Amphotericin B (BioDeep_00000006211)

 

Secondary id: BioDeep_00000398937

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs Antibiotics natural product


代谢物信息卡片


(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid

化学式: C47H73NO17 (923.4878)
中文名称: 两性霉素B
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 67.88%

分子结构信息

SMILES: CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O
InChI: InChI=1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

描述信息

Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
G - Genito urinary system and sex hormones > G01 - Gynecological antiinfectives and antiseptics > G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids > G01AA - Antibiotics
A - Alimentary tract and metabolism > A01 - Stomatological preparations > A01A - Stomatological preparations > A01AB - Antiinfectives and antiseptics for local oral treatment
A - Alimentary tract and metabolism > A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents > A07A - Intestinal antiinfectives > A07AA - Antibiotics
J - Antiinfectives for systemic use > J02 - Antimycotics for systemic use > J02A - Antimycotics for systemic use > J02AA - Antibiotics
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent
Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

同义名列表

19 个代谢物同义名

(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid; (1S,3R,4E,6E,8E,10E,12E,14E,16E,18S,19R,20R,21S,25R,27R,30R,31R,33S,35R,37S,38R)-3-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,30,31,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,12,14,16-heptaene-38-carboxylic acid; Amphotericin b cholesterol dispersion; Amphotericin b colloidal dispersion; Liposomal amphotericin b; Amphotericinum b; Amphortericin b; Amphotericine b; Amphotericin B; Amfotericina b; ABBR amb; Amphotericin; MLS002702966; Fungizone; Amphocil; Amphotec; Ambisome; AMPH-b; Amphotericin B



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

55 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ABCB1, ANXA5, CAT, NOS2, PRNP
Peripheral membrane protein 2 ANXA5, PRTN3
Endoplasmic reticulum membrane 2 CYP51A1, HSP90B1
Nucleus 2 HSP90B1, NOS2
cytosol 9 ANXA5, AVP, CAT, GPT, HSP90B1, LIPE, NOS2, PRNP, PRTN3
dendrite 2 AVP, PRNP
nucleoplasm 2 ATP2B1, NOS2
Cell membrane 7 ABCB1, ATP2B1, CD9, HAVCR1, LIPE, PRNP, PRTN3
Cytoplasmic granule 1 PRTN3
Multi-pass membrane protein 4 ABCB1, ATP2B1, CACNA1I, CD9
Synapse 1 ATP2B1
cell surface 4 ABCB1, EPO, HAVCR1, PRNP
glutamatergic synapse 1 ATP2B1
Golgi apparatus 1 PRNP
Golgi membrane 1 INS
postsynapse 1 PRNP
presynaptic membrane 1 ATP2B1
sarcolemma 1 ANXA5
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 2 LIPE, NOS2
plasma membrane 8 ABCB1, ATP2B1, CACNA1I, CD9, HAVCR1, NOS2, PRNP, PRTN3
synaptic vesicle membrane 1 ATP2B1
terminal bouton 1 PRNP
Membrane 10 ABCB1, ANXA5, ATP2B1, CACNA1I, CAT, CD9, CYP51A1, HSP90B1, LIPE, PRNP
apical plasma membrane 1 ABCB1
basolateral plasma membrane 1 ATP2B1
caveola 1 LIPE
extracellular exosome 10 ABCB1, ANXA5, ATP2B1, CAT, CD9, EPO, GPT, HSP90B1, PRNP, PRTN3
endoplasmic reticulum 2 HSP90B1, PRNP
extracellular space 7 AVP, CD9, EPO, IL17A, IL2, INS, PRTN3
perinuclear region of cytoplasm 2 HSP90B1, NOS2
mitochondrion 2 CAT, PRNP
protein-containing complex 3 CAT, CD9, HSP90B1
intracellular membrane-bounded organelle 5 ATP2B1, CAT, CYP51A1, PRNP, PRTN3
Microsome membrane 1 CYP51A1
postsynaptic density 1 PRNP
Single-pass type I membrane protein 1 HAVCR1
Secreted 6 AVP, EPO, IL17A, IL2, INS, PRTN3
extracellular region 10 ANXA5, AVP, CAT, CD9, EPO, HSP90B1, IL17A, IL2, INS, PRTN3
Mitochondrion outer membrane 1 PRNP
Single-pass membrane protein 2 CYP51A1, PRNP
mitochondrial outer membrane 1 PRNP
mitochondrial matrix 1 CAT
Extracellular side 1 PRTN3
motile cilium 1 HAVCR1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
nuclear membrane 1 PRNP
external side of plasma membrane 4 ANXA5, CD9, IL17A, PRNP
Extracellular vesicle 1 CD9
midbody 1 HSP90B1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Apical cell membrane 1 ABCB1
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 2 PRNP, PRTN3
focal adhesion 4 ANXA5, CAT, CD9, HSP90B1
Peroxisome 2 CAT, NOS2
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 2 ANXA5, HSP90B1
secretory granule 1 AVP
lateral plasma membrane 1 ATP2B1
Zymogen granule membrane 1 ANXA5
cell projection 1 ATP2B1
Basolateral cell membrane 1 ATP2B1
Lipid-anchor, GPI-anchor 1 PRNP
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Melanosome 1 HSP90B1
Presynaptic cell membrane 1 ATP2B1
cell body 1 EPO
side of membrane 1 PRNP
sperm plasma membrane 1 HSP90B1
plasma membrane raft 1 PRTN3
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, EPO, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 HSP90B1, INS
voltage-gated calcium channel complex 1 CACNA1I
endocytic vesicle membrane 1 CD9
extrinsic component of membrane 1 PRNP
transport vesicle 1 INS
Secreted, extracellular exosome 1 CD9
azurophil granule lumen 1 PRTN3
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
neuronal dense core vesicle 1 AVP
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 2 AVP, CD9
Sarcoplasmic reticulum lumen 1 HSP90B1
external side of apical plasma membrane 1 ABCB1
platelet alpha granule membrane 1 CD9
endocytic vesicle lumen 1 HSP90B1
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
inclusion body 1 PRNP
endoplasmic reticulum chaperone complex 1 HSP90B1
endothelial microparticle 1 ANXA5
photoreceptor ribbon synapse 1 ATP2B1


