Nystatin (BioDeep_00000006210)

Main id: BioDeep_00000002459

 

human metabolite blood metabolite Chemicals and Drugs Antibiotics Volatile Flavor Compounds natural product


代谢物信息卡片


(21E,23E,25E,27E,31E,33E)-20-{[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-4,6,8,11,12,16,18,36-octahydroxy-35,37,38-trimethyl-2,14-dioxo-1-oxacyclooctatriaconta-21,23,25,27,31,33-hexaene-17-carboxylic acid

化学式: C47H75NO17 (925.5034740000001)
中文名称: 制霉菌素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C=CC=CCCC=CC=CC=CC=CC(CC(C(C(CC(=O)CC(C(CCC(CC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)C(=O)O)O)OC2C(C(C(C(O2)C)O)N)O
InChI: InChI=1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31?,32?,33?,34?,35?,36?,37?,38?,40?,41-,42+,43+,44-,46+,47+/m0/s1

描述信息

Nystatin is a polyene antifungal drug to which many molds and yeasts are sensitive, including Candida spp. Nystatin has some toxicity associated with it when given intravenously, but it is not absorbed across intact skin or mucous membranes. It is considered a relatively safe drug for treating oral or gastrointestinal fungal infections.
G - Genito urinary system and sex hormones > G01 - Gynecological antiinfectives and antiseptics > G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids > G01AA - Antibiotics
A - Alimentary tract and metabolism > A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents > A07A - Intestinal antiinfectives > A07AA - Antibiotics
D - Dermatologicals > D01 - Antifungals for dermatological use > D01A - Antifungals for topical use > D01AA - Antibiotics
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent
D049990 - Membrane Transport Modulators
D007476 - Ionophores

同义名列表

8 个代谢物同义名

(21E,23E,25E,27E,31E,33E)-20-{[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-4,6,8,11,12,16,18,36-octahydroxy-35,37,38-trimethyl-2,14-dioxo-1-oxacyclooctatriaconta-21,23,25,27,31,33-hexaene-17-carboxylic acid; (21E,23E,25E,27E,31E,33E)-20-[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-4,6,8,11,12,16,18,36-octahydroxy-35,37,38-trimethyl-2,14-dioxo-1-oxacyclooctatriaconta-21,23,25,27,31,33-hexaene-17-carboxylic acid; SCHEMBL1176571; ABBR nyt; Mycostatin; nystatin; NYS; Nystatin



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Vanessa de Carvalho Jovito, Jefferson Muniz de Lima, Marianne de Lucena Rangel, Brenna Louise Cavalcanti Gondim, Paula Lima Nogueira, Ana Claúdia Dantas de Medeiros, Marianna Vieira Sobral, Ricardo Dias de Castro, Lúcio Roberto Cançado Castellano. Anticandida and antibiofilm activities of extract from Schinopsis brasiliensis Engl. against Candida spp. Brazilian oral research. 2024; 38(?):e016. doi: 10.1590/1807-3107bor-2024.vol38.0016. [PMID: 38477802]
  • Filipa Sousa, Cecília Nascimento, Domingos Ferreira, Salette Reis, Paulo Costa. Reviving the interest in the versatile drug nystatin: A multitude of strategies to increase its potential as an effective and safe antifungal agent. Advanced drug delivery reviews. 2023 Jun; 199(?):114969. doi: 10.1016/j.addr.2023.114969. [PMID: 37348678]
  • Sara H Helal, Heba M M Abdel-Aziz, Mustafa M El-Zayat, Mohammed N A Hasaneen. Preparation, characterization and properties of three different nanomaterials either alone or loaded with nystatin or fluconazole antifungals. Scientific reports. 2022 12; 12(1):22110. doi: 10.1038/s41598-022-26523-1. [PMID: 36543853]
  • Eman Maher Zahran, Soad A Mohamad, Ramadan Yahia, Ahmed M Badawi, Ahmed M Sayed, Usama Ramadan Abdelmohsen. Anti-otomycotic potential of nanoparticles of Moringa oleifera leaf extract: an integrated in vitro, in silico and phase 0 clinical study. Food & function. 2022 Oct; 13(21):11083-11096. doi: 10.1039/d2fo02382b. [PMID: 36200448]
  • Almando Geraldi, Andika Pramudya Wardana, Nanik Siti Aminah, Alfinda Novi Kristanti, Aliffa Yusti Sadila, Nabilla Hapsari Wijaya, Mellya Rimadha Andra Wijaya, Noviana Indah Dwi Diningrum, Versa Rachmania Hajar, Yosephine Sri Wulan Manuhara. Tropical Medicinal Plant Extracts from Indonesia as Antifungal Agents against Candida Albicans. Frontiers in bioscience (Landmark edition). 2022 09; 27(9):274. doi: 10.31083/j.fbl2709274. [PMID: 36224024]
  • Vanessa Marques Meccatti, Lívia Mara Alves Figueiredo-Godoi, Thaís Cristine Pereira, Patrícia Michelle Nagai de Lima, Amjad Abu Hasna, Lavinia Barbosa Senna, Maria Cristina Marcucci, Juliana Campos Junqueira, Luciane Dias de Oliveira. The biocompatibility and antifungal effect of Rosmarinus officinalis against Candida albicans in Galleria mellonella model. Scientific reports. 2022 09; 12(1):15611. doi: 10.1038/s41598-022-19425-9. [PMID: 36114199]
