Ryanodine (BioDeep_00000000608)

   

PANOMIX_OTCML-2023


代谢物信息卡片


1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,6aS,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo(1,2)pentaleno(1,6-bc)furan-8-yl ester

化学式: C25H35NO9 (493.23117)
中文名称: 鱼尼汀
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 3.92%

Reviewed

Last reviewed on 2024-08-14.

Cite this Page

Ryanodine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/ryanodine (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000000608). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC1CCC2(C3(CC4(C5(C(C(C3(C5(C2(C1O)O4)O)O)OC(=O)C6=CC=CN6)(C(C)C)O)C)O)C)O
InChI: InChI=1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3/t13-,15+,17+,18-,19+,20-,21-,22+,23+,24+,25+/m0/s1

描述信息

An insecticide alkaloid isolated from South American plant Ryania speciosa.
Ryania is a natural product found in Ryania speciosa and Spigelia anthelmia with data available.
Ryanodine is a poisonous alkaloid found in the South American plant Ryania speciosa (Flacourtiaceae). It was originally used as an insecticide. The compound has extremely high affinity to the open-form ryanodine receptor, a group of calcium channels found in skeletal muscle, smooth muscle, and heart muscle cells. It binds with such high affinity to the receptor that it was used as a label for the first purification of that class of ion channels and gave its name to it.
A methylpyrrole-carboxylate from RYANIA that disrupts the RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL to modify CALCIUM release from SARCOPLASMIC RETICULUM resulting in alteration of MUSCLE CONTRACTION. It was previously used in INSECTICIDES. It is used experimentally in conjunction with THAPSIGARGIN and other inhibitors of CALCIUM ATPASE uptake of calcium into SARCOPLASMIC RETICULUM.

同义名列表

17 个代谢物同义名

Ryanodine; 1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,6aS,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo(1,2)pentaleno(1,6-bc)furan-8-yl ester; 6-(1alpha,5Abeta,8abeta,9-pentahydroxy-7beta-isopropyl-2beta,5beta,8beta-trimethylperhydro-8balpha,9-epoxy-5,8-ethanocyclopenta(1,2-b)indenyl) pyrrole-2-carboxylate; Ground ryania specisa(vahl) stemwood (alkoloid ryanodine); Ryania speciosa, powdered stems of; Ryanodine, >=98\\% (HPLC); UNII-37H6ATE4SA; RYANODINE [MI]; Bonide ryatox; (+)-RYANODINE; Ryania powder; Ryania [ISO]; 37H6ATE4SA; Ryanicide; Ryanexel; Ryanex; Ryania



