Cidofovir (BioDeep_00000006378)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
({[(2S)-1-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid
化学式: C8H14N3O6P (279.062)
中文名称: 西多福韦
谱图信息:
最多检出来源 Mus musculus(blood) 11.75%
分子结构信息
SMILES: C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)O
InChI: InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)
描述信息
Cidofovir is only found in individuals that have used or taken this drug. It is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA synthesis. [Wikipedia]Cidofovir acts through the selective inhibition of viral DNA polymerase.Biochemical data support selective inhibition of CMV DNA polymerase by cidofovir diphosphate, the active intracellular metabolite of cidofovir. Cidofovir diphosphate inhibits herpesvirus polymerases at concentrations that are 8- to 600-fold lower than those needed to inhibit human cellular DNA polymerase alpha, beta, and gamma(1,2,3). Incorporation of cidofovir into the growing viral DNA chain results in reductions in the rate of viral DNA synthesis.
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AB - Nucleosides and nucleotides excl. reverse transcriptase inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C471 - Enzyme Inhibitor > C29575 - DNA Polymerase Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent
D004791 - Enzyme Inhibitors
同义名列表
25 个代谢物同义名
({[(2S)-1-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid; (S)-(3-(4-Amino-2-oxopyrimidin-1(2H)-yl)-1-hydroxypropan-2-yloxy)methylphosphonic acid; [(S)-2-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-1-hydroxymethyl-ethoxymethyl]-phosphonic acid; (S)-(3-(4-Amino-2-oxopyrimidin-1(2H)-yl)-1-hydroxypropan-2-yloxy)methylphosphonate; [(S)-2-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-1-hydroxymethyl-ethoxymethyl]-phosphonate; [1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid; 1-(3-Hydroxy-2-phosphonomethoxypropyl)-4-aminopyrimidin-2(1H)-one; (S)-1-[3-Hydroxy-2-(phosphonylmethoxy)propyl]cytosine; 1-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine; (S)-1-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine; 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine; (S)-1-(3-Hydroxy-2-phosphonomethoxypropyl)cytosine; 1-((3-Hydroxy-2-phosphonylmethoxy)propyl)cytosine; 1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine; Cidofovir, sodium salt; Cidofovir, (+-)-isomer; Cidofovir, (R)-isomer; Cidofovir anhydrous; Cidofovir sodium; (S)-HPMPC; Cidofovir; Vistide; HPMPC; CDV; Cidofovir
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:3696
- KEGG: C06909
- PubChem: 466146
- PubChem: 60613
- HMDB: HMDB0014513
- Metlin: METLIN66562
- DrugBank: DB00369
- ChEMBL: CHEMBL27710
- ChEMBL: CHEMBL152
- Wikipedia: Cidofovir
- MeSH: Cidofovir
- chemspider: 54636
- CAS: 128347-13-7
- CAS: 113852-37-2
- PMhub: MS000019406
- PubChem: 9126
- NIKKAJI: J407.193J
- RefMet: Cidofovir
- KNApSAcK: 3696
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Simone Cesaro. Adenovirus infection in allogeneic hematopoietic cell transplantation.
Transplant infectious disease : an official journal of the Transplantation Society.
2023 Oct; ?(?):e14173. doi:
10.1111/tid.14173. [PMID: 37846850] - Baogang Wang, Binwang Cao, Zhu-Chun Bei, Likun Xu, Dongna Zhang, Liangliang Zhao, Yabin Song, Hongquan Wang. Disulfide-incorporated lipid prodrugs of cidofovir: Synthesis, antiviral activity, and release mechanism.
European journal of medicinal chemistry.
2023 Jun; 258(?):115601. doi:
10.1016/j.ejmech.2023.115601. [PMID: 37390509] - Liyan Niu, Dingfa Liang, Qin Ling, Jing Zhang, Ziwen Li, Deju Zhang, Panpan Xia, Zicheng Zhu, Jitao Lin, Ao Shi, Jianyong Ma, Peng Yu, Xiao Liu. Insights into monkeypox pathophysiology, global prevalence, clinical manifestation and treatments.
Frontiers in immunology.
2023; 14(?):1132250. doi:
10.3389/fimmu.2023.1132250. [PMID: 37026012] - Yuan-Pin Hung, Ching-Chi Lee, Jen-Chieh Lee, Chun-Wei Chiu, Po-Ren Hsueh, Wen-Chien Ko. A brief on new waves of monkeypox and vaccines and antiviral drugs for monkeypox.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.
2022 Oct; 55(5):795-802. doi:
10.1016/j.jmii.2022.08.016. [PMID: 36115792] - Bryan B Guzman, Amanda P Schauer, John A Dunn, Mackenzie L Cottrell, Craig Sykes. A quantitative LC-MS/MS method for the determination of tissue brincidofovir and cidofovir diphosphate in a MuPyV-infected mouse model.
Biomedical chromatography : BMC.
2021 May; 35(5):e5061. doi:
10.1002/bmc.5061. [PMID: 33398885] - Anna Sonstegard, Marc Grossman, Amit Garg. Trichodysplasia Spinulosa in a Kidney Transplant Recipient.
JAMA dermatology.
