(9S,10S)-9,10-dihydroxyoctadecanoate (BioDeep_00000006719)

Main id: BioDeep_00000001049

Secondary id: BioDeep_00000629089

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


threo-9,10-Dihydroxystearic acid

化学式: C18H36O4 (316.2613)
中文名称: 9,10-二羟基硬脂酸
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 85.71%

分子结构信息

SMILES: C(=O)(O)CCCCCCC[C@H]([C@@H](O)CCCCCCCC)O
InChI: InChI=1S/C18H36O4/c1-2-3-4-5-7-10-13-16(19)17(20)14-11-8-6-9-12-15-18(21)22/h16-17,19-20H,2-15H2,1H3,(H,21,22)/t16-,17+/m0/s1



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ALB, DDIT3, EIF5A, HMGB1, NDUFA13, PPARG, PQBP1, PRDX4, PRKN, RCC1
Peripheral membrane protein 5 CYP1B1, EIF5A, HMGB1, NDUFA12, NDUFA7
Endoplasmic reticulum membrane 2 CYP1B1, EIF5A
Nucleus 13 ALB, ALDOA, DDIT3, EIF5A, HMGB1, NCL, NDUFA13, PARP1, PPARG, PQBP1, PRDX4, PRKN, RCC1
cytosol 12 ALB, ALDOA, DDIT3, ECI2, EIF5A, EPHX2, LIPE, NDUFA12, PARP1, PPARG, PRDX4, PRKN
mitochondrial membrane 1 NDUFA13
nuclear body 2 PARP1, PQBP1
centrosome 1 ALB
nucleoplasm 7 HMGB1, NCL, NDUFA13, PARP1, PPARG, PQBP1, RCC1
RNA polymerase II transcription regulator complex 2 DDIT3, PPARG
Cell membrane 2 HMGB1, LIPE
Cytoplasmic side 1 EIF5A
Cytoplasmic granule 1 PQBP1
cell cortex 1 NCL
cell surface 1 HMGB1
Golgi apparatus 2 ALB, PRKN
Golgi membrane 1 INS
mitochondrial inner membrane 3 NDUFA12, NDUFA13, NDUFA7
Cytoplasm, cytosol 3 LIPE, PARP1, PRKN
Presynapse 1 PRKN
endosome 1 HMGB1
plasma membrane 2 HMGB1, NCL
Membrane 8 ALDOA, CYP1B1, ECI2, EIF5A, LIPE, NCL, NDUFA12, PARP1
caveola 1 LIPE
extracellular exosome 5 ALB, ALDOA, EPHX2, NCL, PRDX4
endoplasmic reticulum 4 ALB, HMGB1, PRDX4, PRKN
extracellular space 4 ALB, ALDOA, HMGB1, INS
perinuclear region of cytoplasm 2 PPARG, PRKN
mitochondrion 7 CYP1B1, ECI2, NDUFA12, NDUFA13, NDUFA7, PARP1, PRKN
protein-containing complex 3 ALB, PARP1, RCC1
intracellular membrane-bounded organelle 3 CYP1B1, ECI2, PPARG
Microsome membrane 1 CYP1B1
postsynaptic density 1 PRKN
Secreted 3 ALB, HMGB1, INS
extracellular region 5 ALB, ALDOA, HMGB1, INS, PRDX4
Mitochondrion outer membrane 1 PRKN
Single-pass membrane protein 1 NDUFA13
mitochondrial outer membrane 1 PRKN
Extracellular side 1 HMGB1
anchoring junction 1 ALB
transcription regulator complex 2 DDIT3, PARP1
actin cytoskeleton 1 ALDOA
nucleolus 2 NCL, PARP1
Mitochondrion inner membrane 3 NDUFA12, NDUFA13, NDUFA7
Matrix side 3 NDUFA12, NDUFA13, NDUFA7
Peroxisome 2 ECI2, EPHX2
peroxisomal matrix 2 ECI2, EPHX2
nuclear speck 2 PQBP1, PRKN
Late endosome 1 DDIT3
receptor complex 1 PPARG
Cell projection, neuron projection 1 PRKN
neuron projection 1 PRKN
ciliary basal body 1 ALB
chromatin 4 DDIT3, PARP1, PPARG, RCC1
Chromosome 4 HMGB1, NCL, PARP1, RCC1
centriole 1 ALB
cytoplasmic ribonucleoprotein granule 1 NCL
[Isoform 1]: Mitochondrion 1 ECI2
Nucleus, nucleolus 2 NCL, PARP1
spindle pole 1 ALB
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
blood microparticle 1 ALB
spliceosomal complex 1 NCL
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
nuclear pore 1 EIF5A
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Cornified envelope 1 NCL
Cytoplasm, myofibril, sarcomere, I band 1 ALDOA
Cytoplasm, myofibril, sarcomere, M line 1 ALDOA
I band 1 ALDOA
M band 1 ALDOA
cytoplasmic stress granule 1 PQBP1
Nucleus speckle 1 PQBP1
respiratory chain complex 1 NDUFA13
ubiquitin ligase complex 1 PRKN
respiratory chain complex I 3 NDUFA12, NDUFA13, NDUFA7
ficolin-1-rich granule lumen 3 ALDOA, HMGB1, PRDX4
secretory granule lumen 4 ALDOA, HMGB1, INS, PRDX4
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ALB, INS
transcription repressor complex 1 HMGB1
platelet alpha granule lumen 2 ALB, ALDOA
tertiary granule lumen 1 ALDOA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
aggresome 1 PRKN
condensed nuclear chromosome 1 RCC1
annulate lamellae 1 EIF5A
ribonucleoprotein complex 1 NCL
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
protein-DNA complex 2 DDIT3, PARP1
dopaminergic synapse 1 PRKN
condensed chromosome 1 HMGB1
Lewy body 1 PRKN
Parkin-FBXW7-Cul1 ubiquitin ligase complex 1 PRKN
neuronal ribonucleoprotein granule 1 PQBP1
site of DNA damage 1 PARP1
[Isoform 2]: Peroxisome matrix 1 ECI2
sperm head 1 ALDOA
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
CHOP-C/EBP complex 1 DDIT3
CHOP-ATF3 complex 1 DDIT3
CHOP-ATF4 complex 1 DDIT3
macropinosome membrane 1 NCL
ciliary transition fiber 1 ALB