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiaoyu Hua, Jinchi Yao, Xinyan Liu, Qing Liu, Yuchen Deng, Songhua Li, Carmen R Valdivia, Fei Wang, Marina Pozzolini, Zhaoyong Shou, Héctor H Valdivia, Liang Xiao. Comparison of the structure-function of five newly members of the calcin family. International journal of biological macromolecules. 2024 Jan; 260(Pt 1):129424. doi: 10.1016/j.ijbiomac.2024.129424. [PMID: 38219929]
  • Kafa Walweel, Nicole Beard, Dirk F van Helden, Derek R Laver. Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6. The Journal of general physiology. 2023 08; 155(8):. doi: 10.1085/jgp.202213277. [PMID: 37279522]
  • Samantha C Salvage, Christopher L-H Huang, James A Fraser, Angela F Dulhunty. How does flecainide impact RyR2 channel function?. The Journal of general physiology. 2022 09; 154(9):. doi: 10.1085/jgp.202213089. [PMID: 35713932]
  • Zhuang Zhang, Kaixin Li, Wei Xu, Ni Liang, Dong Chu, Lei Guo. Characterization of the ryanodine receptor gene in Encarsia formosa (Gahan) and its expression profile in response to diamide insecticides. Pesticide biochemistry and physiology. 2021 Oct; 178(?):104921. doi: 10.1016/j.pestbp.2021.104921. [PMID: 34446197]
  • Xiaowei Zhong, Wenting Guo, Jinhong Wei, Yijun Tang, Yingjie Liu, Joe Z Zhang, Vern Hsen Tan, Lin Zhang, Ruiwu Wang, Peter P Jones, Carlo Napolitano, Silvia G Priori, S R Wayne Chen. Identification of loss-of-function RyR2 mutations associated with idiopathic ventricular fibrillation and sudden death. Bioscience reports. 2021 04; 41(4):. doi: 10.1042/bsr20210209. [PMID: 33825858]
  • Shujie Ma, Ting Ma, Meiru Ren, Hai Li, Zhiqing Ma. Insecticidal action of the botanical insecticide wilforine on Mythimna separata (Walker) related with the changes of ryanodine receptor expression. Ecotoxicology and environmental safety. 2021 Apr; 213(?):112025. doi: 10.1016/j.ecoenv.2021.112025. [PMID: 33578098]
  • Fadhel A Alomar, Chengju Tian, Prasanta K Dash, JoEllyn M McMillan, Howard E Gendelman, Santhi Gorantla, Keshore R Bidasee. Efavirenz, atazanavir, and ritonavir disrupt sarcoplasmic reticulum Ca2+ homeostasis in skeletal muscles. Antiviral research. 2021 03; 187(?):104975. doi: 10.1016/j.antiviral.2020.104975. [PMID: 33450312]
  • Ru Jia, Shingo Oda, Tsuyoshi Yokoi. Pharmacological evidence for the involvement of ryanodine receptors in halothane-induced liver injury in mice. Toxicology. 2020 10; 443(?):152560. doi: 10.1016/j.tox.2020.152560. [PMID: 32795494]
  • Zhiqiang Sun, Hui Xu. Ryanodine Receptors for Drugs and Insecticides: An Overview. Mini reviews in medicinal chemistry. 2019; 19(1):22-33. doi: 10.2174/1389557518666180330112908. [PMID: 29600763]
  • Jorge Reyes-García, Edgar Flores-Soto, Abril Carbajal-García, Bettina Sommer, Luis M Montaño. Maintenance of intracellular Ca2+ basal concentration in airway smooth muscle (Review). International journal of molecular medicine. 2018 Dec; 42(6):2998-3008. doi: 10.3892/ijmm.2018.3910. [PMID: 30280184]
  • Christin Schneider, Lisa Gebhardt, Stephanie Arndt, Sigrid Karrer, Julia L Zimmermann, Michael J M Fischer, Anja-Katrin Bosserhoff. Cold atmospheric plasma causes a calcium influx in melanoma cells triggering CAP-induced senescence. Scientific reports. 2018 07; 8(1):10048. doi: 10.1038/s41598-018-28443-5. [PMID: 29968804]
  • Guo-Rui Yuan, Ke-Yi Wang, Xing Mou, Ruo-Yu Luo, Wei Dou, Jin-Jun Wang. Molecular cloning, mRNA expression and alternative splicing of a ryanodine receptor gene from the citrus whitefly, Dialeurodes citri (Ashmead). Pesticide biochemistry and physiology. 2017 Oct; 142(?):59-66. doi: 10.1016/j.pestbp.2017.01.005. [PMID: 29107248]
  • David D Mowrey, Le Xu, Yingwu Mei, Daniel A Pasek, Gerhard Meissner, Nikolay V Dokholyan. Ion-pulling simulations provide insights into the mechanisms of channel opening of the skeletal muscle ryanodine receptor. The Journal of biological chemistry. 2017 08; 292(31):12947-12958. doi: 10.1074/jbc.m116.760199. [PMID: 28584051]
  • Luiz F Ferrari, Dionéia Araldi, Jon D Levine. Regulation of Expression of Hyperalgesic Priming by Estrogen Receptor α in the Rat. The journal of pain. 2017 05; 18(5):574-582. doi: 10.1016/j.jpain.2016.12.017. [PMID: 28089711]
