against Erysipelothrix rhusiopathiae.
Plant cell reports.
2019 Dec; 38(12):1485-1499. doi:
10.1007/s00299-019-02459-1. [PMID: 31432212] - Magdalena Plotka, Malgorzata Kapusta, Sebastian Dorawa, Anna-Karina Kaczorowska, Tadeusz Kaczorowski. Ts2631 Endolysin from the Extremophilic Thermus scotoductus Bacteriophage vB_Tsc2631 as an Antimicrobial Agent against Gram-Negative Multidrug-Resistant Bacteria.
Viruses.
2019 07; 11(7):. doi:
10.3390/v11070657. [PMID: 31323845] - Assaf Raz, Anna Serrano, Anaise Hernandez, Chad W Euler, Vincent A Fischetti. Isolation of Phage Lysins That Effectively Kill Pseudomonas aeruginosa in Mouse Models of Lung and Skin Infection.
Antimicrobial agents and chemotherapy.
2019 07; 63(7):. doi:
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Applied and environmental microbiology.
2019 07; 85(13):. doi:
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Antimicrobial agents and chemotherapy.
2019 04; 63(4):. doi:
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Nature reviews. Microbiology.
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Research in microbiology.
2018 Nov; 169(9):505-514. doi:
10.1016/j.resmic.2018.04.006. [PMID: 29777834] - Sofia Fernandes, Carlos São-José. Enzymes and Mechanisms Employed by Tailed Bacteriophages to Breach the Bacterial Cell Barriers.
Viruses.
2018 07; 10(8):. doi:
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Viruses.
2018 05; 10(5):. doi:
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Scientific reports.
2018 01; 8(1):18. doi:
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Scientific reports.
2017 10; 7(1):13566. doi:
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Nature communications.
2017 09; 8(1):481. doi:
10.1038/s41467-017-00492-w. [PMID: 28883390] - Laura Stoffels, Henry N Taunt, Bambos Charalambous, Saul Purton. Synthesis of bacteriophage lytic proteins against Streptococcus pneumoniae in the chloroplast of Chlamydomonas reinhardtii.
Plant biotechnology journal.
2017 Sep; 15(9):1130-1140. doi:
10.1111/pbi.12703. [PMID: 28160380] - Gayeon Won, Boram Kim, John Hwa Lee. A novel method to generate Salmonella Typhi Ty21a ghosts exploiting the λ phage holin-endolysin system.
Oncotarget.
2017 Jul; 8(29):48186-48195. doi:
10.18632/oncotarget.18383. [PMID: 28637001] - Monika Herten, Evgeny A Idelevich, Sonja Sielker, Karsten Becker, Anna S Scherzinger, Nani Osada, Giovanni B Torsello, Theodosios Bisdas. Vascular Graft Impregnation with Antibiotics: The Influence of High Concentrations of Rifampin, Vancomycin, Daptomycin, and Bacteriophage Endolysin HY-133 on Viability of Vascular Cells.
Medical science monitor basic research.
2017 Jun; 23(?):250-257. doi:
10.12659/msmbr.902879. [PMID: 28652563] - Yoonjee Chang, Hyunjin Yoon, Dong-Hyun Kang, Pahn-Shick Chang, Sangryeol Ryu. Endolysin LysSA97 is synergistic with carvacrol in controlling Staphylococcus aureus in foods.
International journal of food microbiology.
2017 Mar; 244(?):19-26. doi:
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Antimicrobial agents and chemotherapy.
2016 06; 60(6):3480-8. doi:
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Nature communications.
2016 Apr; 7(?):11220. doi:
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PloS one.
2016; 11(9):e0160574. doi:
10.1371/journal.pone.0160574. [PMID: 27611571] - Natalia Kovalskaya, Juli Foster-Frey, David M Donovan, Gary Bauchan, Rosemarie W Hammond. Antimicrobial Activity of Bacteriophage Endolysin Produced in Nicotiana benthamiana Plants.