文献列表

  • Edward J Whittle, Yuanheng Cai, Jantana Keereetaweep, Jin Chai, Peter H Buist, John Shanklin. Castor Stearoyl-ACP Desaturase Can Synthesize a Vicinal Diol by Dioxygenase Chemistry. Plant physiology. 2020 02; 182(2):730-738. doi: 10.1104/pp.19.01111. [PMID: 31806737]
  • Gregory F L Koay, Teong-Guan Chuah, Sumaiya Zainal-Abidin, Salmiah Ahmad, Thomas S Y Choong. Development, characterization and commercial application of palm based dihydroxystearic acid and its derivatives: an overview. Journal of oleo science. 2011; 60(5):237-65. doi: 10.5650/jos.60.237. [PMID: 21502724]
  • Diane Julien-David, Saïd Ennahar, Michel Miesch, Philippe Geoffroy, Francis Raul, Dalal Aoude-Werner, Jean-Marc Lessinger, Eric Marchioni. Effects of oxidation on the hydrolysis by cholesterol esterase of sitosteryl esters as compared to a cholesteryl ester. Steroids. 2009 Oct; 74(10-11):832-6. doi: 10.1016/j.steroids.2009.05.003. [PMID: 19464305]
  • R Awang, M Basri, S Ahmad, A B Salleh. Lipase-catalyzed esterification of palm-based 9,10-dihydroxystearic acid and 1-octanol in hexane--a kinetic study. Biotechnology letters. 2004 Jan; 26(1):11-4. doi: 10.1023/b:bile.0000009452.73477.26. [PMID: 15005144]
  • F Pinot, I Benveniste, J P Salaün, O Loreau, J P Noël, L Schreiber, F Durst. Production in vitro by the cytochrome P450 CYP94A1 of major C18 cutin monomers and potential messengers in plant-pathogen interactions: enantioselectivity studies. The Biochemical journal. 1999 Aug; 342 ( Pt 1)(?):27-32. doi: 10.1042/0264-6021:3420027. [PMID: 10432296]
  • J A Timbrell, J M Wright. Urinary metabolic profile of isoniazid in patients who develop isoniazid-related liver damage. Human toxicology. 1984 Dec; 3(6):485-95. doi: 10.1177/096032718400300603. [PMID: 6526396]