Lithium carbonate (BioDeep_00000006639)
代谢物信息卡片
Lithium carbonate
化学式: CLi2O3 (74.0168)
中文名称: 碳酸锂
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: [Li+].[Li+].C(=O)([O-])[O-]
InChI: /q
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D018692 - Antimanic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
D004791 - Enzyme Inhibitors
同义名列表
2 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:6504
- KEGG: C07964
- KEGGdrug: D00801
- PubChem: 11125
- DrugBank: DB14509
- ChEMBL: CHEMBL1200826
- MeSH: Lithium Carbonate
- CAS: 554-13-2
- PubChem: 10165
- NIKKAJI: J425A
- KNApSAcK: 6504
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Selin Sipahi Kuloğlu, Emine Yalçin, Kültiğin Çavuşoğlu, Ali Acar. Dose-dependent toxicity profile and genotoxicity mechanism of lithium carbonate.
Scientific reports.
2022 08; 12(1):13504. doi:
10.1038/s41598-022-17838-0. [PMID: 35931740] - Ian R McGrane, Faddy A Omar, Natalie F Morgan, Michael D Shuman. Lithium therapy in patients on dialysis: A systematic review.
International journal of psychiatry in medicine.
2022 05; 57(3):187-201. doi:
10.1177/00912174211028544. [PMID: 34176305] - S M Zaki, G H A Hussein, G M Helal, S F Arsanyos, W A Abd Algaleel. Green tea extract modulates lithium-induced thyroid follicular cell damage in rats.
Folia morphologica.
2022; 81(3):594-605. doi:
10.5603/fm.a2021.0052. [PMID: 34018174] - Ryo Obara, Takashi Tomita, Hidekazu Goto, Yukinao Kohda, Tadashi Yoshida, Kenzo Kudo. Effect of antipsychotics on serum lithium levels and white blood cell counts.
Neuropsychopharmacology reports.
2021 12; 41(4):532-537. doi:
10.1002/npr2.12210. [PMID: 34687178] - Ghazal Ghajari, Mohammad Nabiuni, Elaheh Amini. The association between testicular toxicity induced by Li2Co3 and protective effect of Ganoderma lucidum: Alteration of Bax & c-Kit genes expression.
Tissue & cell.
2021 Oct; 72(?):101552. doi:
10.1016/j.tice.2021.101552. [PMID: 33992978] - Koen Van Deun, H Hatch, S Jacobi, W Köhl. Lithium carbonate: Updated reproductive and developmental toxicity assessment using scientific literature and guideline compliant studies.
Toxicology.
2021 09; 461(?):152907. doi:
10.1016/j.tox.2021.152907. [PMID: 34454986] - Lenka Roubalová, Miroslava Vošahlíková, Jiřina Slaninová, Jonáš Kaufman, Martin Alda, Petr Svoboda. Tissue-specific protective properties of lithium: comparison of rat kidney, erythrocytes and brain.
Naunyn-Schmiedeberg's archives of pharmacology.
2021 05; 394(5):955-965. doi:
10.1007/s00210-020-02036-4. [PMID: 33404687] - Marc Augustin, Rahsan Karakavuz, Luise Riester, Michael Grözinger. Lithium Is Likely to Persist in the Brain: Clinical Implications for Electroconvulsive Therapy.
The journal of ECT.
2021 Mar; 37(1):67-70. doi:
10.1097/yct.0000000000000719. [PMID: 33600119] - M A Korolev, P G Madonov, L N Rachkovskaya, N I Suslov, A V Shurlygina, E E Rachkovskii, M V Robinson, A A Kotlyarova, T V Popova, T N Povet'eva, O G Afanas'eva, Yu V Nesterova, A Yu Letyagin. Effect of a New Lithium Preparation on the Behavior of CBA/CaLac Mice in an Experimental Conflict Model.
Bulletin of experimental biology and medicine.
2021 Feb; 170(4):436-439. doi:
10.1007/s10517-021-05084-9. [PMID: 33713221] - Melis Danışman Sonkurt, Harun Olcay Sonkurt. Lithium Intoxication in COVID-19: A Case Report.
Psychiatria Danubina.
2021; 33(2):248-249. doi:
10.24869/psyd.2021.248. [PMID: 34185757] - Vicky M Pham, Jennifer M White, Steven R Gunther, Jonathan T Stewart. Lithium for Carbamazepine-Induced Syndrome of Inappropriate Antidiuretic Hormone.
Clinical neuropharmacology.
