Nystatin (BioDeep_00000006210)

Main id: BioDeep_00000002459

 

human metabolite blood metabolite Chemicals and Drugs Antibiotics natural product


代谢物信息卡片


(21E,23E,25E,27E,31E,33E)-20-{[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-4,6,8,11,12,16,18,36-octahydroxy-35,37,38-trimethyl-2,14-dioxo-1-oxacyclooctatriaconta-21,23,25,27,31,33-hexaene-17-carboxylic acid

化学式: C47H75NO17 (925.5035)
中文名称: 制霉菌素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C=CC=CCCC=CC=CC=CC=CC(CC(C(C(CC(=O)CC(C(CCC(CC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)C(=O)O)O)OC2C(C(C(C(O2)C)O)N)O
InChI: InChI=1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31?,32?,33?,34?,35?,36?,37?,38?,40?,41-,42+,43+,44-,46+,47+/m0/s1

描述信息

Nystatin is a polyene antifungal drug to which many molds and yeasts are sensitive, including Candida spp. Nystatin has some toxicity associated with it when given intravenously, but it is not absorbed across intact skin or mucous membranes. It is considered a relatively safe drug for treating oral or gastrointestinal fungal infections.
G - Genito urinary system and sex hormones > G01 - Gynecological antiinfectives and antiseptics > G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids > G01AA - Antibiotics
A - Alimentary tract and metabolism > A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents > A07A - Intestinal antiinfectives > A07AA - Antibiotics
D - Dermatologicals > D01 - Antifungals for dermatological use > D01A - Antifungals for topical use > D01AA - Antibiotics
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent
D049990 - Membrane Transport Modulators
D007476 - Ionophores

同义名列表

8 个代谢物同义名

(21E,23E,25E,27E,31E,33E)-20-{[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-4,6,8,11,12,16,18,36-octahydroxy-35,37,38-trimethyl-2,14-dioxo-1-oxacyclooctatriaconta-21,23,25,27,31,33-hexaene-17-carboxylic acid; (21E,23E,25E,27E,31E,33E)-20-[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-4,6,8,11,12,16,18,36-octahydroxy-35,37,38-trimethyl-2,14-dioxo-1-oxacyclooctatriaconta-21,23,25,27,31,33-hexaene-17-carboxylic acid; SCHEMBL1176571; ABBR nyt; Mycostatin; nystatin; NYS; Nystatin



