Geniposide (BioDeep_00000000062)

 

Secondary id: BioDeep_00000179383

natural product PANOMIX_OTCML-2023 Volatile Flavor Compounds


代谢物信息卡片


(1S,4aS,7aS)-7-(hydroxymethyl)-1-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-1,4a,5,7a-tetrahydrocyclopenta[d]pyran-4-carboxylic acid methyl ester

化学式: C17H24O10 (388.13694039999996)
中文名称: 栀子苷, 去羟基栀子甙, 京尼平甙, 栀子甙, 京尼平苷
谱图信息: 最多检出来源 Viridiplantae(plant) 1.83%

分子结构信息

SMILES: COC(=O)C(=C2)C([H])(C3)C([H])(C(CO)=C3)C(O2)OC([H])(O1)C(O)C(O)C(O)C(CO)1
InChI: InChI=1S/C17H24O10/c1-24-15(23)9-6-25-16(11-7(4-18)2-3-8(9)11)27-17-14(22)13(21)12(20)10(5-19)26-17/h2,6,8,10-14,16-22H,3-5H2,1H3

描述信息

Geniposide is a terpene glycoside.
Geniposide is a natural product found in Feretia apodanthera, Gardenia jasminoides, and other organisms with data available.
See also: Gardenia jasminoides whole (part of).
Origin: Plant; SubCategory_DNP: Monoterpenoids, Iridoid monoterpenoids
Annotation level-1
Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.
Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.

同义名列表

30 个代谢物同义名

Methyl 7-(hydroxymethyl)-1-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate; (+)-geniposide; Geniposide; (1S,4aS,7aS)-Methyl 7-(hydroxymethyl)-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate; methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate; methyl (1S,4aS,7aR)-7-(hydroxymethyl)-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate; methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate; methyl(1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate; Cyclopenta(c)pyran-4-carboxylic acid, 1-(beta-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-, methyl ester, (1S-(1alpha,4aalpha,7aalpha))-; CYCLOPENTA(C)PYRAN-4-CARBOXYLIC ACID, 1-(.BETA.-D-GLUCOPYRANOSYLOXY)- 1,4A,5,7A-TETRAHYDRO-7-(HYDROXYMETHYL)-, METHYL ESTER, (1S,4AS,7AS)-; (1S)-1alpha-(beta-D-Glucopyranosyloxy)-7-(hydroxymethyl)-1,4aalpha,5,7aalpha-tetrahydrocyclopenta[c]pyran-4-carboxylic Acid Methyl Ester; Cyclopenta[c]pyran-4-carboxylic acid, 1-(beta-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-, methyl ester, (1S,4aS,7aS)-; Cyclopenta(c)pyran-4-carboxylic acid, 1-(beta-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-, methyl ester, (1S,4aS,7aS)-; Methyl (1S)-1alpha-(beta-D-Glucopyranosyloxy)-7-(hydroxymethyl)-1,4aalpha,5,7aalpha-tetrahydrocyclopenta[c]pyran-4-carboxylate; IBFYXTRXDNAPMM-BVTMAQQCSA-N; Geniposide, >=98\\% (HPLC); Genipin 1-glucoside; jasminoidin; Geniposid; (1S,4aS,7aS)-7-(hydroxymethyl)-1-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-1,4a,5,7a-tetrahydrocyclopenta[d]pyran-4-carboxylic acid methyl ester; methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[d]pyran-4-carboxylate; (1S,4aS,7aS)-7-methylol-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[d]pyran-4-carboxylic acid methyl ester; methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[d]pyran-4-carboxylate; ZINC03882101; 24512-63-8; 27745-20-6; C09781; methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate; NCGC00346662-04_C17H24O10_Methyl (1S,4aS,7aS)-1-(beta-D-glucopyranosyloxy)-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate; Geniposide