2021 Jan; 44(1):33-34. doi:
10.1097/wnf.0000000000000421. [PMID: 33201007] - Nataliya Bgatova, Iuliia Taskaeva. Ultrastructure of the kidney filtration barrier in conditions of distant tumor growth and lithium treatment.
Ultrastructural pathology.
2020 Nov; 44(4-6):412-421. doi:
10.1080/01913123.2020.1850962. [PMID: 33251931] - Antonio Crocamo, Pierluigi Demola, Francesco Visioli, Domenico Corradi, Luigi Vignali, Giovanna Pelà. Hypertrophic cardiomyopathy and nephrogenic diabetes insipidus associated with chronic lithium carbonate use.
Psychiatry research.
2020 09; 291(?):113153. doi:
10.1016/j.psychres.2020.113153. [PMID: 32535507] - Miroslava Vosahlikova, Lenka Roubalova, Kristina Cechova, Jonas Kaufman, Stanislav Musil, Ivan Miksik, Martin Alda, Petr Svoboda. Na+/K+-ATPase and lipid peroxidation in forebrain cortex and hippocampus of sleep-deprived rats treated with therapeutic lithium concentration for different periods of time.
Progress in neuro-psychopharmacology & biological psychiatry.
2020 08; 102(?):109953. doi:
10.1016/j.pnpbp.2020.109953. [PMID: 32360816] - Yi-Hsin Lin, Sheng-Wen Liu, Hsein-Lin Wu, Jung-Cheng Kang, Kuo-Yang Huang, Hsuan Huang. Lithium toxicity with prolonged neurologic sequelae following sleeve gastrectomy: A case report and review of literature.
Medicine.
2020 Jul; 99(28):e21122. doi:
10.1097/md.0000000000021122. [PMID: 32664138] - N Bouaziz, H Ben Rejeb, S Ateb, T Fourati, F Chammas, D Baha, R Rosetti, K Kalalou, G Saba, R Benadhira, D Januel. [Thoughts on a favourable evolution of a COVID-19 in a patient with resistant schizophrenia and on a combination of clozapine and paliperidone palmitate].
L'Encephale.
2020 Jun; 46(3S):S126-S127. doi:
10.1016/j.encep.2020.05.009. [PMID: 32475694] - A Czarnywojtek, M Zgorzalewicz-Stachowiak, B Czarnocka, N Sawicka-Gutaj, P Gut, I Krela-Kazmierczak, M Ruchala. Effect of lithium carbonate on the function of the thyroid gland: mechanism of action and clinical implications.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2020 Apr; 71(2):. doi:
10.26402/jpp.2020.2.03. [PMID: 32633237] - Małgorzata Kiełczykowska, Małgorzata Polz-Dacewicz, Ewelina Kopciał, Olga Mitrus, Jacek Kurzepa, Zbigniew Marzec, Irena Musik. Selenium prevents lithium accumulation and does not disturb basic microelement homeostasis in liver and kidney of rats exposed to lithium.
Annals of agricultural and environmental medicine : AAEM.
2020 Mar; 27(1):129-133. doi:
10.26444/aaem/105926. [PMID: 32208591] - Lei Sun, Sergey Yagoda, Baiyun Yao, Christine Graham, Lisa von Moltke. Combination of Olanzapine and Samidorphan Has No Clinically Significant Effect on the Pharmacokinetics of Lithium or Valproate.
Clinical drug investigation.
2020 Jan; 40(1):55-64. doi:
10.1007/s40261-019-00860-y. [PMID: 31584140] - Tomotsugu Seki, Morio Aki, Hirotsugu Kawashima, Tomotaka Miki, Shiro Tanaka, Koji Kawakami, Toshi A Furukawa. Electronic health record nested pragmatic randomized controlled trial of a reminder system for serum lithium level monitoring in patients with mood disorder: KONOTORI study protocol.
Trials.
2019 Dec; 20(1):706. doi:
10.1186/s13063-019-3847-9. [PMID: 31829279] - Tsandni Jamal, Carole Hennequin, Rabah Gahoual, Annie Leyris, Jean-Louis Beaudeux, Frédéric J Baud, Pascal Houzé. Is Capillary Electrophoresis a New Tool to Monitor Acute Lithium Poisoning in Human?†.
Journal of analytical toxicology.