文献列表

  • Paschalis Vergidis, Parham Sendi, Hassan B Alkhateeb, M Hong Nguyen. How do I manage refractory invasive pulmonary aspergillosis. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2024 Jun; 30(6):755-761. doi: 10.1016/j.cmi.2024.01.015. [PMID: 38286175]
  • Sebastian Janik, Rafal Luchowski, Ewa Grela, Wojciech Grudzinski, Wieslaw I Gruszecki. How Does the Antibiotic Amphotericin B Enter Membranes and What Does It Do There?. The journal of physical chemistry letters. 2024 May; 15(18):4823-4827. doi: 10.1021/acs.jpclett.4c00496. [PMID: 38668706]
  • Francelise Bridi Cavassin, Marcello Mihailenko Chaves Magri, Jose Ernesto Vidal, Fabianne Altruda de Moraes Costa Carlesse, Diego Rodrigues Falci, João Luís Baú-Carneiro, Giovanni Luís Breda, Fábio de Araújo Motta, Cássia Silva de Miranda Godoy, Renata de Bastos Ascenço Soares, Carla Sakuma De Oliveira, Ana Verena Almeida Mendes, Hugo Paz Morales, Patrícia Silva Montes, Mariane Taborda, Caroline Martins Rego, Maíra Araujo Félix, Paula Pacheco Katopodis, Julia Raquel da Silva do Ó, Mirela Pereira Lima Abrão, Talita Teles Teixeira Pereira, Flávio Queiroz-Telles. Effectiveness, Tolerability, and Safety of Different Amphotericin B Formulations in Invasive Fungal Infections: A Multicenter, Retrospective, Observational Study. Clinical therapeutics. 2024 Apr; 46(4):322-337. doi: 10.1016/j.clinthera.2024.01.011. [PMID: 38403508]
  • Hanna Stieber, Lara Junghanns, Hannah Wilhelm, Maria Batliner, Alexander Maximilian Aldejohann, Oliver Kurzai, Ronny Martin. The sphingolipid inhibitor myriocin increases Candida auris susceptibility to amphotericin B. Mycoses. 2024 Apr; 67(4):e13723. doi: 10.1111/myc.13723. [PMID: 38551121]
  • Hendra Saputra, Muhammad Safaat, Pugoh Santoso, Rie Wakabayashi, Masahiro Goto, Toki Taira, Noriho Kamiya. Design of Protease-Responsive Antifungal Liposomal Formulation Decorated with a Lipid-Modified Chitin-Binding Domain. International journal of molecular sciences. 2024 Mar; 25(7):. doi: 10.3390/ijms25073567. [PMID: 38612381]
  • ". [Multidisciplinary expert consensus on the clinical rational application of different formulations of amphotericin B (2024 edition)]. Zhonghua nei ke za zhi. 2024 Mar; 63(3):230-257. doi: 10.3760/cma.j.cn112138-20231122-00332. [PMID: 38448188]
  • Gabriel Silva Marques Borges, Thais Tunes Santos, Cristiane Monteiro Pinto, Frédéric Frézard, Verônica Freitas Blanco, Roberta Ondei, Stephen Rumbelow, Lucas Antônio Miranda Ferreira, Marta Marques Gontijo de Aguiar, Gisele Assis Castro Goulart. Distearoyl phosphatidylglycerol and dioleoyl phosphatidylglycerol increase the retention and reduce the toxicity of amphotericin B-loaded in nanoemulsions. Nanomedicine (London, England). 2024 02; 19(5):383-396. doi: 10.2217/nnm-2023-0256. [PMID: 38293893]
  • Lei Chen, Xiuyun Tian, Lanyue Zhang, Wenzhao Wang, Pengjie Hu, Zhongyi Ma, Yeqi Li, Shibin Li, Zhenghao Shen, Xin Fan, Leixin Ye, Weixin Ke, Yao Wu, Guanghou Shui, Meng Xiao, Guang-Jun He, Ying Yang, Wenxia Fang, Fan Bai, Guojian Liao, Min Chen, Xiaorong Lin, Chong Li, Linqi Wang. Brain glucose induces tolerance of Cryptococcus neoformans to amphotericin B during meningitis. Nature microbiology. 2024 Jan; ?(?):. doi: 10.1038/s41564-023-01561-1. [PMID: 38225460]