  • Jacqueline de Oliveira Zoccolotti, Alberto José Cavalheiro, Camilla Olga Tasso, Caroline Correa de Oliveira, Beatriz Ribeiro Ribas, Túlio Morandin Ferrisse, Carlos Alberto de Souza Costa, Janaina Habib Jorge. In vivo antifungal activity and biocompatibility of Cryptocarya moschata. Archives of microbiology. 2022 Aug; 204(9):569. doi: 10.1007/s00203-022-03177-1. [PMID: 35987948]
  • Masoomeh Sadat Hosseini, Babak Kamali, Mohammad Reza Nabid. Multilayered mucoadhesive hydrogel films based on Ocimum basilicum seed mucilage/thiolated alginate/dopamine-modified hyaluronic acid and PDA coating for sublingual administration of nystatin. International journal of biological macromolecules. 2022 Apr; 203(?):93-104. doi: 10.1016/j.ijbiomac.2022.01.031. [PMID: 35033526]
  • Rodrigo C Bassi, Marcelo F G Boriollo. Amphotericin B, fluconazole, and nystatin as development inhibitors of Candida albicans biofilms on a dental prosthesis reline material: Analytical models in vitro. The Journal of prosthetic dentistry. 2022 Feb; 127(2):320-330. doi: 10.1016/j.prosdent.2020.10.018. [PMID: 33279153]
  • Benjamin Kingsley Harley, Anthony Martin Quagraine, David Neglo, Mike Okweesi Aggrey, Emmanuel Orman, Nana Ama Mireku-Gyimah, Cedric Dzidzor Amengor, Jonathan Jato, Yussif Saaka, Theophilus Christian Fleischer. Metabolite profiling, antifungal, biofilm formation prevention and disruption of mature biofilm activities of Erythrina senegalensis stem bark extract against Candida albicans and Candida glabrata. PloS one. 2022; 17(11):e0278096. doi: 10.1371/journal.pone.0278096. [PMID: 36441750]
  • Abolfazl Saravani Jahantiq, Seyyed Amin Ayatollahi Mousavi, Neda Mohamadi, Fariba Sharififar. Inhibitory Effect of Standardized Extract and Fractions of Nigella sativa L. on Nystatin Susceptible and Clinically Nystatin Resistant Candida albicans. Current drug discovery technologies. 2022; 19(5):e120522204695. doi: 10.2174/1570163819666220512164337. [PMID: 35549875]
  • R Ramessur, N Saffar, B Czako, A Agarwal, K Batta. Cutaneous thrombosis associated with skin necrosis following Oxford-AstraZeneca COVID-19 vaccination. Clinical and experimental dermatology. 2021 Dec; 46(8):1610-1612. doi: 10.1111/ced.14819. [PMID: 34189756]
  • Lady Daiane Pereira Leite, Maria Alcionéia Carvalho de Oliveira, Mariana Raquel da Cruz Vegian, Aline da Graça Sampaio, Thalita Mayumi Castaldelli Nishime, Konstantin Georgiev Kostov, Cristiane Yumi Koga-Ito. Effect of Cold Atmospheric Plasma Jet Associated to Polyene Antifungals on Candida albicans Biofilms. Molecules (Basel, Switzerland). 2021 Sep; 26(19):. doi: 10.3390/molecules26195815. [PMID: 34641359]
  • Santhosh Chandar Maddila, Chandrashekhar Voshavar, Porkizhi Arjunan, Rashmi Prakash Chowath, Hari Krishna Reddy Rachamalla, Balaji Balakrishnan, Poonkuzhali Balasubramanian, Rajkumar Banerjee, Srujan Marepally. Cholesterol Sequestration from Caveolae/Lipid Rafts Enhances Cationic Liposome-Mediated Nucleic Acid Delivery into Endothelial Cells. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154626. [PMID: 34361779]
  • Zehra Edis, Samir Haj Bloukh. Facile Synthesis of Bio-Antimicrobials with 'Smart' Triiodides. Molecules (Basel, Switzerland). 2021 Jun; 26(12):. doi: 10.3390/molecules26123553. [PMID: 34200814]
  • Trung Q Ky, Jeong M Park, Katie A McMurry, Sarah M Tischer, Linda J Fitzgerald, Laura Cotiguala. Oropharyngeal candidiasis outcomes in renal transplant recipients receiving nystatin versus no antifungal prophylaxis. Transplant infectious disease : an official journal of the Transplantation Society. 2021 Jun; 23(3):e13559. doi: 10.1111/tid.13559. [PMID: 33387388]
  • Maria Szomek, Peter Reinholdt, Daniel Petersen, Atenisa Caci, Jacob Kongsted, Daniel Wüstner. Direct observation of nystatin binding to the plasma membrane of living cells. Biochimica et biophysica acta. Biomembranes. 2021 02; 1863(2):183528. doi: 10.1016/j.bbamem.2020.183528. [PMID: 33279513]
  • Vanessa M Meccatti, Jonatas R DE Oliveira, Leandro W Figueira, Amandio A Lagareiro Netto, Lucas S Zamarioli, Maria C Marcucci, Samira E A Camargo, Cláudio A T Carvalho, Luciane D DE Oliveira. Rosmarinus officinalis L. (rosemary) extract has antibiofilm effect similar to the antifungal nystatin on Candida samples. Anais da Academia Brasileira de Ciencias. 2021; 93(2):e20190366. doi: 10.1590/0001-3765202120190366. [PMID: 33950151]
