Ginkgolide J (BioDeep_00000006546)

 

Secondary id: BioDeep_00000230179, BioDeep_00000230815

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


(1R,4aR,5R,7aS,9S,10R,11S)-11-tert-butyl-1,4b,10-trihydroxy-5-methyltetrahydro-4bH,9H-9,4a-(epoxymethano)cyclopenta(c)furo(2,3-b)furo(3,2:3,4)cyclopenta(1,2-d)furan-2,6,13(1H,5H)-trione

化学式: C20H24O10 (424.1369)
中文名称: 银杏内酯J, 银杏内酯 J
谱图信息: 最多检出来源 Mus musculus(plant) 10.89%

分子结构信息

SMILES: CC1C(=O)OC2C1(C34C(=O)OC5C3(C2)C6(C(C5O)C(C)(C)C)C(C(=O)OC6O4)O)O
InChI: InChI=1S/C20H24O10/c1-6-12(23)27-7-5-17-11-8(21)9(16(2,3)4)18(17)10(22)13(24)29-15(18)30-20(17,14(25)28-11)19(6,7)26/h6-11,15,21-22,26H,5H2,1-4H3

描述信息

Isolated from Ginkgo biloba (ginkgo). Ginkgolide J is found in ginkgo nuts and fats and oils.
Ginkgolide J is found in fats and oils. Ginkgolide J is isolated from Ginkgo biloba (ginkgo
Ginkgolide J is a main constituent of the non-flavone fraction of Ginkgo biloba with an IC50 range of 12-54 μM, has neuroprotective and anti neuronal apoptotic ability[1][2].
Ginkgolide J is a main constituent of the non-flavone fraction of Ginkgo biloba with an IC50 range of 12-54 μM, has neuroprotective and anti neuronal apoptotic ability[1][2].

同义名列表

7 个代谢物同义名

(1R,4aR,5R,7aS,9S,10R,11S)-11-tert-butyl-1,4b,10-trihydroxy-5-methyltetrahydro-4bH,9H-9,4a-(epoxymethano)cyclopenta(c)furo(2,3-b)furo(3,2:3,4)cyclopenta(1,2-d)furan-2,6,13(1H,5H)-trione; 8-tert-butyl-6,9,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0¹,¹¹.0³,⁷.0⁷,¹¹.0¹³,¹⁷]nonadecane-5,15,18-trione; 8-Tert-butyl-6,9,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadecane-5,15,18-trione; ginkgolide J dihydrate; Ginkgolide J; CID 441296; Ginkgolide J



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ABCB1, AIMP2, CA1, CYP2A6, CYP2B6, CYP2C9, CYP3A4, IL18, NLRP3, NR1I3, NR3C1, PTGS2, RXRA
Peripheral membrane protein 2 CYP2B6, PTGS2
Endosome membrane 1 GPR135
Endoplasmic reticulum membrane 5 CYP2A6, CYP2B6, CYP2C9, CYP3A4, PTGS2
Nucleus 6 AIMP2, NLRP3, NR1I2, NR1I3, NR3C1, RXRA
cytosol 8 AIMP2, CA1, IL18, NLRP3, NR1I3, NR3C1, RXRA, TAT
nuclear body 1 NR1I2
centrosome 1 NR3C1
nucleoplasm 4 NR1I2, NR1I3, NR3C1, RXRA
RNA polymerase II transcription regulator complex 1 RXRA
Cell membrane 3 ABCB1, GLRA2, GPR135
Multi-pass membrane protein 3 ABCB1, GLRA2, GPR135
Golgi apparatus membrane 1 NLRP3
Synapse 2 GLRA2, NR3C1
cell surface 1 ABCB1
Golgi membrane 1 NLRP3
Cytoplasm, cytosol 3 AIMP2, IL18, NLRP3
endosome 1 GPR135
plasma membrane 5 ABCB1, CYP2C9, GLRA2, GPR135, IFNLR1
Membrane 8 ABCB1, AIMP2, CYP2A6, CYP3A4, GLRA2, IFNLR1, NLRP3, NR3C1
apical plasma membrane 1 ABCB1
caveola 1 PTGS2
extracellular exosome 2 ABCB1, CA1
endoplasmic reticulum 2 NLRP3, PTGS2
extracellular space 1 IL18
mitochondrion 3 NLRP3, NR3C1, RXRA
protein-containing complex 2 NR3C1, PTGS2
intracellular membrane-bounded organelle 5 CYP2A6, CYP2B6, CYP2C9, CYP3A4, GLRA2
Microsome membrane 4 CYP2B6, CYP2C9, CYP3A4, PTGS2
Single-pass type I membrane protein 1 IFNLR1
Secreted 2 IL18, NLRP3
extracellular region 2 IL18, NLRP3
mitochondrial matrix 1 NR3C1
transcription regulator complex 2 NR1I2, RXRA
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 NR3C1
Apical cell membrane 1 ABCB1
Cytoplasm, cytoskeleton 1 NR1I3
Cytoplasm, cytoskeleton, spindle 1 NR3C1
spindle 1 NR3C1
GABA-ergic synapse 1 GLRA2
nuclear speck 1 NR3C1
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Postsynaptic cell membrane 1 GLRA2
receptor complex 1 RXRA
neuron projection 2 GLRA2, PTGS2
chromatin 4 NR1I2, NR1I3, NR3C1, RXRA
cell projection 1 GLRA2
Chromosome 1 NR3C1
cytoskeleton 1 NR1I3
transmembrane transporter complex 1 GLRA2
Endomembrane system 1 NLRP3
chloride channel complex 1 GLRA2
microtubule organizing center 1 NLRP3
Nucleus, nucleoplasm 1 NR3C1
intermediate filament cytoskeleton 1 NR1I2
endoplasmic reticulum lumen 1 PTGS2
cytoplasmic microtubule 1 CYP2A6
external side of apical plasma membrane 1 ABCB1
postsynaptic specialization membrane 1 GLRA2
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
[Isoform Alpha]: Cytoplasm 1 NR3C1
[Isoform Beta]: Nucleus 1 NR3C1
[Isoform Alpha-B]: Nucleus 1 NR3C1
glycinergic synapse 1 GLRA2
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Stanislav Jaracz, Shahid Malik, Koji Nakanishi. Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts. Phytochemistry. 2004 Nov; 65(21):2897-902. doi: 10.1016/j.phytochem.2004.08.026. [PMID: 15501258]
  • Chen Ding, Erqin Chen, Weijia Zhou, Robert C Lindsay. A method for extraction and quantification of Ginkgo terpene trilactones. Analytical chemistry. 2004 Aug; 76(15):4332-6. doi: 10.1021/ac049809a. [PMID: 15283569]
  • M G Ferreira, P Braquet, M C Fonteles. Effects of PAF antagonists on renal vascular escape and tachyphylaxis in perfused rabbit kidney. Lipids. 1991 Dec; 26(12):1329-32. doi: 10.1007/bf02536559. [PMID: 1819726]
  • J H Holmes, I Kanfer, H Zwarenstein. Effect of benzodiazepine derivatives on human blood cholinesterase in vitro. Research communications in chemical pathology and pharmacology. 1978 Aug; 21(2):367-70. doi: . [PMID: 29327]
  • H J Hilderson, M J De Wolf, A R Lagrou, W S Dierick. Subcellular structure of bovine thyroid gland. A study on bovine thyroid membranes by buoyant-density-gradient centrifugation in a B-XIV zonal rotor. The Biochemical journal. 1975 Dec; 152(3):601-7. doi: 10.1042/bj1520601. [PMID: 5997]