2021 01; 157(1):105. doi:
10.1001/jamadermatol.2020.3986. [PMID: 33146676] - Kentaro Nagamatsu, Kuniko Takano, Masanori Sakata, Yuka Yanai, Oju Katayama, Shuhei Honda, Natsumi Yoshida, Rie Kawano, Tomoyuki Imamura, Masao Ogata. [Successful treatment with cidofovir for disseminated adenovirus infection accompanied by hemophagocytic syndrome and meningitis in an allogeneic hematopoietic stem cell transplantation recipient].
[Rinsho ketsueki] The Japanese journal of clinical hematology.
2021; 62(4):251-256. doi:
10.11406/rinketsu.62.251. [PMID: 33967148] - Rachel Bush, Felicia Johns, Zachary Betty, Steven Goldstein, Biljana Horn, Lawrence Shoemaker, Kiran Upadhyay. BK virus encephalitis and end-stage renal disease in a child with hematopoietic stem cell transplantation.
Pediatric transplantation.
2020 09; 24(6):e13739. doi:
10.1111/petr.13739. [PMID: 32412694] - Steffen Jockusch, Chuanjuan Tao, Xiaoxu Li, Thomas K Anderson, Minchen Chien, Shiv Kumar, James J Russo, Robert N Kirchdoerfer, Jingyue Ju. A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19.
Antiviral research.
2020 08; 180(?):104857. doi:
10.1016/j.antiviral.2020.104857. [PMID: 32562705] - Graham M Tooker, Kristen A Stafford, Jennifer Nishioka, Ashraf Z Badros, David J Riedel. Intravesicular Cidofovir in the Treatment of BK Virus-Associated Hemorrhagic Cystitis Following Hematopoietic Stem Cell Transplantation.
The Annals of pharmacotherapy.
2020 06; 54(6):547-553. doi:
10.1177/1060028019897896. [PMID: 31876431] - Thomas Mühlbacher, Robert Beck, Silvio Nadalin, Nils Heyne, Martina Guthoff. Low-dose cidofovir and conversion to mTOR-based immunosuppression in polyomavirus-associated nephropathy.
Transplant infectious disease : an official journal of the Transplantation Society.
2020 Apr; 22(2):e13228. doi:
10.1111/tid.13228. [PMID: 31797495] - Kanwaljeet Maken, David K Bland. Hyperbaric oxygen for refractory hemorrhagic cystitis after stem cell transplantation: case report.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc.
2020 Fir; 47(1):125-129. doi:
10.22462/01.03.2020.13. [PMID: 32176953] - Takuya Shimizu, Tadakazu Kondo, Kana Matsumoto, Masakatsu Hishizawa, Kouhei Yamashita, Akifumi Takaori-Kondo. Neutropenia and renal dysfunction due to intravesical cidofovir for virus-associated hemorrhagic cystitis after kidney and allogenic hematopoietic stem cell transplantations.
Transplant infectious disease : an official journal of the Transplantation Society.
2019 Dec; 21(6):e13185. doi:
10.1111/tid.13185. [PMID: 31571390] - Monika Kopečná, Miloslav Macháček, Anna Nováčková, Georgios Paraskevopoulos, Jaroslav Roh, Kateřina Vávrová. Esters of terpene alcohols as highly potent, reversible, and low toxic skin penetration enhancers.
Scientific reports.
2019 10; 9(1):14617. doi:
10.1038/s41598-019-51226-5. [PMID: 31601936] - Vaishnavi Pochineni, Parmjeet Randhawa, Chethan Puttarajappa. Fever and Gross Hematuria in Kidney Transplant Recipient.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2018 10; 72(4):A15-A18. doi:
10.1053/j.ajkd.2018.06.009. [PMID: 30244696] - Eric A Coomes, Amanda Wolfe Jacques, Fotios V Michelis, Dennis Dong Hwan Kim, Santhosh Thyagu, Auro Viswabandya, Jeffrey H Lipton, Hans A Messner, Uday Deotare. Efficacy of Cidofovir in Treatment of BK Virus-Induced Hemorrhagic Cystitis in Allogeneic Hematopoietic Cell Transplant Recipients.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2018 09; 24(9):1901-1905. doi:
10.1016/j.bbmt.2018.04.009. [PMID: 29679772] - Santiago M C Lopez, Marian G Michaels, Michael Green. Adenovirus infection in pediatric transplant recipients: are effective antiviral agents coming our way?.
Current opinion in organ transplantation.
2018 08; 23(4):395-399. doi:
10.1097/mot.0000000000000542. [PMID: 29846196] - Laila Schneidewind, Thomas Neumann, Christian Andreas Schmidt, William Krüger. Comparison of intravenous or intravesical cidofovir in the treatment of BK polyomavirus-associated hemorrhagic cystitis following adult allogeneic stem cell transplantation-A systematic review.
Transplant infectious disease : an official journal of the Transplantation Society.
2018 Aug; 20(4):e12914. doi:
10.1111/tid.12914. [PMID: 29797613] - Lawrence H Lash, Caroline A Lee, Clynn Wilker, Vishal Shah. Transporter-dependent cytotoxicity of antiviral drugs in primary cultures of human proximal tubular cells.
Toxicology.
2018 07; 404-405(?):10-24. doi:
10.1016/j.tox.2018.05.002. [PMID: 29738843] - Ryan M Serrano, Robert K Darragh, John J Parent. Successful treatment of disseminated adenovirus infection with cidofovir and intravenous immunoglobulin in an infant following heart transplant.