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AKT1, ALB, CAT, FBXO32, FST, MAPK14, NFKB1
Peripheral membrane protein 1 CAV1
Endosome membrane 1 TF
Endoplasmic reticulum membrane 1 CAV1
Nucleus 6 AKT1, ALB, FBXO32, FST, MAPK14, NFKB1
cytosol 8 AKT1, ALB, CAT, FBXO32, FRMD7, MAPK14, NFKB1, PRKCQ
centrosome 1 ALB
nucleoplasm 7 AKT1, ATP2B1, FBXO32, FRMD7, GDF11, MAPK14, NFKB1
Cell membrane 5 AKT1, ATP2B1, CAV1, FNDC5, ITGAM
lamellipodium 1 AKT1
Cell projection, growth cone 1 FRMD7
Early endosome membrane 1 CAV1
Multi-pass membrane protein 1 ATP2B1
Golgi apparatus membrane 1 CAV1
Synapse 1 ATP2B1
cell cortex 2 AKT1, CAV1
cell surface 2 ITGAM, TF
glutamatergic synapse 3 AKT1, ATP2B1, MAPK14
Golgi apparatus 2 ALB, CAV1
Golgi membrane 2 CAV1, INS
growth cone 1 FRMD7
neuronal cell body 1 FRMD7
postsynapse 1 AKT1
presynaptic membrane 1 ATP2B1
endosome 1 CAV1
plasma membrane 9 AKT1, ATP2B1, CAV1, FNDC5, FRMD7, IFNLR1, ITGAM, PRKCQ, TF
synaptic vesicle membrane 1 ATP2B1
Membrane 7 AKT1, ATP2B1, CAT, CAV1, FNDC5, IFNLR1, ITGAM
apical plasma membrane 2 CAV1, TF
basolateral plasma membrane 2 ATP2B1, CAV1
caveola 1 CAV1
extracellular exosome 5 ALB, ATP2B1, CAT, ITGAM, TF
endoplasmic reticulum 3 ALB, CAV1, FNDC5
extracellular space 10 ALB, FRMD7, FST, GDF11, IGF1, IL6, INS, ITGAM, MSTN, TF
perinuclear region of cytoplasm 2 CAV1, TF
mitochondrion 3 CAT, MAPK14, NFKB1
protein-containing complex 5 AKT1, ALB, CAT, CAV1, GDF11
intracellular membrane-bounded organelle 3 ATP2B1, CAT, GDF11
Single-pass type I membrane protein 3 FNDC5, IFNLR1, ITGAM
Secreted 8 ALB, FNDC5, GDF11, IGF1, IL6, INS, MSTN, TF
extracellular region 11 ALB, CAT, FNDC5, FST, GDF11, IGF1, IL6, INS, MAPK14, NFKB1, TF
basal part of cell 1 TF
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
transcription regulator complex 1 NFKB1
centriolar satellite 1 PRKCQ
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 ITGAM
Z disc 1 FBXO32
cytoplasmic vesicle 2 CAV1, TF
microtubule cytoskeleton 1 AKT1
Early endosome 1 TF
cell-cell junction 1 AKT1
clathrin-coated pit 1 TF
recycling endosome 1 TF
vesicle 2 AKT1, TF
Membrane raft 2 CAV1, ITGAM
focal adhesion 2 CAT, CAV1
spindle 1 AKT1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 2 CAT, FNDC5
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
lateral plasma membrane 1 ATP2B1
nuclear speck 1 MAPK14
Late endosome 1 TF
Cell projection, neuron projection 1 FRMD7
neuron projection 1 FRMD7
ciliary basal body 2 AKT1, ALB
cilium 1 CAV1
chromatin 1 NFKB1
cell projection 1 ATP2B1
cytoskeleton 1 FRMD7
centriole 1 ALB
Golgi apparatus, trans-Golgi network 1 CAV1
spindle pole 2 ALB, MAPK14
blood microparticle 2 ALB, TF
Basolateral cell membrane 1 ATP2B1
endosome lumen 1 INS
Lipid droplet 1 CAV1
Membrane, caveola 1 CAV1
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
Presynaptic cell membrane 1 ATP2B1
Peroxisome membrane 1 FNDC5
basal plasma membrane 1 TF
exocytic vesicle 1 IGF1
plasma membrane raft 1 ITGAM
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 5 CAT, INS, MAPK14, NFKB1, TF
HFE-transferrin receptor complex 1 TF
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, IL6, INS, TF
platelet alpha granule lumen 2 ALB, IGF1
specific granule lumen 1 NFKB1
endocytic vesicle membrane 1 CAV1
endocytic vesicle 1 TF
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 2 ATP2B1, PRKCQ
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle membrane 1 TF
acrosomal membrane 1 CAV1
integrin complex 1 ITGAM
vesicle coat 1 TF
catalase complex 1 CAT
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
integrin alphaM-beta2 complex 1 ITGAM
interleukin-6 receptor complex 1 IL6