数据库引用编号

101 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

158 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jinhai Lin, Xiaolong Wang, Mingyang Gu, Yuanyuan Chen, Jiongbo Xu, Nhi Van Chau, Junlong Li, Xiaodong Ji, Qingmin Chu, Lijin Qing, Wei Wu. Geniposide ameliorates atherosclerosis by restoring lipophagy via suppressing PARP1/PI3K/AKT signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155617. doi: 10.1016/j.phymed.2024.155617. [PMID: 38614041]
  • Lijuan Liu, Huiling Zhang, Xinran Tang, Mengge Zhang, Yayun Wu, Ya Zhao, Chuanjian Lu, Ruizhi Zhao. Geniposide ameliorates psoriatic skin inflammation by inhibiting the TLR4/MyD88/NF-κB p65 signaling pathway and MMP9. International immunopharmacology. 2024 May; 133(?):112082. doi: 10.1016/j.intimp.2024.112082. [PMID: 38652958]
  • Ruimin Tian, Xianfeng Liu, Yang Xiao, Lijia Jing, Honglin Tao, Lu Yang, Xianli Meng. Huang-Lian-Jie-Du decoction drug-containing serum inhibits IL-1β secretion from D-glucose and PA induced BV2 cells via autophagy/NLRP3 signaling. Journal of ethnopharmacology. 2024 Apr; 323(?):117686. doi: 10.1016/j.jep.2023.117686. [PMID: 38160864]
  • Kanta Noguchi, Daisuke Imahori, Riko Nishiura, Poomraphie Nuntawong, Waraporn Putalun, Hiroyuki Tanaka, Satoshi Morimoto, Seiichi Sakamoto. Advanced quality assessment of Sanshishi (Gardenia jasminoides Ellis) and Kampo medicines using a monoclonal antibody against geniposide. Fitoterapia. 2024 Apr; 174(?):105829. doi: 10.1016/j.fitote.2024.105829. [PMID: 38278422]
  • Zhenxian Li, Haimei Zhu, Hao Liu, Dayue Liu, Jianhe Liu, Yi Zhang, Zhang Qin, Yijia Xu, Yuan Peng, Lihua Ruan, Jintao Li, Yao He, Bin Liu, Yun Long. Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive Bio-liposomes co-loaded with Geniposide and Emodin. Journal of nanobiotechnology. 2024 Mar; 22(1):129. doi: 10.1186/s12951-024-02389-5. [PMID: 38528554]
  • Yuhan Ding, Qian Xiang, Peiyuan Zhu, Manlu Fan, Huaqin Tong, Mengxi Wang, Songyi Cheng, Peng Yu, Haibo Shi, Haowen Zhang, Xiaohu Chen. Qihuang Zhuyu formula alleviates coronary microthrombosis by inhibiting PI3K/Akt/αIIbβ3-mediated platelet activation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Mar; 125(?):155276. doi: 10.1016/j.phymed.2023.155276. [PMID: 38295661]
  • Guiping Ma, Qinqin Dong, Feng Li, Zheng Jin, Jianbin Pi, Wei Wu, Junlong Li. Network pharmacology and in vivo evidence of the pharmacological mechanism of geniposide in the treatment of atherosclerosis. BMC complementary medicine and therapies. 2024 Jan; 24(1):53. doi: 10.1186/s12906-024-04356-x. [PMID: 38267978]
  • Huahua Li, Ziwei Peng, Yang Song, Minhang Dou, Xinying Lu, Minghui Li, Xiaofeng Zhai, Yan Gu, Rexidanmu Mamujiang, Shouying Du, Jie Bai. Study of the permeation-promoting effect and mechanism of solid microneedles on different properties of drugs. Drug delivery. 2023 Dec; 30(1):2165737. doi: 10.1080/10717544.2023.2165737. [PMID: 36644816]
  • Meijuan Yi, Opeyemi B Fasina, Yajing Li, Lan Xiang, Jianhua Qi. Mixture of Peanut Skin Extract, Geniposide, and Isoquercitrin Improves the Hepatic Lipid Accumulation of Mice via Modification of Gut Microbiota Homeostasis and the TLR4 and AMPK Signaling Pathways. International journal of molecular sciences. 2023 Nov; 24(23):. doi: 10.3390/ijms242316684. [PMID: 38069009]
