1-Pyrroline-2-carboxylic acid (BioDeep_00000005240)

 

Secondary id: BioDeep_00001868844

human metabolite Endogenous natural product


代谢物信息卡片


3,4-dihydro-2H-pyrrol-1-ium-5-carboxylate

化学式: C5H7NO2 (113.0477)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(plant) 12.52%

分子结构信息

SMILES: C1CC(=NC1)C(=O)O
InChI: InChI=1S/C5H7NO2/c7-5(8)4-2-1-3-6-4/h1-3H2,(H,7,8)

描述信息

1-Pyrroline-2-carboxylic acid is a terminal product of D-proline metabolism. Specifically D-proline is converted to 1-Pyrroline-2-carboxylic acid via D-amino acid oxidase. This spontaneously breaks down to 2-oxo-5-amino-valerate. [HMDB]
1-Pyrroline-2-carboxylic acid is a terminal product of D-proline metabolism. Specifically D-proline is converted to 1-Pyrroline-2-carboxylic acid via D-amino acid oxidase. This spontaneously breaks down to 2-oxo-5-amino-valerate.

同义名列表

19 个代谢物同义名

3,4-dihydro-2H-pyrrol-1-ium-5-carboxylate; 4,5-dihydro-3H-pyrrol-1-ium-2-carboxylate; 3,4-Dihydro-2H-pyrrole-5-carboxylic acid; 3,4-Dihydro-2H-pyrrole-5-carboxylate; delta1-Pyrroline 2-carboxylic acid; delta1-Pyrroline-2-carboxylic acid; delta-1-Pyrroline-2-carboxylate; D1-Pyrroline 2-carboxylic acid; Δ1-Pyrroline-2-carboxylic acid; delta1-Pyrroline 2-carboxylate; Δ1-pyrroline 2-carboxylic acid; 1-Pyrroline 2-carboxylic acid; 1-Pyrroline-2-carboxylic acid; D1-Pyrroline 2-carboxylate; Δ1-pyrroline 2-carboxylate; 1-Pyrroline-2-carboxylate; 1-Pyrroline 2-carboxylate; 1,2-Didehydroproline; 1-Pyrroline-2-carboxylate



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

45 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(44)

PharmGKB(0)

25 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ARG1, BCL2, CTNNB1, DLK1, MTOR, OAT, PIK3CA, PYCR2, PYCR3
Peripheral membrane protein 1 MTOR
Endoplasmic reticulum membrane 2 BCL2, MTOR
Nucleus 5 ARG1, BCL2, CTNNB1, MTOR, PARP1
cytosol 9 ALDH4A1, ARG1, BCL2, CTNNB1, GLS, MTOR, PARP1, PIK3CA, PYCR3
dendrite 1 MTOR
nuclear body 1 PARP1
phagocytic vesicle 1 MTOR
centrosome 1 CTNNB1
nucleoplasm 6 CTNNB1, MTOR, OAT, PARP1, PRODH, PRODH2
Cell membrane 1 CTNNB1
Cytoplasmic side 1 MTOR
lamellipodium 2 CTNNB1, PIK3CA
Cytoplasmic granule 1 ARG1
Golgi apparatus membrane 1 MTOR
Synapse 2 CTNNB1, GLS
cell cortex 1 CTNNB1
cell junction 1 CTNNB1
glutamatergic synapse 1 CTNNB1
Golgi membrane 2 INS, MTOR
lysosomal membrane 1 MTOR
mitochondrial inner membrane 4 ALDH18A1, OTC, PRODH, PRODH2
presynaptic membrane 1 CTNNB1
Cytoplasm, cytosol 2 GLS, PARP1
Lysosome 1 MTOR
plasma membrane 2 CTNNB1, PIK3CA
Membrane 5 BCL2, CTNNB1, DLK1, MTOR, PARP1
basolateral plasma membrane 1 CTNNB1
extracellular exosome 2 CTNNB1, PEPD
Lysosome membrane 1 MTOR
endoplasmic reticulum 1 BCL2
extracellular space 3 ARG1, DLK1, INS
perinuclear region of cytoplasm 2 CTNNB1, PIK3CA
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
intercalated disc 1 PIK3CA
mitochondrion 11 ALDH18A1, ALDH4A1, BCL2, GLS, OAT, OTC, PARP1, PRODH, PRODH2, PYCR1, PYCR2
protein-containing complex 3 BCL2, CTNNB1, PARP1
intracellular membrane-bounded organelle 2 PRODH, PRODH2
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 1 INS
extracellular region 3 ARG1, ELN, INS
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 2 BCL2, DLK1
mitochondrial outer membrane 2 BCL2, MTOR
Mitochondrion matrix 2 OAT, OTC
mitochondrial matrix 8 ALDH4A1, GLS, OAT, OTC, PRODH, PRODH2, PYCR1, PYCR2
transcription regulator complex 2 CTNNB1, PARP1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
Secreted, extracellular space, extracellular matrix 1 ELN
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
nucleolus 1 PARP1
Wnt signalosome 1 CTNNB1
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
postsynaptic membrane 1 CTNNB1
Mitochondrion inner membrane 1 ALDH18A1
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 1 CTNNB1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
extracellular matrix 1 ELN
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 ELN
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
chromatin 1 PARP1
cell periphery 1 CTNNB1
mitotic spindle 1 PYCR3
Chromosome 1 PARP1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
[Isoform 1]: Mitochondrion 1 GLS
Nucleus, nucleolus 1 PARP1
spindle pole 1 CTNNB1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
site of double-strand break 1 PARP1
intercellular bridge 1 PYCR3
nuclear envelope 2 MTOR, PARP1
Endomembrane system 2 CTNNB1, MTOR
endosome lumen 1 INS
euchromatin 1 CTNNB1
myelin sheath 1 BCL2
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 ARG1
transport vesicle 1 INS
beta-catenin-TCF complex 1 CTNNB1
azurophil granule lumen 1 ARG1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
presynaptic active zone cytoplasmic component 1 CTNNB1
protein-DNA complex 2 CTNNB1, PARP1
[Isoform 3]: Mitochondrion 1 GLS
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CTNNB1
site of DNA damage 1 PARP1
[Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix 1 GLS
[Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix 1 GLS
elastic fiber 1 ELN
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
beta-catenin-TCF7L2 complex 1 CTNNB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Gavin M George, Margaretha J van der Merwe, Adriano Nunes-Nesi, Rolene Bauer, Alisdair R Fernie, Jens Kossmann, James R Lloyd. Virus-induced gene silencing of plastidial soluble inorganic pyrophosphatase impairs essential leaf anabolic pathways and reduces drought stress tolerance in Nicotiana benthamiana. Plant physiology. 2010 Sep; 154(1):55-66. doi: 10.1104/pp.110.157776. [PMID: 20605913]
  • Alessio Aprile, Anna M Mastrangelo, Anna M De Leonardis, Gabor Galiba, Enrica Roncaglia, Francesco Ferrari, Luigi De Bellis, Luana Turchi, Giovanni Giuliano, Luigi Cattivelli. Transcriptional profiling in response to terminal drought stress reveals differential responses along the wheat genome. BMC genomics. 2009 Jun; 10(?):279. doi: 10.1186/1471-2164-10-279. [PMID: 19552804]
  • . . . . doi: . [PMID: 18419821]