  • Neda Sharifi, Zahra Alitaneh, Sahar Asadi, Zeinab Vahidinia, Seyed Mohsen Aghaei Zarch, Ali Esmaeili, Saeid Bagheri-Mohammadi, Sajad Najafi, Yosra Mazhari. Developing nanosize carrier systems for Amphotericin-B: A review on the biomedical application of nanoparticles for the treatment of leishmaniasis and fungal infections. Biotechnology journal. 2024 Jan; 19(1):e2300462. doi: 10.1002/biot.202300462. [PMID: 38073122]
  • Christina Schier, Martin C H Gruhlke, Georg Reucher, Alan J Slusarenko, Lothar Rink. Combating Black Fungus: Using Allicin as a Potent Antifungal Agent against Mucorales. International journal of molecular sciences. 2023 Dec; 24(24):. doi: 10.3390/ijms242417519. [PMID: 38139348]
  • Kashif Hussain, Abdul Jabbar, Khwaja Ali Hasan, Muneeb Ali, Zaheer Ul-Haq, Muhammad Raza Shah, Saeed Ahmad Khan, Md Abdur Rashid, Mohsin Kazi, Muhammad Naseer Abbas. Investigating the self-assembling of nicotinic hydrazide-based amphiphile into nano-range vesicles and its amphotericin B loading applications. Drug delivery. 2023 Dec; 30(1):2174205. doi: 10.1080/10717544.2023.2174205. [PMID: 36785530]
  • Rogayeh Seify, Fahimeh Zahednezhad, Parvin Zakeri-Milani, Hadi Valizadeh. Amphotericin B liposomal formulation: applicable preparation methods, challenges, and tips. Drug development and industrial pharmacy. 2023 Dec; 49(5):367-376. doi: 10.1080/03639045.2023.2215006. [PMID: 37249553]
  • Armando Barragán-Reyes, Luis Esaú López Jácome, Diana Perales-Martínez, Alejandra Nava-Ruiz, María de Lourdes García Hernández, Patricia Cornejo-Juárez, Joaquín Rincón-Zuno, Adrián Camacho, Rafael Franco Cendejas, José M Feliciano Guzmán, Norma E Rivera-Martínez, Diego Ontañón-Zurita, Jesús Reséndiz-Sánchez, Eva Juárez-Hernández, Daniel Aguilar-Zapata. Fusariosis in Mexico: A 10-year retrospective series. Medical mycology. 2023 Dec; 61(12):. doi: 10.1093/mmy/myad112. [PMID: 37944000]
  • Xiaoming Zhong, Jianqiong Yang, Hongyan Liu, Zhiwen Yang, Ping Luo. Potential lipid-based strategies of amphotericin B designed for oral administration in clinical application. Drug delivery. 2023 Dec; 30(1):2161671. doi: 10.1080/10717544.2022.2161671. [PMID: 36601799]
  • Nandha Joyson, Anchal Pathak, Keerti Jain. One Platform Comparison of Polymeric and Lipidic Nanoparticles for the Delivery of Amphotericin B. AAPS PharmSciTech. 2023 Nov; 24(8):226. doi: 10.1208/s12249-023-02672-y. [PMID: 37945925]
  • Arun Maji, Corinne P Soutar, Jiabao Zhang, Agnieszka Lewandowska, Brice E Uno, Su Yan, Yogesh Shelke, Ganesh Murhade, Evgeny Nimerovsky, Collin G Borcik, Andres S Arango, Justin D Lange, Jonnathan P Marin-Toledo, Yinghuan Lyu, Keith L Bailey, Patrick J Roady, Jordan T Holler, Anuj Khandelwal, Anna M SantaMaria, Hiram Sanchez, Praveen R Juvvadi, Gina Johns, Michael J Hageman, Joanna Krise, Teclegiorgis Gebremariam, Eman G Youssef, Ken Bartizal, Kieren A Marr, William J Steinbach, Ashraf S Ibrahim, Thomas F Patterson, Nathan P Wiederhold, David R Andes, Taras V Pogorelov, Charles D Schwieters, Timothy M Fan, Chad M Rienstra, Martin D Burke. Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal. Nature. 2023 Nov; ?(?):. doi: 10.1038/s41586-023-06710-4. [PMID: 37938782]