SCF ubiquitin ligase complex 1 FBXO32
photoreceptor ribbon synapse 1 ATP2B1
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
ciliary transition fiber 1 ALB
caveolar macromolecular signaling complex 1 CAV1
dense body 1 TF
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Vanessa de Carvalho Jovito, Jefferson Muniz de Lima, Marianne de Lucena Rangel, Brenna Louise Cavalcanti Gondim, Paula Lima Nogueira, Ana Claúdia Dantas de Medeiros, Marianna Vieira Sobral, Ricardo Dias de Castro, Lúcio Roberto Cançado Castellano. Anticandida and antibiofilm activities of extract from Schinopsis brasiliensis Engl. against Candida spp. Brazilian oral research. 2024; 38(?):e016. doi: 10.1590/1807-3107bor-2024.vol38.0016. [PMID: 38477802]
  • Filipa Sousa, Cecília Nascimento, Domingos Ferreira, Salette Reis, Paulo Costa. Reviving the interest in the versatile drug nystatin: A multitude of strategies to increase its potential as an effective and safe antifungal agent. Advanced drug delivery reviews. 2023 Jun; 199(?):114969. doi: 10.1016/j.addr.2023.114969. [PMID: 37348678]
  • Sara H Helal, Heba M M Abdel-Aziz, Mustafa M El-Zayat, Mohammed N A Hasaneen. Preparation, characterization and properties of three different nanomaterials either alone or loaded with nystatin or fluconazole antifungals. Scientific reports. 2022 12; 12(1):22110. doi: 10.1038/s41598-022-26523-1. [PMID: 36543853]
  • Eman Maher Zahran, Soad A Mohamad, Ramadan Yahia, Ahmed M Badawi, Ahmed M Sayed, Usama Ramadan Abdelmohsen. Anti-otomycotic potential of nanoparticles of Moringa oleifera leaf extract: an integrated in vitro, in silico and phase 0 clinical study. Food & function. 2022 Oct; 13(21):11083-11096. doi: 10.1039/d2fo02382b. [PMID: 36200448]
  • Almando Geraldi, Andika Pramudya Wardana, Nanik Siti Aminah, Alfinda Novi Kristanti, Aliffa Yusti Sadila, Nabilla Hapsari Wijaya, Mellya Rimadha Andra Wijaya, Noviana Indah Dwi Diningrum, Versa Rachmania Hajar, Yosephine Sri Wulan Manuhara. Tropical Medicinal Plant Extracts from Indonesia as Antifungal Agents against Candida Albicans. Frontiers in bioscience (Landmark edition). 2022 09; 27(9):274. doi: 10.31083/j.fbl2709274. [PMID: 36224024]
  • Vanessa Marques Meccatti, Lívia Mara Alves Figueiredo-Godoi, Thaís Cristine Pereira, Patrícia Michelle Nagai de Lima, Amjad Abu Hasna, Lavinia Barbosa Senna, Maria Cristina Marcucci, Juliana Campos Junqueira, Luciane Dias de Oliveira. The biocompatibility and antifungal effect of Rosmarinus officinalis against Candida albicans in Galleria mellonella model. Scientific reports. 2022 09; 12(1):15611. doi: 10.1038/s41598-022-19425-9. [PMID: 36114199]
  • Jacqueline de Oliveira Zoccolotti, Alberto José Cavalheiro, Camilla Olga Tasso, Caroline Correa de Oliveira, Beatriz Ribeiro Ribas, Túlio Morandin Ferrisse, Carlos Alberto de Souza Costa, Janaina Habib Jorge. In vivo antifungal activity and biocompatibility of Cryptocarya moschata. Archives of microbiology. 2022 Aug; 204(9):569. doi: 10.1007/s00203-022-03177-1. [PMID: 35987948]
  • Masoomeh Sadat Hosseini, Babak Kamali, Mohammad Reza Nabid. Multilayered mucoadhesive hydrogel films based on Ocimum basilicum seed mucilage/thiolated alginate/dopamine-modified hyaluronic acid and PDA coating for sublingual administration of nystatin. International journal of biological macromolecules. 2022 Apr; 203(?):93-104. doi: 10.1016/j.ijbiomac.2022.01.031. [PMID: 35033526]
  • Rodrigo C Bassi, Marcelo F G Boriollo. Amphotericin B, fluconazole, and nystatin as development inhibitors of Candida albicans biofilms on a dental prosthesis reline material: Analytical models in vitro. The Journal of prosthetic dentistry. 2022 Feb; 127(2):320-330. doi: 10.1016/j.prosdent.2020.10.018. [PMID: 33279153]