  • Xiaoyu Pan, Jiechun Chen, Weijie Wang, Ling Chen, Lin Wang, Quan Ma, Jianbo Zhang, Lichao Chen, Gang Wang, Meixi Zhang, Hao Wu, Ruochuan Cheng. Resveratrol-induced antinociception is involved in calcium channels and calcium/caffeine-sensitive pools. Oncotarget. 2017 Feb; 8(6):9399-9409. doi: 10.18632/oncotarget.14090. [PMID: 28030799]
  • Kengo Masuda, Masanori Nagatomo, Masayuki Inoue. Chemical Conversion of Ryanodol to Ryanodine. Chemical & pharmaceutical bulletin. 2016 Jul; 64(7):874-9. doi: 10.1248/cpb.c16-00214. [PMID: 27010543]
  • Saumitra Pitake, Raymond S Ochs. Membrane depolarization increases ryanodine sensitivity to Ca2+ release to the cytosol in L6 skeletal muscle cells: Implications for excitation-contraction coupling. Experimental biology and medicine (Maywood, N.J.). 2016 04; 241(8):854-62. doi: 10.1177/1535370215619706. [PMID: 26643865]
  • Saša M Trailović, Darko Marinković, Jelena Nedeljković Trailović, Mirjana Milovanović, Djordje S Marjanović, Milan R Aničić. Pharmacological and morphological characteristics of the muscular system of the giant liver fluke (Fascioloides magna - Bassi 1875). Experimental parasitology. 2015 Dec; 159(?):136-42. doi: 10.1016/j.exppara.2015.09.012. [PMID: 26429130]
  • Pedro Segura-Chama, Patricia López-Bistrain, Elia Martha Pérez-Armendáriz, Nicolás Jiménez-Pérez, Diana Millán-Aldaco, Arturo Hernández-Cruz. Enhanced Ca(2+)-induced Ca(2+) release from intracellular stores contributes to catecholamine hypersecretion in adrenal chromaffin cells from spontaneously hypertensive rats. Pflugers Archiv : European journal of physiology. 2015 Nov; 467(11):2307-23. doi: 10.1007/s00424-015-1702-8. [PMID: 25791627]
  • Mei Hong Zhu, Tae Sik Sung, Kate O'Driscoll, Sang Don Koh, Kenton M Sanders. Intracellular Ca(2+) release from endoplasmic reticulum regulates slow wave currents and pacemaker activity of interstitial cells of Cajal. American journal of physiology. Cell physiology. 2015 Apr; 308(8):C608-20. doi: 10.1152/ajpcell.00360.2014. [PMID: 25631870]
  • Tatiana Adasme, Andrea Paula-Lima, Cecilia Hidalgo. Inhibitory ryanodine prevents ryanodine receptor-mediated Ca²⁺ release without affecting endoplasmic reticulum Ca²⁺ content in primary hippocampal neurons. Biochemical and biophysical research communications. 2015 Feb; 458(1):57-62. doi: 10.1016/j.bbrc.2015.01.065. [PMID: 25623539]
  • Vicente Lumbreras, Esperanza Bas, Chhavi Gupta, Suhrud M Rajguru. Pulsed infrared radiation excites cultured neonatal spiral and vestibular ganglion neurons by modulating mitochondrial calcium cycling. Journal of neurophysiology. 2014 Sep; 112(6):1246-55. doi: 10.1152/jn.00253.2014. [PMID: 24920028]
  • Saptarshi Mukherjee, N Lowri Thomas, Alan J Williams. Insights into the gating mechanism of the ryanodine-modified human cardiac Ca2+-release channel (ryanodine receptor 2). Molecular pharmacology. 2014 Sep; 86(3):318-29. doi: 10.1124/mol.114.093757. [PMID: 25002270]
  • Guillaume Gilbert, Thomas Ducret, Roger Marthan, Jean-Pierre Savineau, Jean-François Quignard. Stretch-induced Ca2+ signalling in vascular smooth muscle cells depends on Ca2+ store segregation. Cardiovascular research. 2014 Jul; 103(2):313-23. doi: 10.1093/cvr/cvu069. [PMID: 24692174]
  • Pura Bolaños, Alis Guillen, Adriana Gámez, Carlo Caputo. Quantifying SOCE fluorescence measurements in mammalian muscle fibres. The effects of ryanodine and osmotic shocks. Journal of muscle research and cell motility. 2013 Dec; 34(5-6):379-93. doi: 10.1007/s10974-013-9360-y. [PMID: 24129906]
  • Michel Ronjat, José Pablo Finkelstein, Paola Llanos, Luis Montecinos, Hicham Bichraoui, Michel De Waard, Cecilia Hidalgo, Ricardo Bull. Redox-sensitive stimulation of type-1 ryanodine receptors by the scorpion toxin maurocalcine. Cell calcium. 2013 May; 53(5-6):357-65. doi: 10.1016/j.ceca.2013.03.004. [PMID: 23623374]
  • R A Bannister. Dantrolene-induced inhibition of skeletal L-type Ca2+ current requires RyR1 expression. BioMed research international. 2013; 2013(?):390493. doi: 10.1155/2013/390493. [PMID: 23509717]
  • Yingwu Mei, Le Xu, Henning F Kramer, Ginger H Tomberlin, Claire Townsend, Gerhard Meissner. Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107. PloS one. 2013; 8(1):e54208. doi: 10.1371/journal.pone.0054208. [PMID: 23349825]