Cardiology in the young.
2018 Jun; 28(6):888-889. doi:
10.1017/s1047951118000379. [PMID: 29690948] - Jennifer H Foster, W Susan Cheng, Ngoc-Yen Nguyen, Robert Krance, Caridad Martinez. Intravesicular cidofovir for BK hemorrhagic cystitis in pediatric patients after hematopoietic stem cell transplant.
Pediatric transplantation.
2018 05; 22(3):e13141. doi:
10.1111/petr.13141. [PMID: 29388318] - Min Luo, Elisabetta Groaz, Steven De Jonghe, Robert Snoeck, Graciela Andrei, Piet Herdewijn. Amidate Prodrugs of Cyclic 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine with Potent Anti-Herpesvirus Activity.
ACS medicinal chemistry letters.
2018 Apr; 9(4):381-385. doi:
10.1021/acsmedchemlett.8b00079. [PMID: 29670705] - Michel Bossens, Maud Jost, Catherine Van Pachterbeke, Viviane De Maertelaer, Philippe Simon, Francis Frankenne, Philippe Hubert, Brigitte Evrard, Robert Snoeck. Safety and tolerance of cidofovir as a 2\% gel for local application in high-grade cervical intraepithelial neoplasia: A phase 1 investigation.
International journal of clinical pharmacology and therapeutics.
2018 Mar; 56(3):134-141. doi:
10.5414/cp203126. [PMID: 29319498] - K M Baradhi, R L Aure, J-M El-Amm. High-dose Valganciclovir Treatment for Resistant Cytomegalovirus Colitis due to UL97 and UL54 Mutations.
Transplantation proceedings.
2018 Jan; 50(1):142-144. doi:
10.1016/j.transproceed.2017.11.013. [PMID: 29407298] - Andrew D Santeusanio, Benjamin E Lukens, Judy Eun. Antiviral treatment of BK virus viremia after kidney transplantation.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2017 Dec; 74(24):2037-2045. doi:
10.2146/ajhp160585. [PMID: 29222360] - Surabhi B Vora, Adam W Brothers, Janet A Englund. Renal Toxicity in Pediatric Patients Receiving Cidofovir for the Treatment of Adenovirus Infection.
Journal of the Pediatric Infectious Diseases Society.
2017 Nov; 6(4):399-402. doi:
10.1093/jpids/pix011. [PMID: 28419263] - I A Echenique, D Beltran, L Ramirez-Ruiz, N Najafian, N Agrawal. Ganciclovir Dosing Strategies and Development of Cytomegalovirus Resistance in a Kidney Transplant Recipient: A Case Report.
Transplantation proceedings.
2017 Sep; 49(7):1560-1564. doi:
10.1016/j.transproceed.2017.02.046. [PMID: 28838440] - Min Luo, Elisabetta Groaz, Graciela Andrei, Robert Snoeck, Raj Kalkeri, Roger G Ptak, Tracy Hartman, Robert W Buckheit, Dominique Schols, Steven De Jonghe, Piet Herdewijn. Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
Journal of medicinal chemistry.
2017 07; 60(14):6220-6238. doi:
10.1021/acs.jmedchem.7b00416. [PMID: 28682067] - Hagit Achdout, Shlomo Lustig, Tomer Israely, Noam Erez, Boaz Politi, Hadas Tamir, Ofir Israeli, Trevor Waner, Sharon Melamed, Nir Paran. Induction, treatment and prevention of eczema vaccinatum in atopic dermatitis mouse models.
Vaccine.
2017 07; 35(33):4245-4254. doi:
10.1016/j.vaccine.2017.06.014. [PMID: 28625523] - J Bruminhent, P Rotjanapan, S P Watcharananan. Epidemiology and Outcome of Ganciclovir-Resistant Cytomegalovirus Infection After Solid Organ Transplantation: A Single Transplant Center Experience in Thailand.
Transplantation proceedings.
2017 06; 49(5):1048-1052. doi:
10.1016/j.transproceed.2017.03.053. [PMID: 28583524] - Monika Kopečná, Miloslav Macháček, Eva Prchalová, Petr Štěpánek, Pavel Drašar, Martin Kotora, Kateřina Vávrová. Dodecyl Amino Glucoside Enhances Transdermal and Topical Drug Delivery via Reversible Interaction with Skin Barrier Lipids.
Pharmaceutical research.
2017 03; 34(3):640-653. doi:
10.1007/s11095-016-2093-z. [PMID: 28070753] - Hugo Bonatti, Costi D Sifri, Clara Larcher, Stefan Schneeberger, Camille Kotton, Christian Geltner. Use of Cidofovir for Cytomegalovirus Disease Refractory to Ganciclovir in Solid Organ Recipients.
Surgical infections.
2017 Feb; 18(2):128-136. doi:
10.1089/sur.2015.266. [PMID: 27849440] - Shigeyuki Murono, Yosuke Nakanishi, Akira Tsuji, Kazuhira Endo, Satoru Kondo, Naohiro Wakisaka, Tomokazu Yoshizaki. Intralesional cidofovir injection for recurrent respiratory papillomatosis in Japan.
Auris, nasus, larynx.
2016 Oct; 43(5):541-5. doi:
10.1016/j.anl.2016.01.005. [PMID: 26860235] - Michael G Ison, Randall T Hayden. Adenovirus.