  • Oleg O Glebov. Understanding SARS-CoV-2 endocytosis for COVID-19 drug repurposing. The FEBS journal. 2020 09; 287(17):3664-3671. doi: 10.1111/febs.15369. [PMID: 32428379]
  • João Xavier da Silva Neto, Helen Paula Silva da Costa, Ilka Maria Vasconcelos, Mirella Leite Pereira, Jose Tadeu Abreu Oliveira, Tiago Deiveson Pereira Lopes, Lucas Pinheiro Dias, Nadine Monteiro Salgueiro Araújo, Luiz Francisco Wemmenson Gonçalves Moura, Mauricio Fraga Van Tilburg, Maria Izabel Florindo Guedes, Larissa Alves Lopes, Eva Gomes Morais, Daniele de Oliveira Bezerra de Sousa. Role of membrane sterol and redox system in the anti-candida activity reported for Mo-CBP2, a protein from Moringa oleifera seeds. International journal of biological macromolecules. 2020 Jan; 143(?):814-824. doi: 10.1016/j.ijbiomac.2019.09.142. [PMID: 31734363]
  • M Chevalier, A Doglio, R Rajendran, G Ramage, I Prêcheur, S Ranque. Inhibition of adhesion-specific genes by Solidago virgaurea extract causes loss of Candida albicans biofilm integrity. Journal of applied microbiology. 2019 Jul; 127(1):68-77. doi: 10.1111/jam.14289. [PMID: 31013388]
  • Suhua Chen, Hao He, Hui Yang, Bin Tan, Enmei Liu, Xiaodong Zhao, Yao Zhao. The role of lipid rafts in cell entry of human metapneumovirus. Journal of medical virology. 2019 06; 91(6):949-957. doi: 10.1002/jmv.25414. [PMID: 30698826]
  • V A Vainshtein, L N Nikolaevich, G G Sultanova, A A Bagirova, T Dzh Pashazade, V Kh Gasimova, T P Tagi-Zade, Kh M Kasumov. Effect of Chemically Transformed Macrocyclic Polyene Antibiotics on Tumor Cells. Bulletin of experimental biology and medicine. 2019 Apr; 166(6):735-738. doi: 10.1007/s10517-019-04429-9. [PMID: 31020586]
  • Tingting Zhao, Li Cui, Xiangqian Yu, Zhonghai Zhang, Xiaojuan Shen, Xiuguo Hua. Entry of sapelovirus into IPEC-J2 cells is dependent on caveolae-mediated endocytosis. Virology journal. 2019 03; 16(1):37. doi: 10.1186/s12985-019-1144-6. [PMID: 30909932]
  • Diego Romário Silva, Pedro Luiz Rosalen, Irlan Almeida Freires, Janaína de Cássia Orlandi Sardi, Rennaly Freitas Lima, Josy Goldoni Lazarini, Tereza Karla Vieira Lopes da Costa, Jozinete Vieira Pereira, Gustavo Pina Godoy, Edja Maria Melo de Brito Costa. Anadenanthera Colubrina vell Brenan: anti-Candida and antibiofilm activities, toxicity and therapeutical action. Brazilian oral research. 2019; 33(?):e023. doi: 10.1590/1807-3107bor-2019.vol33.0023. [PMID: 30970088]
  • Ming-Kai Jhan, Ting-Jing Shen, Po-Chun Tseng, Yung-Ting Wang, Chiou-Feng Lin. Signaling of Macrophage Inflammatory Protein (MIP)-3β Facilitates Dengue Virus-Induced Microglial Cell Migration. Viruses. 2018 12; 10(12):. doi: 10.3390/v10120690. [PMID: 30563082]
  • S Otašević, S Momčilović, M Petrović, O Radulović, N M Stojanović, V Arsić-Arsenijević. The dietary modification and treatment of intestinal Candida overgrowth - a pilot study. Journal de mycologie medicale. 2018 Dec; 28(4):623-627. doi: 10.1016/j.mycmed.2018.08.002. [PMID: 30166063]
  • Jae Seung Yang, Jun Ho Jeon, Mi Seon Jang, Seok-Seong Kang, Ki Bum Ahn, Manki Song, Cheol-Heui Yun, Seung Hyun Han. Vibrio cholerae OmpU induces IL-8 expression in human intestinal epithelial cells. Molecular immunology. 2018 01; 93(?):47-54. doi: 10.1016/j.molimm.2017.11.005. [PMID: 29145158]
  • A G Dos Santos, J T Marquês, A C Carreira, I R Castro, A S Viana, M-P Mingeot-Leclercq, R F M de Almeida, L C Silva. The molecular mechanism of Nystatin action is dependent on the membrane biophysical properties and lipid composition. Physical chemistry chemical physics : PCCP. 2017 Nov; 19(44):30078-30088. doi: 10.1039/c7cp05353c. [PMID: 29098221]
  • Janaina de Cássia Orlandi Sardi, Irlan Almeida Freires, Josy Goldoni Lazarini, Juliana Infante, Severino Matias de Alencar, Pedro Luiz Rosalen. Unexplored endemic fruit species from Brazil: Antibiofilm properties, insights into mode of action, and systemic toxicity of four Eugenia spp. Microbial pathogenesis. 2017 Apr; 105(?):280-287. doi: 10.1016/j.micpath.2017.02.044. [PMID: 28259673]
  • Masanori Honsho, Yuichi Abe, Yukio Fujiki. Plasmalogen biosynthesis is spatiotemporally regulated by sensing plasmalogens in the inner leaflet of plasma membranes. Scientific reports. 2017 03; 7(?):43936. doi: 10.1038/srep43936. [PMID: 28272479]