  • Lina Sun, Li Cui, Changhui Rui, Xiaojing Yan, Daibin Yang, Huizhu Yuan. Modulation of the expression of ryanodine receptor mRNA from Plutella xylostella as a result of diamide insecticide application. Gene. 2012 Dec; 511(2):265-73. doi: 10.1016/j.gene.2012.09.027. [PMID: 23010195]
  • Scott R Hadley, Quintin Blood, Monica Rubalcava, Edith Waskel, Britney Lumbard, Petersen Le, Lawrence D Longo, John N Buchholz, Sean M Wilson. Maternal high-altitude hypoxia and suppression of ryanodine receptor-mediated Ca2+ sparks in fetal sheep pulmonary arterial myocytes. American journal of physiology. Lung cellular and molecular physiology. 2012 Nov; 303(9):L799-813. doi: 10.1152/ajplung.00009.2012. [PMID: 22962012]
  • Bo Zeng, Gui-Lan Chen, Shang-Zhong Xu. Store-independent pathways for cytosolic STIM1 clustering in the regulation of store-operated Ca(2+) influx. Biochemical pharmacology. 2012 Oct; 84(8):1024-35. doi: 10.1016/j.bcp.2012.07.013. [PMID: 22842488]
  • Hisao Yamamura, Yuji Imaizumi. Total internal reflection fluorescence imaging of Ca(2+)-induced Ca(2+) release in mouse urinary bladder smooth muscle cells. Biochemical and biophysical research communications. 2012 Oct; 427(1):54-9. doi: 10.1016/j.bbrc.2012.08.145. [PMID: 22975345]
  • Maura Porta, Paula L Diaz-Sylvester, Jake T Neumann, Ariel L Escobar, Sidney Fleischer, Julio A Copello. Coupled gating of skeletal muscle ryanodine receptors is modulated by Ca2+, Mg2+, and ATP. American journal of physiology. Cell physiology. 2012 Sep; 303(6):C682-97. doi: 10.1152/ajpcell.00150.2012. [PMID: 22785120]
  • Antoni Wrzosek, Zuzana Tomaskova, Karol Ondrias, Agnieszka Lukasiak, Adam Szewczyk. The potassium channel opener CGS7184 activates Ca²⁺ release from the endoplasmic reticulum. European journal of pharmacology. 2012 Sep; 690(1-3):60-7. doi: 10.1016/j.ejphar.2012.06.029. [PMID: 22760070]
  • O Iu Velykopols'ka, B O Man'ko, V V Man'ko. [Endoplasmic-mitochondrial Ca(2+)-functional unit: dependence of respiration of secretory cells on activity of ryanodine- and IP3 - sensitive Ca(2+)-channels]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). 2012 Sep; 84(5):76-88. doi: . [PMID: 23342638]
  • Roozbeh Aschar-Sobbi, Teresa L Emmett, Gary J Kargacin, Margaret E Kargacin. Phospholamban phosphorylation increases the passive calcium leak from cardiac sarcoplasmic reticulum. Pflugers Archiv : European journal of physiology. 2012 Sep; 464(3):295-305. doi: 10.1007/s00424-012-1124-9. [PMID: 22772476]
  • K J Grim, A J Abcejo, A Barnes, V Sathish, D F Smelter, G C Ford, M A Thompson, Y S Prakash, C M Pabelick. Caveolae and propofol effects on airway smooth muscle. British journal of anaesthesia. 2012 Sep; 109(3):444-53. doi: 10.1093/bja/aes130. [PMID: 22542538]
  • Tomihiro Imai, Emiko Tsuda, Takayoshi Hozuki, Rika Yamauchi, Masaki Saitoh, Shin Hisahara, Hiroaki Yoshikawa, Masakatsu Motomura, Jun Kawamata, Shun Shimohama. Early effect of tacrolimus in improving excitation-contraction coupling in myasthenia gravis. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2012 Sep; 123(9):1886-90. doi: 10.1016/j.clinph.2012.01.017. [PMID: 22386321]
  • Chun Hong Shao, Chengju Tian, Shouqiang Ouyang, Caronda J Moore, Fadhel Alomar, Ina Nemet, Alicia D'Souza, Ryoji Nagai, Shelby Kutty, George J Rozanski, Sasanka Ramanadham, Jaipaul Singh, Keshore R Bidasee. Carbonylation induces heterogeneity in cardiac ryanodine receptor function in diabetes mellitus. Molecular pharmacology. 2012 Sep; 82(3):383-99. doi: 10.1124/mol.112.078352. [PMID: 22648972]
  • R O Bates, M E Doumit, N E Raney, E E Helman, C W Ernst. Association of halothane sensitivity with growth and meat quality in pigs. Animal : an international journal of animal bioscience. 2012 Sep; 6(9):1537-42. doi: 10.1017/s1751731112000134. [PMID: 23031527]
  • Alberto González, María de los Angeles Cabrera, Macarena Mellado, Susana Cabello, Seabastián Márquez, Bernardo Morales, Alejandra Moenne. Copper-induced intracellular calcium release requires extracellular calcium entry and activation of L-type voltage-dependent calcium channels in Ulva compressa. Plant signaling & behavior. 2012 Jul; 7(7):728-32. doi: 10.4161/psb.20355. [PMID: 22751323]