Journal of microbiology and biotechnology.
2016 Jan; 26(1):160-70. doi:
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Applied microbiology and biotechnology.
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Food chemistry.
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Food chemistry.
2012 Dec; 135(3):1273-83. doi:
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Chemical communications (Cambridge, England).
2012 Nov; 48(90):11097-9. doi:
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Molecular genetics and metabolism.
2012 Nov; 107(3):335-44. doi:
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Bioresource technology.
2012 Nov; 124(?):446-54. doi:
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Molecular human reproduction.
2012 Nov; 18(11):546-53. doi:
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Development and psychopathology.
2012 Nov; 24(4):1391-400. doi:
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Pharmaceutical research.
2012 Nov; 29(11):3143-55. doi:
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Biomedical chromatography : BMC.
2012 Nov; 26(11):1377-85. doi:
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Journal of pharmaceutical and biomedical analysis.
2012 Nov; 70(?):476-84. doi:
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Journal of bioscience and bioengineering.
2012 Nov; 114(5):485-9. doi:
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Journal of inherited metabolic disease.
2012 Nov; 35(6):1011-9. doi:
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Molecular bioSystems.
2012 Oct; 8(12):3314-24. doi:
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Molecular bioSystems.
2012 Oct; 8(12):3281-7. doi:
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Journal of proteomics.
2012 Oct; 75(18):5724-33. doi:
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FEBS letters.
2012 Oct; 586(20):3653-7. doi:
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Vaccine.
2012 Oct; 30(47):6706-12. doi:
10.1016/j.vaccine.2012.08.028. [PMID: 22975025] - Marzanna Hęś, Katarzyna Waszkowiak, Krystyna Szymandera-Buszka. The effect of iodine salts on lipid oxidation and changes in nutritive value of protein in stored processed meats.
Meat science.
2012 Oct; 92(2):139-43. doi:
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The New phytologist.
2012 Oct; 196(1):13-28. doi:
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Amino acids.
2012 Oct; 43(4):1593-603. doi:
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Virus research.
2012 Oct; 169(1):276-81. doi:
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International journal of systematic and evolutionary microbiology.
2012 Oct; 62(Pt 10):2405-2409. doi:
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Journal of natural products.
2012 Sep; 75(9):1584-8. doi:
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Journal of agricultural and food chemistry.
2012 Sep; 60(38):9727-36. doi:
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Journal of visualized experiments : JoVE.
2012 Sep; ?(67):. doi:
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The Journal of biological chemistry.
2012 Sep; 287(39):32312-23. doi:
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The Journal of biological chemistry.
2012 Sep; 287(39):32967-80. doi:
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Chemical research in toxicology.
2012 Sep; 25(9):1868-77. doi:
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Molecular genetics and metabolism.
2012 Sep; 107(1-2):72-80. doi:
10.1016/j.ymgme.2012.03.021. [PMID: 22520952] - Jinrong Wan, Kiwamu Tanaka, Xue-Cheng Zhang, Geon Hui Son, Laurent Brechenmacher, Tran Hong Nha Nguyen, Gary Stacey. LYK4, a lysin motif receptor-like kinase, is important for chitin signaling and plant innate immunity in Arabidopsis.
Plant physiology.
2012 Sep; 160(1):396-406. doi:
10.1104/pp.112.201699. [PMID: 22744984] - Athanasios Dalakouras, Elena Dadami, Michele Zwiebel, Gabi Krczal, Michael Wassenegger. Transgenerational maintenance of transgene body CG but not CHG and CHH methylation.
Epigenetics.
2012 Sep; 7(9):1071-8. doi:
10.4161/epi.21644. [PMID: 22863736] - Menny Kirma, Wagner L Araújo, Alisdair R Fernie, Gad Galili. The multifaceted role of aspartate-family amino acids in plant metabolism.
Journal of experimental botany.