  • Doaa M Abdel-Rahman, Basim Anwar Shehata Messiha, Fares E M Ali, Amany A Azouz. Regulation of renal nitric oxide and eNOS/iNOS expression by tadalafil participates in the mitigation of amphotericin B-induced renal injury: Down-regulation of NF-κB/iNOS/caspase-3 signaling. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Oct; ?(?):. doi: 10.1007/s00210-023-02787-w. [PMID: 37891258]
  • Carlos Ezquer-Garin, Gerardo Aguilar, Rafael Ferriols-Lisart, Manuel Alos-Almiñana. Validated HPLC-UV method for amphotericin B quantification in a critical patient receiving AmBisome and treated with extracorporeal replacement therapies. Biomedical chromatography : BMC. 2023 Sep; ?(?):e5749. doi: 10.1002/bmc.5749. [PMID: 37727118]
  • Ilvana Caklovica Kucukkaya, Cafer Ikbal Gulsever, Ilyas Dolas, Gonca Erkose Genc, Mert Ahmet Kuskucu, Pulat Akin Sabanci, Zayre Erturan. First case of Rhinocladiella mackenziei brain abscess in Turkey: Case report and review of the literature. Mycoses. 2023 09; 66(9):755-766. doi: 10.1111/myc.13601. [PMID: 37165906]
  • Martin Hoenigl, Jeffrey D Jenks, Matthias Egger, Marcio Nucci, George R Thompson. Treatment of Fusarium Infection of the Central Nervous System: A Review of Past Cases to Guide Therapy for the Ongoing 2023 Outbreak in the United States and Mexico. Mycopathologia. 2023 Aug; ?(?):. doi: 10.1007/s11046-023-00790-6. [PMID: 37653167]
  • Kevin Ehemann, Andrés Contreras, Adriana Marcela Celis-Ramírez. In vitro sensitivity of Malassezia furfur isolates from HIV-positive and negative patients to antifungal agents. Biomedica : revista del Instituto Nacional de Salud. 2023 Aug; 43(Sp. 1):120-131. doi: 10.7705/biomedica.6871. [PMID: 37721914]
  • David R Boulware, Mucunguzi Atukunda, Enock Kagimu, Abdu K Musubire, Andrew Akampurira, Lillian Tugume, Kenneth Ssebambulidde, John Kasibante, Laura Nsangi, Timothy Mugabi, Jane Gakuru, Sarah Kimuda, Derrick Kasozi, Suzan Namombwe, Isaac Turyasingura, Morris K Rutakingirwa, Edward Mpoza, Enos Kigozi, Conrad Muzoora, Jayne Ellis, Caleb P Skipper, Theresa Matkovits, Peter R Williamson, Darlisha A Williams, Ann Fieberg, Kathy H Hullsiek, Mahsa Abassi, Biyue Dai, David B Meya. Oral Lipid Nanocrystal Amphotericin B for Cryptococcal Meningitis: A Randomized Clinical Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2023 Aug; ?(?):. doi: 10.1093/cid/ciad440. [PMID: 37606364]
  • Daniela P Lage, Vívian T Martins, Danniele L Vale, Camila S Freitas, Breno L Pimenta, Gabriel J L Moreira, Fernanda F Ramos, Isabela A G Pereira, Raquel S Bandeira, Marcelo M de Jesus, Fernanda Ludolf, Grasiele S V Tavares, Miguel A Chávez-Fumagalli, Bruno M Roatt, Myron Christodoulides, Eduardo A F Coelho. The association between rLiHyp1 protein plus adjuvant and amphotericin B is an effective immunotherapy against visceral leishmaniasis in mice. Acta tropica. 2023 Jul; ?(?):106986. doi: 10.1016/j.actatropica.2023.106986. [PMID: 37453579]