  • Jin-Chao Xiao, Ling Wang, Li Zhang, Ming-Yan Chi, Yong Huang, Zi-Peng Gong, Lin Zheng, Feng He. [Determination of plasma protein binding rate of Shuganning Injection using equilibrium dialysis and UPLC-MS/MS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Nov; 48(22):6183-6190. doi: 10.19540/j.cnki.cjcmm.20230618.204. [PMID: 38114225]
  • Yuxin Gan, Chenyu Wang, Chenfeng Xu, Pingping Zhang, Shutong Chen, Lei Tang, Junbing Zhang, Huahao Zhang, Shenhua Jiang. Simultaneous extraction of crocin and geniposide from gardenia fruits (Gardenia jasminoides Ellis) by probe-type ultrasound-assisted natural deep eutectic solvents and their inhibition effects on low density lipoprotein oxidation. Ultrasonics sonochemistry. 2023 Oct; 101(?):106658. doi: 10.1016/j.ultsonch.2023.106658. [PMID: 37913593]
  • Dewen Zhang, Jian He, Xian Ding, Rui Wang, Wei Chen. Geniposide improves CLP-induced sepsis model prognosis by upregulating PPARγ to modulate monocyte phenotype and cytokine network. Shock (Augusta, Ga.). 2023 Oct; ?(?):. doi: 10.1097/shk.0000000000002239. [PMID: 37878499]
  • Jinhan Wu, Shiqi Mao, Xiang Wu, Yi Zhao, Weijun Zhang, Feng Zhu. Jasminoidin reduces ischemic stroke injury by regulating microglia polarization via PASK-EEF1A1 axis. Chemical biology & drug design. 2023 Sep; ?(?):. doi: 10.1111/cbdd.14354. [PMID: 37743322]
  • Xuan Zhang, Xiangyi Su, Xiaoyue Yu, Xinyue Zhang, Xuelin Guo, Guige Hou, Chunhua Wang, Hongjuan Li. Preparative separation of iridoid glucosides and crocins from Gardeniae Fructus using sequential macroporous resin column chromatography and evaluation of their anti-inflammatory and antioxidant activities. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2023 Sep; 1229(?):123887. doi: 10.1016/j.jchromb.2023.123887. [PMID: 37714051]
  • Xinyu Zeng, Jiajie Jiang, Simiao Liu, Qichao Hu, Sihan Hu, Jinhao Zeng, Xiao Ma, Xiaomei Zhang. Bidirectional effects of geniposide in liver injury: Preclinical evidence construction based on meta-analysis. Journal of ethnopharmacology. 2023 Aug; ?(?):117061. doi: 10.1016/j.jep.2023.117061. [PMID: 37598771]
  • Qian Zhou, Bin Chen, Yijiao Xu, Yue Wang, Ziheng He, Xueting Cai, Yu Qin, Juan Ye, Yang Yang, Jianping Shen, Peng Cao. Geniposide protects against neurotoxicity in mouse models of rotenone-induced Parkinson's disease involving the mTOR and Nrf2 pathways. Journal of ethnopharmacology. 2023 Jul; ?(?):116914. doi: 10.1016/j.jep.2023.116914. [PMID: 37451492]
  • Xinyu Xu, Bihua Chen, Juan Zhang, Siren Lan, Shasha Wu, Weiwei Xie. Transcriptome and metabolome analysis revealed the changes of Geniposide and Crocin content in Gardenia jasminoides fruit. Molecular biology reports. 2023 Jul; ?(?):. doi: 10.1007/s11033-023-08613-z. [PMID: 37392282]
  • Baitao Li, Yu Zhao, Xiaomao Zhou, Cheng Peng, Xiaotong Yan, Tianyu Zou. Geniposide improves depression by promoting the expression of synapse-related proteins through the Creb1/Six3os1 axis. Gene. 2023 Jun; ?(?):147564. doi: 10.1016/j.gene.2023.147564. [PMID: 37311497]