  • Nina D Ullrich, Héctor H Valdivia, Ernst Niggli. PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca2+ sensitivity. Journal of molecular and cellular cardiology. 2012 Jul; 53(1):33-42. doi: 10.1016/j.yjmcc.2012.03.015. [PMID: 22487381]
  • Elodie Vandenhaute, Maxime Culot, Fabien Gosselet, Lucie Dehouck, Catherine Godfraind, Michel Franck, Jean Plouët, Roméo Cecchelli, Marie-Pierre Dehouck, Marie-Magdeleine Ruchoux. Brain pericytes from stress-susceptible pigs increase blood-brain barrier permeability in vitro. Fluids and barriers of the CNS. 2012 Jun; 9(1):11. doi: 10.1186/2045-8118-9-11. [PMID: 22569151]
  • Dan J Nonneman, Tami Brown-Brandl, Shuna A Jones, Ralph T Wiedmann, Gary A Rohrer. A defect in dystrophin causes a novel porcine stress syndrome. BMC genomics. 2012 Jun; 13(?):233. doi: 10.1186/1471-2164-13-233. [PMID: 22691118]
  • Takashi Udagawa, Kazushige Hanaoka, Masahiro Kawamura, Tatsuo Hosoya. Characteristics of spontaneous calcium oscillations in renal tubular epithelial cells. Clinical and experimental nephrology. 2012 Jun; 16(3):389-98. doi: 10.1007/s10157-012-0588-4. [PMID: 22278600]
  • M Shirali, A Doeschl-Wilson, P W Knap, C Duthie, E Kanis, J A M van Arendonk, R Roehe. Nitrogen excretion at different stages of growth and its association with production traits in growing pigs. Journal of animal science. 2012 Jun; 90(6):1756-65. doi: 10.2527/jas.2011-4547. [PMID: 22178856]
  • H Plattner, I M Sehring, I K Mohamed, K Miranda, W De Souza, R Billington, A Genazzani, E-M Ladenburger. Calcium signaling in closely related protozoan groups (Alveolata): non-parasitic ciliates (Paramecium, Tetrahymena) vs. parasitic Apicomplexa (Plasmodium, Toxoplasma). Cell calcium. 2012 May; 51(5):351-82. doi: 10.1016/j.ceca.2012.01.006. [PMID: 22387010]
  • Niels Voigt, Na Li, Qiongling Wang, Wei Wang, Andrew W Trafford, Issam Abu-Taha, Qiang Sun, Thomas Wieland, Ursula Ravens, Stanley Nattel, Xander H T Wehrens, Dobromir Dobrev. Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation. 2012 May; 125(17):2059-70. doi: 10.1161/circulationaha.111.067306. [PMID: 22456474]
  • Allen E Silverstone, Paula F Rosenbaum, Ruth S Weinstock, Scott M Bartell, Herman R Foushee, Christie Shelton, Marian Pavuk. Polychlorinated biphenyl (PCB) exposure and diabetes: results from the Anniston Community Health Survey. Environmental health perspectives. 2012 May; 120(5):727-32. doi: 10.1289/ehp.1104247. [PMID: 22334129]
  • Nicole Hansmeier, Tzu-Chiao Chao, Lynn R Goldman, Frank R Witter, Rolf U Halden. Prioritization of biomarker targets in human umbilical cord blood: identification of proteins in infant blood serving as validated biomarkers in adults. Environmental health perspectives. 2012 May; 120(5):764-9. doi: 10.1289/ehp.1104190. [PMID: 22538116]
  • Colin W Taylor, Philippa Dale. Intracellular Ca(2+) channels - a growing community. Molecular and cellular endocrinology. 2012 Apr; 353(1-2):21-8. doi: 10.1016/j.mce.2011.08.028. [PMID: 21889573]
  • Wei-Hua Jiang, Wei-Ping Lu, Wen-Chao Guo, Zhen-Han Xia, Wen-Jun Fu, Guo-Qing Li. Chlorantraniliprole susceptibility in Leptinotarsa decemlineata in the north Xinjiang Uygur autonomous region in China. Journal of economic entomology. 2012 Apr; 105(2):549-54. doi: 10.1603/ec11194. [PMID: 22606826]
  • Matthew T Conner, Alex C Conner, Charlotte E Bland, Luke H J Taylor, James E P Brown, H Rheinallt Parri, Roslyn M Bill. Rapid aquaporin translocation regulates cellular water flow: mechanism of hypotonicity-induced subcellular localization of aquaporin 1 water channel. The Journal of biological chemistry. 2012 Mar; 287(14):11516-25. doi: 10.1074/jbc.m111.329219. [PMID: 22334691]
  • Yijun Tang, Xixi Tian, Ruiwu Wang, Michael Fill, S R Wayne Chen. Abnormal termination of Ca2+ release is a common defect of RyR2 mutations associated with cardiomyopathies. Circulation research. 2012 Mar; 110(7):968-77. doi: 10.1161/circresaha.111.256560. [PMID: 22374134]