  • Larissa Rangel Peixoto, Pedro Luiz Rosalen, Gabriela Lacet Silva Ferreira, Irlan Almeida Freires, Fabíola Galbiatti de Carvalho, Lúcio Roberto Castellano, Ricardo Dias de Castro. Antifungal activity, mode of action and anti-biofilm effects of Laurus nobilis Linnaeus essential oil against Candida spp. Archives of oral biology. 2017 Jan; 73(?):179-185. doi: 10.1016/j.archoralbio.2016.10.013. [PMID: 27771586]
  • Kátia Andrea de Menezes Torres, Sônia Maria Rolim Rosa Lima, Suely Mitoi Ykko Ueda. Activity of the aqueous extract of Schinus terebinthifolius Raddi on strains of the Candida genus. Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia. 2016 Dec; 38(12):593-599. doi: 10.1055/s-0036-1597694. [PMID: 28038478]
  • Chanettee Chanthick, Rattiyaporn Kanlaya, Rattanaporn Kiatbumrung, Sa-Nga Pattanakitsakul, Visith Thongboonkerd. Caveolae-mediated albumin transcytosis is enhanced in dengue-infected human endothelial cells: A model of vascular leakage in dengue hemorrhagic fever. Scientific reports. 2016 08; 6(?):31855. doi: 10.1038/srep31855. [PMID: 27546060]
  • Saskia Preissner, Isabell Kastner, Eyke Schütte, Stefan Hartwig, Andrea Maria Schmidt-Westhausen, Sebastian Paris, Robert Preissner, Moritz Hertel. Adjuvant antifungal therapy using tissue tolerable plasma on oral mucosa and removable dentures in oral candidiasis patients: a randomised double-blinded split-mouth pilot study. Mycoses. 2016 Jul; 59(7):467-75. doi: 10.1111/myc.12495. [PMID: 26932256]
  • Ryan S Clark, Samuel T Pellom, Burthia Booker, Aramandla Ramesh, Tongwen Zhang, Anil Shanker, Mark Maguire, Paul D Juarez, Matthews-Juarez Patricia, Michael A Langston, Maureen Y Lichtveld, Darryl B Hood. Validation of research trajectory 1 of an Exposome framework: Exposure to benzo(a)pyrene confers enhanced susceptibility to bacterial infection. Environmental research. 2016 Apr; 146(?):173-84. doi: 10.1016/j.envres.2015.12.027. [PMID: 26765097]
  • A Chokoeva, A Kouzmanov, Z Ivanova, L Zisova, G Amalie, P Petleshkova, Ts Miteva-Katrandzhieva, M Krasteva, E Uchikova. [INVESTIGATION ON ANTIFUNGAL SUSCEPTIBILITY OF CANDIDA YEASTS IN PREGNANT PATIENTS WITH CONFIRMED VULVOVAGINAL CANDIDIASIS AND THEIR NEWBORNS.]. Akusherstvo i ginekologiia. 2016 ; 55(4):20-29. doi: . [PMID: 29370489]
  • Seyed Isaac Hashemy, Shideh Gharaei, Samaneh Vasigh, Sanaz Kargozar, Banafsheh Alirezaei, Fereshteh Jahed Keyhani, Maryam Amirchaghmaghi. Oxidative stress factors and C-reactive protein in patients with oral lichen planus before and 2 weeks after treatment. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2016 Jan; 45(1):35-40. doi: 10.1111/jop.12326. [PMID: 26058710]
  • Špela Zemljič Jokhadar, Bojan Božič, Luka Kristanc, Gregor Gomišček. Osmotic Effects Induced by Pore-Forming Agent Nystatin: From Lipid Vesicles to the Cell. PloS one. 2016; 11(10):e0165098. doi: 10.1371/journal.pone.0165098. [PMID: 27788169]
  • Alex C D Salyer, Giuseppe Caruso, Karishma K Khetani, Lauren M Fox, Subbalakshmi S Malladi, Sunil A David. Identification of Adjuvantic Activity of Amphotericin B in a Novel, Multiplexed, Poly-TLR/NLR High-Throughput Screen. PloS one. 2016; 11(2):e0149848. doi: 10.1371/journal.pone.0149848. [PMID: 26919709]
  • Christina M Guerra, Richard N Formica, Sanjay Kulkarni, William S Asch, Eric M Tichy. Duration of prophylaxis against fungal infection in kidney transplant recipients. Progress in transplantation (Aliso Viejo, Calif.). 2015 Dec; 25(4):311-5. doi: 10.7182/pit2015929. [PMID: 26645924]
  • Pallavi Bassi, Gurpreet Kaur. Bioadhesive vaginal drug delivery of nystatin using a derivatized polymer: Development and characterization. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2015 Oct; 96(?):173-84. doi: 10.1016/j.ejpb.2015.07.018. [PMID: 26235393]
  • David C Okechukwu, Mumuni A Momoh, Charles O Esimone. Evaluation of the anti-candidal activity of methanolic leaf extract of cleistopholis patens (fam. Annonaceae) on candida species isolated from stage II HIV patients. African health sciences. 2015 Sep; 15(3):789-96. doi: 10.4314/ahs.v15i3.12. [PMID: 26957966]
  • Hala Abdallah Farrag, Alzahraa A-Karam El-Din, Zeinab Galal Mohamed El-Sayed, Soheir Abdel-Latifissa, Mona Mohamed Kamal. Microbial colonization of irradiated pathogenic yeast to catheter surfaces: Relationship between adherence, cell surface hydrophobicity, biofilm formation and antifungal susceptibility. A scanning electron microscope analysis. International journal of radiation biology. 2015 Jun; 91(6):519-27. doi: 10.3109/09553002.2015.1021959. [PMID: 25758055]