2012 Sep; 63(14):4995-5001. doi:
10.1093/jxb/ers119. [PMID: 22516796] - Peter Bross, Jane B Frederiksen, Anne S Bie, Jakob Hansen, Johan Palmfeldt, Marit N Nielsen, Morten Duno, Allan M Lund, Ernst Christensen. Heterozygosity for an in-frame deletion causes glutaryl-CoA dehydrogenase deficiency in a patient detected by newborn screening: investigation of the effect of the mutant allele.
Journal of inherited metabolic disease.
2012 Sep; 35(5):787-96. doi:
10.1007/s10545-011-9437-y. [PMID: 22231382] - Pauline Rival, Françoise de Billy, Jean-Jacques Bono, Clare Gough, Charles Rosenberg, Sandra Bensmihen. Epidermal and cortical roles of NFP and DMI3 in coordinating early steps of nodulation in Medicago truncatula.
Development (Cambridge, England).
2012 Sep; 139(18):3383-91. doi:
10.1242/dev.081620. [PMID: 22874912] - Hae-Ryong Song, Yoo-Sun Noh. Rhythmic oscillation of histone acetylation and methylation at the Arabidopsis central clock loci.
Molecules and cells.
2012 Sep; 34(3):279-87. doi:
10.1007/s10059-012-0103-5. [PMID: 22878891] - Adrian Stephen Wolferstan Tordiffe, George Frederick van der Watt, Fred Reyers. Cystine urolithiasis in a caracal (Caracal caracal).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2012 Sep; 43(3):649-51. doi:
10.1638/2011-0236r1.1. [PMID: 23082535] - Lin Zhang, Haifeng Jin, Xuegang Guo, Zhao Yang, Lina Zhao, Shanhong Tang, Ping Mo, Kaichun Wu, Yongzhan Nie, Yanglin Pan, Daiming Fan. Distinguishing pancreatic cancer from chronic pancreatitis and healthy individuals by (1)H nuclear magnetic resonance-based metabonomic profiles.
Clinical biochemistry.
2012 Sep; 45(13-14):1064-9. doi:
10.1016/j.clinbiochem.2012.05.012. [PMID: 22613268] - Eun Young Kim, Won Kon Kim, Hyo Jin Kang, Jeong-Hoon Kim, Sang J Chung, Yeon Soo Seo, Sung Goo Park, Sang Chul Lee, Kwang-Hee Bae. Acetylation of malate dehydrogenase 1 promotes adipogenic differentiation via activating its enzymatic activity.
Journal of lipid research.
2012 Sep; 53(9):1864-76. doi:
10.1194/jlr.m026567. [PMID: 22693256] - T Chen, X Zhang, Y Long, H Yu, X Ran, Y Gao, H Lu, X Xie, X Chen, Y Ren, J Shi, H Tian. The association of plasma free amino acids with liver enzymes in Type 2 diabetic patients.
Journal of endocrinological investigation.
2012 Sep; 35(8):772-5. doi:
10.3275/8059. [PMID: 22071500] - Daniele Rubert Nogueira, Montserrat Mitjans, M Carmen Morán, Lourdes Pérez, M Pilar Vinardell. Membrane-destabilizing activity of pH-responsive cationic lysine-based surfactants: role of charge position and alkyl chain length.
Amino acids.
2012 Sep; 43(3):1203-15. doi:
10.1007/s00726-011-1176-8. [PMID: 22134583] - Zhituo Li, Huaishu Shen, Yingmei Zhang, Ming Lu, Xin Qiao, Xianzhi Meng, Bei Sun, Dongbo Xue, Weihui Zhang. Metabolomic study of serum from rabbits with acute acalculous cholecystitis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2012 Sep; 61(9):987-95. doi:
10.1007/s00011-012-0491-1. [PMID: 22618202] - Eduard A Struys, Levinus A Bok, Dina Emal, Saskia Houterman, Michel A Willemsen, Cornelis Jakobs. The measurement of urinary Δ¹-piperideine-6-carboxylate, the alter ego of α-aminoadipic semialdehyde, in Antiquitin deficiency.