  • Robert Zorec, Alfonso Araque, Giorgio Carmignoto, Philip G Haydon, Alexei Verkhratsky, Vladimir Parpura. Astroglial excitability and gliotransmission: an appraisal of Ca2+ as a signalling route. ASN neuro. 2012 Mar; 4(2):. doi: 10.1042/an20110061. [PMID: 22313347]
  • Lourdes Figueroa, Vyacheslav M Shkryl, Jingsong Zhou, Carlo Manno, Atsuya Momotake, Gustavo Brum, Lothar A Blatter, Graham C R Ellis-Davies, Eduardo Ríos. Synthetic localized calcium transients directly probe signalling mechanisms in skeletal muscle. The Journal of physiology. 2012 Mar; 590(6):1389-411. doi: 10.1113/jphysiol.2011.225854. [PMID: 22310315]
  • Alberto González, M de Los Ángeles Cabrera, M Josefa Henríquez, Rodrigo A Contreras, Bernardo Morales, Alejandra Moenne. Cross talk among calcium, hydrogen peroxide, and nitric oxide and activation of gene expression involving calmodulins and calcium-dependent protein kinases in Ulva compressa exposed to copper excess. Plant physiology. 2012 Mar; 158(3):1451-62. doi: 10.1104/pp.111.191759. [PMID: 22234999]
  • Patrik Rorsman, Matthias Braun, Quan Zhang. Regulation of calcium in pancreatic α- and β-cells in health and disease. Cell calcium. 2012 Mar; 51(3-4):300-8. doi: 10.1016/j.ceca.2011.11.006. [PMID: 22177710]
  • Shreesh Kumar Ojha, Saurabh Bharti, Sujata Joshi, Santosh Kumari, Dharamvir Singh Arya. Protective effect of hydroalcoholic extract of Andrographis paniculata on ischaemia-reperfusion induced myocardial injury in rats. The Indian journal of medical research. 2012 Mar; 135(?):414-21. doi: . [PMID: 22561631]
  • Reno C Reyes, Alexei Verkhratsky, Vladimir Parpura. Plasmalemmal Na+/Ca2+ exchanger modulates Ca2+-dependent exocytotic release of glutamate from rat cortical astrocytes. ASN neuro. 2012 Jan; 4(1):. doi: 10.1042/an20110059. [PMID: 22268447]
  • William G Pierce, Christopher Zanette, Noel M Caplice, John J Mackrill. Calcium signalling in adult endothelial outgrowth cells. Biochemical and biophysical research communications. 2012 Jan; 417(1):358-63. doi: 10.1016/j.bbrc.2011.11.115. [PMID: 22155247]
  • Panjamaporn Sangwung, Todd M Greco, Yanzhuang Wang, Harry Ischiropoulos, William C Sessa, Yasuko Iwakiri. Proteomic identification of S-nitrosylated Golgi proteins: new insights into endothelial cell regulation by eNOS-derived NO. PloS one. 2012; 7(2):e31564. doi: 10.1371/journal.pone.0031564. [PMID: 22363674]
  • Rüdiger Thul, Stephen Coombes, Martin D Bootman. Persistence of pro-arrhythmic spatio-temporal calcium patterns in atrial myocytes: a computational study of ping waves. Frontiers in physiology. 2012; 3(?):279. doi: 10.3389/fphys.2012.00279. [PMID: 22934033]
  • Ramón Rodrigo. Prevention of postoperative atrial fibrillation: novel and safe strategy based on the modulation of the antioxidant system. Frontiers in physiology. 2012; 3(?):93. doi: 10.3389/fphys.2012.00093. [PMID: 22518106]
  • Elena Galfré, Samantha J Pitt, Elisa Venturi, Mano Sitsapesan, Nathan R Zaccai, Krasimira Tsaneva-Atanasova, Stephen O'Neill, Rebecca Sitsapesan. FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6. PloS one. 2012; 7(2):e31956. doi: 10.1371/journal.pone.0031956. [PMID: 22363773]
  • Antony Galione, Kai-Ting Chuang. Pyridine nucleotide metabolites and calcium release from intracellular stores. Advances in experimental medicine and biology. 2012; 740(?):305-23. doi: 10.1007/978-94-007-2888-2_13. [PMID: 22453948]
  • Johanna T Lanner. Ryanodine receptor physiology and its role in disease. Advances in experimental medicine and biology. 2012; 740(?):217-34. doi: 10.1007/978-94-007-2888-2_9. [PMID: 22453944]
  • Jianjun Wang, Yanqing Li, Zhaojun Han, Youli Zhu, Zhijuan Xie, Jian Wang, Yaping Liu, Xianchun Li. Molecular characterization of a ryanodine receptor gene in the rice leaffolder, Cnaphalocrocis medinalis (Guenée). PloS one. 2012; 7(5):e36623. doi: 10.1371/journal.pone.0036623. [PMID: 22567170]
  • David Križaj. Calcium stores in vertebrate photoreceptors. Advances in experimental medicine and biology. 2012; 740(?):873-89. doi: 10.1007/978-94-007-2888-2_39. [PMID: 22453974]
  • Emeline Van Goethem, Elizabeth A Silva, Hui Xiao, Nathalie C Franc. The Drosophila TRPP cation channel, PKD2 and Dmel/Ced-12 act in genetically distinct pathways during apoptotic cell clearance. PloS one. 2012; 7(2):e31488. doi: 10.1371/journal.pone.0031488. [PMID: 22347485]