  • Takahito Moriyama, Takashi Takei, Mitsuyo Itabashi, Keiko Uchida, Ken Tsuchiya, Kosaku Nitta. Caveolae may enable albumin to enter human renal glomerular endothelial cells. Journal of cellular biochemistry. 2015 Jun; 116(6):1060-9. doi: 10.1002/jcb.25061. [PMID: 25640083]
  • Evgeny G Chulkov, Ludmila V Schagina, Olga S Ostroumova. Membrane dipole modifiers modulate single-length nystatin channels via reducing elastic stress in the vicinity of the lipid mouth of a pore. Biochimica et biophysica acta. 2015 Jan; 1848(1 Pt A):192-9. doi: 10.1016/j.bbamem.2014.09.004. [PMID: 25223717]
  • Yang Chen, Guanghua Liu, Lifang Guo, Hui Wang, Yan Fu, Yongzhang Luo. Enhancement of tumor uptake and therapeutic efficacy of EGFR-targeted antibody cetuximab and antibody-drug conjugates by cholesterol sequestration. International journal of cancer. 2015 Jan; 136(1):182-94. doi: 10.1002/ijc.28950. [PMID: 24798787]
  • Carolina Piña-Vázquez, Magda Reyes-López, Guillermo Mendoza-Hernández, Rosa María Bermúdez-Cruz, Mireya de la Garza. Identification of phosphatidylcholine transfer protein-like in the parasite Entamoeba histolytica. Biochimie. 2014 Dec; 107 Pt B(?):223-34. doi: 10.1016/j.biochi.2014.09.007. [PMID: 25223890]
  • A Mansourian, N Boojarpour, S Ashnagar, J Momen Beitollahi, A R Shamshiri. The comparative study of antifungal activity of Syzygium aromaticum, Punica granatum and nystatin on Candida albicans; an in vitro study. Journal de mycologie medicale. 2014 Dec; 24(4):e163-8. doi: 10.1016/j.mycmed.2014.07.001. [PMID: 25442923]
  • Luka Kristanc, Bojan Božič, Gregor Gomišček. The role of sterols in the lipid vesicle response induced by the pore-forming agent nystatin. Biochimica et biophysica acta. 2014 Oct; 1838(10):2635-45. doi: 10.1016/j.bbamem.2014.05.019. [PMID: 24863056]
  • Evgeny G Chulkov, Svetlana S Efimova, Ludmila V Schagina, Olga S Ostroumova. Direct visualization of solid ordered domains induced by polyene antibiotics in giant unilamellar vesicles. Chemistry and physics of lipids. 2014 Oct; 183(?):204-7. doi: 10.1016/j.chemphyslip.2014.07.008. [PMID: 25068758]
  • Paul J J Mandigers, Mirjam B H M Duijvestijn, Nynke Ankringa, Sofie Maes, Elise van Essen, Anky H W Schoormans, Alexander J German, Dirk J Houwers. The clinical significance of Cyniclomyces guttulatus in dogs with chronic diarrhoea, a survey and a prospective treatment study. Veterinary microbiology. 2014 Aug; 172(1-2):241-7. doi: 10.1016/j.vetmic.2014.05.018. [PMID: 24908274]
  • Julia Valitova, Albina Sulkarnayeva, Ekaterina Kotlova, Anastasia Ponomareva, Fakhima K Mukhitova, Lyaisan Murtazina, Irina Ryzhkina, Richard Beckett, Farida Minibayeva. Sterol binding by methyl-β-cyclodextrin and nystatin--comparative analysis of biochemical and physiological consequences for plants. The FEBS journal. 2014 Apr; 281(8):2051-60. doi: 10.1111/febs.12761. [PMID: 24612537]
  • Mirjana Marčetić, Dragana Božić, Marina Milenković, Nevenka Malešević, Siniša Radulović, Nada Kovačević. Antimicrobial, antioxidant and anti-inflammatory activity of young shoots of the smoke tree, Cotinus coggygria Scop. Phytotherapy research : PTR. 2013 Nov; 27(11):1658-63. doi: 10.1002/ptr.4919. [PMID: 23280933]
  • Deiry Marín-Quintero, Francisco Fernández-Campos, Ana C Calpena-Campmany, María J Montes-López, Beatriz Clares-Naveros, Alfonso Del Pozo-Carrascosa. Formulation design and optimization for the improvement of nystatin-loaded lipid intravenous emulsion. Journal of pharmaceutical sciences. 2013 Nov; 102(11):4015-23. doi: 10.1002/jps.23711. [PMID: 23970386]
  • Débora C Reis, Angel A Recio Despaigne, Jeferson G Da Silva, Nayane F Silva, Camila F Vilela, Isolda C Mendes, Jacqueline A Takahashi, Heloisa Beraldo. Structural studies and investigation on the activity of imidazole-derived thiosemicarbazones and hydrazones against crop-related fungi. Molecules (Basel, Switzerland). 2013 Oct; 18(10):12645-62. doi: 10.3390/molecules181012645. [PMID: 24129274]
  • Gamze Demirel, Istemi Han Celik, Omer Erdeve, Sibel Saygan, Ugur Dilmen, Fuat Emre Canpolat. Prophylactic Saccharomyces boulardii versus nystatin for the prevention of fungal colonization and invasive fungal infection in premature infants. European journal of pediatrics. 2013 Oct; 172(10):1321-6. doi: 10.1007/s00431-013-2041-4. [PMID: 23703468]