  • Yajuan Bi, Yanchao Xing, Chunshan Gui, Yiqing Tian, Mingzhe Zhang, Yao Yao, Ge Hu, Lifeng Han, Feng He, Youcai Zhang. Potential Involvement of Organic Anion Transporters in Drug Interactions with Shuganning Injection, a Traditional Chinese Patent Medicine. Planta medica. 2023 May; ?(?):. doi: 10.1055/a-2085-2367. [PMID: 37236232]
  • Xiaoju Zhuge, Xiaosheng Jin, Tingting Ji, Rongzhou Li, Liwei Xue, Weilai Yu, Zijiao Quan, Haibin Tong, Fang Xu. Geniposide ameliorates dextran sulfate sodium-induced ulcerative colitis via KEAP1-Nrf2 signaling pathway. Journal of ethnopharmacology. 2023 May; 314(?):116626. doi: 10.1016/j.jep.2023.116626. [PMID: 37187359]
  • Peikun He, Hao Wang, Saibo Cheng, Fang Hu, Lifang Zhang, Weicong Chen, Yuling Xu, Yaxin Zhang, Yuyan Gu, Zhaoyong Li, Yao Jin, Xiaoyu Liu, Yuhua Jia. Geniposide ameliorates atherosclerosis by regulating macrophage polarization via perivascular adipocyte-derived CXCL14. Journal of ethnopharmacology. 2023 May; ?(?):116532. doi: 10.1016/j.jep.2023.116532. [PMID: 37149071]
  • Zhuorui Shan, Junfeng Jia, Qiuju Wang, Yizhe Cui. Network pharmacology-based analysis on geniposide, a component of gardenia jasminoides, beneficial effects to alleviate LPS-induced immune stress in piglets. International immunopharmacology. 2023 Feb; 117(?):109894. doi: 10.1016/j.intimp.2023.109894. [PMID: 36863144]
  • Huajie Tian, Yi Fang, Wei Liu, Jun Wang, Jianan Zhao, Hao Tang, Yixiao Yin, Yiyang Hu, Jinghua Peng. Inhibition on XBP1s-driven lipogenesis by Qushi Huayu Decoction contributes to amelioration of hepatic steatosis induced by fructose. Journal of ethnopharmacology. 2023 Jan; 301(?):115806. doi: 10.1016/j.jep.2022.115806. [PMID: 36216198]
  • Hong-Ying Chen, Peng-Fei Yao, Yan-Qi Han, Xu Xu, Jun Xu, Bi-Yan Pan, Dong-Sheng Ouyang, Tie-Jun Zhang. ["Component-target-efficacy" network analysis and experimental verification of Qingkailing Oral Preparation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Jan; 48(1):170-182. doi: 10.19540/j.cnki.cjcmm.20220920.401. [PMID: 36725269]
  • Yu Zhao, Qian Zhang, Yuzhu Yan, Xinbo Wang, Yin Shao, Cheng Mei, Tianyu Zou. Antidepressant-like effects of geniposide in chronic unpredictable mild stress-induced mice by regulating the circ_0008405/miR-25-3p/Gata2 and Oip5os1/miR-25-3p/Gata2 networks. Phytotherapy research : PTR. 2022 Dec; ?(?):. doi: 10.1002/ptr.7702. [PMID: 36515407]
  • Mu-Xuan Wang, Min-Min Wang, Chao Liu, Jia-Shu Chen, Jian-Shu Liu, Xu Guo, Meng-Qi Zhang, Jing Zhang, Jin-Yue Sun, Zhi-Xin Liao. A geniposide-phospholipid complex ameliorates posthyperuricemia chronic kidney disease induced by inflammatory reactions and oxidative stress. European journal of pharmacology. 2022 Sep; 930(?):175157. doi: 10.1016/j.ejphar.2022.175157. [PMID: 35870480]
  • Jia-Shu Chen, Mu-Xuan Wang, Min-Min Wang, Yu-Kai Zhang, Xu Guo, Ying-Ying Chen, Meng-Qi Zhang, Jin-Yue Sun, Yu-Fa Liu, Chao Liu. Synthesis and biological evaluation of geniposide derivatives as inhibitors of hyperuricemia, inflammatory and fibrosis. European journal of medicinal chemistry. 2022 Jul; 237(?):114379. doi: 10.1016/j.ejmech.2022.114379. [PMID: 35468514]