  • Cedric Viero, N Lowri Thomas, Joanne Euden, Sammy A Mason, Christopher H George, Alan J Williams. Techniques and methodologies to study the ryanodine receptor at the molecular, subcellular and cellular level. Advances in experimental medicine and biology. 2012; 740(?):183-215. doi: 10.1007/978-94-007-2888-2_8. [PMID: 22453943]
  • Catherine Leclerc, Isabelle Néant, Marc Moreau. The calcium: an early signal that initiates the formation of the nervous system during embryogenesis. Frontiers in molecular neuroscience. 2012; 5(?):3. doi: 10.3389/fnmol.2012.00064. [PMID: 22593733]
  • Agnieszka Korga, Jaroslaw Dudka, Franciszek Burdan, Justyna Sliwinska, Slawomir Mandziuk, Katarzyna Dawidek-Pietryka. The redox imbalance and the reduction of contractile protein content in rat hearts administered with L-thyroxine and Doxorubicin. Oxidative medicine and cellular longevity. 2012; 2012(?):681367. doi: 10.1155/2012/681367. [PMID: 22530076]
  • U Deniz Dincer. Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy?. Diabetes, metabolic syndrome and obesity : targets and therapy. 2012; 5(?):89-99. doi: 10.2147/dmso.s30005. [PMID: 22563249]
  • Shweta A Raina, Jeffrey Tsai, Montserrat Samsó, James D Fessenden. FRET-based localization of fluorescent protein insertions within the ryanodine receptor type 1. PloS one. 2012; 7(6):e38594. doi: 10.1371/journal.pone.0038594. [PMID: 22719904]
  • Elisa Mitiko Kawamoto, Carmen Vivar, Simonetta Camandola. Physiology and pathology of calcium signaling in the brain. Frontiers in pharmacology. 2012; 3(?):61. doi: 10.3389/fphar.2012.00061. [PMID: 22518105]
  • Justyna Sliwinska, Jaroslaw Dudka, Agnieszka Korga, Franciszek Burdan, Wlodzimierz Matysiak, Barbara Jodlowska-Jedrych, Slawomir Mandziuk, Katarzyna Dawidek-Pietryka. Tirapazamine-doxorubicin interaction referring to heart oxidative stress and Ca²⁺ balance protein levels. Oxidative medicine and cellular longevity. 2012; 2012(?):890826. doi: 10.1155/2012/890826. [PMID: 22666522]
  • Kandaswamy Selvakumar, Senthamilselvan Bavithra, Gunasekaran Krishnamoorthy, Prabhu Venkataraman, Jagadeesan Arunakaran. Polychlorinated biphenyls-induced oxidative stress on rat hippocampus: a neuroprotective role of quercetin. TheScientificWorldJournal. 2012; 2012(?):980314. doi: 10.1100/2012/980314. [PMID: 22272182]
  • Sung Young Kim, Sang Chul Park. Physiological antioxidative network of the bilirubin system in aging and age-related diseases. Frontiers in pharmacology. 2012; 3(?):45. doi: 10.3389/fphar.2012.00045. [PMID: 22457648]
  • Lucia Golini, Christophe Chouabe, Christine Berthier, Vincenza Cusimano, Mara Fornaro, Robert Bonvallet, Luca Formoso, Emiliana Giacomello, Vincent Jacquemond, Vincenzo Sorrentino. Junctophilin 1 and 2 proteins interact with the L-type Ca2+ channel dihydropyridine receptors (DHPRs) in skeletal muscle. The Journal of biological chemistry. 2011 Dec; 286(51):43717-43725. doi: 10.1074/jbc.m111.292755. [PMID: 22020936]
  • Tamer M A Mohamed, Delvac Oceandy, Min Zi, Sukhpal Prehar, Nasser Alatwi, Yanwen Wang, Mohamed A Shaheen, Riham Abou-Leisa, Celine Schelcher, Zeinab Hegab, Florence Baudoin, Michael Emerson, Mamas Mamas, Giulietta Di Benedetto, Manuela Zaccolo, Ming Lei, Elizabeth J Cartwright, Ludwig Neyses. Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain. The Journal of biological chemistry. 2011 Dec; 286(48):41520-41529. doi: 10.1074/jbc.m111.290411. [PMID: 21965681]
  • Toshiaki Haraki, Toshimichi Yasuda, Keiko Mukaida, Takako Migita, Hiroshi Hamada, Masashi Kawamoto. Mutated p.4894 RyR1 function related to malignant hyperthermia and congenital neuromuscular disease with uniform type 1 fiber (CNMDU1). Anesthesia and analgesia. 2011 Dec; 113(6):1461-7. doi: 10.1213/ane.0b013e318232053e. [PMID: 21926372]
  • Simran Preet, Sanjay Bharati, Geeta Shukla, Ashwani Koul, Praveen Rishi. Evaluation of amoebicidal potential of Paneth cell cryptdin-2 against Entamoeba histolytica. PLoS neglected tropical diseases. 2011 Dec; 5(12):e1386. doi: 10.1371/journal.pntd.0001386. [PMID: 22206022]