  • Do-Hyung Kim, Byung-Yong Rhim, Seong-Kug Eo, Koanhoi Kim. Differential regulation of CC chemokine ligand 2 and CXCL8 by antifungal agent nystatin in macrophages. Biochemical and biophysical research communications. 2013 Aug; 437(3):392-6. doi: 10.1016/j.bbrc.2013.06.087. [PMID: 23831464]
  • Yuxin Chen, Hong Zeng, Jun Tian, Xiaoquan Ban, Bingxin Ma, Youwei Wang. Antifungal mechanism of essential oil from Anethum graveolens seeds against Candida albicans. Journal of medical microbiology. 2013 Aug; 62(Pt 8):1175-1183. doi: 10.1099/jmm.0.055467-0. [PMID: 23657528]
  • Ilaine T S Gehrke, Alexandre T Neto, Marcelo Pedroso, Clarice P Mostardeiro, Ivana B M Da Cruz, Ubiratan F Silva, Vinicius Ilha, Ionara I Dalcol, Ademir F Morel. Antimicrobial activity of Schinus lentiscifolius (Anacardiaceae). Journal of ethnopharmacology. 2013 Jul; 148(2):486-91. doi: 10.1016/j.jep.2013.04.043. [PMID: 23684720]
  • L A P Pinelli, A A B Montandon, S C T Corbi, T A Moraes, L M G Fais. Ricinus communis treatment of denture stomatitis in institutionalised elderly. Journal of oral rehabilitation. 2013 May; 40(5):375-80. doi: 10.1111/joor.12039. [PMID: 23438045]
  • Rita Semis, Sarah Kagan, Israela Berdicevsky, Itzhack Polacheck, Esther Segal. Mechanism of activity and toxicity of Nystatin-Intralipid. Medical mycology. 2013 May; 51(4):422-31. doi: 10.3109/13693786.2012.731712. [PMID: 23088298]
  • Janine S R Godoy, Patrícia de Souza Bonfim-Mendonça, Sandra S Nakamura, Sérgio S Yamada, Cristiane Shinobu-Mesquita, Neli Pieralisi, Adriana Fiorini, Terezinha I E Svidzinski. Colonization of the oral cavity by yeasts in patients with chronic renal failure undergoing hemodialysis. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2013 Mar; 42(3):229-34. doi: 10.1111/jop.12003. [PMID: 22978344]
  • Wen Ouyang, Chunxu Yang, Simin Zhang, Yu Liu, Bo Yang, Junhong Zhang, Fuxiang Zhou, Yunfeng Zhou, Conghua Xie. Absence of death receptor translocation into lipid rafts in acquired TRAIL-resistant NSCLC cells. International journal of oncology. 2013 Feb; 42(2):699-711. doi: 10.3892/ijo.2012.1748. [PMID: 23258590]
  • Paolo Manzoni, Daniele De Luca, Mauro Stronati, Evelyne Jacqz-Aigrain, Giulia Ruffinazzi, Martina Luparia, Elena Tavella, Elena Boano, Elio Castagnola, Michael Mostert, Daniele Farina. Prevention of nosocomial infections in neonatal intensive care units. American journal of perinatology. 2013 Feb; 30(2):81-8. doi: 10.1055/s-0032-1333131. [PMID: 23292914]
  • Rattiyaporn Kanlaya, Kitisak Sintiprungrat, Sakdithep Chaiyarit, Visith Thongboonkerd. Macropinocytosis is the major mechanism for endocytosis of calcium oxalate crystals into renal tubular cells. Cell biochemistry and biophysics. 2013; 67(3):1171-9. doi: 10.1007/s12013-013-9630-8. [PMID: 23695784]
  • Elina Siljamäki, Nina Rintanen, Maija Kirsi, Paula Upla, Wei Wang, Mikko Karjalainen, Elina Ikonen, Varpu Marjomäki. Cholesterol dependence of collagen and echovirus 1 trafficking along the novel α2β1 integrin internalization pathway. PloS one. 2013; 8(2):e55465. doi: 10.1371/journal.pone.0055465. [PMID: 23393580]
  • Maurice Ouédraogo, Kiessoun Konaté, Alexis Nicaise Lepengué, Alain Souza, Bertrand M'Batchi, Laya L Sawadogo. Free radical scavenging capacity, anticandicidal effect of bioactive compounds from Sida cordifolia L., in combination with nystatin and clotrimazole and their effect on specific immune response in rats. Annals of clinical microbiology and antimicrobials. 2012 Dec; 11(?):33. doi: 10.1186/1476-0711-11-33. [PMID: 23268761]
  • Rita Semis, Shai Shmuel Nili, Ariel Munitz, Zeev Zaslavsky, Itzhack Polacheck, Esther Segal. Pharmacokinetics, tissue distribution and immunomodulatory effect of intralipid formulation of nystatin in mice. The Journal of antimicrobial chemotherapy. 2012 Jul; 67(7):1716-21. doi: 10.1093/jac/dks117. [PMID: 22499997]
  • Armelle T Mbaveng, Victor Kuete, Bathelemy Ngameni, Veronique P Beng, Bonaventure T Ngadjui, Jacobus J Marion Meyer, Namrita Lall. Antimicrobial activities of the methanol extract and compounds from the twigs of Dorstenia mannii (Moraceae). BMC complementary and alternative medicine. 2012 Jun; 12(?):83. doi: 10.1186/1472-6882-12-83. [PMID: 22747736]
  • James B Perianayagam, S K Sharma, K K Pillai, A Pandurangan, D Kesavan. Evaluation of antimicrobial activity of ethanol extract and compounds isolated from Trichodesma indicum (Linn.) R. Br. root. Journal of ethnopharmacology. 2012 Jun; 142(1):283-6. doi: 10.1016/j.jep.2012.04.020. [PMID: 22543169]