Journal of inherited metabolic disease.
2012 Sep; 35(5):909-16. doi:
10.1007/s10545-011-9443-0. [PMID: 22249334] - Kamila Borowczyk, Joanna Tisończyk, Hieronim Jakubowski. Metabolism and neurotoxicity of homocysteine thiolactone in mice: protective role of bleomycin hydrolase.
Amino acids.
2012 Sep; 43(3):1339-48. doi:
10.1007/s00726-011-1207-5. [PMID: 22227865] - Abdulaziz A Al-Qarawi, Abeer Hashem, Elsayed F Abd-Allah. Seed mycoflora of Ephedra aphylla and amino acid profile of seed-borne Aspergillus flavus.
Acta microbiologica et immunologica Hungarica.
2012 Sep; 59(3):311-20. doi:
10.1556/amicr.59.2012.3.2. [PMID: 22982635] - Sarah C Atkinson, Con Dogovski, Renwick C J Dobson, Matthew A Perugini. Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from Agrobacterium tumefaciens.
Acta crystallographica. Section F, Structural biology and crystallization communications.
2012 Sep; 68(Pt 9):1040-7. doi:
10.1107/s1744309112033052. [PMID: 22949190] - Jianghui Hou. Regulation of paracellular transport in the distal nephron.
Current opinion in nephrology and hypertension.
2012 Sep; 21(5):547-51. doi:
10.1097/mnh.0b013e328355cb47. [PMID: 22691877] - Laura A Lallemand, Chloe Zubieta, Soon Goo Lee, Yechun Wang, Samira Acajjaoui, Joanna Timmins, Sean McSweeney, Joseph M Jez, James G McCarthy, Andrew A McCarthy. A structural basis for the biosynthesis of the major chlorogenic acids found in coffee.
Plant physiology.
2012 Sep; 160(1):249-60. doi:
10.1104/pp.112.202051. [PMID: 22822210] - Sang-Ho Park, Tim L Sit, Kook-Hyung Kim, Steven A Lommel. The Red clover necrotic mosaic virus capsid protein N-terminal lysine-rich motif is a determinant of symptomatology and virion accumulation.
Molecular plant pathology.
2012 Sep; 13(7):744-54. doi:
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American journal of physiology. Renal physiology.
2012 Sep; 303(5):F700-10. doi:
10.1152/ajprenal.00139.2012. [PMID: 22718890] - Mariya S Liyasova, Lawrence M Schopfer, Oksana Lockridge. Cresyl saligenin phosphate, an organophosphorus toxicant, makes covalent adducts with histidine, lysine, and tyrosine residues of human serum albumin.
Chemical research in toxicology.
2012 Aug; 25(8):1752-61. doi:
10.1021/tx300215g. [PMID: 22793878] - Martin Jahnke, John Trowsdale, Adrian P Kelly. Structural requirements for recognition of major histocompatibility complex class II by membrane-associated RING-CH (MARCH) protein E3 ligases.
The Journal of biological chemistry.
2012 Aug; 287(34):28779-89. doi:
10.1074/jbc.m112.381541. [PMID: 22761441] - Mariana Utrera, Mario Estévez. Oxidation of myofibrillar proteins and impaired functionality: underlying mechanisms of the carbonylation pathway.
Journal of agricultural and food chemistry.
2012 Aug; 60(32):8002-11. doi:
10.1021/jf302111j. [PMID: 22838408] - Daniele Rubert Nogueira, Montserrat Mitjans, M Antonia Busquets, Lourdes Pérez, M Pilar Vinardell. Phospholipid bilayer-perturbing properties underlying lysis induced by pH-sensitive cationic lysine-based surfactants in biomembranes.
Langmuir : the ACS journal of surfaces and colloids.