Microbiology spectrum.
2016 08; 4(4):. doi:
10.1128/microbiolspec.dmih2-0020-2015. [PMID: 27726766] - M Mohamed, S Parajuli, B Muth, B C Astor, S E Panzer, D Mandelbrot, W Zhong, A Djamali. In kidney transplant recipients with BK polyomavirus infection, early BK nephropathy, microvascular inflammation, and serum creatinine are risk factors for graft loss.
Transplant infectious disease : an official journal of the Transplantation Society.
2016 Jun; 18(3):361-71. doi:
10.1111/tid.12530. [PMID: 26998753] - Ila M Saunders, Amit Lahoti, Roy F Chemaly, Cynthia Trevino, Michael Westmoreland, Chitra Hosing. Topical cidofovir-induced acute kidney injury in two severely immunocompromised patients with refractory multidrug-resistant herpes simplex virus infections.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2016 Apr; 22(2):325-31. doi:
10.1177/1078155214560921. [PMID: 25488905] - Samuel L Aitken, Jian Zhou, Shashank S Ghantoji, Dimitrios P Kontoyiannis, Roy B Jones, Vincent H Tam, Roy F Chemaly. Pharmacokinetics and safety of intravesicular cidofovir in allogeneic HSCT recipients.
The Journal of antimicrobial chemotherapy.
2016 Mar; 71(3):727-30. doi:
10.1093/jac/dkv393. [PMID: 26612873] - Tom T G Nieskens, Janny G P Peters, Marieke J Schreurs, Niels Smits, Rob Woestenenk, Katja Jansen, Thom K van der Made, Melanie Röring, Constanze Hilgendorf, Martijn J Wilmer, Rosalinde Masereeuw. A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity.
The AAPS journal.
2016 Mar; 18(2):465-75. doi:
10.1208/s12248-016-9871-8. [PMID: 26821801] - Laura K McMullan, Mike Flint, Julie Dyall, César Albariño, Gene G Olinger, Scott Foster, Phiroze Sethna, Lisa E Hensley, Stuart T Nichol, E Randall Lanier, Christina F Spiropoulou. The lipid moiety of brincidofovir is required for in vitro antiviral activity against Ebola virus.
Antiviral research.
2016 Jan; 125(?):71-8. doi:
10.1016/j.antiviral.2015.10.010. [PMID: 26526586] - Eric C Ledbetter, Chloe B Spertus, Matthew R Pennington, Gerlinde R Van de Walle, Bonnie E Judd, Hussni O Mohammed. In Vitro and In Vivo Evaluation of Cidofovir as a Topical Ophthalmic Antiviral for Ocular Canine Herpesvirus-1 Infections in Dogs.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2015 Dec; 31(10):642-9. doi:
10.1089/jop.2015.0024. [PMID: 26418618] - Amy E Caruso Brown, Mindy N Cohen, Suhong Tong, Rebecca S Braverman, James F Rooney, Roger Giller, Myron J Levin. Pharmacokinetics and safety of intravenous cidofovir for life-threatening viral infections in pediatric hematopoietic stem cell transplant recipients.
Antimicrobial agents and chemotherapy.
2015 Jul; 59(7):3718-25. doi:
10.1128/aac.04348-14. [PMID: 25733509] - Shigeyuki Murono, Yosuke Nakanishi, Akira Tsuji, Kazuhira Endo, Satoru Kondo, Naohiro Wakisaka, Hiroshi Yoshida, Tomokazu Yoshizaki. Trends in the management of recurrent respiratory papillomatosis in Japan.
Auris, nasus, larynx.
2015 Jun; 42(3):218-20. doi:
10.1016/j.anl.2014.10.006. [PMID: 25454156] - Liesl K Jeffers-Francis, Raquel Burger-Calderon, Jennifer Webster-Cyriaque. Effect of Leflunomide, Cidofovir and Ciprofloxacin on replication of BKPyV in a salivary gland in vitro culture system.
Antiviral research.
2015 Jun; 118(?):46-55. doi:
10.1016/j.antiviral.2015.02.002. [PMID: 25790744] - Seung-Shin Lee, Jae-Sook Ahn, Sung-Hoon Jung, Seo-Yeon Ahn, Jae-Yong Kim, Hee-Chang Jang, Seung-Ji Kang, Mi-Ok Jang, Deok-Hwan Yang, Yeo-Kyeoung Kim, Je-Jung Lee, Hyeoung-Joon Kim. Treatment of BK virus-associated hemorrhagic cystitis with low-dose intravenous cidofovir in patients undergoing allogeneic hematopoietic cell transplantation.
The Korean journal of internal medicine.
2015 Mar; 30(2):212-8. doi:
10.3904/kjim.2015.30.2.212. [PMID: 25750563] - Gertjan Lugthart, Marloes A Oomen, Cornelia M Jol-van der Zijde, Lynne M Ball, Dorine Bresters, Wouter J W Kollen, Frans J Smiers, Clementien L Vermont, Robbert G M Bredius, Marco W Schilham, Maarten J D van Tol, Arjan C Lankester. The effect of cidofovir on adenovirus plasma DNA levels in stem cell transplantation recipients without T cell reconstitution.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2015 Feb; 21(2):293-9. doi:
10.1016/j.bbmt.2014.10.012. [PMID: 25464118] - Diana F Florescu, Heather E Chambers, Fang Qiu, Megan A Keck, David F Mercer, Michael C Morris, Marius C Florescu. Cidofovir in pediatric solid organ transplant recipients: University of Nebraska experience.