  • Jinshuang Wang, Qin Ye, Ningxiang Yu, Weiwei Huan, Jingliang Sun, Xiaohua Nie, Xianghe Meng. Preparation of multiresponsive hydrophilic molecularly imprinted microspheres for rapid separation of gardenia yellow and geniposide from gardenia fruit. Food chemistry. 2022 Apr; 374(?):131610. doi: 10.1016/j.foodchem.2021.131610. [PMID: 34823938]
  • Sheng-Jie Dai, Qiao-Yun Zhang, Qing Lan, Yong Chen, You-Zhi Zhang, Qi Huang. [PK2/PKR1 signaling pathway participates in geniposide protection against diabetic nephropathy in mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Mar; 47(6):1611-1617. doi: 10.19540/j.cnki.cjcmm.20211122.401. [PMID: 35347960]
  • Jing Leng, Hua-Jie Tian, Yi Fang, Yi-Yang Hu, Jing-Hua Peng. Amelioration of Non-Alcoholic Steatohepatitis by Atractylodes macrocephala Polysaccharide, Chlorogenic Acid, and Geniposide Combination Is Associated With Reducing Endotoxin Gut Leakage. Frontiers in cellular and infection microbiology. 2022; 12(?):827516. doi: 10.3389/fcimb.2022.827516. [PMID: 35865826]
  • Siting Gao, Qin Feng. The Beneficial Effects of Geniposide on Glucose and Lipid Metabolism: A Review. Drug design, development and therapy. 2022; 16(?):3365-3383. doi: 10.2147/dddt.s378976. [PMID: 36213380]
  • Jinxin Liu, Chunmei Song, Chenzhipeng Nie, Yujie Sun, Yu Wang, Lamei Xue, Mingcong Fan, Haifeng Qian, Li Wang, Yan Li. A novel regulatory mechanism of geniposide for improving glucose homeostasis mediated by circulating RBP4. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jan; 95(?):153862. doi: 10.1016/j.phymed.2021.153862. [PMID: 34856473]
  • Yizhou Zheng, Yaosheng Xiao, Di Zhang, Shanshan Zhang, Jing Ouyang, Linfu Li, Weimei Shi, Rui Zhang, Hai Liu, Qi Jin, Zhixi Chen, Daohua Xu, Longhuo Wu. Geniposide Ameliorated Dexamethasone-Induced Cholesterol Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis. Cells. 2021 12; 10(12):. doi: 10.3390/cells10123424. [PMID: 34943934]
  • Muxuan Wang, Jiashu Chen, Ruirui Zhang, Xinyan Guo, Daxia Chen, Xu Guo, Yingying Chen, Yuhao Wu, Jinyue Sun, Yufa Liu, Chao Liu. Design, synthesis and bioactive evaluation of geniposide derivatives for antihyperuricemic and nephroprotective effects. Bioorganic chemistry. 2021 11; 116(?):105321. doi: 10.1016/j.bioorg.2021.105321. [PMID: 34500305]
  • Xumin Zhang, Kai Liu, Mingyi Shi, Long Xie, Mao Deng, Huijuan Chen, Xiaofang Li. Therapeutic potential of catalpol and geniposide in Alzheimer's and Parkinson's diseases: A snapshot of their underlying mechanisms. Brain research bulletin. 2021 09; 174(?):281-295. doi: 10.1016/j.brainresbull.2021.06.020. [PMID: 34216649]
  • Jinyan Wan, Yu Long, Songyu Liu, Yulu Zhang, Yan Xiang, Dan Li, Ai Shi, Yu Shuang, Ying Li, Yanan He, Nan Li, Yongmei Guan. Geniposide-Loaded Liposomes for Brain Targeting: Development, Evaluation, and In Vivo Studies. AAPS PharmSciTech. 2021 Aug; 22(7):222. doi: 10.1208/s12249-021-02093-9. [PMID: 34409515]
