Gentamicin (BioDeep_00000006570)

   

human metabolite blood metabolite Chemicals and Drugs Antibiotics natural product


代谢物信息卡片


2-{[4,6-diamino-3-({3-amino-6-[1-(methylamino)ethyl]oxan-2-yl}oxy)-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol

化学式: C21H43N5O7 (477.3162)
中文名称: 庆大霉素
谱图信息: 最多检出来源 Homo sapiens(blood) 16.59%

Reviewed

Last reviewed on 2024-10-31.

Cite this Page

Gentamicin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/gentamicin (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000006570). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(C1CCC(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)NC
InChI: InChI=1S/C21H43N5O7/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20/h9-20,25-29H,5-8,22-24H2,1-4H3

描述信息

A complex of three different closely related aminoglycoside sulfates, Gentamicins C1, C2, and C1(subA), obtained from Micromonospora purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit protein synthesis (genetic translation). [PubChem]
D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06A - Antibiotics for topical use
S - Sensory organs > S03 - Ophthalmological and otological preparations > S03A - Antiinfectives > S03AA - Antiinfectives
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01G - Aminoglycoside antibacterials
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AA - Antibiotics
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D005839 - Gentamicins
S - Sensory organs > S02 - Otologicals > S02A - Antiinfectives > S02AA - Antiinfectives
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
C254 - Anti-Infective Agent > C258 - Antibiotic

同义名列表

17 个代谢物同义名

2-{[4,6-diamino-3-({3-amino-6-[1-(methylamino)ethyl]oxan-2-yl}oxy)-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol; Sulfate, gentamicin; Gentamicin sulfate; Gentamicin C1; Gentamycins; Gentamicins; Gentamycin; Gentacycol; gentamicin; g Myticin; Garamycin; g-Myticin; Genticin; Gentavet; GMyticin; Gentamicin C1; Gentamicin



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 2 ALB, CLU
Peripheral membrane protein 2 CLU, CYP27A1
Endoplasmic reticulum membrane 1 ZDHHC16
Mitochondrion membrane 2 CLU, CYP27A1
Nucleus 3 ALB, CLU, PLCZ1
cytosol 7 ALB, B2M, CLU, GPT, LIPE, NRK, PLCZ1
mitochondrial membrane 1 CLU
centrosome 1 ALB
nucleoplasm 1 PLCZ1
Cell membrane 2 B2M, LIPE
Cytoplasmic side 1 CLU
lamellipodium 1 STX2
Early endosome membrane 1 B2M
Multi-pass membrane protein 1 ZDHHC16
Synapse 1 CLU
cell surface 3 B2M, CLU, STRC
Golgi apparatus 4 ALB, B2M, CLU, ZDHHC16
Golgi membrane 2 B2M, INS
lysosomal membrane 2 B2M, EGF
mitochondrial inner membrane 2 CLU, CYP27A1
synaptic vesicle 1 STX2
Cytoplasm, cytosol 2 CLU, LIPE
plasma membrane 3 B2M, EGF, STX2
Membrane 6 B2M, EGF, LIPE, NRK, STX2, ZDHHC16
basolateral plasma membrane 1 STX2
caveola 1 LIPE
extracellular exosome 7 ALB, B2M, BMP3, CLU, EGF, GPT, LYZ
endoplasmic reticulum 3 ALB, B2M, CLU
extracellular space 11 ALB, B2M, BMP3, CLU, CRP, CXCL8, EGF, IL10, INS, LYZ, STX2
perinuclear region of cytoplasm 2 CLU, PLCZ1
mitochondrion 2 CLU, CYP27A1
protein-containing complex 3 ALB, CLU, STX2
intracellular membrane-bounded organelle 2 CLU, STX2
pronucleus 1 PLCZ1
Secreted 8 ALB, B2M, BMP3, CLU, CRP, CXCL8, IL10, INS
extracellular region 10 ALB, B2M, BMP3, CLU, CRP, CXCL8, EGF, IL10, INS, LYZ
mitochondrial matrix 1 CYP27A1
anchoring junction 1 ALB
external side of plasma membrane 1 B2M
nucleolus 1 PLCZ1
presynaptic active zone membrane 1 STX2
Cytoplasm, perinuclear region 2 CLU, PLCZ1
Mitochondrion inner membrane 1 CYP27A1
focal adhesion 1 B2M
collagen-containing extracellular matrix 1 CLU
ciliary basal body 1 ALB
Late endosome membrane 1 B2M
phagocytic vesicle membrane 1 B2M
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, CLU
Recycling endosome membrane 1 B2M
Endomembrane system 1 STX2
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Cell projection, stereocilium 1 STRC
Cell projection, kinocilium 1 STRC
kinocilium 1 STRC
stereocilium tip 1 STRC
SNARE complex 1 STX2
[Isoform 4]: Cytoplasm 1 CLU
Microsome 1 CLU
secretory granule lumen 1 INS
HFE-transferrin receptor complex 1 B2M
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, B2M, INS
platelet alpha granule lumen 3 ALB, CLU, EGF
specific granule lumen 2 B2M, LYZ
tertiary granule lumen 2 B2M, LYZ
transport vesicle 1 INS
azurophil granule lumen 1 LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
ER to Golgi transport vesicle membrane 1 B2M
clathrin-coated endocytic vesicle membrane 1 EGF
apical dendrite 1 CLU
MHC class I peptide loading complex 1 B2M
spherical high-density lipoprotein particle 1 CLU
[Isoform 1]: Secreted 1 CLU
MHC class I protein complex 1 B2M
MHC class II protein complex 1 B2M
sperm head 1 PLCZ1
neurofibrillary tangle 1 CLU
Cytoplasmic vesicle, secretory vesicle, chromaffin granule 1 CLU
chromaffin granule 1 CLU
[Isoform 6]: Cytoplasm 1 CLU
perinuclear endoplasmic reticulum lumen 1 CLU
ciliary transition fiber 1 ALB
early endosome lumen 1 B2M