The Pediatric infectious disease journal.
2015 Jan; 34(1):47-51. doi:
10.1097/inf.0000000000000487. [PMID: 25010830] - William S M Wold, Karoly Toth. New drug on the horizon for treating adenovirus.
Expert opinion on pharmacotherapy.
2015; 16(14):2095-9. doi:
10.1517/14656566.2015.1083975. [PMID: 26330121] - Paul Jennings, Daniel Crean, Lydia Aschauer, Alice Limonciel, Konrad Moenks, Georg Kern, Philip Hewitt, Karl Lhotta, Arno Lukas, Anja Wilmes, Martin O Leonard. Interleukin-19 as a translational indicator of renal injury.
Archives of toxicology.
2015 Jan; 89(1):101-6. doi:
10.1007/s00204-014-1237-3. [PMID: 24714768] - S A Kuten, S J Patel, R J Knight, L W Gaber, J M DeVos, A O Gaber. Observations on the use of cidofovir for BK virus infection in renal transplantation.
Transplant infectious disease : an official journal of the Transplantation Society.
2014 Dec; 16(6):975-83. doi:
10.1111/tid.12313. [PMID: 25412701] - Ann E Tollefson, Jacqueline F Spencer, Baoling Ying, R Mark L Buller, William S M Wold, Karoly Toth. Cidofovir and brincidofovir reduce the pathology caused by systemic infection with human type 5 adenovirus in immunosuppressed Syrian hamsters, while ribavirin is largely ineffective in this model.
Antiviral research.
2014 Dec; 112(?):38-46. doi:
10.1016/j.antiviral.2014.10.005. [PMID: 25453340] - Frank Van der Aa, Ian Beckley, Dirk de Ridder. Polyomavirus BK--a potential new therapeutic target for painful bladder syndrome/interstitial cystitis?.
Medical hypotheses.
2014 Sep; 83(3):317-20. doi:
10.1016/j.mehy.2014.06.004. [PMID: 24973060] - Victoria A Olson, Scott K Smith, Scott Foster, Yu Li, E Randall Lanier, Irina Gates, Lawrence C Trost, Inger K Damon. In vitro efficacy of brincidofovir against variola virus.
Antimicrobial agents and chemotherapy.
2014 Sep; 58(9):5570-1. doi:
10.1128/aac.02814-14. [PMID: 24957837] - A M Lachiewicz, R Cianciolo, M B Miller, V K Derebail. Adenovirus causing fever, upper respiratory infection, and allograft nephritis complicated by persistent asymptomatic viremia.
Transplant infectious disease : an official journal of the Transplantation Society.
2014 Aug; 16(4):648-52. doi:
10.1111/tid.12248. [PMID: 24966111] - Sunwen Chou, Ronald J Ercolani, Malaya K Sahoo, Martina I Lefterova, Lynne M Strasfeld, Benjamin A Pinsky. Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing.
Antimicrobial agents and chemotherapy.
2014 Aug; 58(8):4697-702. doi:
10.1128/aac.03214-14. [PMID: 24890586] - Leslie Ingraham, Mansong Li, J Larry Renfro, Sonda Parker, Arpine Vapurcuyan, Imad Hanna, Ryan M Pelis. A plasma concentration of α-ketoglutarate influences the kinetic interaction of ligands with organic anion transporter 1.
Molecular pharmacology.
2014 Jul; 86(1):86-95. doi:
10.1124/mol.114.091777. [PMID: 24770989] - Matthias G Vossen, Klaus-Bernhard Gattringer, Walter Jäger, Stefanie Kraff, Florian Thalhammer. Single-dose pharmacokinetics of cidofovir in continuous venovenous hemofiltration.
Antimicrobial agents and chemotherapy.
2014; 58(4):1952-5. doi:
10.1128/aac.01343-13. [PMID: 24419341] - H J Kwon, J H Kang, J W Lee, N-G Chung, H-K Kim, B Cho. Treatment of BK virus-associated hemorrhagic cystitis in pediatric hematopoietic stem cell transplant recipients with cidofovir: a single-center experience.
Transplant infectious disease : an official journal of the Transplantation Society.
2013 Dec; 15(6):569-74. doi:
10.1111/tid.12136. [PMID: 24028353] - Natacha Coen, Sophie Duraffour, Lieve Naesens, Marcela Krecmerová, Joost Van den Oord, Robert Snoeck, Graciela Andrei. Evaluation of novel acyclic nucleoside phosphonates against human and animal gammaherpesviruses revealed an altered metabolism of cyclic prodrugs upon Epstein-Barr virus reactivation in P3HR-1 cells.
Journal of virology.
2013 Nov; 87(22):12422-32. doi:
10.1128/jvi.02231-13. [PMID: 24027315] - Jana Mandíková, Marie Volková, Petr Pávek, Michal Česnek, Zlatko Janeba, Vladimír Kubíček, František Trejtnar. Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates.
Toxicology.