2012 Aug; 28(32):11687-98. doi:
10.1021/la300626y. [PMID: 22816661] - Vincent Coustham, Peijin Li, Amy Strange, Clare Lister, Jie Song, Caroline Dean. Quantitative modulation of polycomb silencing underlies natural variation in vernalization.
Science (New York, N.Y.).
2012 Aug; 337(6094):584-7. doi:
10.1126/science.1221881. [PMID: 22798408] - Mari Carmen Herranz, Vicente Pallas, Frederic Aparicio. Multifunctional roles for the N-terminal basic motif of Alfalfa mosaic virus coat protein: nucleolar/cytoplasmic shuttling, modulation of RNA-binding activity, and virion formation.
Molecular plant-microbe interactions : MPMI.
2012 Aug; 25(8):1093-103. doi:
10.1094/mpmi-04-12-0079-r. [PMID: 22746826] - Sani Hlais, Dana R Abou Reslan, Hiba K Sarieddine, Lara Nasreddine, Ghazi Taan, Sami Azar, Omar A Obeid. Effect of lysine, vitamin B(6), and carnitine supplementation on the lipid profile of male patients with hypertriglyceridemia: a 12-week, open-label, randomized, placebo-controlled trial.
Clinical therapeutics.
2012 Aug; 34(8):1674-82. doi:
10.1016/j.clinthera.2012.06.019. [PMID: 22818869] - Catherine B Dieck, Austin Wood, Irena Brglez, Marcela Rojas-Pierce, Wendy F Boss. Increasing phosphatidylinositol (4,5) bisphosphate biosynthesis affects plant nuclear lipids and nuclear functions.
Plant physiology and biochemistry : PPB.
2012 Aug; 57(?):32-44. doi:
10.1016/j.plaphy.2012.05.011. [PMID: 22677448] - Hue T Tran, R Glen Uhrig, Mhairi Nimick, Greg B Moorhead. Interfacing protein lysine acetylation and protein phosphorylation: ancient modifications meet on ancient proteins.
Plant signaling & behavior.
2012 Aug; 7(8):901-3. doi:
10.4161/psb.20704. [PMID: 22827947] - Andrea A Gust, Roland Willmann, Yoshitake Desaki, Heini M Grabherr, Thorsten Nürnberger. Plant LysM proteins: modules mediating symbiosis and immunity.
Trends in plant science.
2012 Aug; 17(8):495-502. doi:
10.1016/j.tplants.2012.04.003. [PMID: 22578284] - Chongsheng He, Xiaofan Chen, Hai Huang, Lin Xu. Reprogramming of H3K27me3 is critical for acquisition of pluripotency from cultured Arabidopsis tissues.
PLoS genetics.
2012 Aug; 8(8):e1002911. doi:
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2012 Aug; 26(8):3563-74. doi:
10.1096/fj.12-207894. [PMID: 22549509] - Tsun-Yung Kuo, Chuen-Lin Huang, Jung-Mou Yang, Wei-Jung Huang, Nai-Kuei Huang, Yue-Wen Chen, Ren-Jye Lin, Ying-Chen Yang. The role of ribosylated-BSA in regulating PC12 cell viability.
Cell biology and toxicology.
2012 Aug; 28(4):255-67. doi:
10.1007/s10565-012-9220-3. [PMID: 22543687] - Zsolt Lohinai, Beata Keremi, Eva Szoko, Tamas Tabi, Csaba Szabo, Zsolt Tulassay, Martin Levine. Bacterial lysine decarboxylase influences human dental biofilm lysine content, biofilm accumulation, and subclinical gingival inflammation.
Journal of periodontology.
2012 Aug; 83(8):1048-56. doi:
10.1902/jop.2011.110474. [PMID: 22141361] - Jung Min Ko, Choong Ho Shin, Sei Won Yang, Moon Woo Seong, Sung Sup Park, Junghan Song. The first Korean case of lysinuric protein intolerance: presented with short stature and increased somnolence.
Journal of Korean medical science.
2012 Aug; 27(8):961-4. doi:
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