2019 Aug; 43(7):571-578. doi:
10.1093/jat/bkz013. [PMID: 30877800] - Daichi Yamaguchi, Yasuhiro Tsuji, Miki Sonoda, Kenji Shin, Hiroko Kito, Chika Ogami, Hidefumi Kasai, Hideto To, Hidetoshi Kamimura. Population Pharmacokinetics and Exposure-Response of Lithium Carbonate in Patients Based on Tubular Reabsorption Mechanisms.
European journal of drug metabolism and pharmacokinetics.
2019 Jun; 44(3):329-338. doi:
10.1007/s13318-018-0536-0. [PMID: 30536114] - Milan Dastych, Oldřich Synek, Jana Gottwaldová. Impact of Long-Term Lithium Treatment on Renal Function in Patients With Bipolar Disorder Based on Novel Biomarkers.
Journal of clinical psychopharmacology.
2019 May; 39(3):238-242. doi:
10.1097/jcp.0000000000001030. [PMID: 30932947] - Sanny B Kumar, Rozy Kamal, Anna Khan, Vijayta D Chadha. Dose optimization of lithium to increase the uptake and retention of I-131 in rat thyroid.
Radiation and environmental biophysics.
2019 05; 58(2):257-262. doi:
10.1007/s00411-019-00783-4. [PMID: 30810817] - C Couffignal, J Bertrand, S Sportiche, Marine Jarroir, S El Balkhi, N Djebrani-Oussedik, J Poupon, X Declèves, F Mentré, F Bellivier. Population pharmacokinetic modeling of sustained release lithium in the serum, erythrocytes and urine of patients with bipolar disorder.
European journal of clinical pharmacology.
2019 Apr; 75(4):519-528. doi:
10.1007/s00228-018-2605-3. [PMID: 30554270] - Douglas E Teixeira, Diogo B Peruchetti, Leandro S Silva, Rodrigo P Silva-Aguiar, Morgana B Oquendo, João Luiz Silva-Filho, Christina M Takiya, José Henrique Leal-Cardoso, Ana Acacia S Pinheiro, Celso Caruso-Neves. Lithium ameliorates tubule-interstitial injury through activation of the mTORC2/protein kinase B pathway.
PloS one.
2019; 14(4):e0215871. doi:
10.1371/journal.pone.0215871. [PMID: 31002704] - Ai Goto, Yuji Nakamura, Nur Jaharat Lubna, Koki Chiba, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsuhiko T Naito, Atsushi Sugiyama. Analysis of Safety Margin of Lithium Carbonate Against Cardiovascular Adverse Events Assessed in the Halothane-Anesthetized Dogs.
Cardiovascular toxicology.
2018 12; 18(6):530-536. doi:
10.1007/s12012-018-9464-0. [PMID: 29845450] - Michael Dixon, Vikram Luthra, Christopher Todd. Use of cinacalcet in lithium-induced hyperparathyroidism.
BMJ case reports.
2018 Aug; 2018(?):. doi:
10.1136/bcr-2018-225154. [PMID: 30158262] - Nathaniel J Himmel, Yirong Wang, Daniel A Rodriguez, Michael A Sun, Mitsi A Blount. Chronic lithium treatment induces novel patterns of pendrin localization and expression.
American journal of physiology. Renal physiology.
2018 08; 315(2):F313-F322. doi:
10.1152/ajprenal.00065.2018. [PMID: 29667915] - Priti Bhardwaj, Kinnri Jain, Devinder Kumar Dhawan. Lithium Treatment Aggregates the Adverse Effects on Erythrocytes Subjected to Arsenic Exposure.
Biological trace element research.
2018 Jul; 184(1):206-213. doi:
10.1007/s12011-017-1168-y. [PMID: 28988373] - R Niessen, T Sottiaux, A Schillaci, F Lejeune. [Lithium toxicity after bariatric surgery].
Revue medicale de Liege.
2018 Feb; 73(2):82-87. doi:
NULL. [PMID: 29517871] - Priyakshi Kalita-De Croft, Jennifer J Bedford, John P Leader, Robert J Walker. Amiloride modifies the progression of lithium-induced renal interstitial fibrosis.
Nephrology (Carlton, Vic.).
2018 Jan; 23(1):20-30. doi:
10.1111/nep.12929. [PMID: 27682266] - Cristian Rodelo-Haad, Maria L Agüera, Rosa Ortega, Ana Martinez-Lopez, M Dolores Navarro, Alberto Rodriguez-Benot, Pedro Aljama. Lithium-associated nephropathy in the renal allograft.
Kidney international.