  • Mahin Bakhshi, Jamileh-Bigom Taheri, Samira Basir Shabestari, Anett Tanik, Roozbeh Pahlevan. Comparison of therapeutic effect of aqueous extract of garlic and nystatin mouthwash in denture stomatitis. Gerodontology. 2012 Jun; 29(2):e680-4. doi: 10.1111/j.1741-2358.2011.00544.x. [PMID: 22126338]
  • Catherine Baugé, Nicolas Girard, Sylvain Leclercq, Philippe Galéra, Karim Boumédiene. Regulatory mechanism of transforming growth factor beta receptor type II degradation by interleukin-1 in primary chondrocytes. Biochimica et biophysica acta. 2012 May; 1823(5):983-6. doi: 10.1016/j.bbamcr.2012.02.017. [PMID: 22425785]
  • Cheryl S Watson, Yow-Jiun Jeng, Guangzhen Hu, Ann Wozniak, Nataliya Bulayeva, Jutatip Guptarak. Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-α interactions with G protein-αi and caveolin I. Steroids. 2012 Apr; 77(5):424-32. doi: 10.1016/j.steroids.2011.12.025. [PMID: 22230296]
  • Barbara Kaczorowska-Hac, Joanna Stefanowicz, Teresa Stachowicz-Stencel, Marta Kozlowska, Elzbieta Adamkiewicz-Drozynska, Anna Balcerska. Methemoglobinemia in postchemotherapy stomatitis topical treatment: 2 pediatric cases. Journal of pediatric hematology/oncology. 2012 Mar; 34(2):137-9. doi: 10.1097/mph.0b013e3182172532. [PMID: 21900833]
  • R Tester, F Al-Ghazzewi, N Shen, Z Chen, F Chen, J Yang, D Zhang, M Tang. The use of konjac glucomannan hydrolysates to recover healthy microbiota in infected vaginas treated with an antifungal agent. Beneficial microbes. 2012 Mar; 3(1):61-6. doi: 10.3920/bm2011.0021. [PMID: 22348910]
  • Karla K A Santos, Edinardo F F Matias, Celestina E S Souza, Saulo R Tintino, Maria F B M Braga, Glaucia M M Guedes, Lavouisier F B Nogueira, Edson C Morais, José G M Costa, Irwin R A Menezes, Henrique D M Coutinho. Anti-Candida activity of Mentha arvensis and Turnera ulmifolia. Journal of medicinal food. 2012 Mar; 15(3):322-4. doi: 10.1089/jmf.2011.0128. [PMID: 22082100]
  • Yanjun Yang, Haiyan Jin, Yong Chen, Weiqiang Lin, Chaoqun Wang, Zhehao Chen, Ning Han, Hongwu Bian, Muyuan Zhu, Junhui Wang. A chloroplast envelope membrane protein containing a putative LrgB domain related to the control of bacterial death and lysis is required for chloroplast development in Arabidopsis thaliana. The New phytologist. 2012 Jan; 193(1):81-95. doi: 10.1111/j.1469-8137.2011.03867.x. [PMID: 21916894]
  • Chiaki Kondo, Miwa Aoki, Emi Yamamoto, Yutaka Tonomura, Minoru Ikeda, Masako Kaneto, Jyoji Yamate, Mikinori Torii, Takeki Uehara. Predictive genomic biomarkers for drug-induced nephrotoxicity in mice. The Journal of toxicological sciences. 2012; 37(4):723-37. doi: 10.2131/jts.37.723. [PMID: 22863853]
  • Ramashish Kumar, Aniruddha Saha, Dipanwita Saha. A new antifungal coumarin from Clausena excavata. Fitoterapia. 2012 Jan; 83(1):230-3. doi: 10.1016/j.fitote.2011.11.003. [PMID: 22088496]
  • Cristiana Caliceti, Laura Zambonin, Cecilia Prata, Francesco Vieceli Dalla Sega, Gabriele Hakim, Silvana Hrelia, Diana Fiorentini. Effect of plasma membrane cholesterol depletion on glucose transport regulation in leukemia cells. PloS one. 2012; 7(7):e41246. doi: 10.1371/journal.pone.0041246. [PMID: 22859971]
  • Julia N Valitova, Farida V Minibayeva, Ekaterina R Kotlova, Alexander V Novikov, Alexey L Shavarda, Lyaisan I Murtazina, Irina S Ryzhkina. Effects of sterol-binding agent nystatin on wheat roots: the changes in membrane permeability, sterols and glycoceramides. Phytochemistry. 2011 Oct; 72(14-15):1751-9. doi: 10.1016/j.phytochem.2011.06.004. [PMID: 21726881]
  • Carsten Schwan, Thilo Nölke, Anna S Kruppke, Daniel M Schubert, Alexander E Lang, Klaus Aktories. Cholesterol- and sphingolipid-rich microdomains are essential for microtubule-based membrane protrusions induced by Clostridium difficile transferase (CDT). The Journal of biological chemistry. 2011 Aug; 286(33):29356-29365. doi: 10.1074/jbc.m111.261925. [PMID: 21705797]
  • Didier Colin, Emeric Limagne, Sylvie Jeanningros, Arnaud Jacquel, Gérard Lizard, Anne Athias, Philippe Gambert, Aziz Hichami, Norbert Latruffe, Eric Solary, Dominique Delmas. Endocytosis of resveratrol via lipid rafts and activation of downstream signaling pathways in cancer cells. Cancer prevention research (Philadelphia, Pa.). 2011 Jul; 4(7):1095-106. doi: 10.1158/1940-6207.capr-10-0274. [PMID: 21467134]