2013 Sep; 311(3):135-46. doi:
10.1016/j.tox.2013.07.004. [PMID: 23856525] - Scott H James, Nathan B Price, Caroll B Hartline, E Randall Lanier, Mark N Prichard. Selection and recombinant phenotyping of a novel CMX001 and cidofovir resistance mutation in human cytomegalovirus.
Antimicrobial agents and chemotherapy.
2013 Jul; 57(7):3321-5. doi:
10.1128/aac.00062-13. [PMID: 23650158] - Derya Mutlu, Imran Sağlık, Mustafa Koyun, Elif Comak, Esvet Mutlu, Arife Uslu Gökçeoğlu, Serpil Cağla Doğan, Ayhan Dinçkan, Sakine Halide Akbaş, Bahar Akkaya, Sema Akman, Gültekin Süleymanlar, Dilek Colak. [BK virus infections in pediatric kidney transplant recipients].
Mikrobiyoloji bulteni.
2013 Jul; 47(3):461-71. doi:
10.5578/mb.4957. [PMID: 23971923] - Richard J Knight, Lillian W Gaber, Samir J Patel, Jennifer M DeVos, Linda W Moore, A Osama Gaber. Screening for BK viremia reduces but does not eliminate the risk of BK nephropathy: a single-center retrospective analysis.
Transplantation.
2013 Apr; 95(7):949-54. doi:
10.1097/tp.0b013e31828423cd. [PMID: 23545506] - Craig S Derkay, Peter G Volsky, Clark A Rosen, Seth M Pransky, J Scott McMurray, Neil K Chadha, Patrick Froehlich. Current use of intralesional cidofovir for recurrent respiratory papillomatosis.
The Laryngoscope.
2013 Mar; 123(3):705-12. doi:
10.1002/lary.23673. [PMID: 23070868] - Ivan S Krylov, Boris A Kashemirov, John M Hilfinger, Charles E McKenna. Evolution of an amino acid based prodrug approach: stay tuned.
Molecular pharmaceutics.
2013 Feb; 10(2):445-58. doi:
10.1021/mp300663j. [PMID: 23339402] - J D Momper, Y Zhao, R Shapiro, K S Schonder, Y Gao, P S Randhawa, R Venkataramanan. Pharmacokinetics of low-dose cidofovir in kidney transplant recipients with BK virus infection.
Transplant infectious disease : an official journal of the Transplantation Society.
2013 Feb; 15(1):34-41. doi:
10.1111/tid.12014. [PMID: 23025519] - Minna Koskenvuo, Alexis Dumoulin, Irmeli Lautenschlager, Eeva Auvinen, Laura Mannonen, Veli-Jukka Anttila, Kirsi Jahnukainen, Ulla M Saarinen-Pihkala, Hans H Hirsch. BK polyomavirus-associated hemorrhagic cystitis among pediatric allogeneic bone marrow transplant recipients: treatment response and evidence for nosocomial transmission.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.
2013 Jan; 56(1):77-81. doi:
10.1016/j.jcv.2012.09.003. [PMID: 22999487] - Ugo Pradère, Vincent Roy, Aurélien Montagu, Ozkan Sari, Manabu Hamada, Jan Balzarini, Robert Snoeck, Graciela Andrei, Luigi A Agrofoglio. Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4'-phosphono-but-2'-en-1'-yl]purine nucleosides.
European journal of medicinal chemistry.
2012 Nov; 57(?):126-33. doi:
10.1016/j.ejmech.2012.08.042. [PMID: 23047229] - Tanya Pereira, Claudia P Rojas, Monica T Garcia-Buitrago, Jayanthi Chandar, Carolyn Abitbol, Wacharee Seeherunvong, Paolo Rusconi, Jocelyn H Bruce, Gaston Zilleruelò. A child with BK virus infection: inadequacy of current therapeutic strategies.
Pediatric transplantation.
2012 Nov; 16(7):E269-74. doi:
10.1111/j.1399-3046.2011.01602.x. [PMID: 22129324] - Marie-Michèle Blouin, Richard Cloutier, Réal Noël. Intralesional cidofovir in the treatment of cutaneous warts in a renal transplant patient.
Journal of cutaneous medicine and surgery.
2012 Nov; 16(6):462-4. doi:
10.1177/120347541201600622. [PMID: 23149209] - Mitan R Gokulgandhi, Megha Barot, Mahuya Bagui, Dhananjay Pal, Ashim K Mitra. Transporter-targeted lipid prodrugs of cyclic cidofovir: a potential approach for the treatment of cytomegalovirus retinitis.
Journal of pharmaceutical sciences.
2012 Sep; 101(9):3249-63. doi:
10.1002/jps.23140. [PMID: 22499243] - Kyoko Taniguchi, Satoshi Yoshihara, Hiroya Tamaki, Tsuguto Fujimoto, Kazuhiro Ikegame, Katsuji Kaida, Jun Nakata, Takayuki Inoue, Ruri Kato, Tatsuya Fujioka, Masaya Okada, Toshihiro Soma, Hiroyasu Ogawa. Incidence and treatment strategy for disseminated adenovirus disease after haploidentical stem cell transplantation.
Annals of hematology.
2012 Aug; 91(8):1305-12. doi:
10.1007/s00277-012-1440-3. [PMID: 22476883] - T Nishikawa, K Nakashima, R Fukano, J Okamura, J Inagaki. Successful treatment with plasma exchange for disseminated cidofovir-resistant adenovirus disease in a pediatric SCT recipient.
