Glutaryl-CoA (BioDeep_00000630366)
Main id: BioDeep_00000004157
代谢物信息卡片
化学式: C26H42N7O19P3S (881.1469)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O)O
InChI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/t14-,19-,20-,21+,25-/m1/s1
描述信息
An omega-carboxyacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with one of the carboxy groups of glutaric acid.
同义名列表
5 个代谢物同义名
Glutaryl-CoA; 3-phosphoadenosine 5-{3-[(3R)-4-{[3-({2-[(4-carboxybutanoyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-3-hydroxy-2,2-dimethyl-4-oxobutyl] dihydrogen diphosphate}; 4-carboxybutanoyl-CoA;4-carboxybutanoyl-coenzyme A;coenzyme A, S-(hydrogen pentanedioate);glutaryl-coenzyme A; CoA 5:1;O2; Glutaryl-CoA
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:15524
- KEGG: C00527
- PubChem: 3081383
- LipidMAPS: LMFA07050324
- CAS: 3131-84-8
- MetaboLights: MTBLC15524
- PubChem: 3810
- PDB-CCD: GRA
- 3DMET: B04695
- NIKKAJI: J1.748.735C
- RefMet: Glutaryl-CoA
- KNApSAcK: 15524
分类词条
相关代谢途径
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaohan Cui, Xiao Yun, Meiling Sun, Renzhi Li, Xiajie Lyu, Yuanxiang Lao, Xihu Qin, Wenbin Yu. HMGCL-induced β-hydroxybutyrate production attenuates hepatocellular carcinoma via DPP4-mediated ferroptosis susceptibility.
Hepatology international.
2022 Dec; ?(?):. doi:
10.1007/s12072-022-10459-9. [PMID: 36508088] - Damián A Madrigal-Aguilar, Adilene Gonzalez-Silva, Blanca Rosales-Acosta, Celia Bautista-Crescencio, Jossué Ortiz-Álvarez, Carlos H Escalante, Jaime Sánchez-Navarrete, César Hernández-Rodríguez, Germán Chamorro-Cevallos, Joaquín Tamariz, Lourdes Villa-Tanaca. Antifungal Activity of Fibrate-Based Compounds and Substituted Pyrroles That Inhibit the Enzyme 3-Hydroxy-methyl-glutaryl-CoA Reductase of Candida glabrata (CgHMGR), Thus Decreasing Yeast Viability and Ergosterol Synthesis.
Microbiology spectrum.
2022 04; 10(2):e0164221. doi:
10.1128/spectrum.01642-21. [PMID: 35377226] - Yuanyuan Hu, John E Cronan. α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism.
Nature communications.
2020 11; 11(1):5598. doi:
10.1038/s41467-020-19251-5. [PMID: 33154364] - Manman Zhang, Chao Gao, Xiaoting Guo, Shiting Guo, Zhaoqi Kang, Dan Xiao, Jinxin Yan, Fei Tao, Wen Zhang, Wenyue Dong, Pan Liu, Chen Yang, Cuiqing Ma, Ping Xu. Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving L-2-hydroxyglutarate.
Nature communications.
2018 05; 9(1):2114. doi:
10.1038/s41467-018-04513-0. [PMID: 29844506] - Chai Siah Ku, Bohkyung Kim, Tho X Pham, Yue Yang, Curtis L Weller, Timothy P Carr, Young-Ki Park, Ji-Young Lee. Hypolipidemic Effect of a Blue-Green Alga (Nostoc commune) Is Attributed to Its Nonlipid Fraction by Decreasing Intestinal Cholesterol Absorption in C57BL/6J Mice.
Journal of medicinal food.
2015 Nov; 18(11):1214-22. doi:
10.1089/jmf.2014.0121. [PMID: 26161942] - Nicole M Wolf, Kristin Mueller, Frank Hirche, Erika Most, Josef Pallauf, Andreas S Mueller. Study of molecular targets influencing homocysteine and cholesterol metabolism in growing rats by manipulation of dietary selenium and methionine concentrations.
The British journal of nutrition.
2010 Aug; 104(4):520-32. doi:
10.1017/s0007114510000899. [PMID: 20350341] - Maria A K Westin, Mary C Hunt, Stefan E H Alexson. The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes.
The Journal of biological chemistry.
2005 Nov; 280(46):38125-32. doi:
10.1074/jbc.m508479200. [PMID: 16141203] - D B Hyman, K Tanaka. Specific glutaryl-CoA dehydrogenating activity is deficient in cultured fibroblasts from glutaric aciduria patients.
The Journal of clinical investigation.
1984 Mar; 73(3):778-84. doi:
10.1172/jci111271. [PMID: 6423663] - N J Brandt, S Brandt, E Christensen, N Gregersen, K Rasmussen. Glutaric aciduria in progressive choreo-athetosis.
Clinical genetics.
1978 Jan; 13(1):77-80. doi:
10.1111/j.1399-0004.1978.tb04131.x. [PMID: 624191]