文献列表

  • Yixin Rui, Xiumeng Zhang, Xinran Min, Hongxiao Xie, Xiuying Ma, Funeng Geng, Rong Liu. Unlocking renal Restoration: Mesaconine from Aconitum plants restore mitochondrial function to halt cell apoptosis in acute kidney injury. International immunopharmacology. 2024 May; 133(?):112170. doi: 10.1016/j.intimp.2024.112170. [PMID: 38691919]
  • Yanwen Zhuang, Yu Ouyang, Li Ding, Miaowen Xu, Fanfeng Shi, Dan Shan, Dawei Cao, Xiaowei Cao. Source Tracing of Kidney Injury via the Multispectral Fingerprint Identified by Machine Learning-Driven Surface-Enhanced Raman Spectroscopic Analysis. ACS sensors. 2024 May; 9(5):2622-2633. doi: 10.1021/acssensors.4c00407. [PMID: 38700898]
  • Marina M Stanković, Petar M Ristivojević, Đurđa D Ivković, Milena G Milutinović, Jelena N Terzić, Olgica D Stefanović. A comprehensive study on Geranium robertianum L. antibacterial potential. Journal of applied microbiology. 2024 May; 135(5):. doi: 10.1093/jambio/lxae106. [PMID: 38658191]
  • Hai Bang Pan, Yan Cui, Zhi Hang Wu, Ying Meng, Tian Ming Wang, Qi Fu, Qian Chen, Quan Xin Chen, Bo Wang. Effect of Different Local Antibiotic Regimens on Prevention of Postoperative Infection in Clean Surgical Wounds: A Systematic Review and Network Meta-analysis. Advances in skin & wound care. 2024 Apr; 37(4):216-223. doi: 10.1097/asw.0000000000000094. [PMID: 38353666]
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  • Xue Wang, Liming Fu, Shaoning Guo, Xuedong Fang. A meta-analysis examined the effect of topical nursing application of antimicrobial as a prophylaxis for the stoppage of surgical wound infection in colorectal surgery. International wound journal. 2023 Aug; 20(6):2010-2019. doi: 10.1111/iwj.14064. [PMID: 36727574]
  • Michalina Adaszyńska-Skwirzyńska, Sławomir Zych, Mateusz Bucław, Danuta Majewska, Małgorzata Dzięcioł, Danuta Szczerbińska. Evaluation of the Antibacterial Activity of Gentamicin in Combination with Essential Oils Isolated from Different Cultivars and Morphological Parts of Lavender (Lavandula angustifolia Mill.) against Selected Bacterial Strains. Molecules (Basel, Switzerland). 2023 Jul; 28(15):. doi: 10.3390/molecules28155781. [PMID: 37570751]
  • Arefeh Ebadati, Mojgan Oshaghi, Sara Saeedi, Parastoo Parsa, Vahid Pirhajati Mahabadi, Morteza Karimi, Atefeh Jahandideh Hajiebrahimdehi, Michael R Hamblin, Mahdi Karimi. Mechanism and antibacterial synergies of poly(Dabco-BBAC) nanoparticles against multi-drug resistant Pseudomonas aeruginosa isolates from human burns. Bioorganic chemistry. 2023 Jul; 140(?):106718. doi: 10.1016/j.bioorg.2023.106718. [PMID: 37566942]
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  • Yuanwang Liu, Minmin Feng, Anders Johansen, Dengmiao Cheng, Jianming Xue, Yao Feng, Shuanghu Fan, Zhaojun Li. Composting reduces the risks of antibiotic resistance genes in maize seeds posed by gentamicin fermentation waste. The Science of the total environment. 2023 Apr; 870(?):161785. doi: 10.1016/j.scitotenv.2023.161785. [PMID: 36736399]
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  • Fatima Saleem, Naila Safdar, Iram Fatima, Azra Yasmin, Wajid Hussain. Functionalization of ampicillin and gentamicin with biogenic copper nanoparticles (CuNPs) remodel antimicrobial and cytotoxic outcome against MDR clinical isolates. Archives of microbiology. 2023 Feb; 205(3):88. doi: 10.1007/s00203-023-03425-y. [PMID: 36781492]
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  • Zhang Ruijuan, Xiao Li, Wang Yingjie, Wang Rui, Lu Chunqing. Effects of Catheter Tracking Management on Urinary Tract Function and Infection Rates in Patients With Spinal Cord Injury. Alternative therapies in health and medicine. 2023 Jan; ?(?):. doi: . [PMID: 36634314]
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  • Lin Yue, Ya-Ru Yang, Wen-Xian Ma, Hong-Yan Wang, Qian-Wen Fan, Yue-Yue Wang, Chao Li, Jing Wang, Zi-Mu Hu, Xue-Fu Wang, Feng-He Li, Ming-Ming Liu, Juan Jin, Chao Shi, Jia-Gen Wen. Epigallocatechin Gallate Attenuates Gentamicin-Induced Nephrotoxicity by Suppressing Apoptosis and Ferroptosis. Molecules (Basel, Switzerland). 2022 Dec; 27(23):. doi: 10.3390/molecules27238564. [PMID: 36500657]
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