Bone marrow transplantation.
2012 Aug; 47(8):1138-9. doi:
10.1038/bmt.2011.227. [PMID: 22080967] - Zina Korvasová, Lukáš Drašar, Josef Mašek, Pavlína Turánek Knotigová, Pavel Kulich, Ján Matiašovic, Kamil Kovařčík, Eliška Bartheldyová, Štěpán Koudelka, Michaela Škrabalová, Andrew D Miller, Antonín Holý, Miroslav Ledvina, Jaroslav Turánek. Antiviral effect of HPMPC (Cidofovir®), entrapped in cationic liposomes: in vitro study on MDBK cell and BHV-1 virus.
Journal of controlled release : official journal of the Controlled Release Society.
2012 Jun; 160(2):330-8. doi:
10.1016/j.jconrel.2012.01.040. [PMID: 22326403] - Mira Keddis, Nelson Leung, Sandra Herrmann, Ziad El-Zoghby, Sanjeev Sethi. Adenovirus-induced interstitial nephritis following umbilical cord blood transplant for chronic lymphocytic leukemia.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2012 Jun; 59(6):886-90. doi:
10.1053/j.ajkd.2011.10.056. [PMID: 22405484] - Bayindir Cimsit, Eric M Tichy, Sonya B Patel, Richard Rosencrantz, Sukru Emre. Treatment of adenovirus hepatitis with cidofovir in a pediatric liver transplant recipient.
Pediatric transplantation.
2012 May; 16(3):E90-3. doi:
10.1111/j.1399-3046.2010.01443.x. [PMID: 21226811] - Irmeli Lautenschlager, Raymund R Razonable. Human herpesvirus-6 infections in kidney, liver, lung, and heart transplantation: review.
Transplant international : official journal of the European Society for Organ Transplantation.
2012 May; 25(5):493-502. doi:
10.1111/j.1432-2277.2012.01443.x. [PMID: 22356254] - Diana F Florescu, Steven A Pergam, Michael N Neely, Fang Qiu, Christine Johnston, SingSing Way, Jane Sande, Deborah A Lewinsohn, Judith A Guzman-Cottrill, Michael L Graham, Genovefa Papanicolaou, Joanne Kurtzberg, Joseph Rigdon, Wendy Painter, Herve Mommeja-Marin, Randall Lanier, Maggie Anderson, Charles van der Horst. Safety and efficacy of CMX001 as salvage therapy for severe adenovirus infections in immunocompromised patients.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2012 May; 18(5):731-8. doi:
10.1016/j.bbmt.2011.09.007. [PMID: 21963623] - Hart B Moss, Sai Chavala, Emil Say, Melissa B Miller. Ganciclovir-resistant cytomegalovirus (CMV) retinitis in a patient with wild-type CMV in her plasma.
Journal of clinical microbiology.
2012 May; 50(5):1796-9. doi:
10.1128/jcm.00029-12. [PMID: 22337988] - Wendy Painter, Alice Robertson, Lawrence C Trost, Susan Godkin, Bernhard Lampert, George Painter. First pharmacokinetic and safety study in humans of the novel lipid antiviral conjugate CMX001, a broad-spectrum oral drug active against double-stranded DNA viruses.
Antimicrobial agents and chemotherapy.
2012 May; 56(5):2726-34. doi:
10.1128/aac.05983-11. [PMID: 22391537] - Dirk R J Kuypers. Management of polyomavirus-associated nephropathy in renal transplant recipients.
Nature reviews. Nephrology.
2012 Apr; 8(7):390-402. doi:
10.1038/nrneph.2012.64. [PMID: 22508181] - Petra M Goldsmith, Mir Mubariz Husain, Andrew Carmichael, Hongyi Zhang, Stephen J Middleton. Case report: Multidrug-resistant cytomegalovirus in a modified multivisceral transplant recipient.
Transplantation.
2012 Apr; 93(7):e30-2. doi:
10.1097/tp.0b013e318249b163. [PMID: 22450598] - Scott Parker, Nanhai G Chen, Scott Foster, Hollyce Hartzler, Ed Hembrador, Dennis Hruby, Robert Jordan, Randall Lanier, George Painter, Wesley Painter, John E Sagartz, Jill Schriewer, R Mark Buller. Evaluation of disease and viral biomarkers as triggers for therapeutic intervention in respiratory mousepox - an animal model of smallpox.
Antiviral research.
2012 Apr; 94(1):44-53. doi:
10.1016/j.antiviral.2012.02.005. [PMID: 22381921] - Raveen Parboosing, Glenn E M Maguire, Patrick Govender, Hendrik G Kruger. Nanotechnology and the treatment of HIV infection.
Viruses.
2012 04; 4(4):488-520. doi:
10.3390/v4040488. [PMID: 22590683] - Erin J Plosa, Jennifer C Esbenshade, M Paige Fuller, Jörn-Hendrik Weitkamp. Cytomegalovirus infection.
Pediatrics in review.
2012 Apr; 33(4):156-63; quiz 163. doi:
10.1542/pir.33-4-156. [PMID: 22474112] - Melissa C Mackey. Intravesicular cidofovir for the treatment of polyomavirus-associated hemorrhagic cystitis.
The Annals of pharmacotherapy.