2018 01; 93(1):273. doi:
10.1016/j.kint.2017.08.032. [PMID: 29291824] - Anouar Ben Saad, Brahmi Dalel, Ilhem Rjeibi, Amani Smida, Sana Ncib, Nacim Zouari, Lazhar Zourgui. Phytochemical, antioxidant and protective effect of cactus cladodes extract against lithium-induced liver injury in rats.
Pharmaceutical biology.
2017 Dec; 55(1):516-525. doi:
10.1080/13880209.2016.1255976. [PMID: 27951739] - Ivana Stetkarova, Vaclav Bocek, Alsu Gismatullina, Zuzana Svobodova, Tomas Peisker. Severe chronic lithium intoxication in patient treated for bipolar disorder.
Neuro endocrinology letters.
2017 Dec; 38(6):397-400. doi:
NULL. [PMID: 29298279] - Vladan Sekulić, Milena Rajić, Marina Vlajković, Slobodan Ilić, Miloš Stević, Marko Kojić. The effect of short-term treatment with lithium carbonate on the outcome of radioiodine therapy in patients with long-lasting Graves' hyperthyroidism.
Annals of nuclear medicine.
2017 Dec; 31(10):744-751. doi:
10.1007/s12149-017-1206-z. [PMID: 28895066] - Robert C Young, Benoit H Mulsant, Martha Sajatovic, Ariel G Gildengers, Laszlo Gyulai, Rayan K Al Jurdi, John Beyer, Jovier Evans, Samprit Banerjee, Rebecca Greenberg, Patricia Marino, Mark E Kunik, Peijun Chen, Marna Barrett, Herbert C Schulberg, Martha L Bruce, Charles F Reynolds, George S Alexopoulos. GERI-BD: A Randomized Double-Blind Controlled Trial of Lithium and Divalproex in the Treatment of Mania in Older Patients With Bipolar Disorder.
The American journal of psychiatry.
2017 11; 174(11):1086-1093. doi:
10.1176/appi.ajp.2017.15050657. [PMID: 29088928] - Maria Gałuszko-Węgielnik, Katarzyna Jakuszkowiak-Wojten, Mariusz Stanisław Wiglusz, Joanna Szarmach, Adam Włodarczyk, Marta Herstowska, Wiesław Jerzy Cubała. Lithium therapeutic dose monitoring in human saliva.
Psychiatria Danubina.
2017 Sep; 29(Suppl 3):361-364. doi:
NULL. [PMID: 28953792] - Małgorzata Kiełczykowska, Irena Musik, Jacek Kurzepa, Renata Żelazowska, Anna Lewandowska, Marek Paździor, Joanna Kocot. The Influence of Lithium and/or Selenium Treatment on Homeostasis of Chosen Bioelements in Rats.
Biological trace element research.
2017 Jul; 178(1):79-85. doi:
10.1007/s12011-016-0906-x. [PMID: 27957665] - Ahsan Habib, Darrell Sawmiller, Song Li, Yang Xiang, David Rongo, Jun Tian, Huayan Hou, Jin Zeng, Adam Smith, Shengnuo Fan, Brian Giunta, Takashi Mori, Glenn Currier, Douglas Ronald Shytle, Jun Tan. LISPRO mitigates β-amyloid and associated pathologies in Alzheimer's mice.
Cell death & disease.
2017 06; 8(6):e2880. doi:
10.1038/cddis.2017.279. [PMID: 28617434] - Liuxing Feng, Jun Wang, Yanjie Cui, Naijie Shi, Haifeng Li, Hongmei Li. Development of certified reference materials for electrolytes in human serum (GBW09124-09126).
Analytical and bioanalytical chemistry.
2017 May; 409(13):3483-3493. doi:
10.1007/s00216-017-0287-9. [PMID: 28324127] - Armağan Özdemir, Cana Aksoy Poyraz, Burç Ç Poyraz, Nazife G Usta Sağlam, Semra Enginkaya, Nesrin Tomruk. Use of Lithium in Severe Acute Manic Episodes: Retrospective Prescription Practice From a Tertiary Inpatient Unit.
Journal of psychiatric practice.
2017 05; 23(3):167-172. doi:
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Metabolic brain disease.
2017 04; 32(2):519-528. doi:
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Minerva endocrinologica.
2017 Mar; 42(1):8-14. doi:
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Journal of biochemical and molecular toxicology.
2017 Feb; 31(2):. doi:
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Pharmacopsychiatry.
2017 Jan; 50(1):41-42. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Dec; 84(?):1099-1107. doi:
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Pharmacopsychiatry.
2016 Sep; 49(5):177-181. doi:
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BMC psychiatry.