  • Benjamin Kingsley Harley, Anthony Martin Quagraine, David Neglo, Mike Okweesi Aggrey, Emmanuel Orman, Nana Ama Mireku-Gyimah, Cedric Dzidzor Amengor, Jonathan Jato, Yussif Saaka, Theophilus Christian Fleischer. Metabolite profiling, antifungal, biofilm formation prevention and disruption of mature biofilm activities of Erythrina senegalensis stem bark extract against Candida albicans and Candida glabrata. PloS one. 2022; 17(11):e0278096. doi: 10.1371/journal.pone.0278096. [PMID: 36441750]
  • Abolfazl Saravani Jahantiq, Seyyed Amin Ayatollahi Mousavi, Neda Mohamadi, Fariba Sharififar. Inhibitory Effect of Standardized Extract and Fractions of Nigella sativa L. on Nystatin Susceptible and Clinically Nystatin Resistant Candida albicans. Current drug discovery technologies. 2022; 19(5):e120522204695. doi: 10.2174/1570163819666220512164337. [PMID: 35549875]
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  • Santhosh Chandar Maddila, Chandrashekhar Voshavar, Porkizhi Arjunan, Rashmi Prakash Chowath, Hari Krishna Reddy Rachamalla, Balaji Balakrishnan, Poonkuzhali Balasubramanian, Rajkumar Banerjee, Srujan Marepally. Cholesterol Sequestration from Caveolae/Lipid Rafts Enhances Cationic Liposome-Mediated Nucleic Acid Delivery into Endothelial Cells. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154626. [PMID: 34361779]
  • Zehra Edis, Samir Haj Bloukh. Facile Synthesis of Bio-Antimicrobials with 'Smart' Triiodides. Molecules (Basel, Switzerland). 2021 Jun; 26(12):. doi: 10.3390/molecules26123553. [PMID: 34200814]
  • Trung Q Ky, Jeong M Park, Katie A McMurry, Sarah M Tischer, Linda J Fitzgerald, Laura Cotiguala. Oropharyngeal candidiasis outcomes in renal transplant recipients receiving nystatin versus no antifungal prophylaxis. Transplant infectious disease : an official journal of the Transplantation Society. 2021 Jun; 23(3):e13559. doi: 10.1111/tid.13559. [PMID: 33387388]
  • Maria Szomek, Peter Reinholdt, Daniel Petersen, Atenisa Caci, Jacob Kongsted, Daniel Wüstner. Direct observation of nystatin binding to the plasma membrane of living cells. Biochimica et biophysica acta. Biomembranes. 2021 02; 1863(2):183528. doi: 10.1016/j.bbamem.2020.183528. [PMID: 33279513]
  • Vanessa M Meccatti, Jonatas R DE Oliveira, Leandro W Figueira, Amandio A Lagareiro Netto, Lucas S Zamarioli, Maria C Marcucci, Samira E A Camargo, Cláudio A T Carvalho, Luciane D DE Oliveira. Rosmarinus officinalis L. (rosemary) extract has antibiofilm effect similar to the antifungal nystatin on Candida samples. Anais da Academia Brasileira de Ciencias. 2021; 93(2):e20190366. doi: 10.1590/0001-3765202120190366. [PMID: 33950151]
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  • Janaina de Cássia Orlandi Sardi, Irlan Almeida Freires, Josy Goldoni Lazarini, Juliana Infante, Severino Matias de Alencar, Pedro Luiz Rosalen. Unexplored endemic fruit species from Brazil: Antibiofilm properties, insights into mode of action, and systemic toxicity of four Eugenia spp. Microbial pathogenesis. 2017 Apr; 105(?):280-287. doi: 10.1016/j.micpath.2017.02.044. [PMID: 28259673]
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  • Chanettee Chanthick, Rattiyaporn Kanlaya, Rattanaporn Kiatbumrung, Sa-Nga Pattanakitsakul, Visith Thongboonkerd. Caveolae-mediated albumin transcytosis is enhanced in dengue-infected human endothelial cells: A model of vascular leakage in dengue hemorrhagic fever. Scientific reports. 2016 08; 6(?):31855. doi: 10.1038/srep31855. [PMID: 27546060]
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