adenosine 5-phosphoramidate (BioDeep_00000005331)

   


代谢物信息卡片


adenosine 5-phosphoramidate

化学式: C10H15N6O6P (346.0791)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(lipidsearch) 43.33%

分子结构信息

SMILES: C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(N)O)O)O)N
InChI: InChI=1S/C10H15N6O6P/c11-8-5-9(14-2-13-8)16(3-15-5)10-7(18)6(17)4(22-10)1-21-23(12,19)20/h2-4,6-7,10,17-18H,1H2,(H2,11,13,14)(H3,12,19,20)/t4-,6-,7-,10-/m1/s1

描述信息

The phosphoramadite analogue of AMP.

同义名列表

1 个代谢物同义名

adenosine 5-phosphoramidate



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 BCL2, CCR2, CTNNB1, FHIT, HINT1, HINT2, HPGDS, MITF, PRKCI, PYGB, RAPGEF6, RUVBL2
Peripheral membrane protein 1 HSD17B6
Endoplasmic reticulum membrane 2 ACSL6, BCL2
Nucleus 9 BCL2, CTNNB1, FHIT, HINT1, MITF, PRKCI, RAD50, RUVBL2, USF2
cytosol 9 BCL2, CTNNB1, FHIT, HINT1, HPGDS, MITF, PRKCI, RAPGEF6, RUVBL2
dendrite 1 CCR2
centrosome 3 CTNNB1, RAPGEF6, RUVBL2
nucleoplasm 8 CTNNB1, HINT1, HPGDS, MITF, PRKCI, RAD50, RUVBL2, USF2
Cell membrane 3 CCR2, CTNNB1, RAPGEF6
lamellipodium 1 CTNNB1
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 1 CCR2
Synapse 1 CTNNB1
cell cortex 1 CTNNB1
cell junction 1 CTNNB1
glutamatergic synapse 2 CTNNB1, PRKCI
Golgi membrane 1 PRKCI
lysosomal membrane 1 MITF
neuronal cell body 1 CCR2
presynaptic membrane 1 CTNNB1
endosome 1 PRKCI
plasma membrane 7 ACSL6, CCR2, CTNNB1, FHIT, HINT1, PRKCI, RAPGEF6
Membrane 8 ACSL6, BCL2, CCR2, CTNNB1, PRKCI, PYGB, RAD50, RUVBL2
apical plasma membrane 2 PRKCI, RAPGEF6
basolateral plasma membrane 1 CTNNB1
brush border 1 PRKCI
extracellular exosome 5 CTNNB1, HINT1, PRKCI, PYGB, RUVBL2
Lysosome membrane 1 MITF
Lumenal side 1 HSD17B6
endoplasmic reticulum 3 ACSL6, BCL2, HSD17B6
perinuclear region of cytoplasm 2 CCR2, CTNNB1
Schaffer collateral - CA1 synapse 2 CTNNB1, PRKCI
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 2 CTNNB1, PRKCI
mitochondrion 3 BCL2, FHIT, HINT2
protein-containing complex 4 BCL2, CTNNB1, MITF, RAD50
intracellular membrane-bounded organelle 3 HPGDS, HSD17B6, USF2
Microsome membrane 2 ACSL6, HSD17B6
extracellular region 1 PYGB
Mitochondrion outer membrane 2 ACSL6, BCL2
Single-pass membrane protein 2 ACSL6, BCL2
mitochondrial outer membrane 3 ACSL6, BCL2, HINT2
mitochondrial matrix 1 HINT2
transcription regulator complex 1 CTNNB1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 CCR2
perikaryon 1 CCR2
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
microtubule cytoskeleton 1 PRKCI
Wnt signalosome 1 CTNNB1
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
postsynaptic membrane 1 CTNNB1
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 1 CTNNB1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
peroxisomal membrane 1 ACSL6
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
chromatin 2 MITF, USF2
cell leading edge 1 PRKCI
cell periphery 1 CTNNB1
Chromosome 1 RAD50
cytoskeleton 1 HINT1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
spindle pole 1 CTNNB1
Chromosome, telomere 1 RAD50
chromosome, telomeric region 1 RAD50
NuA4 histone acetyltransferase complex 1 RUVBL2
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
site of double-strand break 1 RAD50
intercellular bridge 1 PRKCI
fibrillar center 2 CCR2, FHIT
Endomembrane system 1 CTNNB1
euchromatin 2 CTNNB1, RUVBL2
myelin sheath 1 BCL2
Peroxisome membrane 1 ACSL6
MLL1 complex 1 RUVBL2
nuclear matrix 1 RUVBL2
histone deacetylase complex 1 HINT1
endocytic vesicle 1 RAPGEF6
Schmidt-Lanterman incisure 1 PRKCI
tight junction 1 PRKCI
beta-catenin-TCF complex 1 CTNNB1
Single-pass type III membrane protein 1 ACSL6
azurophil granule lumen 1 PYGB
Dynein axonemal particle 1 RUVBL2
condensed nuclear chromosome 1 RAD50
presynaptic active zone cytoplasmic component 1 CTNNB1
ribonucleoprotein complex 1 RUVBL2
protein folding chaperone complex 1 RUVBL2
RPAP3/R2TP/prefoldin-like complex 1 RUVBL2
protein-DNA complex 1 CTNNB1
nucleosome 1 RUVBL2
Swr1 complex 1 RUVBL2
catenin complex 1 CTNNB1
BRCA1-C complex 1 RAD50
chromosomal region 1 RAD50
Mre11 complex 1 RAD50
Ino80 complex 1 RUVBL2
BAD-BCL-2 complex 1 BCL2
beta-catenin-TCF7L2 complex 1 CTNNB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
PAR polarity complex 1 PRKCI
R2TP complex 1 RUVBL2


文献列表

  • Dilip K Tosh, Christopher M Brackett, Young-Hwan Jung, Zhan-Guo Gao, Monimoy Banerjee, Brian S J Blagg, Kenneth A Jacobson. Biological Evaluation of 5'-(N-Ethylcarboxamido)adenosine Analogues as Grp94-Selective Inhibitors. ACS medicinal chemistry letters. 2021 Mar; 12(3):373-379. doi: 10.1021/acsmedchemlett.0c00509. [PMID: 33738064]
  • Małgorzata Pietrowska-Borek, Katarzyna Nuc, Andrzej Guranowski. Exogenous adenosine 5'-phosphoramidate behaves as a signal molecule in plants; it augments metabolism of phenylpropanoids and salicylic acid in Arabidopsis thaliana seedlings. Plant physiology and biochemistry : PPB. 2015 Sep; 94(?):144-52. doi: 10.1016/j.plaphy.2015.05.013. [PMID: 26079287]
  • Andrzej Guranowski, Anna M Wojdyła, Anna M Rydzik, Janusz Stepiński, Jacek Jemielity. Plant nucleoside 5'-phosphoramidate hydrolase; simple purification from yellow lupin (Lupinus luteus) seeds and properties of homogeneous enzyme. Acta biochimica Polonica. 2011; 58(1):131-6. doi: . [PMID: 21403921]
  • Pawel Bieganowski, Preston N Garrison, Santosh C Hodawadekar, Gerard Faye, Larry D Barnes, Charles Brenner. Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. The Journal of biological chemistry. 2002 Mar; 277(13):10852-60. doi: 10.1074/jbc.m111480200. [PMID: 11805111]