  • Ling Xu, Xiu-juan Qu, Yun-peng Liu, Jing Liu, Ye Zhang, Ke-zuo Hou, You-hong Jiang. [Cisplatin enhances TRAIL-induced apoptosis in gastric cancer cells through clustering death receptor 4 into lipid rafts]. Zhonghua zhong liu za zhi [Chinese journal of oncology]. 2011 Jul; 33(7):484-8. doi: . [PMID: 22093622]
  • Yang Chen, Shan Wang, Xinan Lu, Haoran Zhang, Yan Fu, Yongzhang Luo. Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways. Blood. 2011 Jun; 117(23):6392-403. doi: 10.1182/blood-2010-12-322867. [PMID: 21482707]
  • Ling Xu, Xiujuan Qu, Ying Luo, Ye Zhang, Jing Liu, Jinglei Qu, Lingyun Zhang, Yunpeng Liu. Epirubicin enhances TRAIL-induced apoptosis in gastric cancer cells by promoting death receptor clustering in lipid rafts. Molecular medicine reports. 2011 May; 4(3):407-11. doi: 10.3892/mmr.2011.439. [PMID: 21468584]
  • Shahnaz Shahidi-Noghabi, Els J M Van Damme, Winnok H De Vos, Guy Smagghe. Internalization of Sambucus nigra agglutinins I and II in insect midgut CF-203 cells. Archives of insect biochemistry and physiology. 2011 Apr; 76(4):211-22. doi: 10.1002/arch.20405. [PMID: 21254203]
  • Jörg D Schulzke, Susanne Andres, Maren Amasheh, Anja Fromm, Dorothee Günzel. Anti-diarrheal mechanism of the traditional remedy Uzara via reduction of active chloride secretion. PloS one. 2011 Mar; 6(3):e18107. doi: 10.1371/journal.pone.0018107. [PMID: 21479205]
  • Hari Raghu, Prasanna Kumar Sodadasu, Rama Rao Malla, Christopher S Gondi, Norman Estes, Jasti S Rao. Localization of uPAR and MMP-9 in lipid rafts is critical for migration, invasion and angiogenesis in human breast cancer cells. BMC cancer. 2010 Nov; 10(?):647. doi: 10.1186/1471-2407-10-647. [PMID: 21106094]
  • K S Récamier, A Hernández-Gómez, J González-Damián, I Ortega-Blake. Effect of membrane structure on the action of polyenes: I. Nystatin action in cholesterol- and ergosterol-containing membranes. The Journal of membrane biology. 2010 Sep; 237(1):31-40. doi: 10.1007/s00232-010-9304-z. [PMID: 20872217]
  • J González-Damián, I Ortega-Blake. Effect of membrane structure on the action of polyenes II: nystatin activity along the phase diagram of ergosterol- and cholesterol-containing POPC membranes. The Journal of membrane biology. 2010 Sep; 237(1):41-9. doi: 10.1007/s00232-010-9301-2. [PMID: 20871987]
  • Haque M Shamsul, Akira Hasebe, Mitsuhiro Iyori, Makoto Ohtani, Kazuto Kiura, Diya Zhang, Yasunori Totsuka, Ken-ichiro Shibata. The Toll-like receptor 2 (TLR2) ligand FSL-1 is internalized via the clathrin-dependent endocytic pathway triggered by CD14 and CD36 but not by TLR2. Immunology. 2010 Jun; 130(2):262-72. doi: 10.1111/j.1365-2567.2009.03232.x. [PMID: 20113368]
  • Yvonne Maria te Welscher, Lynden Jones, Martin Richard van Leeuwen, Jan Dijksterhuis, Ben de Kruijff, Gary Eitzen, Eefjan Breukink. Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol. Antimicrobial agents and chemotherapy. 2010 Jun; 54(6):2618-25. doi: 10.1128/aac.01794-09. [PMID: 20385867]
  • Yu N Valitova, E R Kotlova, A V Novikov, A L Shavarda, K A Artemenko, R A Zubarev, F V Minibayeva. Binding of sterols affects membrane functioning and sphingolipid composition in wheat roots. Biochemistry. Biokhimiia. 2010 May; 75(5):554-61. doi: 10.1134/s0006297910050032. [PMID: 20632933]
  • Ebru Mete, Canan Ozelgul, Cavit Kazaz, Dilsad Yurdakul, Fikrettin Sahin, Halise Inci Gul. Synthesis and antifungal activity of 1-aryl-3-phenethylamino-1-propanone hydrochlorides and 3-aroyl-4-aryl-1-phenethyl-4-piperidinols. Archiv der Pharmazie. 2010 May; 343(5):291-300. doi: 10.1002/ardp.200900136. [PMID: 20232370]
  • Roberto Kolter. Biofilms in lab and nature: a molecular geneticist's voyage to microbial ecology. International microbiology : the official journal of the Spanish Society for Microbiology. 2010 Mar; 13(1):1-7. doi: 10.2436/20.1501.01.105. [PMID: 20890834]
  • Kimon Violaris, Tracy Carbone, David Bateman, Olajide Olawepo, Brinda Doraiswamy, Meena LaCorte. Comparison of fluconazole and nystatin oral suspensions for prophylaxis of systemic fungal infection in very low birthweight infants. American journal of perinatology. 2010 Jan; 27(1):73-8. doi: 10.1055/s-0029-1224871. [PMID: 19504425]
  • Tom Schilling, Claudia Eder. Importance of lipid rafts for lysophosphatidylcholine-induced caspase-1 activation and reactive oxygen species generation. Cellular immunology. 2010; 265(2):87-90. doi: 10.1016/j.cellimm.2010.08.003. [PMID: 20832779]