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Pakistan journal of pharmaceutical sciences.
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Biological trace element research.
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Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics.
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Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
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PloS one.
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Journal of pharmacy practice.
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Journal of applied toxicology : JAT.
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Bipolar disorders.
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Patologicheskaia fiziologiia i eksperimental'naia terapiia.
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Journal of psychiatric practice.
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Psychopharmacology.
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Human psychopharmacology.
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Toxicological sciences : an official journal of the Society of Toxicology.
2015 Jan; 143(1):185-95. doi:
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Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists.
2014 Dec; 22(6):591-2. doi:
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Psychopharmacology.
2014 Dec; 231(24):4623-36. doi:
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Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2014 Sep; 10(3):303-6. doi:
10.1007/s13181-013-0366-z. [PMID: 24381125] - Rafael T de Sousa, Marcus V Zanetti, Geraldo F Busatto, Margaret G Mouro, Carlos A Zarate, Wagner F Gattaz, Elisa M Higa, Rodrigo Machado-Vieira. Lithium increases nitric oxide levels in subjects with bipolar disorder during depressive episodes.
Journal of psychiatric research.
2014 Aug; 55(?):96-100. doi:
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Journal of clinical pharmacy and therapeutics.
2014 Aug; 39(4):452-4. doi:
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ACS chemical neuroscience.
2014 Jun; 5(6):484-9. doi:
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Biological trace element research.
2014 Jun; 158(3):359-64. doi:
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Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2014 Jun; 18(3):265-71. doi:
10.1111/1744-9987.12214. [PMID: 24965293] - Marie-Catherine Boll, Leo Bayliss, Steven Vargas-Cañas, Jorge Burgos, Sergio Montes, Guillermo Peñaloza-Solano, Camilo Rios, Mireya Alcaraz-Zubeldia. Clinical and biological changes under treatment with lithium carbonate and valproic acid in sporadic amyotrophic lateral sclerosis.
Journal of the neurological sciences.
2014 May; 340(1-2):103-8. doi:
10.1016/j.jns.2014.03.005. [PMID: 24667005] - Taylor A Nichols, Shannon J Drayton, Jeffrey Borckardt, David J Taber. Lithium dosing equations: are they accurate?.
The Annals of pharmacotherapy.
2014 May; 48(5):596-600. doi:
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Movement disorders : official journal of the Movement Disorder Society.
2014 Apr; 29(4):575-7. doi:
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Journal of psychiatric research.
2014 Mar; 50(?):36-41. doi:
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American journal of therapeutics.
2014 Mar; 21(2):e31-4. doi:
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Rivista di psichiatria.
2014 Jan; 49(1):12-21. doi:
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Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica.
2014; 116(2):130-7. doi:
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Acta medica Iranica.
2014; 52(10):734-9. doi:
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Journal of clinical psychopharmacology.
2013 Dec; 33(6):806-9. doi:
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L'Encephale.
2013 Sep; 39(4):306-12. doi:
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Journal of the American Dental Association (1939).
2013 Sep; 144(9):1010-3. doi:
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Progress in neuro-psychopharmacology & biological psychiatry.
2013 Jun; 43(?):230-7. doi:
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Thyroid : official journal of the American Thyroid Association.
2013 Jun; 23(6):766-70. doi:
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L'Encephale.
2013 May; 39 Suppl 1(?):S22-8. doi:
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Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia.
2013 May; 30(3):. doi:
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Bipolar disorders.
2013 May; 15(3):333-7. doi:
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International immunopharmacology.
2013 May; 16(1):35-40. doi:
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Acta neurologica Taiwanica.
2013 Mar; 22(1):32-5. doi:
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The international journal of neuropsychopharmacology.
2013 Mar; 16(2):365-76. doi:
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Nephrology (Carlton, Vic.).
2012 Nov; 17(8):776-9. doi:
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Rivista di psichiatria.
2012 Nov; 47(6):515-26. doi:
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Thyroid : official journal of the American Thyroid Association.
2012 Oct; 22(10):1002-6. doi:
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Acta psychiatrica Scandinavica.
2012 Sep; 126(3):186-97. doi:
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Psychiatria polska.
2012 Jul; 46(4):627-36. doi:
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Biological trace element research.
2012 Jun; 147(1-3):59-62. doi:
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Pharmaceutical development and technology.
2012 May; 17(3):375-82. doi:
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Psychiatrike = Psychiatriki.
2012 Apr; 23(2):143-8. doi:
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Journal of physiology and biochemistry.
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