2012 Mar; 46(3):442-6. doi:
10.1345/aph.1q430. [PMID: 22395246] - Danny K Hua, Kirsten Howard, Jonathan C Craig, Jeremy R Chapman, Germaine Wong. Cost-effectiveness of cidofovir treatment of polyomavirus nephropathy in kidney transplant recipients.
Transplantation.
2012 Jan; 93(2):188-94. doi:
10.1097/tp.0b013e31823e7b0e. [PMID: 22186937] - F Lecomte, C Hubert, S Demarche, C De Bleye, A Dispas, M Jost, F Frankenne, A Ceccato, E Rozet, Ph Hubert. Comparison of the quantitative performances and measurement uncertainty estimates obtained during method validation versus routine applications of a novel hydrophilic interaction chromatography method for the determination of cidofovir in human plasma.
Journal of pharmaceutical and biomedical analysis.
2012 Jan; 57(?):153-65. doi:
10.1016/j.jpba.2011.08.040. [PMID: 21959349] - William Arndt, Chandra Mitnik, Karen L Denzler, Stacy White, Robert Waters, Bertram L Jacobs, Yvan Rochon, Victoria A Olson, Inger K Damon, Jeffrey O Langland. In vitro characterization of a nineteenth-century therapy for smallpox.
PloS one.
2012; 7(3):e32610. doi:
10.1371/journal.pone.0032610. [PMID: 22427855] - Mary K McCarthy, Jason B Weinberg. Eicosanoids and respiratory viral infection: coordinators of inflammation and potential therapeutic targets.
Mediators of inflammation.
2012; 2012(?):236345. doi:
10.1155/2012/236345. [PMID: 22665949] - Scott W Cousins, Diego G Espinosa-Heidmann, Daniel M Miller, Simone Pereira-Simon, Eleut P Hernandez, Hsin Chien, Courtney Meier-Jewett, Richard D Dix. Macrophage activation associated with chronic murine cytomegalovirus infection results in more severe experimental choroidal neovascularization.
PLoS pathogens.
2012; 8(4):e1002671. doi:
10.1371/journal.ppat.1002671. [PMID: 22570607] - M Huber, R Stahlmann. [Adverse ocular drug reactions of systemic antimicrobial agents].
Deutsche medizinische Wochenschrift (1946).
2012 Jan; 137(3):85-9. doi:
10.1055/s-0031-1298808. [PMID: 22241448] - Jovana Cukuranovic, Sladjana Ugrenovic, Ivan Jovanovic, Milan Visnjic, Vladisav Stefanovic. Viral infection in renal transplant recipients.
TheScientificWorldJournal.
2012; 2012(?):820621. doi:
10.1100/2012/820621. [PMID: 22654630] - A I Sánchez Fructuoso, N Calvo, I Perez-Flores, R Valero, B Rodríguez-Sánchez, D García de Viedma, P Muñoz, A Barrientos. Mammalian target of rapamycin signal inhibitors could play a role in the treatment of BK polyomavirus nephritis in renal allograft recipients.
Transplant infectious disease : an official journal of the Transplantation Society.
2011 Dec; 13(6):584-91. doi:
10.1111/j.1399-3062.2011.00649.x. [PMID: 21585634] - M Angeles Marcos. [Resistance studies: when are they indicated?].
Enfermedades infecciosas y microbiologia clinica.
2011 Dec; 29 Suppl 6(?):24-7. doi:
10.1016/s0213-005x(11)70053-2. [PMID: 22541918] - Angela Capobianchi, Anna Paola Iori, Francesca Romana Mauro, Giovanni Fernando Torelli, Alessandra Micozzi, Corrado Girmenia, Robin Foà, Giuseppe Gentile. Longitudinal analysis of human herpesvirus-8 DNA and antibodies in an Italian allogeneic stem cell transplant recipient.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.
2011 Nov; 52(3):247-50. doi:
10.1016/j.jcv.2011.07.003. [PMID: 21839673] - Vikas R Dharnidharka, Husam A Abdulnour, Carlos E Araya. The BK virus in renal transplant recipients-review of pathogenesis, diagnosis, and treatment.
Pediatric nephrology (Berlin, Germany).
2011 Oct; 26(10):1763-74. doi:
10.1007/s00467-010-1716-6. [PMID: 21161285] - Duvuru Geetha, Shyam Parkhie, Girish N Nadkarni, Chun He, Tariq Shafi. Polyomavirus-associated nephropathy: a comparison of 2 different strategies for immunosuppression reduction.
Medicine.
2011 Sep; 90(5):296-302. doi:
10.1097/md.0b013e31822f238e. [PMID: 21857366] - Valeria M Zakharova, Michaela Serpi, Ivan S Krylov, Larryn W Peterson, Julie M Breitenbach, Katherine Z Borysko, John C Drach, Mindy Collins, John M Hilfinger, Boris A Kashemirov, Charles E McKenna. Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies.
Journal of medicinal chemistry.
2011 Aug; 54(16):5680-93. doi:
10.1021/jm2001426. [PMID: 21812420] - Elisavet Moutzouri, Evangelos N Liberopoulos, Moses Elisaf. Life-threatening hypophosphataemia in a cirrhotic patient with jaundice.
Archives of medical science : AMS.
2011 Aug; 7(4):736-9. doi:
10.5114/aoms.2011.24148. [PMID: 22291814]