  • Tiancai Lai, Jianya Su. Assessment of resistance risk in Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae) to chlorantraniliprole. Pest management science. 2011 Nov; 67(11):1468-72. doi: 10.1002/ps.2201. [PMID: 21594963]
  • Cristina Romei, Silvia Di Prisco, Maurizio Raiteri, Luca Raiteri. Glycine release provoked by disturbed Na⁺, Na⁺ and Ca²⁺ homeostasis in cerebellar nerve endings: roles of Ca²⁺ channels, Na⁺/Ca²⁺ exchangers and GlyT2 transporter reversal. Journal of neurochemistry. 2011 Oct; 119(1):50-63. doi: 10.1111/j.1471-4159.2011.07401.x. [PMID: 21790607]
  • Lu Gan, Wei Jiang, Yun-Fei Xiao, Lin Deng, Lun-Da Gu, Zhi-Yun Guo, Zhi-Chao Zhou, Dan Wu, Hong-Bo Xin. Disruption of CD38 gene enhances cardiac functions by elevating serum testosterone in the male null mice. Life sciences. 2011 Sep; 89(13-14):491-7. doi: 10.1016/j.lfs.2011.07.020. [PMID: 21840325]
  • Michael Y Song, Ayako Makino, Jason X-J Yuan. Role of reactive oxygen species and redox in regulating the function of transient receptor potential channels. Antioxidants & redox signaling. 2011 Sep; 15(6):1549-65. doi: 10.1089/ars.2010.3648. [PMID: 21126186]
  • Congying Chen, Huashui Ai, Jun Ren, Wanbo Li, Pinghua Li, Ruimin Qiao, Jing Ouyang, Ming Yang, Junwu Ma, Lusheng Huang. A global view of porcine transcriptome in three tissues from a full-sib pair with extreme phenotypes in growth and fat deposition by paired-end RNA sequencing. BMC genomics. 2011 Sep; 12(?):448. doi: 10.1186/1471-2164-12-448. [PMID: 21906321]
  • Amy D Hanna, Marie Janczura, Eric Cho, Angela F Dulhunty, Nicole A Beard. Multiple actions of the anthracycline daunorubicin on cardiac ryanodine receptors. Molecular pharmacology. 2011 Sep; 80(3):538-49. doi: 10.1124/mol.111.073478. [PMID: 21697274]
  • Derek R Laver, Dirk F van Helden. Three independent mechanisms contribute to tetracaine inhibition of cardiac calcium release channels. Journal of molecular and cellular cardiology. 2011 Sep; 51(3):357-69. doi: 10.1016/j.yjmcc.2011.05.009. [PMID: 21624373]
  • Jake T Neumann, Julio A Copello. Cross-reactivity of ryanodine receptors with plasma membrane ion channel modulators. Molecular pharmacology. 2011 Sep; 80(3):509-17. doi: 10.1124/mol.111.071167. [PMID: 21665944]
  • Grace E Stutzmann, Mark P Mattson. Endoplasmic reticulum Ca(2+) handling in excitable cells in health and disease. Pharmacological reviews. 2011 Sep; 63(3):700-27. doi: 10.1124/pr.110.003814. [PMID: 21737534]
  • Paola Pizzo, Valentina Lissandron, Paola Capitanio, Tullio Pozzan. Ca(2+) signalling in the Golgi apparatus. Cell calcium. 2011 Aug; 50(2):184-92. doi: 10.1016/j.ceca.2011.01.006. [PMID: 21316101]
  • JianYe Yuan, JiYan Zhou, ZhiBi Hu, Guang Ji, JianQun Xie, DaZheng Wu. The effects of jatrorrhizine on contractile responses of rat ileum. European journal of pharmacology. 2011 Aug; 663(1-3):74-9. doi: 10.1016/j.ejphar.2011.05.002. [PMID: 21596029]
  • Mihai Gheorghiade, Andrew P Ambrosy, Mara Ferrandi, Patrizia Ferrari. Combining SERCA2a activation and Na-K ATPase inhibition: a promising new approach to managing acute heart failure syndromes with low cardiac output. Discovery medicine. 2011 Aug; 12(63):141-51. doi: NULL. [PMID: 21878191]
  • Shi Pan, Shin-Young Ryu, Shey-Shing Sheu. Distinctive characteristics and functions of multiple mitochondrial Ca2+ influx mechanisms. Science China. Life sciences. 2011 Aug; 54(8):763-9. doi: 10.1007/s11427-011-4203-9. [PMID: 21786199]
  • Simon Kaja, Jill D Hilgenberg, Volodymyr Rybalchenko, Wanda E Medina-Ortiz, Elaine V Gregg, Peter Koulen. Polycystin-2 expression and function in adult mouse lacrimal acinar cells. Investigative ophthalmology & visual science. 2011 Jul; 52(8):5605-11. doi: 10.1167/iovs.10-7114. [PMID: 21508103]
  • Chengju Tian, Chun Hong Shao, Caronda J Moore, Shelby Kutty, Timothy Walseth, Cyrus DeSouza, Keshore R Bidasee. Gain of function of cardiac ryanodine receptor in a rat model of type 1 diabetes. Cardiovascular research. 2011 Jul; 91(2):300-9. doi: 10.1093/cvr/cvr076. [PMID: 21421556]
  • Evangelia Pantazaka, Colin W Taylor. Differential distribution, clustering, and lateral diffusion of subtypes of the inositol 1,4,5-trisphosphate receptor. The Journal of biological chemistry. 2011 Jul; 286(26):23378-87. doi: 10.1074/jbc.m111.236372. [PMID: 21550988]