  • Joseph P Lynch, George G Zhanel. Part 2: mucormycosis: focus on therapy. Expert review of anti-infective therapy. 2023 Jun; ?(?):1-12. doi: 10.1080/14787210.2023.2224564. [PMID: 37300820]
  • Kaushik Thanki, Tushar Date, Sanyog Jain. Enabling Oral Amphotericin B Delivery by Merging the Benefits of Prodrug Approach and Nanocarrier-Mediated Drug Delivery. ACS biomaterials science & engineering. 2023 06; 9(6):2879-2890. doi: 10.1021/acsbiomaterials.0c01505. [PMID: 33587853]
  • Shabi Parvez, Ganesh Yadagiri, Kanika Arora, Aaqib Javaid, Anurag Kumar Kushwaha, Om Prakash Singh, Shyam Sundar, Shyam Lal Mudavath. Coalition of Biological Agent (Melatonin) With Chemotherapeutic Agent (Amphotericin B) for Combating Visceral Leishmaniasis via Oral Administration of Modified Solid Lipid Nanoparticles. ACS biomaterials science & engineering. 2023 06; 9(6):2902-2910. doi: 10.1021/acsbiomaterials.1c00859. [PMID: 34463477]
  • Camila S Freitas, Samira S Santiago, Daniela P Lage, Luciana M R Antinarelli, Fabrício M Oliveira, Danniele L Vale, Vívian T Martins, Lícia N D Magalhaes, Raquel S Bandeira, Fernanda F Ramos, Isabela A G Pereira, Marcelo M de Jesus, Fernanda Ludolf, Grasiele S V Tavares, Adilson V Costa, Rafaela S Ferreira, Elaine S Coimbra, Róbson R Teixeira, Eduardo A F Coelho. In vitro evaluation of antileishmanial activity, mode of action and cellular response induced by vanillin synthetic derivatives against Leishmania species able to cause cutaneous and visceral leishmaniasis. Experimental parasitology. 2023 May; 251(?):108555. doi: 10.1016/j.exppara.2023.108555. [PMID: 37247802]
  • Rong-Jing Dong, Jun Li, Yi Zhang, Jia-Sheng Li, Lu-Hui Yang, Yi-Qun Kuang, Rui-Rui Wang, Yu-Ye Li. Thalidomide promotes NLRP3/caspase-1-mediated pyroptosis of macrophages in Talaromyces marneffei infection. Microbial pathogenesis. 2023 May; ?(?):106168. doi: 10.1016/j.micpath.2023.106168. [PMID: 37224982]
  • Daniela Peruzzu, Katia Fecchi, Giulietta Venturi, Maria Cristina Gagliardi. Repurposing Amphotericin B and Its Liposomal Formulation for the Treatment of Human Mpox. International journal of molecular sciences. 2023 May; 24(10):. doi: 10.3390/ijms24108896. [PMID: 37240241]
  • Jennifer C Chan, Jonathan Dear, Carrie Palm, Krystle Reagan. Incidence of acute kidney injury in dogs with systemic mycotic infections treated with amphotericin B (1996-2020). Journal of veterinary internal medicine. 2023 May; ?(?):. doi: 10.1111/jvim.16728. [PMID: 37148178]
  • Kristelle Hughes, Thanh Binh Le, Patrick Van Der Smissen, Donatienne Tyteca, Marie-Paule Mingeot-Leclercq, Joëlle Quetin-Leclercq. The Antileishmanial Activity of Eugenol Associated with Lipid Storage Reduction Rather Than Membrane Properties Alterations. Molecules (Basel, Switzerland). 2023 May; 28(9):. doi: 10.3390/molecules28093871. [PMID: 37175277]
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