  • Fengtao Li, Lijun Song, Jing Chen, Yu Chen, Yongjun Li, Meizi Huang, Wenchang Zhao. Effect of genipin-1-β-d-gentiobioside on diabetic nephropathy in mice by activating AMP-activated protein kinase/silencing information regulator-related enzyme 1/ nuclear factor-κB pathway. The Journal of pharmacy and pharmacology. 2021 Aug; 73(9):1201-1211. doi: 10.1093/jpp/rgab041. [PMID: 33792721]
  • HuiMin Li, Yan Wang, Bin Wang, Min Li, JiPing Liu, HongLian Yang, YongHeng Shi. Baicalin and Geniposide Inhibit Polarization and Inflammatory Injury of OGD/R-Treated Microglia by Suppressing the 5-LOX/LTB4 Pathway. Neurochemical research. 2021 Jul; 46(7):1844-1858. doi: 10.1007/s11064-021-03305-1. [PMID: 33891262]
  • Yusha Luo, Fangyuan Gao, Ruirui Chang, Xingjie Zhang, Jie Zhong, Jun Wen, Jianlin Wu, Tingting Zhou. Metabolomics based comprehensive investigation of Gardeniae Fructus induced hepatotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Jul; 153(?):112250. doi: 10.1016/j.fct.2021.112250. [PMID: 33964367]
  • Bo Zhang, Hong-Sheng Chang, Kai-Li Hu, Xue Yu, Li-Na Li, Xiang-Qing Xu. Combination of Geniposide and Eleutheroside B Exerts Antidepressant-like Effect on Lipopolysaccharide-Induced Depression Mice Model. Chinese journal of integrative medicine. 2021 Jul; 27(7):534-541. doi: 10.1007/s11655-019-3051-5. [PMID: 31784933]
  • Yang Wen, You-Wei Chen, Ai-Hong Meng, Ming Zhao, Song-Hua Fang, Yan-Qing Ma. Idiopathic mesenteric phlebosclerosis associated with long-term oral intake of geniposide. World journal of gastroenterology. 2021 Jun; 27(22):3097-3108. doi: 10.3748/wjg.v27.i22.3097. [PMID: 34168411]
  • Deng Ran, Wu Hong, Wang Yan, Wang Mengdie. Properties and molecular mechanisms underlying geniposide-mediated therapeutic effects in chronic inflammatory diseases. Journal of ethnopharmacology. 2021 Jun; 273(?):113958. doi: 10.1016/j.jep.2021.113958. [PMID: 33639206]
  • Menglin Zheng, Ke Li, Tong Chen, Shengnan Liu, Ling He. Geniposide protects depression through BTK/JAK2/STAT1 signaling pathway in lipopolysaccharide-induced depressive mice. Brain research bulletin. 2021 05; 170(?):65-73. doi: 10.1016/j.brainresbull.2021.02.008. [PMID: 33561536]
  • Theodomir Dusabimana, Eun Jung Park, Jihyun Je, Kyuho Jeong, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park. Geniposide Improves Diabetic Nephropathy by Enhancing ULK1-Mediated Autophagy and Reducing Oxidative Stress through AMPK Activation. International journal of molecular sciences. 2021 Feb; 22(4):. doi: 10.3390/ijms22041651. [PMID: 33562139]
  • Kena Lv, Jingjing Zhu, Shuangshuang Zheng, Zeren Jiao, Yi Nie, Fei Song, Tianqing Liu, Kedong Song. Evaluation of inhibitory effects of geniposide on a tumor model of human breast cancer based on 3D printed Cs/Gel hybrid scaffold. Materials science & engineering. C, Materials for biological applications. 2021 Feb; 119(?):111509. doi: 10.1016/j.msec.2020.111509. [PMID: 33321605]
  • Xin Xin, Yue Jin, Xin Wang, Beiyu Cai, Ziming An, Yi-Yang Hu, Qin Feng. A Combination of Geniposide and Chlorogenic Acid Combination Ameliorates Nonalcoholic Steatohepatitis in Mice by Inhibiting Kupffer Cell Activation. BioMed research international. 2021; 2021(?):6615881. doi: 10.1155/2021/6615881. [PMID: 34095305]
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